المؤلفون: Ashley C. Almarjawi, Kemi E. Wright, Brett D. Buist, John Cairney, Tony T. Ton, Bonnie J. Furzer

المصدر: Pediatric Exercise Science. :1-8

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health, Physical Therapy, Sports Therapy and Rehabilitation, Orthopedics and Sports Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f346d963c16903282e173b76009d80b1
https://doi.org/10.1123/pes.2022-0058

المؤلفون: Owens TD; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Brameld KA; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Verner EJ; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Ton T; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Li X; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Zhu J; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Masjedizadeh MR; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Bradshaw JM; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Hill RJ; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Tam D; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Bisconte A; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Kim EO; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Francesco M; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Xing Y; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Shu J; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Karr D; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., LaStant J; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Finkle D; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Loewenstein N; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Haberstock-Debic H; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Taylor MJ; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Nunn P; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Langrish CL; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States., Goldstein DM; Principia Biopharma, a Sanofi Company, 220 E Grand Ave, South San Francisco, California 94080, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Apr 14; Vol. 65 (7), pp. 5300-5316. Date of Electronic Publication: 2022 Mar 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/therapeutic use , Signal Transduction*, Agammaglobulinaemia Tyrosine Kinase ; Animals ; Dogs

المؤلفون: Brameld KA; Principia Biopharma, Inc. , 400 East Jamie Court, South San Francisco, California 94080, United States., Owens TD; Principia Biopharma, Inc. , 400 East Jamie Court, South San Francisco, California 94080, United States., Verner E; Principia Biopharma, Inc. , 400 East Jamie Court, South San Francisco, California 94080, United States., Venetsanakos E; Principia Biopharma, Inc. , 400 East Jamie Court, South San Francisco, California 94080, United States., Bradshaw JM; Principia Biopharma, Inc. , 400 East Jamie Court, South San Francisco, California 94080, United States., Phan VT; Principia Biopharma, Inc. , 400 East Jamie Court, South San Francisco, California 94080, United States., Tam D; Principia Biopharma, Inc. , 400 East Jamie Court, South San Francisco, California 94080, United States., Leung K; Principia Biopharma, Inc. , 400 East Jamie Court, South San Francisco, California 94080, United States., Shu J; Principia Biopharma, Inc. , 400 East Jamie Court, South San Francisco, California 94080, United States., LaStant J; Principia Biopharma, Inc. , 400 East Jamie Court, South San Francisco, California 94080, United States., Loughhead DG; Principia Biopharma, Inc. , 400 East Jamie Court, South San Francisco, California 94080, United States., Ton T; Principia Biopharma, Inc. , 400 East Jamie Court, South San Francisco, California 94080, United States., Karr DE; Principia Biopharma, Inc. , 400 East Jamie Court, South San Francisco, California 94080, United States., Gerritsen ME; Principia Biopharma, Inc. , 400 East Jamie Court, South San Francisco, California 94080, United States., Goldstein DM; Principia Biopharma, Inc. , 400 East Jamie Court, South San Francisco, California 94080, United States., Funk JO; Principia Biopharma, Inc. , 400 East Jamie Court, South San Francisco, California 94080, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2017 Aug 10; Vol. 60 (15), pp. 6516-6527. Date of Electronic Publication: 2017 Jul 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Neoplasms/*drug therapy , Pyridones/*pharmacology , Pyrimidines/*pharmacology , Receptors, Fibroblast Growth Factor/*antagonists & inhibitors, Animals ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacokinetics ; Cell Line, Tumor ; Dogs ; Drug Design ; Drug Stability ; Female ; Humans ; Intestinal Absorption ; Macaca fascicularis ; Male ; Pyridones/administration & dosage ; Pyridones/chemical synthesis ; Pyridones/pharmacokinetics ; Pyrimidines/administration & dosage ; Pyrimidines/chemical synthesis ; Pyrimidines/pharmacokinetics ; Rats, Sprague-Dawley ; Receptor, Fibroblast Growth Factor, Type 1/antagonists & inhibitors ; Receptor, Fibroblast Growth Factor, Type 2/antagonists & inhibitors ; Receptor, Fibroblast Growth Factor, Type 3/antagonists & inhibitors ; Receptor, Fibroblast Growth Factor, Type 4/antagonists & inhibitors ; Solubility ; Structure-Activity Relationship

المؤلفون: Bradshaw JM; Principia Biopharma, South San Francisco, California, USA., McFarland JM; Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California, San Francisco, California, USA., Paavilainen VO; Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California, San Francisco, California, USA., Bisconte A; Principia Biopharma, South San Francisco, California, USA., Tam D; Principia Biopharma, South San Francisco, California, USA., Phan VT; Principia Biopharma, South San Francisco, California, USA., Romanov S; Nanosyn Inc., Santa Clara, California, USA., Finkle D; Principia Biopharma, South San Francisco, California, USA., Shu J; Principia Biopharma, South San Francisco, California, USA., Patel V; Principia Biopharma, South San Francisco, California, USA., Ton T; Principia Biopharma, South San Francisco, California, USA., Li X; Principia Biopharma, South San Francisco, California, USA., Loughhead DG; Principia Biopharma, South San Francisco, California, USA., Nunn PA; Principia Biopharma, South San Francisco, California, USA., Karr DE; Principia Biopharma, South San Francisco, California, USA., Gerritsen ME; Principia Biopharma, South San Francisco, California, USA., Funk JO; Principia Biopharma, South San Francisco, California, USA., Owens TD; Principia Biopharma, South San Francisco, California, USA., Verner E; Principia Biopharma, South San Francisco, California, USA., Brameld KA; Principia Biopharma, South San Francisco, California, USA., Hill RJ; Principia Biopharma, South San Francisco, California, USA., Goldstein DM; Principia Biopharma, South San Francisco, California, USA., Taunton J; Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California, San Francisco, California, USA.

المصدر: Nature chemical biology [Nat Chem Biol] 2015 Jul; Vol. 11 (7), pp. 525-31. Date of Electronic Publication: 2015 May 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Acrylamides/*pharmacokinetics , B-Lymphocytes/*drug effects , Cyanoacrylates/*pharmacokinetics , Protein Kinase Inhibitors/*pharmacokinetics , Protein-Tyrosine Kinases/*antagonists & inhibitors, Acrylamides/chemical synthesis ; Agammaglobulinaemia Tyrosine Kinase ; Animals ; B-Lymphocytes/enzymology ; B-Lymphocytes/pathology ; Cell Line, Tumor ; Crystallography, X-Ray ; Cyanoacrylates/chemical synthesis ; Dasatinib ; Female ; Gene Expression ; Humans ; Ligands ; Molecular Docking Simulation ; Protein Kinase Inhibitors/chemical synthesis ; Protein Structure, Tertiary ; Protein-Tyrosine Kinases/chemistry ; Protein-Tyrosine Kinases/genetics ; Pyrimidines/pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Sf9 Cells ; Spodoptera ; Structure-Activity Relationship ; Substrate Specificity ; Thiazoles/pharmacokinetics ; Time Factors

المؤلفون: Leivers M; GlaxoSmithKline Research & Development , 5 Moore Drive, Research Triangle Park, North Carolina 27709, United States., Miller JF, Chan SA, Lauchli R, Liehr S, Mo W, Ton T, Turner EM, Youngman M, Falls JG, Long S, Mathis A, Walker J

المصدر: Journal of medicinal chemistry [J Med Chem] 2014 Mar 13; Vol. 57 (5), pp. 1964-75. Date of Electronic Publication: 2013 Nov 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents/*pharmacology , Enzyme Inhibitors/*pharmacology , Hepacivirus/*drug effects , Pyridazines/*pharmacology , Viral Nonstructural Proteins/*antagonists & inhibitors, Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacokinetics ; Dogs ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacokinetics ; Hepacivirus/enzymology ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Pyridazines/chemistry ; Pyridazines/pharmacokinetics ; Rats ; Structure-Activity Relationship

المؤلفون: Vijaykumar D; Celera, 180 Kimball Way, South San Francisco, CA 94979, USA. dvijayku@hotmail.com, Rai R, Shaghafi M, Ton T, Torkelson S, Leahy EM, Riggs JR, Hu H, Sprengeler PA, Shrader WD, O'Bryan C, Cabuslay R, Sanford E, Gjerstadt E, Liu L, Sukbuntherng J, Young WB

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Jul 15; Vol. 16 (14), pp. 3829-32. Date of Electronic Publication: 2006 May 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Anticoagulants/*chemical synthesis , Anticoagulants/*pharmacology , Factor VIIa/*antagonists & inhibitors , Thrombosis/*drug therapy, Administration, Oral ; Animals ; Biological Availability ; Rats ; Structure-Activity Relationship ; Thrombin/antagonists & inhibitors

المؤلفون: Rai R; Celera, 180 Kimball Way, South San Francisco, CA 94080, USA. roopa.rai@hotmail.com, Kolesnikov A, Sprengeler PA, Torkelson S, Ton T, Katz BA, Yu C, Hendrix J, Shrader WD, Stephens R, Cabuslay R, Sanford E, Young WB

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Apr 15; Vol. 16 (8), pp. 2270-3. Date of Electronic Publication: 2006 Feb 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Aminopyridines/*chemistry , Factor VIIa/*antagonists & inhibitors , Fibrinolytic Agents/*chemical synthesis , Heterocyclic Compounds/*chemical synthesis , Thromboplastin/*antagonists & inhibitors, Aminopyridines/pharmacology ; Binding Sites ; Crystallography, X-Ray ; Drug Design ; Fibrinolytic Agents/pharmacology ; Heterocyclic Compounds/pharmacology ; Humans ; Structure-Activity Relationship

المؤلفون: Shrader WD; Celera Genomics, 180 Kimball Way, South San Francisco, CA 94080, USA. bill.shrader@celera.com, Kolesnikov A, Burgess-Henry J, Rai R, Hendrix J, Hu H, Torkelson S, Ton T, Young WB, Katz BA, Yu C, Tang J, Cabuslay R, Sanford E, Janc JW, Sprengeler PA

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2006 Mar 15; Vol. 16 (6), pp. 1596-600. Date of Electronic Publication: 2006 Jan 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Factor VIIa/*antagonists & inhibitors, Binding Sites ; Factor Xa Inhibitors ; Humans ; Hydrogen Bonding ; Protein Binding ; Prothrombin/antagonists & inhibitors ; Structure-Activity Relationship ; Trypsin/metabolism