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1
المؤلفون: Sho Sato, Andy Sykes, Stuart Stafford, Yoshihiko Tagawa, Rosa Fradley, Shyam Bechar, Eimear Howley, Tomoki Yoneyama, Toshal Patel, Toshiya Moriwaki, Satoru Asahi
المصدر: Pharmaceutical Research
مصطلحات موضوعية: D-Amino-Acid Oxidase, Male, Kinetics, D-amino acid oxidase, Pharmaceutical Science, PK/PD, multilayer quantitative model, Blood–brain barrier, Mice, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, medicine, Animals, Pharmacology (medical), 030304 developmental biology, TAK-831, Pharmacology, 0303 health sciences, Oxidase test, Dose-Response Relationship, Drug, Chemistry, Organic Chemistry, Brain, D-amino acid oxidase inhibitor, Quantitative model, Receptor–ligand kinetics, Mice, Inbred C57BL, medicine.anatomical_structure, Pharmacodynamics, Schizophrenia, Biophysics, Molecular Medicine, target occupancy, 030217 neurology & neurosurgery, Research Paper, Biotechnology
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2
المؤلفون: Tamara J. van Steeg, Akihiko Goto, Takeshi Wakabayashi, Toshiya Moriwaki, Yoshihiko Tagawa, Joost DeJongh, Yoshiyuki Furukawa, Sho Sato, Tetsuya Tsukamoto, Yuu Moriya, Satoru Asahi
المصدر: Biopharmaceutics & Drug Disposition. 38:373-380
مصطلحات موضوعية: Male, 0301 basic medicine, Physiologically based pharmacokinetic modelling, Repeated dosing, Pharmaceutical Science, Adipose tissue, Pharmacology, Body weight, Models, Biological, 030226 pharmacology & pharmacy, Rats, Sprague-Dawley, 03 medical and health sciences, Dogs, 0302 clinical medicine, Pharmacokinetics, Animals, Toxicokinetics, Computer Simulation, Pharmacology (medical), Chemistry, General Medicine, 030104 developmental biology, Adipose Tissue, Indenes, Biochemistry, Plasma concentration
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3
المؤلفون: Hideki Hirabayashi, Syunsuke Yamamoto, Yohei Kosugi, Toshiya Moriwaki
المصدر: Pharmaceutical research. 35(10)
مصطلحات موضوعية: Male, Swine, Pharmaceutical Science, Absorption (skin), Femoral artery, Pharmacology, Inhibitor of apoptosis, 030226 pharmacology & pharmacy, Intestinal absorption, Inhibitor of Apoptosis Proteins, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Oral administration, medicine.artery, Tetrahydroisoquinolines, medicine, Animals, Humans, Pharmacology (medical), ATP Binding Cassette Transporter, Subfamily B, Member 1, P-glycoprotein, Glycoproteins, biology, Chemistry, Organic Chemistry, Antagonist, Bioavailability, Rats, Intestinal Absorption, Food, 030220 oncology & carcinogenesis, Pyrazines, biology.protein, Molecular Medicine, Acridines, LLC-PK1 Cells, Oligopeptides, Biotechnology, Signal Transduction
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4
المؤلفون: Yasushi Fujioka, Teruaki Okuda, Hideki Hirabayashi, Yohei Kosugi, Toshiya Moriwaki, Tomoko Igari
المصدر: Xenobiotica. 44:336-344
مصطلحات موضوعية: Drug, Health, Toxicology and Mutagenesis, media_common.quotation_subject, Pharmacology, Biology, Toxicology, Risk Assessment, Biochemistry, Inhibitory Concentration 50, Pharmacokinetics, Drug Discovery, Humans, Drug Interactions, Enzyme Inhibitors, IC50, Cells, Cultured, media_common, Cryopreservation, Drug discovery, General Medicine, Recombinant Proteins, Kinetics, Blood, Area Under Curve, Hepatocytes, Cytokines, Risk assessment, Early phase, Drug metabolism, Human cytochrome
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5
المؤلفون: Hiroshi Sugimoto, Hideki Hirabayashi, Nobuyuki Amano, Toshiya Moriwaki
المصدر: Drug Metabolism and Disposition. 41:683-688
مصطلحات موضوعية: Loperamide, Digoxin, Swine, Tariquidar, Pharmaceutical Science, Pharmacology, Blood–brain barrier, IVIVC, medicine, Animals, Humans, Drug Interactions, ATP Binding Cassette Transporter, Subfamily B, Member 1, P-glycoprotein, biology, Chemistry, In vitro, medicine.anatomical_structure, Verapamil, Blood-Brain Barrier, Quinolines, biology.protein, LLC-PK1 Cells, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d64e8bf41313eddacbd6cbbb1f6bddd
https://doi.org/10.1124/dmd.112.049577 -
6
المؤلفون: Hitomi Yamasaki, Naohiro Kawaguchi, Junzo Takahashi, Satoru Asahi, Hideki Hirabayashi, Akio Morohashi, Masami Nonaka, Toshiya Moriwaki
المصدر: Xenobiotica; the fate of foreign compounds in biological systems. 47(12)
مصطلحات موضوعية: CYP2B6, Vonoprazan, Health, Toxicology and Mutagenesis, Metabolite, Biology, Pharmacology, Toxicology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Sulfation, Gastrointestinal Agents, Pyrroles, Sulfonamides, CYP3A4, Primary metabolite, General Medicine, Metabolism, In vitro, Cytochrome P-450 CYP2C19, chemistry, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology
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7
المؤلفون: Takahiro Kondo, Akio Morohashi, Ai Bernards, Satoru Asahi, Toshiya Moriwaki, Naohiro Kawaguchi, Masami Nonaka, Toshiyuki Takeuchi, Akifumi Kogame, Yoshihiko Tagawa, Hitomi Yamasaki
المصدر: Xenobiotica; the fate of foreign compounds in biological systems. 47(3)
مصطلحات موضوعية: Vonoprazan, Health, Toxicology and Mutagenesis, Metabolite, Potassium, chemistry.chemical_element, Pharmacology, Toxicology, 030226 pharmacology & pharmacy, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Feces, 0302 clinical medicine, Dogs, Pharmacokinetics, Oral administration, medicine, Animals, Bile, Pyrroles, Tissue Distribution, Sulfonamides, Stomach, Proton Pump Inhibitors, General Medicine, Metabolism, Rats, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Glucuronide
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8
المؤلفون: Satoru Asahi, Takuya Ebihara, Yoshihiko Tagawa, Yuu Moriya, Takahiro Kondo, Toshiyuki Takeuchi, Toshiya Moriwaki
المصدر: Drug research. 66(6)
مصطلحات موضوعية: Liver cytology, Estrone, 030204 cardiovascular system & hematology, Lapaquistat Acetate, 03 medical and health sciences, Squalene, chemistry.chemical_compound, 0302 clinical medicine, Piperidines, Cyclosporin a, Drug Discovery, medicine, Animals, Humans, Carbon Radioisotopes, Cells, Cultured, Farnesyl-diphosphate farnesyltransferase, biology, Transporter, General Medicine, Rats, Organic anion-transporting polypeptide, Oxazepines, medicine.anatomical_structure, Farnesyl-Diphosphate Farnesyltransferase, chemistry, Biochemistry, Liver, 030220 oncology & carcinogenesis, Hepatocyte, biology.protein, Cyclosporine, Hepatocytes
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ac747c175b1454b753ea3b44ad7f1c8
https://pubmed.ncbi.nlm.nih.gov/27011383 -
9
المؤلفون: Takuya Ebihara, Toshiya Moriwaki, Satoru Asahi, K. Teshima, Takahiro Kondo, Yoshihiko Tagawa
المصدر: Drug research. 66(6)
مصطلحات موضوعية: 0301 basic medicine, Male, Administration, Oral, 030204 cardiovascular system & hematology, Pharmacology, Lapaquistat Acetate, 03 medical and health sciences, Feces, 0302 clinical medicine, Dogs, Pharmacokinetics, Piperidines, Oral administration, Drug Discovery, Medicine, Animals, Bile, Tissue Distribution, Carbon Radioisotopes, Enzyme Inhibitors, Enterohepatic circulation, ADME, Gastric Absorption, business.industry, General Medicine, Bioavailability, Rats, Oxazepines, 030104 developmental biology, Farnesyl-Diphosphate Farnesyltransferase, Liver, Pharmacodynamics, Toxicity, Injections, Intravenous, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe2600391b697fd6d9d59027c9ab6d9
https://pubmed.ncbi.nlm.nih.gov/26839207 -
10
المؤلفون: Muneto Mogi, Yuka Ikegami, Klaus Urbahns, Masaomi Tajimi, Takeshi Yura, Marumo Makiko, David Madge, Noriyuki Yamamoto, Kayo Yasoshima, Tsutomu Masuda, Jang Bahadur Gupta, Nagahiro Yoshida, Fiona Chan, Hiroshi Fujishima, Toshiya Moriwaki
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3408-3411
مصطلحات موضوعية: Eudysmic ratio, Chemistry, Organic Chemistry, Clinical Biochemistry, Antagonist, TRPV1, Administration, Oral, Biological Availability, TRPV Cation Channels, Pharmaceutical Science, Naphthols, Pharmacology, Biochemistry, Rats, Bioavailability, Rats, Sprague-Dawley, Sprague dawley, Drug Discovery, Animals, Molecular Medicine, Potency, Enantiomer, Receptor, Molecular Biology