المؤلفون: Charlene Bashore, Sumit Prakash, Matthew C. Johnson, Ryan J. Conrad, Ivy A. Kekessie, Suzie J. Scales, Noriko Ishisoko, Tracy Kleinheinz, Peter S. Liu, Nataliya Popovych, Aaron T. Wecksler, Lijuan Zhou, Christine Tam, Inna Zilberleyb, Rajini Srinivasan, Robert A. Blake, Aimin Song, Steven T. Staben, Yingnan Zhang, David Arnott, Wayne J. Fairbrother, Scott A. Foster, Ingrid E. Wertz, Claudio Ciferri, Erin C. Dueber

المصدر: Nature Chemical Biology. 19:55-63

مصطلحات موضوعية: Ligases, Proteasome Endopeptidase Complex, Ubiquitin-Protein Ligases, Cryoelectron Microscopy, Proteolysis, Nuclear Proteins, Cell Biology, Molecular Biology, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cffe718a8e978d9932a3400ef0703fa
https://doi.org/10.1038/s41589-022-01218-w

المؤلفون: Christopher McBride, Lynnie Trzoss, Davide Povero, Milos Lazic, Geza Ambrus-Aikelin, Angelina Santini, Rama Pranadinata, Gretchen Bain, Ryan Stansfield, Jeffrey A. Stafford, James Veal, Ryan Takahashi, Justin Ly, Shu Chen, Liling Liu, Marika Nespi, Robert Blake, Arna Katewa, Tracy Kleinheinz, Swathi Sujatha-Bhaskar, Nandhini Ramamoorthi, Jessica Sims, Brent McKenzie, Mark Chen, Mark Ultsch, Matthew Johnson, Jeremy Murray, Claudio Ciferri, Steven T. Staben, Michael J. Townsend, Craig E. Stivala

المصدر: Journal of Medicinal Chemistry. 65:14721-14739

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::44ab527cf94dae143f3c4497446ed964
https://doi.org/10.1021/acs.jmedchem.2c01250

المؤلفون: Peter S. Dragovich, Mingtao He, Leanna Staben, Hongyan Zhang, Melinda M. Mulvihill, Catherine Wilson, Hao Zhou, Tracy Kleinheinz, Binqing Wei, Jianfeng Xin, Nicole Blaquiere, Fanwei Meng, John S. Wai, Susan Kaufman, Liang Liu, Rebecca K. Rowntree, Steven T. Staben, Jing Wang, Katherine R. Kozak, Josefa dela Cruz-Chuh, Zijin Xu, Steven J. Hartman, Robert A. Blake, Xiaoyu Zhu, Sunil Bhakta, Donglu Zhang, Hui Yao, Aimee O'Donohue, Jack Sadowsky, Qi Liu, Pragya Adhikari, Liling Liu, Ying Lu, Thomas H. Pillow, Jinhua Chen, Emel Adaligil, Karen E. Gascoigne

المصدر: Journal of Medicinal Chemistry. 64:2534-2575

مصطلحات موضوعية: BRD4, Immunoconjugates, medicine.drug_class, Cell Cycle Proteins, Monoclonal antibody, 01 natural sciences, 03 medical and health sciences, Ubiquitin, Antigen, Antigens, Neoplasm, In vivo, Drug Discovery, LNCaP, medicine, Humans, Cell Proliferation, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Antibodies, Monoclonal, Dipeptides, 0104 chemical sciences, Cell biology, 010404 medicinal & biomolecular chemistry, Von Hippel-Lindau Tumor Suppressor Protein, PC-3 Cells, Proteolysis, biology.protein, Molecular Medicine, Oxidoreductases, Heterocyclic Compounds, 3-Ring, Linker, Intracellular, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eaea12dee6f95904b15f4c9e925d0b1
https://doi.org/10.1021/acs.jmedchem.0c01845

المؤلفون: Kuen Yeap, John S. Wai, Maia Vinogradova, Yu Zhong, Lori Friedman, Xiaojing Wang, Daniel Otwine, Jiangpeng Liao, Nick Ray, James R. Kiefer, Vidhi Mody, Jun Li, Fabien Roussel, Deepak Sampath, Simon Charles Goodacre, Jun Liang, Michelle Nannini, Sharada Labadie, Xiaoping Zheng, Ellen Ingalla, Steven J. Hartman, Birong Zhang, Jae H. Chang, Tao Wang, Yingqing Ran, Jason R. Zbieg, Amy Sambrone, Kwong Wah Lai, Amy Young, Ciara Metcalfe, Neville James Mclean, Robert A. Blake, Tracy Kleinheinz

المصدر: ACS Med Chem Lett

مصطلحات موضوعية: Fulvestrant, 010405 organic chemistry, Chemistry, Organic Chemistry, Azetidine, Uterus, Antagonist, Estrogen receptor, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Breast cancer, medicine.anatomical_structure, Drug Discovery, medicine, Cancer research, Estrogen receptor alpha, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe42f6062f9f361a3f700a527fd2a8dc
https://doi.org/10.1021/acsmedchemlett.0c00224

المؤلفون: Martin O'Rourke, Nicholas Charles Ray, Thomas Gelzleichter, Leah Schutt, Ellen Ingalla, Neville James Mclean, Xiaojing Wang, Stephen Daly, Yingqing Ran, Jiangpeng Liao, Tommy Lai, Yu Zhong, Jun Liang, Sharada Labadie, Lori Friedman, Amy Sambrone, Jun Li, Robert A. Blake, Tao Wang, Liu Zhiguo, Birong Zhang, Steven J. Hartman, Jae H. Chang, Wei Zhou, Jane Guan, Vidhi Mody, Jonathan White, Fabien Roussel, Antonio G. DiPasquale, Jason R. Zbieg, Daniel F. Ortwine, Amy Young, James R. Kiefer, Maia Vinogradova, Simon Charles Goodacre, Deepak Sampath, Tracy Kleinheinz, Xiaoping Zheng, Jennifer M. Giltnane, Lorn Kategaya, Ingrid E. Wertz, Matthew Gill, Ciara Metcalfe, Siew Kuen Yeap, John S. Wai, Jason Oeh, Michelle Nannini

المصدر: Journal of medicinal chemistry. 64(16)

مصطلحات موضوعية: Phases of clinical research, Estrogen receptor, Antineoplastic Agents, Breast Neoplasms, Mice, Structure-Activity Relationship, Breast cancer, Dogs, In vivo, Drug Discovery, medicine, Animals, Humans, Dosing, Molecular Structure, Chemistry, Antagonist, Estrogen Receptor alpha, medicine.disease, Xenograft Model Antitumor Assays, In vitro, Rats, Macaca fascicularis, Cell culture, Cancer research, MCF-7 Cells, Molecular Medicine, Female, Estrogen Receptor Antagonists, Carbolines

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee86fe3f8068fbb2ff9647a59eadb710
https://pubmed.ncbi.nlm.nih.gov/34251202

المؤلفون: Steven J. Hartman, Ying Lu, Wentao Wei, Hao Zhou, Geoffrey Del Rosario, Robert A. Blake, Xiaoyu Zhu, Nicholas Corr, Aaron Fullerton, Shang-Fan Yu, Peter S. Dragovich, Jing Wang, Rebecca K. Rowntree, Donglu Zhang, Hui Yao, Emel Adaligil, Fan Jiang, Hongyan Zhang, Jack Sadowsky, John S. Wai, Jinhua Chen, Thomas H. Pillow, Susan Kaufman, Zijin Xu, Katherine R. Kozak, Jeremy Murray, Shenhua Zhang, Leanna Staben, Josefa dela Cruz-Chuh, Pragya Adhikari, Aimee O'Donohue, Tracy Kleinheinz, Liling Liu, Melinda M. Mulvihill, William S. Sawyer, Yongxin Zhao, Binqing Wei

المصدر: Journal of medicinal chemistry. 64(5)

مصطلحات موضوعية: BRD4, Immunoconjugates, Antineoplastic Agents, Cell Cycle Proteins, Mice, SCID, 01 natural sciences, 03 medical and health sciences, Mouse xenograft, Ubiquitin, In vivo, Antigens, Neoplasm, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, 030304 developmental biology, Cell Proliferation, 0303 health sciences, biology, Chemistry, Antibodies, Monoclonal, Dipeptides, Xenograft Model Antitumor Assays, In vitro, 0104 chemical sciences, Cell biology, 010404 medicinal & biomolecular chemistry, Proteasome, Von Hippel-Lindau Tumor Suppressor Protein, Proteolysis, biology.protein, Molecular Medicine, Female, Antibody, Oxidoreductases, Heterocyclic Compounds, 3-Ring, Conjugate, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519ca8bb4de4ed4b24ce14fe281e518e
https://pubmed.ncbi.nlm.nih.gov/33596073

المؤلفون: Mingtao He, Chun Sing Li, Yongxin Zhao, Deepak Sampath, Leanna Staben, Ingrid E. Wertz, Hao Zhou, Rebecca K. Rowntree, Ellen Ingalla, Xinxin Wang, Richard Zang, Ying Lu, Qi Liu, Jiawei Lu, Gail Lewis Phillips, Binqing Wei, Fanwei Meng, Nicole Blaquiere, Yun-Xing Cheng, Steven T. Staben, Keyang Xu, Jinping Han, Tommy Lai, Kaishan Peng, Kunpeng Wan, Peter S. Dragovich, Lingyao Meng, Tracy Kleinheinz, Jinhua Chen, Amrita V. Kamath, John S. Wai, Carl Ng, Pragya Adhikari, Steven J. Hartman, Jianfeng Xin, Jintang He, Douglas D. Leipold, Thomas H. Pillow, Donglu Zhang, Hui Yao, Jack Sadowsky, Robert A. Blake, Willem den Besten

المصدر: Bioorganicmedicinal chemistry letters. 30(4)

مصطلحات موضوعية: Immunoconjugates, medicine.drug_class, Receptor, ErbB-2, Clinical Biochemistry, Pharmaceutical Science, Estrogen receptor, Antineoplastic Agents, Monoclonal antibody, 01 natural sciences, Biochemistry, In vivo, Drug Discovery, medicine, Humans, Molecular Biology, Drug Carriers, 010405 organic chemistry, Chemistry, Organic Chemistry, Estrogen Receptor alpha, Antibodies, Monoclonal, Fusion protein, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Drug Design, Drug delivery, Proteolysis, MCF-7 Cells, Molecular Medicine, Estrogen receptor alpha, Linker, Intracellular

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b430d3962bed89cedef999868cf940f
https://pubmed.ncbi.nlm.nih.gov/31902710

المؤلفون: Kuen Yeap, Birong Zhang, Jae H. Chang, Lori Friedman, Nick Ray, Jiangpeng Liao, Xiaojing Wang, Amy Sambrone, Jun Li, Yu Zhong, Ellen Ingalla, Jason R. Zbieg, Daniel F. Ortwine, Vidhi Mody, John S. Wai, Tao Wang, Maia Vinogradova, Sharada Labadie, Steven J. Hartman, Tracy Kleinheinz, Nev McLean, Tommy Lai, Simon Charles Goodacre, Deepak Sampath, Jun Liang, Fabien Roussel, James R. Kiefer, Ciara Metcalfe, Xiaoping Zheng, Yingqing Ran, Michelle Nannini, Robert A. Blake

المصدر: Bioorganic & Medicinal Chemistry Letters. 50:128335

مصطلحات موضوعية: Drug, Protein Conformation, media_common.quotation_subject, Clinical Biochemistry, Pharmaceutical Science, Estrogen receptor, Antineoplastic Agents, Breast Neoplasms, Pharmacology, Biochemistry, Mice, Route of administration, Breast cancer, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Molecular Biology, media_common, Dose-Response Relationship, Drug, Molecular Structure, Fulvestrant, Chemistry, Organic Chemistry, Antagonist, medicine.disease, Xenograft Model Antitumor Assays, Bioavailability, Receptors, Estrogen, MCF-7 Cells, Molecular Medicine, Female, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4ca868520e02822732a1114f5f125c
https://doi.org/10.1016/j.bmcl.2021.128335

المؤلفون: William F. Forrest, Sumit Prakash, Vickie Tsui, Adam R. Renslo, Richard Pastor, Christiaan Klijn, Frank Peale, Mark McCleland, Lorna Kategaya, Carsten Schwerdtfeger, Zachary Stiffler, Matthias Trost, Frederick Cohen, Priyadarshini Jaishankar, Kevin R Clark, Paola Di Lello, Bradley B. Brasher, Florian Gnad, Michael C. M. Kwok, Johanna Heideker, Jeremy Murray, Jason Drummond, Xiaojing Wang, Maria Stella Ritorto, Till Maurer, Maureen Beresini, Matthew T. Chang, James A. Ernst, Taylur P. Ma, Robert A. Blake, Elizabeth Blackwood, Dario R. Alessi, Michelle R. Arkin, Lionel Rouge, Kebing Yu, Brian R. Hearn, Travis W. Bainbridge, Eva Lin, Tracy Kleinheinz, Yinyan Tang, Chudi Ndubaku, Scott E. Martin, John-Paul Upton, Ingrid E. Wertz

المصدر: Nature. 550:534-538

مصطلحات موضوعية: 0301 basic medicine, Multidisciplinary, biology, Ubiquitin binding, Plasma protein binding, Ubiquitin-conjugating enzyme, Small molecule, Ubiquitin ligase, Deubiquitinating enzyme, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Biochemistry, Proteasome, Ubiquitin, 030220 oncology & carcinogenesis, biology.protein

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2cc98dd9db2eb6f51008b4a3df458a39
https://doi.org/10.1038/nature24006

المؤلفون: Lorna Kategaya, Paola Di Lello, Lionel Rougé, Richard Pastor, Kevin R. Clark, Jason Drummond, Tracy Kleinheinz, Eva Lin, John-Paul Upton, Sumit Prakash, Johanna Heideker, Mark McCleland, M

المصدر: Nature, Nature. 550(7677):534-538

الإتاحة: https://ideas.repec.org/a/nat/nature/v550y2017i7677d10.1038_nature24006.html