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1دورية أكاديمية
المؤلفون: Osamu Suzuki, Kiyoshi Mizukami, Maki Etori, Yoshitaka Sogawa, Nana Takagi, Hiroshi Tsuchida, Kiyoshi Morimoto, Taiji Goto, Toshiharu Yoshino, Tsuyoshi Mikkaichi, Kazuki Hirahara, Satoshi Nakamura, Hiroaki Maeda
المصدر: Journal of Pharmacological Sciences, Vol 123, Iss 3, Pp 219-226 (2013)
مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
Relation: http://www.sciencedirect.com/science/article/pii/S1347861319302440; https://doaj.org/toc/1347-8613
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2
المؤلفون: Satoshi Nakamura, Toshiharu Yoshino, Osamu Suzuki, Hiroaki Maeda, Taiji Goto
المصدر: Acta Pharmaceutica, Vol 65, Iss 2, Pp 191-197 (2015)
Acta Pharmaceutica
Volume 65
Issue 2مصطلحات موضوعية: Adult, Cyclopropanes, Lipopolysaccharides, Male, phosphodiesterase 4B, phosphodiesterase 4D, mononuclear cells, neutrophils, Cyclohexanecarboxylic Acids, Aminopyridines, Pharmaceutical Science, Pharmacology, Leukotriene B4, Peripheral blood mononuclear cell, PDE4B, Nitriles, medicine, Humans, Interleukin 8, Roflumilast, Pharmaceutical industry, Dose-Response Relationship, Drug, Tumor Necrosis Factor-alpha, Chemistry, Chemotaxis, phosphodiesterase 4d, Interleukin-8, Cilomilast, Phosphodiesterase, General Medicine, phosphodiesterase 4b, Cyclic Nucleotide Phosphodiesterases, Type 4, Benzamides, Leukocytes, Mononuclear, Female, Tumor necrosis factor alpha, Phosphodiesterase 4 Inhibitors, HD9665-9675, medicine.drug
وصف الملف: application/pdf
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3
المؤلفون: Mizuki Takahashi, Kiyoshi Mizukami, Maki Etori, Yoshida Kenichi, Osamu Suzuki, Taiji Goto, Hiroshi Tsuchida, Takeshi Murata, Tomomi Yoshitomi, Toshiharu Yoshino, Takanori Yamazaki, Akiko Shiina, Shigeki Sasaki, Nana Takagi, Hisashi Takahashi, Masato Tomii, Yoshitaka Sogawa, Naoki Nakao, Tsuyoshi Mikkaichi
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:893-899
مصطلحات موضوعية: Models, Molecular, Pyrimidine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Ring (chemistry), Biochemistry, Inhibitory Concentration 50, chemistry.chemical_compound, PDE4B, Drug Discovery, Side chain, Humans, Enzyme Inhibitors, Molecular Biology, IC50, Phenylacetates, chemistry.chemical_classification, Binding Sites, Molecular Structure, Drug discovery, Organic Chemistry, Cyclic S-Oxides, Enzyme, chemistry, Molecular Medicine, Phosphodiesterase 4 Inhibitors, Selectivity
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4
المؤلفون: Naoki Nakao, Mizuki Takahashi, Yoshitaka Sogawa, Taiji Goto, Osamu Suzuki, Akiko Shiina, Toshiharu Yoshino, Tsuyoshi Mikkaichi, Kazuki Hirahara, Kiyoshi Mizukami, Tomoko Takahashi, Shigeki Sasaki, Masashi Hasegawa
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:3325-3328
مصطلحات موضوعية: Lipopolysaccharides, Lung Diseases, Pyrimidine, Stereochemistry, Clinical Biochemistry, Anti-Inflammatory Agents, Benzeneacetamides, Pharmaceutical Science, Crystal structure, Crystallography, X-Ray, Biochemistry, Catalysis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Catalytic Domain, Drug Discovery, Splenocyte, Animals, Humans, PDE4 Inhibitors, Molecular Biology, IC50, Binding Sites, Bicyclic molecule, Tumor Necrosis Factor-alpha, Chemistry, Organic Chemistry, Cyclic Nucleotide Phosphodiesterases, Type 4, Cyclic S-Oxides, Pyrimidines, Molecular Medicine, Phosphodiesterase 4 Inhibitors, Spleen, Protein Binding
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5
المؤلفون: Kenji Yoshikawa, Toshiharu Yoshino, Makoto Takemura, Akiyoshi Mochizuki, Toshiharu Ohta, Tsutomu Nagata, Kouichi Uoto, Yoshihiro Yokomizo, Hiroyuki Naito, Katsuhiro Kawakami, Hideyuki Kanno, Makoto Suzuki
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:2133-2140
مصطلحات موضوعية: Models, Molecular, Serine Proteinase Inhibitors, Molecular model, medicine.drug_mechanism_of_action, Stereochemistry, Carboxylic acid, Clinical Biochemistry, Factor Xa Inhibitor, Substituent, Pharmaceutical Science, Ethylenediamine, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Structure–activity relationship, Moiety, Molecular Biology, chemistry.chemical_classification, Organic Chemistry, chemistry, Drug Design, Molecular Medicine, Factor Xa Inhibitors
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6
المؤلفون: Makoto Suzuki, Tsutomu Nagata, Hideyuki Kanno, Toshiharu Yoshino, Satoshi Komoriya, Toshiharu Ohta, Kenji Yoshikawa, Yumi Nakamoto, Shozo Kobayashi, Kengo Watanabe, Noriyasu Haginoya, Akiyoshi Mochizuki
المصدر: Bioorganic & Medicinal Chemistry. 17:8221-8233
مصطلحات موضوعية: medicine.drug_mechanism_of_action, Molecular model, Stereochemistry, medicine.drug_class, Antithrombin III, Clinical Biochemistry, Factor Xa Inhibitor, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Moiety, Molecular Biology, Cyclohexylamines, Binding Sites, Molecular Structure, Bicyclic molecule, Chemistry, Organic Chemistry, Anticoagulants, Drug Design, Lipophilicity, Molecular Medicine, Protein Binding
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7
المؤلفون: Samuel J. Danishefsky, Fay Ng, Toshiharu Yoshino
المصدر: Journal of the American Chemical Society. 128:14185-14191
مصطلحات موضوعية: Chemistry, Stereochemistry, Allene, Absolute configuration, Total synthesis, Stereoisomerism, General Chemistry, Biochemistry, Catalysis, Cycloaddition, Alkadienes, Lactones, chemistry.chemical_compound, Colloid and Surface Chemistry, Cyclization
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8
المؤلفون: Satoshi Komoriya, Yumiko Isobe, Akiyoshi Mochizuki, Noriyasu Haginoya, Haruhiko Horino, Makoto Suzuki, Masanori Suzuki, Tsutomu Nagata, Toshiharu Yoshino, Taketoshi Furugoori, Shozo Kobayashi, Takayasu Nagahara
المصدر: Bioorganic & Medicinal Chemistry. 13:3927-3954
مصطلحات موضوعية: Serine Proteinase Inhibitors, medicine.drug_mechanism_of_action, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Factor Xa Inhibitor, Administration, Oral, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Blood Coagulation, Molecular Biology, Active metabolite, Binding Sites, biology, Chemistry, Aryl, Organic Chemistry, Anticoagulants, Biological activity, Rats, Intestinal Absorption, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Blood Coagulation Tests, Lead compound, Factor Xa Inhibitors
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9
المؤلفون: Yasuyuki, Takeda, Toshiharu, Yoshino, Kouichi, Uoto, Jun, Chiba, Takashi, Ishiyama, Michio, Iwahana, Takeshi, Jimbo, Noriko, Tanaka, Hirofumi, Terasawa, Tsunehiko, Soga
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:185-190
مصطلحات موضوعية: Paclitaxel, Cell Survival, Organic Chemistry, Clinical Biochemistry, Melanoma, Experimental, Molecular Conformation, Pharmaceutical Science, Crystallography, X-Ray, Antineoplastic Agents, Phytogenic, Biochemistry, Mice, Solubility, Drug Discovery, Tumor Cells, Cultured, Animals, Humans, Molecular Medicine, Indicators and Reagents, Drug Screening Assays, Antitumor, Molecular Biology, Neoplasm Transplantation
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10
المؤلفون: Toshiharu Yoshino, Kouichi Uoto, Takeshi Jimbo, Shin Iimura, Satoru Ohsuki, Tsunehiko Soga, Jun Chiba, Michio Iwahana, Hirofumi Terasawa
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:407-410
مصطلحات موضوعية: Chemistry, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Analogue synthesis, Orally active, Docetaxel, Oral administration, In vivo, Drug Discovery, medicine, Molecular Medicine, Cytotoxicity, Molecular Biology, B16 melanoma, 10-deoxy-10-C-morpholinoethyl docetaxel, medicine.drug