يعرض 1 - 10 نتائج من 11 نتيجة بحث عن '"Tristan Gallenne"', وقت الاستعلام: 0.91s تنقيح النتائج
  1. 1
    Abstract 952: The bispecific antibody MCLA-129 impairs NSCLC tumor growth by targeting EGFR and c-MET, inhibiting ligand-induced signaling and promoting ADCC and ADCP

    المؤلفون: Qingyu Shu, Liang Deng, Rinse Klooster, Wenxin Xu, Cecile Geuijen, John de Kruif, Li Mao, Wei Liu, Martijn van Rosmalen, Mark Throsby, Tristan Gallenne, David J. de Gorter, Mario Di Matteo, Alexandre Deshiere, Christian Wohn, Massimiliano Mazzone, Berina Eppink

    المصدر: Cancer Research. 81:952-952

    مصطلحات موضوعية: Antibody-dependent cell-mediated cytotoxicity, Cancer Research, C-Met, biology, Cancer, medicine.disease, Receptor tyrosine kinase, chemistry.chemical_compound, T790M, Oncology, chemistry, Cancer cell, medicine, biology.protein, Cancer research, Erlotinib, Antibody, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::02db516a6d3a502f8247e3d00df0acc7
    https://doi.org/10.1158/1538-7445.am2021-952

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  2. 2
    Abstract 957: Zenocutuzumab: An antibody that can overcome HER3 mediated HRG signalling in tumor cells by docking on HER2

    المؤلفون: Linda Johanna Aleida Hendriks, John de Kruif, Tristan Gallenne, David Andre Baptiste Maussang-Detaille, Jan P. Gerlach, Mark Throsby, Cecile Geuijen, Arjen Kramer

    المصدر: Cancer Research. 81:957-957

    مصطلحات موضوعية: Cancer Research, biology, Kinase, medicine.drug_class, Chemistry, Cancer, medicine.disease, Monoclonal antibody, body regions, Oncology, Pancreatic cancer, Cancer research, medicine, biology.protein, Avidity, Antibody, skin and connective tissue diseases, Protein kinase B, PI3K/AKT/mTOR pathway

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1870ef6a23712987a502e0c5dd841105
    https://doi.org/10.1158/1538-7445.am2021-957

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  3. 3
    Abstract LB-C07: Preclinical evaluation of MCLA-129: A bispecific antibody targeting c-MET and EGFR

    المؤلفون: John dekruif, Rinse Klooster, Therese Visser, Mario Di Matteo, Willem Bartelink, Cecile Geuijen, Sarah Trusso Cafarello, Tristan Gallenne, Berina Eppink, Mark Throsby, Carina Bartelink-Clements, Roy Nijhuis, Massimiliano Mazzone

    المصدر: Molecular Cancer Therapeutics. 18:LB-C07

    مصطلحات موضوعية: Antibody-dependent cell-mediated cytotoxicity, Cancer Research, C-Met, Cetuximab, biology, business.industry, chemistry.chemical_compound, Gefitinib, Oncology, chemistry, In vivo, Cancer research, medicine, biology.protein, Erlotinib, Antibody, business, Tyrosine kinase, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::44726f0e30edb38b62556335f9242771
    https://doi.org/10.1158/1535-7163.targ-19-lb-c07

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  4. 4
    Identification of a pharmacologically tractable Fra-1/ADORA2B axis promoting breast cancer metastasis

    المؤلفون: Fabien Reyal, Marjon A. Smit, Jamila Laoukili, Sedef Iskit, Thomas R. Geiger, Alexandre Prieur, Ben S. Wittner, Bastiaan Evers, Boris Rodenko, Wilbert Zwart, Tristan Gallenne, Martin H. van Vliet, Hugo M. Horlings, Christophe Desmet, Lodewyk F. A. Wessels, Daniel S. Peeper, Abderrahrim Ajouaou, Nils L. Visser, John Zevenhoven, Sridhar Ramaswamy

    المصدر: Proceedings of the National Academy of Sciences. 110:5139-5144

    مصطلحات موضوعية: CA15-3, Transplantation, Heterologous, Mice, Nude, Breast Neoplasms, Biology, Receptor, Adenosine A2B, Metastasis, Mice, Breast cancer, RNA interference, Cell Line, Tumor, medicine, Animals, Humans, Gene silencing, Neoplasm Invasiveness, Pseudopodia, Neoplasm Metastasis, Transcription factor, Mice, Inbred BALB C, Multidisciplinary, medicine.disease, Xenograft Model Antitumor Assays, Metastatic breast cancer, Adenosine A2 Receptor Antagonists, Rats, Gene Expression Regulation, Neoplastic, Cancer cell, Immunology, Cancer research, Female, Proto-Oncogene Proteins c-fos, Neoplasm Transplantation

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b944ca6c04f2f3ce2ffb52ece6a510b8
    https://doi.org/10.1073/pnas.1222085110

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  5. 5
    Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members

    المؤلفون: John A. Hickman, Olivier Geneste, Stéphen Manon, Philippe Juin, Belinda Noël, Pierre-François Cartron, Tristan Gallenne, Eric Hervouet, François M. Vallette, Lisa Oliver, Fabien Gautier

    المصدر: Journal of Cell Biology. 185:279-290

    مصطلحات موضوعية: biology, Bcl-2 family, Cell Biology, Plasma protein binding, biology.organism_classification, Cell biology, Biphenyl compound, Bcl-2-associated X protein, Apoptosis, RNA interference, hemic and lymphatic diseases, Puma, biology.protein, Cancer research, BCL-2 Gene Family, biological phenomena, cell phenomena, and immunity

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9e9c28f19360dddee34318bdc482dadd
    https://doi.org/10.1083/jcb.200809153

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  6. 6
    The Small Organic Compound HA14-1 Prevents Bcl-2 Interaction with Bax to Sensitize Malignant Glioma Cells to Induction of Cell Death

    المؤلفون: Florence Manero, René Grée, François M. Vallette, Fabien Gautier, Danielle Gree, Olivier Geneste, Pierre-François Cartron, Philippe Juin, Tristan Gallenne, Nicolas Cauquil

    المصدر: Cancer Research. 66:2757-2764

    مصطلحات موضوعية: Cancer Research, Programmed cell death, Molecular Sequence Data, Mice, Nude, Apoptosis, Stimulation, Biology, Mice, In vivo, Glioma, Antineoplastic Combined Chemotherapy Protocols, Nitriles, medicine, Animals, Humans, Cytotoxic T cell, Benzopyrans, Amino Acid Sequence, Etoposide, bcl-2-Associated X Protein, Drug Synergism, medicine.disease, Combined Modality Therapy, Xenograft Model Antitumor Assays, In vitro, Proto-Oncogene Proteins c-bcl-2, Oncology, Cancer cell, Cancer research, Female, Glioblastoma, DNA Damage

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba85fa195358052a171981b899faedd
    https://doi.org/10.1158/0008-5472.can-05-2097

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  7. 7
    Abstract 33: The binding mode of the bispecific anti-HER2xHER3 antibody MCLA-128 is responsible for its potent inhibition of HRG-driven tumorigenesis

    المؤلفون: Ton Logtenberg, Camilla De Nardis, Mark Throsby, Lex Bakker, Cecile Geuijen, Eric Rovers, John de Kruif, Robert Doornbos, Piet Gros, Carina Bartelink-Clements, David Andre Baptiste Maussang-Detaille, Linda Johanna Aleida Hendriks, Tristan Gallenne

    المصدر: Cancer Research. 77:33-33

    مصطلحات موضوعية: Cancer Research, Biodistribution, biology, medicine.drug_class, Chemistry, Alanine scanning, Monoclonal antibody, medicine.disease_cause, Molecular biology, Epitope, In vitro, Oncology, In vivo, medicine, biology.protein, Antibody, skin and connective tissue diseases, Carcinogenesis

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d70c6a05d8eeeb50ed0c9ea3212800b9
    https://doi.org/10.1158/1538-7445.am2017-33

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  8. 8
    Abstract LB-261: Mechanism of action of MCLA-128, a humanized bispecific IgG1 antibody targeting the HER2:HER3 heterodimer

    المؤلفون: Cecile Geuijen, Nellie Nieuwenhuizen, John de Kruif, Arjen Kramer, Katinka van Zoest, Willem Bartelink, Rob Roovers, Vanessa Zondag-van der Zande, Mark Throsby, Leo S. Price, Renate den Blanken-Smit, David Andre Baptiste Maussang-Detaille, Linda Kaldenberg, Therese Visser, Lex Bakker, Tristan Gallenne, Eric Rovers, Setareh van Driel, Robert Doornbos, Pieter-Fokko van Loo, Ton Logtenberg, Roy Nijhuis, Stefan R. Braam, Carina Clements

    المصدر: Cancer Research. 75:LB-261

    مصطلحات موضوعية: Antibody-dependent cell-mediated cytotoxicity, Cancer Research, medicine.drug_class, Cell growth, Biology, Monoclonal antibody, Molecular biology, chemistry.chemical_compound, Oncology, chemistry, medicine, Pertuzumab, Growth inhibition, skin and connective tissue diseases, Protein kinase B, Tyrosine kinase, PI3K/AKT/mTOR pathway, medicine.drug

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8e4ddd222a9fec86a3788cee73ea3cb8
    https://doi.org/10.1158/1538-7445.am2015-lb-261

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  9. 9
    The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA

    المؤلفون: Fabien Gautier, Philippe Juin, Florence Manero, Khaled Meflah, Tristan Gallenne, Patricia Vusio, Pierre-François Cartron, François M. Vallette, Gwenola Bougras

    المساهمون: JUIN, Philippe Paul, Recherches en cancérologie, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), IFR26, Ligue Départementale de Lutte contre le Cancer du Comité de Montbéliard (Doubs), Ligue Nationale contre le Cancer, Association pour la Recherche contre le Cancer no. 4715, Association pour la Recherche contre le Cancer no. 4772

    المصدر: Molecular Cell
    Molecular Cell, Cell Press, 2004, 16, pp.807-818. ⟨10.1016/j.molcel.2004.10.028⟩

    مصطلحات موضوعية: Time Factors, Protein Conformation, Peptide, Apoptosis, Bioinformatics, medicine.disease_cause, Ligands, Protein Structure, Secondary, Puma, [SDV.BBM.BC] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], bcl-2-Associated X Protein, chemistry.chemical_classification, Mutation, biology, Ligand (biochemistry), Recombinant Proteins, Cell biology, Mitochondria, Protein Transport, Proto-Oncogene Proteins c-bcl-2, biological phenomena, cell phenomena, and immunity, BH3 Interacting Domain Death Agonist Protein, Plasmids, Protein Binding, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Cell Line, [SDV.CAN] Life Sciences [q-bio]/Cancer, BH3 peptide, Proto-Oncogene Proteins, Two-Hybrid System Techniques, medicine, Humans, Immunoprecipitation, [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biochemistry [q-bio.BM], [SDV.BC] Life Sciences [q-bio]/Cellular Biology, Molecular Biology, Cell-Free System, Dose-Response Relationship, Drug, Cell Biology, Surface Plasmon Resonance, biology.organism_classification, Bh3 only, Protein Structure, Tertiary, chemistry, Microscopy, Fluorescence, Helix, Tumor Suppressor Protein p53, Apoptosis Regulatory Proteins, Carrier Proteins, Peptides, Function (biology)

    وصف الملف: application/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a30855175855d7831f34cb566c740b0
    https://pubmed.ncbi.nlm.nih.gov/15574335

    View record from ScienceDirect
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  10. 10
    Preclinical activity of MCLA-128, an ADCC enhanced bispecific IgG1 antibody targeting the HER2:HER3 heterodimer

    المؤلفون: Setareh Shamsili, John de Kruif, Linda Kaldenberg, Leo S. Price, Nellie Nieuwenhuizen, Vanessa Zondag-van der Zande, Rob Roovers, Ton Logtenberg, Roy Nijhuis, Lex Bakker, Mark Throsby, Carina Clements, Renate den Blanken-Smit, Pieter Fokko Van Loo, Arjen Kramer, Willem Bartelink, Cecile Geuijen, Eric Rovers, Therese Visser, Tristan Gallenne

    المصدر: Journal of Clinical Oncology. 32:560-560

    مصطلحات موضوعية: Antibody-dependent cell-mediated cytotoxicity, Cancer Research, Oncology, Immunology, Antibody targeting, Cancer research, Malignant cells, Biology, skin and connective tissue diseases, neoplasms

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ddf52a08abed45c298121afe95212dea
    https://doi.org/10.1200/jco.2014.32.15_suppl.560

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