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المؤلفون: Sushovan Guha, Christopher R. Ireson, Enrique Rozengurt, Bharat B. Aggarwal, Sunil Krishnan, Juri Gelovani, James Sinnett-Smith, Yoichi Matsuo, Parmeswaran Diagaradjane, Dipen Maru, Muddasar Farooq, Alexandra Boakes, Caroline Foxton, Azadeh Bagherzadeh, Mark Charles, Tony Raynham, Rachel Sutherland, Stephen Jamieson, Lloyd Kelland, Bokyung Sung, Amit Deorukhkar, Zhimin Tong, Nobuo Ochi, Ajaikumar B. Kunnumakkara, Kuzhuvelil B. Harikumar
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab32f00e1cc289882edd000632bf0373
https://doi.org/10.1158/1535-7163.c.6531675.v1 -
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المؤلفون: Sushovan Guha, Christopher R. Ireson, Enrique Rozengurt, Bharat B. Aggarwal, Sunil Krishnan, Juri Gelovani, James Sinnett-Smith, Yoichi Matsuo, Parmeswaran Diagaradjane, Dipen Maru, Muddasar Farooq, Alexandra Boakes, Caroline Foxton, Azadeh Bagherzadeh, Mark Charles, Tony Raynham, Rachel Sutherland, Stephen Jamieson, Lloyd Kelland, Bokyung Sung, Amit Deorukhkar, Zhimin Tong, Nobuo Ochi, Ajaikumar B. Kunnumakkara, Kuzhuvelil B. Harikumar
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146fb75ff91e4ab866310a4198e944e7
https://doi.org/10.1158/1535-7163.22484955 -
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المؤلفون: Mar Jimenez Quesada, Ellen Catherine Macdonald, Allan M. Jordan, Caroline Foxton, Huib Ovaa, Pritom Shah, Elisabeth Trivier, Aurore Lejeune, Tony Raynham, Wouter H. Moolenaar, Muddasar Farooq, Martin Stockley, P.J. Owen, James R. Hitchin, Jana Skeete, Michelle Pritchard, Irene Farre Gutierrez, Hamish Ryder, Niall M. Hamilton, Andrew P. Turnbull, Anne Cheasty, Leon Pang, Alexandra Stowell, Susan M. Boyd
المصدر: Bioorganic and Medicinal Chemistry Letters, 26(22), 5403-5410
مصطلحات موضوعية: 0301 basic medicine, Pyridines, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Inflammation, Crystallography, X-Ray, Biochemistry, Mice, 03 medical and health sciences, 0302 clinical medicine, In vivo, Neoplasms, Drug Discovery, Hydrolase, medicine, Animals, Humans, Molecular Targeted Therapy, Enzyme Inhibitors, Molecular Biology, Cancer, biology, Phosphoric Diester Hydrolases, Chemistry, Zinc ion, Organic Chemistry, Active site, Lysophosphatidic acid (LPA), Autotaxin (ATX), Small molecule, Molecular Docking Simulation, 030104 developmental biology, Lysophospholipase, Lysophosphatidylcholine (LPC), 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, lipids (amino acids, peptides, and proteins), Lysophospholipids, medicine.symptom, Autotaxin
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a7b70a8962d8c311e0ac46deffdc0f8
https://hdl.handle.net/1887/111844 -
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المؤلفون: Hiroki Wada, Tony Raynham, Rebekah E. Beevers, Jeremy Major, Jess Taylor, Neil Grimster, David W. Walker, Parminder Kaur Ruprah, Svenja Burckhardt, Hannah Fiona Sore, James Nally, Alison Reid, Steven P. Langston, Andrew H. Henry, Helen J. Payne, Yvonne Ferguson, John C Reader, Eva Figueroa, Michael Shaw, Abid Masood, Nawaz Mohammed Khan, Valérie Reader, Lloyd J. Payne, Kerry Jenkins, Stephen Thompson, Ruth Adams, Matthew Stirling, Richard J. Boyce, Adam C. Talbot, Gilles Raphy, Jones Mark, Robert Judkins, James M. Cobb, Justine Y.Q. Lai
المصدر: Medicinal Research Reviews. 25:310-330
مصطلحات موضوعية: Pharmacology, Indoles, Kinase, Chemistry, High-throughput screening, Imidazoles, Naphthalenes, Isoquinolines, High-performance liquid chromatography, Combinatorial chemistry, Scavenger (chemistry), Serine, Pyrimidines, Purines, Drug Design, Drug Discovery, Molecular Medicine, Organic chemistry, Threonine, Kinase binding, Protein Kinase Inhibitors, Tyrosine kinase
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المؤلفون: Helen J. Payne, James M. Cobb, Justine Y.Q. Lai, Neil Grimster, Lloyd J. Payne, Tony Raynham, Nawaz Mohammed Khan, Jess Taylor
المصدر: Tetrahedron Letters. 43:7557-7560
مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Solid-phase synthesis, Chemistry, Yield (chemistry), Amide, Organic Chemistry, Drug Discovery, Biochemistry, Combinatorial chemistry, Linker, Alkyl
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المؤلفون: Darby G. Brooke, Graham J. Atwell, William A. Denny, Jack U. Flanagan, Daniel M. Heinrich, Tony Raynham, Stephen M. F. Jamieson, Elisabeth Trivier, Shevan Silva, Andrew P. Turnbull, Laurent Rigoreau
المصدر: Bioorganicmedicinal chemistry. 22(3)
مصطلحات موضوعية: Models, Molecular, Ketone, 3-Hydroxysteroid Dehydrogenases, Stereochemistry, Morpholines, Clinical Biochemistry, Pharmaceutical Science, Chemistry Techniques, Synthetic, Ring (chemistry), Crystallography, X-Ray, Biochemistry, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Catalytic Domain, Drug Discovery, Moiety, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Molecular Structure, Organic Chemistry, Aldo-Keto Reductase Family 1 Member C3, Active site, Hydrogen Bonding, Piperazine, chemistry, biology.protein, Hydroxyprostaglandin Dehydrogenases, Molecular Medicine, Oxyanion hole, Cyclo-oxygenase
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المؤلفون: Marianne Cardno, Sarah Burrage, Mark Bradley, Tony Raynham, Glyn Williams, Carl Allen, Vinay Swali, Jonathan W. Essex
المصدر: Scopus-Elsevier
مصطلحات موضوعية: Models, Molecular, chemistry.chemical_classification, Alanine, Magnetic Resonance Spectroscopy, Molecular Mimicry, Molecular Sequence Data, Organic Chemistry, Regioselectivity, Peptide, General Chemistry, Sulfides, Lantibiotics, Combinatorial chemistry, Mass Spectrometry, Catalysis, Anti-Bacterial Agents, chemistry.chemical_compound, Solid-phase synthesis, chemistry, Biomimetic synthesis, Stereoselectivity, Amino Acid Sequence, Peptides, Lanthionine, Cysteine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::165c863ed5ebbd78dd7375d384c82396
https://doi.org/10.1002/(sici)1521-3765(20000417)6:8<1455::aid-chem1455>3.0.co;2-m -
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المؤلفون: Tony Raynham, Sarah Burrage, Mark Bradley
المصدر: Tetrahedron Letters. 39:2831-2834
مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Chemistry, Dehydroalanine, Organic Chemistry, Drug Discovery, Organic chemistry, Biochemistry, Combinatorial chemistry, Amino acid
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المؤلفون: Shevan Silva, William A. Denny, Stephen M. F. Jamieson, Andrew P. Turnbull, Laurent Rigoreau, Tony Raynham, Elisabeth Trivier, Jack U. Flanagan, Daniel M. Heinrich
المصدر: European journal of medicinal chemistry. 62
مصطلحات موضوعية: Models, Molecular, 3-Hydroxysteroid Dehydrogenases, Stereochemistry, Reductase, Ring (chemistry), chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Humans, Carboxylate, Enzyme Inhibitors, Pharmacology, chemistry.chemical_classification, Aldo-keto reductase, Sulfonamides, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Aldo-Keto Reductase Family 1 Member C3, General Medicine, HCT116 Cells, Pyrrolidinones, Sulfonamide, Enzyme, chemistry, Biochemistry, Hydroxyprostaglandin Dehydrogenases, Oxyanion hole
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المؤلفون: Shevan Silva, Jack U. Flanagan, Daniel M. Heinrich, Ewald Schroeder, S.S. Samlal, P.J. Owen, Andrew P. Turnbull, Laurent Rigoreau, Tony Raynham, Emma J Hamilton, Darby G. Brooke, Christelle Soudy, Graham J. Atwell, William A. Denny, Elisabeth Trivier, Stephen M. F. Jamieson
المصدر: Journal of medicinal chemistry. 55(17)
مصطلحات موضوعية: chemistry.chemical_classification, Models, Molecular, 3-Hydroxysteroid Dehydrogenases, Chemistry, Stereochemistry, Aldo-Keto Reductase Family 1 Member C3, Benzoates, Sulfonamide, chemistry.chemical_compound, Structure-Activity Relationship, Enzyme, Biochemistry, Amide, Drug Discovery, Hydroxyprostaglandin Dehydrogenases, Molecular Medicine, Structure–activity relationship, Humans, Carboxylate, Hydroxysteroid dehydrogenase, Oxyanion hole, Enzyme Inhibitors, Benzoic acid
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