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1كتاب إلكتروني
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2
المؤلفون: James M. Trevillyan, Charles W. Hutchins, Thorsten Oost, Mike A. Stashko, Gang Liu, Tom Lubben, Cele Abad-Zapatero, Bruce G. Szczepankiewicz, Zhili Xin, Steve J. Ballaron, Philip J. Hajduk, Mike R Jirousek, Zhonghua Pei
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:1887-1890
مصطلحات موضوعية: Phosphoric monoester hydrolases, T-Lymphocytes, Clinical Biochemistry, Pharmaceutical Science, Protein tyrosine phosphatase, Crystallography, X-Ray, Ligands, Benzoates, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Catalytic Domain, Drug Discovery, Hydrolase, Combinatorial Chemistry Techniques, Enzyme Inhibitors, Phosphotyrosine, Molecular Biology, Protein Tyrosine Phosphatase, Non-Receptor Type 1, chemistry.chemical_classification, Binding Sites, Molecular Structure, biology, Organic Chemistry, Metabolism, Amides, In vitro, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Protein Tyrosine Phosphatases
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3
المؤلفون: Bradley A. Zinker, Stephen W. Fesik, Bruce G. Szczepankiewicz, Charles W. Hutchins, Heng Liang, Cele Abad-Zapatero, David A. Janowick, Amanda K Mika, James M. Trevillyan, Mike A. Stashko, Zhonghua Pei, Steve J. Ballaron, Zhili Xin, Philip J. Hajduk, Michael R. Jirousek, Gang Liu, Tom Lubben
المصدر: Journal of medicinal chemistry. 46(11)
مصطلحات موضوعية: Phosphotyrosine binding, Blood Glucose, Male, Models, Molecular, Magnetic Resonance Spectroscopy, Phenylalanine, Molecular Sequence Data, Administration, Oral, Biological Availability, Protein tyrosine phosphatase, Crystallography, X-Ray, Permeability, Mice, Structure-Activity Relationship, In vivo, Catalytic Domain, Drug Discovery, para-Aminobenzoates, Structure–activity relationship, Animals, Humans, Hypoglycemic Agents, Aminobenzoates, Amino Acid Sequence, Binding site, Enzyme Inhibitors, chemistry.chemical_classification, Protein Tyrosine Phosphatase, Non-Receptor Type 1, biology, Chemistry, Stereoisomerism, Rats, Enzyme, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Signal transduction, Caco-2 Cells, Protein Tyrosine Phosphatases, 4-Aminobenzoic Acid, hormones, hormone substitutes, and hormone antagonists