المؤلفون: Trojniak AE; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7363, USA., Dang VQ; The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, FL, 33458, USA., Czekner KM; The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, FL, 33458, USA; The Skaggs Graduate School of Chemical and Biological Sciences at Scripps Research, Jupiter, FL, 33458, USA., Russo RJ; The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, FL, 33458, USA; The Skaggs Graduate School of Chemical and Biological Sciences at Scripps Research, Jupiter, FL, 33458, USA., Mather LM; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7363, USA., Stahl EL; The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, FL, 33458, USA., Cameron MD; The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, FL, 33458, USA., Bohn LM; The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, FL, 33458, USA; The Skaggs Graduate School of Chemical and Biological Sciences at Scripps Research, Jupiter, FL, 33458, USA., Aubé J; Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599-7363, USA. Electronic address: jaube@unc.edu.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2024 Oct 05; Vol. 276, pp. 116627. Date of Electronic Publication: 2024 Jun 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Opioid, kappa*/agonists , Receptors, Opioid, kappa*/metabolism , Triazoles*/chemistry , Triazoles*/pharmacology , Triazoles*/chemical synthesis, Structure-Activity Relationship ; Humans ; Molecular Structure ; GTP-Binding Proteins/metabolism ; Dose-Response Relationship, Drug ; Animals

المؤلفون: Kapadia K; Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, United States., Trojniak AE; Division of Chemical Biology and Medicinal Chemistry, and the Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, Eshelman School of Pharmacy, 125 Mason Farm Road, Chapel Hill, North Carolina 27599, United States., Guzmán Rodríguez KB; Division of Chemical Biology and Medicinal Chemistry, and the Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, Eshelman School of Pharmacy, 125 Mason Farm Road, Chapel Hill, North Carolina 27599, United States., Klus NJ; Division of Chemical Biology and Medicinal Chemistry, and the Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, Eshelman School of Pharmacy, 125 Mason Farm Road, Chapel Hill, North Carolina 27599, United States., Huntley C; University of Kansas High-Throughput Screening Laboratory, University of Kansas, 2034 Becker Drive, Lawrence, Kansas 66047, United States., McDonald P; University of Kansas High-Throughput Screening Laboratory, University of Kansas, 2034 Becker Drive, Lawrence, Kansas 66047, United States., Roy A; University of Kansas High-Throughput Screening Laboratory, University of Kansas, 2034 Becker Drive, Lawrence, Kansas 66047, United States., Frankowski KJ; Division of Chemical Biology and Medicinal Chemistry, and the Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, Eshelman School of Pharmacy, 125 Mason Farm Road, Chapel Hill, North Carolina 27599, United States., Aubé J; Division of Chemical Biology and Medicinal Chemistry, and the Center for Integrative Chemical Biology and Drug Discovery, University of North Carolina, Eshelman School of Pharmacy, 125 Mason Farm Road, Chapel Hill, North Carolina 27599, United States., Muma NA; Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, United States.

المصدر: ACS chemical neuroscience [ACS Chem Neurosci] 2022 Aug 03; Vol. 13 (15), pp. 2315-2337. Date of Electronic Publication: 2022 Jul 14.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Huntington Disease*/metabolism , Neurodegenerative Diseases*, Animals ; Calcium/metabolism ; Calmodulin/metabolism ; Huntingtin Protein/genetics ; Huntingtin Protein/metabolism ; Mice ; Nerve Tissue Proteins/metabolism

المؤلفون: Lau J; Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, California 90095, United States., Trojniak AE; Department of Chemistry, Hope College, Holland, Michigan 49423, United States., Maraugha MJ; Department of Chemistry, Hope College, Holland, Michigan 49423, United States., VanZanten AJ; Department of Chemistry, Hope College, Holland, Michigan 49423, United States., Osterbaan AJ; Department of Chemistry, Hope College, Holland, Michigan 49423, United States., Serino AC; Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, California 90095, United States., Ohnsorg ML; Department of Chemistry, Hope College, Holland, Michigan 49423, United States., Cheung KM; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California 90095, United States., Ashby DS; Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, California 90095, United States., Weiss PS; Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, California 90095, United States.; Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States.; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California 90095, United States., Dunn BS; Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, California 90095, United States.; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California 90095, United States., Anderson ME; Department of Chemistry, Hope College, Holland, Michigan 49423, United States.; Department of Chemistry, Furman University, Greenville, South Carolina 29613, United States.

المصدر: Chemistry of materials : a publication of the American Chemical Society [Chem Mater] 2019 Nov 12; Vol. 31 (21), pp. 8977-8986. Date of Electronic Publication: 2019 Oct 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: The Society Country of Publication: United States NLM ID: 9884133 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0897-4756 (Print) Linking ISSN: 08974756 NLM ISO Abbreviation: Chem Mater Subsets: PubMed not MEDLINE