المؤلفون: Sarah A. Teichmann, Lia S. Campos, Emma Dann, Sophie Pritchard, K Saeb Parsy, Ni Huang, Justin Engelbert, Sara F. Vieira, Krishnaa T. Mahbubani, Steve Lisgo, Matthias Zilbauer, Minal Patel, Holm H. Uhlig, Morgan, Aaron M. Fleming, Matilda Katan, Hamish W King, Omer Ali Bayraktar, C Dominguez-Conde, Natsuhiko Kumasaka, Clatworthy, Krzysztof Polanski, Francesca Perrone, Rasa Elmentaite, Emily Stephenson, Steven Leonard, S. van Dongen, Kerstin B. Meyer, Komal Nayak, I Goh Kai’En, Kylie R. James, Muzlifah Haniffa, CE Hook, John C. Marioni, Monika Dabrowska, Liam Bolt, Lira Mamanova, Rachel A. Botting, Trw Oliver, Kenny Roberts

مصطلحات موضوعية: Cell type, Cell, Inflammation, Biology, medicine.disease, Inflammatory bowel disease, Cell biology, Pathogenesis, medicine.anatomical_structure, Immune system, medicine, Enteric nervous system, medicine.symptom, Homeostasis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d86585a8384d2ee5755a1183e3a060cc
https://doi.org/10.1101/2021.04.07.438755

المؤلفون: Oliver TRW; Department of Histopathology and Cytology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire CB2 0QQ, United Kingdom.; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1RQ, United Kingdom., Behjati S; Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1RQ, United Kingdom to3@sanger.ac.uk sb31@sanger.ac.uk.; Department of Paediatrics, University of Cambridge, Cambridge, Cambridgeshire CB2 0QQ, United Kingdom.; Department of Paediatric Haematology and Oncology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire CB2 0QQ, United Kingdom.

المصدر: Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2024 May 01. Date of Electronic Publication: 2024 May 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 101571139 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-1422 (Electronic) Linking ISSN: 21571422 NLM ISO Abbreviation: Cold Spring Harb Perspect Med Subsets: MEDLINE

المؤلفون: Treger TD; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Paediatrics, University of Cambridge, Cambridge, CB2 0QQ, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Lawrence JEG; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Anderson ND; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Coorens THH; Broad Institute of MIT and Harvard, Cambridge, 02142 MA, USA., Letunovska A; UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.; NIHR Great Ormond Street Hospital Biomedical Research Centre, London, WC1N 3JH, UK., Abby E; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Lee-Six H; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Oliver TRW; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK., Al-Saadi R; UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.; NIHR Great Ormond Street Hospital Biomedical Research Centre, London, WC1N 3JH, UK., Tullus K; UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.; NIHR Great Ormond Street Hospital Biomedical Research Centre, London, WC1N 3JH, UK., Morcrette G; UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.; NIHR Great Ormond Street Hospital Biomedical Research Centre, London, WC1N 3JH, UK., Hutchinson JC; NIHR Great Ormond Street Hospital Biomedical Research Centre, London, WC1N 3JH, UK., Rampling D; NIHR Great Ormond Street Hospital Biomedical Research Centre, London, WC1N 3JH, UK., Sebire N; UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.; NIHR Great Ormond Street Hospital Biomedical Research Centre, London, WC1N 3JH, UK., Pritchard-Jones K; UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK., Young MD; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK., Mitchell TJ; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK.; Early Cancer Institute, University of Cambridge, Cambridge, CB2 0XZ, UK., Jones PH; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK.; Department of Oncology, University of Cambridge, Cambridge, CB2 OXZ, UK., Tran M; Specialist Centre for Kidney Cancer, Royal Free Hospital, London, NW3 2QG, UK. m.tran@ucl.ac.uk.; Faculty of Medical Sciences, Division of Surgery and Interventional Science, University College London, London, NW3 2PS, UK. m.tran@ucl.ac.uk., Behjati S; Wellcome Sanger Institute, Hinxton, CB10 1SA, UK. sb31@sanger.ac.uk.; Department of Paediatrics, University of Cambridge, Cambridge, CB2 0QQ, UK. sb31@sanger.ac.uk.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB2 0QQ, UK. sb31@sanger.ac.uk., Chowdhury T; UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK. Tanzina.Chowdhury@gosh.nhs.uk.; NIHR Great Ormond Street Hospital Biomedical Research Centre, London, WC1N 3JH, UK. Tanzina.Chowdhury@gosh.nhs.uk.

المصدر: Nature communications [Nat Commun] 2023 Sep 25; Vol. 14 (1), pp. 5826. Date of Electronic Publication: 2023 Sep 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Renin*/metabolism , Kidney Neoplasms*/metabolism, Humans ; Juxtaglomerular Apparatus/metabolism ; Juxtaglomerular Apparatus/pathology ; Kidney Glomerulus/pathology ; Signal Transduction/genetics ; Receptor, Notch1/genetics

المؤلفون: Li R; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Ferdinand JR; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK., Loudon KW; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK., Bowyer GS; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK., Laidlaw S; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Muyas F; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Mamanova L; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Neves JB; UCL Division of Surgery and Interventional Science, Royal Free Hospital, London NW3 2PS, UK; Specialist Centre for Kidney Cancer, Royal Free Hospital, London NW3 2PS, UK., Bolt L; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Fasouli ES; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Lawson ARJ; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Young MD; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Hooks Y; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Oliver TRW; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK., Butler TM; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Armitage JN; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK., Aho T; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK., Riddick ACP; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK., Gnanapragasam V; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK., Welsh SJ; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK., Meyer KB; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Warren AY; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK., Tran MGB; UCL Division of Surgery and Interventional Science, Royal Free Hospital, London NW3 2PS, UK; Specialist Centre for Kidney Cancer, Royal Free Hospital, London NW3 2PS, UK., Stewart GD; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK., Cortés-Ciriano I; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Behjati S; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK., Clatworthy MR; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK., Campbell PJ; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK., Teichmann SA; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK; Department of Physics, Cavendish Laboratory, JJ Thomson Avenue, Cambridge CB3 0HE, UK. Electronic address: st9@sanger.ac.uk., Mitchell TJ; Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK; Cambridge University Hospitals NHS Foundation Trust and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK; Department of Surgery, University of Cambridge, Cambridge CB2 0QQ, UK. Electronic address: tjm@sanger.ac.uk.

المصدر: Cancer cell [Cancer Cell] 2022 Dec 12; Vol. 40 (12), pp. 1583-1599.e10. Date of Electronic Publication: 2022 Nov 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Renal Cell*/genetics , Kidney Neoplasms*/genetics, Humans ; Transcriptome ; Gene Expression Profiling ; Epithelial-Mesenchymal Transition ; Tumor Microenvironment/genetics ; Single-Cell Analysis

المؤلفون: Oliver TRW; Wellcome Sanger Institute, Hinxton, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Chappell L; Wellcome Sanger Institute, Hinxton, UK., Sanghvi R; Wellcome Sanger Institute, Hinxton, UK., Deighton L; Wellcome Sanger Institute, Hinxton, UK., Ansari-Pour N; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Dentro SC; Wellcome Sanger Institute, Hinxton, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK., Young MD; Wellcome Sanger Institute, Hinxton, UK., Coorens THH; Wellcome Sanger Institute, Hinxton, UK., Jung H; Wellcome Sanger Institute, Hinxton, UK., Butler T; Wellcome Sanger Institute, Hinxton, UK., Neville MDC; Wellcome Sanger Institute, Hinxton, UK., Leongamornlert D; Wellcome Sanger Institute, Hinxton, UK., Sanders MA; Wellcome Sanger Institute, Hinxton, UK.; Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands., Hooks Y; Wellcome Sanger Institute, Hinxton, UK., Cagan A; Wellcome Sanger Institute, Hinxton, UK., Mitchell TJ; Wellcome Sanger Institute, Hinxton, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Cortes-Ciriano I; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Cambridge, UK., Warren AY; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Wedge DC; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Manchester Cancer Research Centre, Division of Cancer Sciences, University of Manchester, Manchester, UK., Heer R; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Newcastle Urology, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Coleman N; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Pathology, University of Cambridge, Cambridge, UK., Murray MJ; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Pathology, University of Cambridge, Cambridge, UK., Campbell PJ; Wellcome Sanger Institute, Hinxton, UK., Rahbari R; Wellcome Sanger Institute, Hinxton, UK. rr11@sanger.ac.uk., Behjati S; Wellcome Sanger Institute, Hinxton, UK. sb31@sanger.ac.uk.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. sb31@sanger.ac.uk.; Department of Paediatrics, University of Cambridge, Cambridge, UK. sb31@sanger.ac.uk.

المصدر: Nature communications [Nat Commun] 2022 Aug 11; Vol. 13 (1), pp. 4272. Date of Electronic Publication: 2022 Aug 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms, Germ Cell and Embryonal*/genetics , Testicular Neoplasms*/genetics, Child ; Genomics ; Humans ; Male ; Transcriptome/genetics

المؤلفون: Coorens THH; Wellcome Sanger Institute, Hinxton, UK., Oliver TRW; Wellcome Sanger Institute, Hinxton, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Sanghvi R; Wellcome Sanger Institute, Hinxton, UK., Sovio U; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Cook E; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Vento-Tormo R; Wellcome Sanger Institute, Hinxton, UK., Haniffa M; Wellcome Sanger Institute, Hinxton, UK.; Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.; Department of Dermatology, Royal Victoria Infirmary, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Young MD; Wellcome Sanger Institute, Hinxton, UK., Rahbari R; Wellcome Sanger Institute, Hinxton, UK., Sebire N; Great Ormond Street Hospital for Children NHS Foundation Trust, NIHR Great Ormond Street Hospital Biomedical Research Centre, London, UK.; UCL Great Ormond Street Institute of Child Health, London, UK., Campbell PJ; Wellcome Sanger Institute, Hinxton, UK., Charnock-Jones DS; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK. dscj1@cam.ac.uk.; Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. dscj1@cam.ac.uk., Smith GCS; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. gcss2@cam.ac.uk.; Department of Obstetrics and Gynaecology, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Cambridge, UK. gcss2@cam.ac.uk.; Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. gcss2@cam.ac.uk., Behjati S; Wellcome Sanger Institute, Hinxton, UK. sb31@sanger.ac.uk.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. sb31@sanger.ac.uk.; Department of Paediatrics, University of Cambridge, Cambridge, UK. sb31@sanger.ac.uk.

المصدر: Nature [Nature] 2022 Mar; Vol. 603 (7901), pp. E17.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Moore L; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.; Department of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Cagan A; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Coorens THH; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Neville MDC; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Sanghvi R; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Sanders MA; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.; Department of Hematology, Erasmus University Medical Center, Rotterdam, Netherlands., Oliver TRW; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.; Department of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Leongamornlert D; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Ellis P; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.; Inivata, Cambridge, UK., Noorani A; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Mitchell TJ; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Butler TM; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Hooks Y; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Warren AY; Department of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Jorgensen M; Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Dawson KJ; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Menzies A; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., O'Neill L; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Latimer C; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Teng M; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., van Boxtel R; Princess Máxima Center for Pediatric Oncology and Oncode Institute, Utrecht, Netherlands., Iacobuzio-Donahue CA; Department of Pathology, Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Martincorena I; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Heer R; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Newcastle Urology, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Campbell PJ; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK., Fitzgerald RC; MRC Cancer Unit, University of Cambridge, Cambridge, UK., Stratton MR; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK. mrs@sanger.ac.uk., Rahbari R; Cancer, Ageing and Somatic Mutation (CASM), Wellcome Sanger Institute, Hinxton, UK. rr11@sanger.ac.uk.

المصدر: Nature [Nature] 2021 Sep; Vol. 597 (7876), pp. 381-386. Date of Electronic Publication: 2021 Aug 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Germ-Line Mutation* , Mutation Rate*, Germ Cells/*metabolism , Organ Specificity/*genetics, Aged ; Clone Cells/metabolism ; Female ; Health ; Humans ; Male ; Microdissection ; Middle Aged ; Oxidative Stress ; Spermatogonia/metabolism

المؤلفون: Elmentaite R; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Kumasaka N; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Roberts K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Fleming A; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge, UK., Dann E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., King HW; Centre for Immunobiology, Blizard Institute, Queen Mary University of London, London, UK., Kleshchevnikov V; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Dabrowska M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Pritchard S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Bolt L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Vieira SF; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Mamanova L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Huang N; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Perrone F; Department of Paediatrics, University of Cambridge, Cambridge, UK., Goh Kai'En I; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Lisgo SN; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Katan M; Structural and Molecular Biology, Division of Biosciences, University College London, London, UK., Leonard S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Oliver TRW; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Hook CE; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Nayak K; Department of Paediatrics, University of Cambridge, Cambridge, UK., Campos LS; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Domínguez Conde C; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Stephenson E; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Engelbert J; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Botting RA; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Polanski K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., van Dongen S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Patel M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Morgan MD; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Marioni JC; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Cambridge, UK.; Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK., Bayraktar OA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Meyer KB; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., He X; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Barker RA; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences and Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Uhlig HH; Translational Gastroenterology Unit, John Radcliffe Hospital, University of Oxford, Oxford, UK.; Department of Paediatrics, University of Oxford, Oxford, UK.; NIHR Oxford Biomedical Research Centre, Oxford, UK., Mahbubani KT; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Zilbauer M; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals Trust, Cambridge, UK.; Wellcome-MRC Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK., Clatworthy MR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.; Molecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge, UK., Haniffa M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., James KR; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK. k.james@garvan.org.au.; Garvan Institute of Medical Research, The Kinghorn Cancer Centre, Darlinghurst, New South Wales, Australia. k.james@garvan.org.au., Teichmann SA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK. st9@sanger.ac.uk.; Theory of Condensed Matter Group, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge, UK. st9@sanger.ac.uk.

المصدر: Nature [Nature] 2021 Sep; Vol. 597 (7875), pp. 250-255. Date of Electronic Publication: 2021 Sep 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Aging* , Health*, Enteric Nervous System/*cytology , Fetus/*cytology , Intestines/*cytology , Intestines/*growth & development , Lymph Nodes/*cytology , Lymph Nodes/*growth & development, Adult ; Animals ; Child ; Crohn Disease/pathology ; Datasets as Topic ; Enteric Nervous System/anatomy & histology ; Enteric Nervous System/embryology ; Enteric Nervous System/growth & development ; Epithelial Cells/cytology ; Female ; Fetus/anatomy & histology ; Fetus/embryology ; Humans ; Intestines/embryology ; Intestines/innervation ; Lymph Nodes/embryology ; Lymph Nodes/pathology ; Mice ; Mice, Inbred C57BL ; Organogenesis ; Receptors, IgG/metabolism ; Signal Transduction ; Spatio-Temporal Analysis ; Time Factors

المؤلفون: Coorens THH; Wellcome Sanger Institute, Hinxton, UK., Moore L; Wellcome Sanger Institute, Hinxton, UK.; Department of Pathology, University of Cambridge, Cambridge, UK., Robinson PS; Wellcome Sanger Institute, Hinxton, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Sanghvi R; Wellcome Sanger Institute, Hinxton, UK., Christopher J; Wellcome Sanger Institute, Hinxton, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Hewinson J; Wellcome Sanger Institute, Hinxton, UK., Przybilla MJ; Wellcome Sanger Institute, Hinxton, UK., Lawson ARJ; Wellcome Sanger Institute, Hinxton, UK., Spencer Chapman M; Wellcome Sanger Institute, Hinxton, UK.; Department of Haematology, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Cagan A; Wellcome Sanger Institute, Hinxton, UK., Oliver TRW; Wellcome Sanger Institute, Hinxton, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Neville MDC; Wellcome Sanger Institute, Hinxton, UK., Hooks Y; Wellcome Sanger Institute, Hinxton, UK., Noorani A; Wellcome Sanger Institute, Hinxton, UK., Mitchell TJ; Wellcome Sanger Institute, Hinxton, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Fitzgerald RC; MRC Cancer Unit, University of Cambridge, Biomedical Campus, Cambridge, UK., Campbell PJ; Wellcome Sanger Institute, Hinxton, UK., Martincorena I; Wellcome Sanger Institute, Hinxton, UK., Rahbari R; Wellcome Sanger Institute, Hinxton, UK., Stratton MR; Wellcome Sanger Institute, Hinxton, UK. mrs@sanger.ac.uk.

المصدر: Nature [Nature] 2021 Sep; Vol. 597 (7876), pp. 387-392. Date of Electronic Publication: 2021 Aug 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Cell Lineage/*genetics , Embryo, Mammalian/*cytology , Embryo, Mammalian/*metabolism , Embryonic Development/*genetics, Brain/metabolism ; Chromosomes, Human, Y/genetics ; Clone Cells/metabolism ; Germ-Line Mutation/genetics ; Humans ; Male ; Mosaicism ; Organ Specificity/genetics ; Polymorphism, Single Nucleotide/genetics

المؤلفون: Young MD; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. my4@sanger.ac.uk., Mitchell TJ; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Custers L; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Margaritis T; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Morales-Rodriguez F; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Oncode Institute, Utrecht, The Netherlands., Kwakwa K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Khabirova E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Kildisiute G; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Oliver TRW; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., de Krijger RR; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands., van den Heuvel-Eibrink MM; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Comitani F; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Piapi A; UCL Great Ormond Street Hospital Institute of Child Health, London, UK., Bugallo-Blanco E; UCL Great Ormond Street Hospital Institute of Child Health, London, UK., Thevanesan C; UCL Great Ormond Street Hospital Institute of Child Health, London, UK., Burke C; UCL Great Ormond Street Hospital Institute of Child Health, London, UK., Prigmore E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Ambridge K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Roberts K; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Braga FAV; Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Coorens THH; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Del Valle I; UCL Great Ormond Street Hospital Institute of Child Health, London, UK., Wilbrey-Clark A; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Mamanova L; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Stewart GD; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Gnanapragasam VJ; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK.; Cambridge Urology Translational Research and Clinical Trials office, Cambridge Biomedical Campus Cambridge CB2 0QQ University of Cambridge, Cambridge, UK., Rampling D; Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Sebire N; NIHR Great Ormond Street Hospital BRC and Institute of Child Health, London, UK., Coleman N; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Pathology, University of Cambridge, Cambridge, UK., Hook L; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Pathology, University of Cambridge, Cambridge, UK., Warren A; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Haniffa M; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.; Intitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK., Kool M; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.; Hopp Children´s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Division of Pediatric Neurooncology, Heidelberg, Germany., Pfister SM; Hopp Children´s Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.; German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Division of Pediatric Neurooncology, Heidelberg, Germany.; Heidelberg University Hospital, Department of Pediatric Hematology and Oncology, Heidelberg, Germany., Achermann JC; UCL Great Ormond Street Hospital Institute of Child Health, London, UK., He X; MRC-WT Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK., Barker RA; MRC-WT Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Clinical Neuroscience, University of Cambridge, Cambridge, UK., Shlien A; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada.; Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada., Bayraktar OA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Teichmann SA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.; Cavendish Laboratory, University of Cambridge, Cambridge, UK., Holstege FC; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Meyer KB; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Drost J; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. j.drost@prinsesmaximacentrum.nl.; Oncode Institute, Utrecht, The Netherlands. j.drost@prinsesmaximacentrum.nl., Straathof K; UCL Great Ormond Street Hospital Institute of Child Health, London, UK. k.straathof@ucl.ac.uk.; Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. k.straathof@ucl.ac.uk., Behjati S; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. sb31@sanger.ac.uk.; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. sb31@sanger.ac.uk.; Department of Paediatrics, University of Cambridge, Cambridge, UK. sb31@sanger.ac.uk.

المصدر: Nature communications [Nat Commun] 2021 Jun 23; Vol. 12 (1), pp. 3896. Date of Electronic Publication: 2021 Jun 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Transcriptome*, Kidney/*metabolism , Kidney Neoplasms/*genetics , RNA, Messenger/*genetics , RNA-Seq/*methods , Single-Cell Analysis/*methods, Adult ; Algorithms ; Child ; Fetus/metabolism ; Gene Expression Regulation, Developmental ; Humans ; Kidney/embryology ; Kidney Neoplasms/embryology ; Kidney Neoplasms/metabolism ; Models, Genetic ; Signal Transduction/genetics