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المؤلفون: Mahin Abad Dar, Franziska Maiwald, Diego Benítez, Laurent Meijer, Nadège Loaëc, Conrad Kunick, Lutz Preu, Hanna Erdmann, Marcelo A. Comini, Oliver Koch, Diego Charquero, Christoph Hölscher
المساهمون: Technische Universität Braunschweig = Technical University of Braunschweig [Braunschweig], Institut Pasteur de Montevideo, Réseau International des Instituts Pasteur (RIIP), Forschungszentrum Borstel - Research Center Borstel, Technische Universität Dortmund [Dortmund] (TU), ManRos Therapeutics, This project was funded by the German 'Bundesministerium für Bildung und Forschung' (KMU-innovativ 5, Förderkennzeichen 0315814, to F. M., M. A. D., O. K., C. H., and C. K.). The support of FOCEM (MERCOSUR Structural Convergence Fund, COF 03/11) and ANII (grant Innova Uruguay, agreement DCI-ALA/2007/19.040 between Uruguay and the European Commission, INI_X_2011_1_4077 and POS_NAC_2013_1_114477) is acknowledged by M. A. C., D. B. and D. C.. L. M. was supported by a grant from the ‘Agence Nationale de la Recherche’ (ANR- 11-RPIB-0016 grant, Transleish).
المصدر: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2014, 83, pp.274-283. ⟨10.1016/j.ejmech.2014.06.020⟩مصطلحات موضوعية: MESH: Trypanocidal Agents/chemical synthesis, MESH: Benzazepines/toxicity, Nagana, Mice, Chalcones, MESH: Structure-Activity Relationship, MESH: Cell Proliferation/drug effects, Human trypanosomiasis, Drug Discovery, MESH: Animals, MESH: Benzazepines/chemistry, biology, MESH: Trypanosoma brucei brucei/physiology, Chemistry, MESH: Macrophages/drug effects, General Medicine, Trypanocidal Agents, 3. Good health, MESH: Trypanocidal Agents/pharmacology, Biochemistry, Paullones, MESH: Trypanocidal Agents/toxicity, MESH: Trypanosomiasis, African/parasitology, Trypanosoma brucei brucei, Cell Line, Structure-Activity Relationship, Heck reaction, parasitic diseases, medicine, Animals, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, MESH: Trypanosoma brucei brucei/drug effects, MESH: Drug Design, MESH: Mice, Cell Proliferation, Pharmacology, MESH: Humans, MESH: Benzazepines/chemical synthesis, MESH: Trypanocidal Agents/chemistry, Macrophages, Organic Chemistry, MESH: Benzazepines/pharmacology, Benzazepines, biology.organism_classification, medicine.disease, Antiparasitic agent, Cinnamides, MESH: Cell Line, Trypanosomiasis, African, Drug Design, Trypanosoma
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المؤلفون: Jeremy N. Skepper, Dirk Saerens, Senthil Kumar A. Natesan, Lea Brys, Mark C. Field, Alexandros Nikolaou, Serge Muyldermans, Stefan Magez, Etienne Pays, David Perez-Morga, Katja Conrath, Benoit Stijlemans, Patrick De Baetselier, Guy Caljon
المساهمون: Cellular and Molecular Immunology, Molecular and Biochemical Pharmacology
المصدر: Vrije Universiteit Brussel
PLoS Pathogens, Vol 7, Iss 6, p e1002072 (2011)
PLoS Pathogens
P L o S Pathogens, 7 (6مصطلحات موضوعية: Models, Molecular, Trypanocidal Agents -- pharmacology -- therapeutic use, Antibody Affinity, Antibodies, Protozoan, Epitope, Mice, Trypanosome brucei, Down-Regulation -- drug effects, Molecular Cell Biology, Biology (General), Cells, Cultured, chemistry.chemical_classification, 0303 health sciences, biology, trypanosomiasis therapeutics, Trypanosoma brucei brucei -- immunology -- metabolism -- physiology -- ultrastructure, Sciences bio-médicales et agricoles, Trypanocidal Agents, nanobodies, Endocytosis, 3. Good health, Cell biology, Antibodies, Protozoan -- immunology -- pharmacology -- therapeutic use, Antibody, Endocytosis -- drug effects, Variant Surface Glycoproteins, Trypanosoma, Sciences exactes et naturelles, Research Article, Biotechnology, trypanolytic agent, Trypanosomiasis, African -- immunology -- metabolism -- therapy, QH301-705.5, Immunology, Molecular Sequence Data, Trypanosoma brucei brucei, Down-Regulation, Trypanosoma brucei, Microbiology, Models, Biological, 03 medical and health sciences, Virology, parasitic diseases, Genetics, Antigenic variation, Animals, Humans, Amino Acid Sequence, variant-specific surface glycoprotein, Molecular Biology, Biology, 030304 developmental biology, 030306 microbiology, Variant Surface Glycoproteins, Trypanosoma -- immunology, RC581-607, biology.organism_classification, Molecular biology, Complement system, Mice, Inbred C57BL, Trypanosomiasis, African, chemistry, biology.protein, Trypanosoma, Nanoparticles, Parasitology, Immunologic diseases. Allergy, Glycoprotein
وصف الملف: 1 full-text file(s): application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b0c24441acd735f0e34b460deb7685
https://doi.org/10.1371/journal.ppat.1002072 -
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المؤلفون: Inês Loureiro, Jane MacDougall, Isbaal. Ramos, Paul Kong Thoo-Lin, Meritxell Roura, Anabela Cordeiro-da-Silva, Alain Pruvost, Joana Tavares, David Costa, Hadjer Loukil, Nuno A. G. Graça, Luís Gaspar, Ian K. Pemberton
المساهمون: Instituto de Investigação e Inovação em Saúde
المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAPمصطلحات موضوعية: 0301 basic medicine, Pentamidine/pharmacology, Naphthalimides/pharmacology, Neurons/metabolism, Mitochondria, Liver, Microsomes, Liver/metabolism, Pharmacology, Parasite load, Parasite Load, Neurons/cytology, Mice, 0302 clinical medicine, Macrophages/drug effects, Drug Stability, Trypanocidal Agents/chemical synthesis, Liver/drug effects, Trypanosoma brucei brucei/drug effects, Pharmacology (medical), African trypanosomiasis, Trypanosoma brucei brucei/metabolism, Hepatocytes/cytology, Neurons, Mice, Inbred BALB C, biology, Trypanosoma brucei brucei/growth & development, Trypanocidal Agents, 3. Good health, Naphthalimides, Infectious Diseases, Liver, Microsomes, Liver, Female, Trypanosomiasis, African/parasitology, Hepatocytes/drug effects, medicine.drug, Liver/metabolism, 030231 tropical medicine, Trypanosoma brucei brucei, Primary Cell Culture, Mitochondria, Liver/metabolism, Trypanosoma brucei, Cell Line, 03 medical and health sciences, Structure-Activity Relationship, Inhibitory Concentration 50, Macrophages/metabolism, medicine, Mitochondria, Liver/drug effects, Structure–activity relationship, Animals, Humans, Experimental Therapeutics, Pentamidine, Trypanocidal agent, Naphthalimides/chemical synthesis, Trypanosomiasis, African/mortality, business.industry, Macrophages, Hepatocytes/metabolism, Macrophages/cytology, medicine.disease, biology.organism_classification, Neurons/drug effects, Survival Analysis, 030104 developmental biology, Trypanosomiasis, African, Cell culture, Trypanosomiasis, African/pathology, Immunology, Hepatocytes, Trypanosomiasis, African/drug therapy, Microsomes, Liver/drug effects, business, Trypanosomiasis, Trypanocidal Agents/pharmacology
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5fa525ec4ee871c187c8e2ab92ea4a7
https://repositorio-aberto.up.pt/handle/10216/118203 -
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المؤلفون: Susan Wyllie, Paul G. Wyatt, Alan H. Fairlamb, Malcolm F. G. Stevens, Geoffrey Wells, Janine König
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: Amide Synthases/metabolism, Time Factors, Spermidine, Thioredoxin reductase, Trypanothione, Protozoan Proteins, Amide Synthases/genetics, Biochemistry, chemistry.chemical_compound, Thioredoxins, Cysteine/metabolism, Trypanosomiasis/drug therapy, Trypanosoma brucei brucei/metabolism, Thioredoxins/genetics, biology, Glutathione/genetics, Drug Action, Thioredoxins/metabolism, Glutathione, Trypanocidal Agents, Trypanosoma brucei brucei/genetics, Tryparedoxin Peroxidase, Thiol, Drug, medicine.symptom, Thioredoxin, Antineoplastic Agents/pharmacology, Peroxidase, Protozoan Proteins/metabolism, Trypanosomiasis/genetics, Cysteine/genetics, Glutathione/analogs & derivatives, Trypanosoma brucei brucei, Trypanosomiasis/metabolism, Antineoplastic Agents, Trypanosoma brucei, Trypanosome, Dose-Response Relationship, Amide Synthases, Trypanosomiasis, medicine, Spermidine/analogs & derivatives, Animals, Benzothiazoles/pharmacology, Benzothiazoles, Cysteine, Molecular Biology, Hydroquinones/pharmacology, Dose-Response Relationship, Drug, Cell Biology, biology.organism_classification, Glutathione/metabolism, Spermidine/metabolism, Hydroquinones, Metabolism, Mechanism of action, chemistry, biology.protein, Peroxiredoxin, Trypanocidal Agents/pharmacology, Quinol
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644701f01b2fea36b4b7629a41fa03c3
http://europepmc.org/articles/PMC3048735 -
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المؤلفون: Fijolek, Artur, Hofer, Anders, Thelander, Lars
المصدر: Journal of biological chemistry. 282(16):11858-11865
مصطلحات موضوعية: Animals, Carbon-Nitrogen Ligases/*biosynthesis/*chemistry, Cytidine/chemistry, Cytosine/chemistry, Dose-Response Relationship, Drug, Enzyme Inhibitors/pharmacology, Humans, Kinetics, Male, Mice, Inbred C57BL, Trypanocidal Agents/pharmacology, Trypanosoma brucei brucei/*enzymology, Trypanosoma brucei gambiense/*enzymology, Trypanosomiasis, African/*therapy
وصف الملف: print
URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-6341
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17331943&dopt=Citation -
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المؤلفون: Hofer, Anders, Steverding, D, Chabes, Andrei, Brun, R, Thelander, Lars
المصدر: Proceedings of the National Academy of Sciences of the U S A. 98(11):6412-6
مصطلحات موضوعية: Adenosine Triphosphate/metabolism, Animals, Carbon-Nitrogen Ligases/*antagonists & inhibitors, Cells, Cultured, Cytidine/pharmacology, Cytidine Triphosphate/biosynthesis/metabolism, Diazooxonorleucine/*pharmacology/therapeutic use, Enzyme Inhibitors/*pharmacology/therapeutic use, Fibroblasts/cytology, Guanine/pharmacology, Guanosine Triphosphate/metabolism, Humans, Hypoxanthines/pharmacology, Intracellular Fluid, Isoxazoles/*pharmacology/therapeutic use, Mice, Inbred BALB C, Trypanocidal Agents/*pharmacology/therapeutic use, Trypanosoma brucei brucei/drug effects/*enzymology/growth & development, Trypanosomiasis, African/blood/*drug therapy/parasitology, Uridine Triphosphate/metabolism
وصف الملف: print
URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-9176
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=11353848&dopt=Citation -
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المؤلفون: Munirathinam Sundaramoorthy, Etienne Pays, Michael R. Waterman, W. David Nes, Benoit Vanhollebeke, Joel M. Harp, Hee Won Park, Minu Chaudhuri, Tatiana Y. Hargrove, Fernando Villalta, Zdzislaw Wawrzak, Galina I. Lepesheva
المصدر: The Journal of biological chemistry, 285 (3
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Trypanocidal Agents -- therapeutic use, Enzyme Inhibitors -- metabolism, Crystallography, X-Ray, Ligands, Biochemistry, Substrate Specificity, Sterol 14-Demethylase, Protein structure, Cytochrome P-450 Enzyme System, Enzyme Inhibitors -- pharmacology, Cytochrome P-450 Enzyme Inhibitors, Benzamides -- pharmacology, Enzyme Inhibitors -- therapeutic use, Trypanocidal Agents -- chemistry, Trypanosoma brucei brucei -- drug effects, Trypanosoma brucei brucei -- enzymology, Enzyme Inhibitors, Benzamides -- metabolism, Cytochrome P-450 Enzyme System -- metabolism, biology, Sciences bio-médicales et agricoles, Trypanosomiasis, African -- drug therapy, Trypanocidal Agents, Sterols, Protein Structure and Folding, Benzamides, Trypanocidal Agents -- metabolism, Antiparasitic, medicine.drug_class, Trypanosoma brucei brucei, Trypanosoma brucei, Benzamides -- therapeutic use, Trypanocidal Agents -- pharmacology, Enzyme activator, Enzyme Inhibitors -- chemistry, Microsomes, medicine, Humans, Amino Acid Sequence, Molecular Biology, Benzamides -- chemistry, Active site, Cell Biology, biology.organism_classification, Sterol, Microsomes -- enzymology, Trypanosomiasis, African, Cytochrome P-450 Enzyme System -- chemistry, Drug Design, Sterols -- biosynthesis, biology.protein, Biocatalysis, Cytochrome P-450 Enzyme System -- antagonists & inhibitors
وصف الملف: 2 full-text file(s): application/pdf; application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10f25cf6d7a799ccbb98ab7ab7cd026
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/51605 -
8مورد إلكتروني
المصدر: Journal of Ethnopharmacology; 3; 569 - 575; 96
مصطلحات الفهرس: New Caledonia, Vanuatu, Leishmanicidal activity, Trypanocidal activity, Animals, Drug Evaluation, Preclinical, Leishmania donovani/drug effects, Mice, Microbial Sensitivity Tests, Plant Extracts/chemistry, Plant Extracts/pharmacology, Plants, Medicinal/chemistry, Trypanocidal Agents/chemistry, Trypanocidal Agents/pharmacology, Trypanosoma cruzi/drug effects, Artículo
URL:
http://dspace.conacyt.gov.py/xmlui/handle/123456789/42275 http://dspace.conacyt.gov.py/jspui/bitstream/123456789/42275/1/2004screeningofnewcaledonianandvanuatumedicinalplantsforantiprotozoalactivity.pdf http://dspace.conacyt.gov.py/jspui/bitstream/123456789/42275/1/2004 screening of new caledonian and vanuatu medicinal plants for antiprotozoal activity.pdf -
9مورد إلكتروني
المصدر: Journal of Ethnopharmacology; 3; 569 - 575; 96
مصطلحات الفهرس: New Caledonia, Vanuatu, Leishmanicidal activity, Trypanocidal activity, Animals, Drug Evaluation, Preclinical, Leishmania donovani/drug effects, Mice, Microbial Sensitivity Tests, Plant Extracts/chemistry, Plant Extracts/pharmacology, Plants, Medicinal/chemistry, Trypanocidal Agents/chemistry, Trypanocidal Agents/pharmacology, Trypanosoma cruzi/drug effects, Artículo
URL:
http://dspace.conacyt.gov.py/xmlui/handle/123456789/42275 http://dspace.conacyt.gov.py/jspui/bitstream/123456789/42275/1/2004screeningofnewcaledonianandvanuatumedicinalplantsforantiprotozoalactivity.pdf http://dspace.conacyt.gov.py/jspui/bitstream/123456789/42275/1/2004 screening of new caledonian and vanuatu medicinal plants for antiprotozoal activity.pdf -
10مورد إلكتروني
المصدر: P L o S Pathogens, 7 (6
مصطلحات الفهرس: Sciences exactes et naturelles, Sciences bio-médicales et agricoles, Amino Acid Sequence, Animals, Antibodies, Protozoan -- immunology -- pharmacology -- therapeutic use, Antibody Affinity, Cells, Cultured, Down-Regulation -- drug effects, Endocytosis -- drug effects, Humans, Mice, Mice, Inbred C57BL, Models, Biological, Models, Molecular, Molecular Sequence Data, Nanoparticles, Trypanocidal Agents -- pharmacology -- therapeutic use, Trypanosoma brucei brucei -- immunology -- metabolism -- physiology -- ultrastructure, Trypanosomiasis, African -- immunology -- metabolism -- therapy, Variant Surface Glycoproteins, Trypanosoma -- immunology, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article
URL:
https://dipot.ulb.ac.be/dspace/bitstream/2013/160716/4/doi_146170.pdf http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/160716 http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL
