المؤلفون: von Känel C; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland., Oeljeklaus S; Faculty of Chemistry and Pharmacy, Biochemistry II, Theodor Boveri-Institute, University of Würzburg, Würzburg, Germany., Wenger C; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland., Stettler P; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland., Harsman A; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland., Warscheid B; Faculty of Chemistry and Pharmacy, Biochemistry II, Theodor Boveri-Institute, University of Würzburg, Würzburg, Germany., Schneider A; Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland.

المصدر: Molecular microbiology [Mol Microbiol] 2024 Jun; Vol. 121 (6), pp. 1112-1126. Date of Electronic Publication: 2024 Apr 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8712028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2958 (Electronic) Linking ISSN: 0950382X NLM ISO Abbreviation: Mol Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Trypanosoma brucei brucei*/metabolism , Trypanosoma brucei brucei*/genetics , Trypanosoma brucei brucei*/enzymology , Protozoan Proteins*/metabolism , Protozoan Proteins*/genetics , Mitochondrial Membranes*/metabolism , Protein Transport* , Mitochondria*/metabolism , Mitochondrial Membrane Transport Proteins*/metabolism , Mitochondrial Membrane Transport Proteins*/genetics, Mitochondrial Precursor Protein Import Complex Proteins ; Mitochondrial Proteins/metabolism ; Mitochondrial Proteins/genetics ; Membrane Transport Proteins/metabolism ; Membrane Transport Proteins/genetics ; Protein Subunits/metabolism

المؤلفون: Ahmed M; Department of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford OX3 0BP, UK., Wheeler R; Peter Medawar Building for Pathogen Research , University of Oxford, Oxford OX1 3SY, UK., Týč J; Biology Centre CAS, Institute of Parasitology, Branišovská 1160/31, 370 05 České Budějovice, Czech Republic., Shafiq S; Department of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford OX3 0BP, UK., Sunter J; Department of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford OX3 0BP, UK., Vaughan S; Department of Biological and Medical Sciences, Oxford Brookes University, Gipsy Lane, Oxford OX3 0BP, UK.

المصدر: Journal of cell science [J Cell Sci] 2024 May 15; Vol. 137 (10). Date of Electronic Publication: 2024 Jun 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE

مواضيع طبية MeSH: Trypanosoma brucei brucei*/genetics , Trypanosoma brucei brucei*/metabolism , Protozoan Proteins*/genetics , Protozoan Proteins*/metabolism, Conserved Sequence ; Basal Bodies/metabolism ; Protein Transport ; Time Factors ; Flagella/genetics ; Flagella/metabolism ; Gene Expression Regulation ; Cilia/genetics ; Cilia/metabolism

المؤلفون: Dawoody Nejad L; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. ladan.dawoody1@gmail.com.; Institute of Biochemistry and Molecular Medicine, University of Bern, Bern, Switzerland. ladan.dawoody1@gmail.com.; Graduate School for Cellular and Biochemical Sciences, University of Bern, Bern, Switzerland. ladan.dawoody1@gmail.com., Annese T; Department of Translational Biomedicine and Neuroscience, University of Bari, Bari, Italy.; Department of Medicine and Surgery, Libera Università del Mediterraneo (LUM) Giuseppe Degennaro, Bari, Italy., Ribatti D; Department of Translational Biomedicine and Neuroscience, University of Bari, Bari, Italy.

المصدر: Molecular biology reports [Mol Biol Rep] 2024 Apr 26; Vol. 51 (1), pp. 578. Date of Electronic Publication: 2024 Apr 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

مواضيع طبية MeSH: Trypanosoma brucei brucei*/enzymology , Trypanosoma brucei brucei*/genetics , Lysosomes*/metabolism , Lysosomes*/enzymology, Glycerol/*analogs & derivatives, Triglycerides/metabolism ; Protozoan Proteins/metabolism ; Protozoan Proteins/genetics ; Phosphatidate Phosphatase/metabolism ; Phosphatidate Phosphatase/genetics ; RNA Interference ; Diphosphates/metabolism ; Phosphoric Monoester Hydrolases/metabolism ; Phosphoric Monoester Hydrolases/genetics ; Diglycerides/metabolism ; Phosphatidic Acids/metabolism

المؤلفون: Militello KT; Biology Department, State University of New York at Geneseo, Geneseo, NY, United States of America., Leigh J; Biology Department, State University of New York at Geneseo, Geneseo, NY, United States of America., Pusateri M; Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, United States of America., Read LK; Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, United States of America., Vogler D; Biology Department, State University of New York at Geneseo, Geneseo, NY, United States of America.

المصدر: PloS one [PLoS One] 2024 Apr 25; Vol. 19 (4), pp. e0298521. Date of Electronic Publication: 2024 Apr 25 (Print Publication: 2024).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Trypanosoma brucei brucei*/genetics , Trypanosoma brucei brucei*/enzymology , Trypanosoma brucei brucei*/metabolism , RNA, Ribosomal*/metabolism , RNA, Ribosomal*/genetics , RNA Processing, Post-Transcriptional*, Methyltransferases/metabolism ; Methyltransferases/genetics ; Protozoan Proteins/metabolism ; Protozoan Proteins/genetics ; RNA, Protozoan/metabolism ; RNA, Protozoan/genetics ; RNA Interference ; Methylation

المؤلفون: McDermott SM; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, United States., Pham V; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States., Oliver B; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States., Carnes J; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States., Sather DN; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, United States., Stuart KD; Center for Global Infectious Disease Research, Seattle Children's Research Institute, Seattle, WA, United States.; Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, United States.

المصدر: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2024 Apr 08; Vol. 14, pp. 1381155. Date of Electronic Publication: 2024 Apr 08 (Print Publication: 2024).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Protozoan Proteins*/genetics , Protozoan Proteins*/metabolism , Ribonuclease III*/genetics , Ribonuclease III*/metabolism , RNA Editing* , Trypanosoma brucei brucei*/genetics , Trypanosoma brucei brucei*/metabolism , Trypanosoma brucei brucei*/growth & development, Amino Acid Substitution ; DNA Mutational Analysis ; High-Throughput Nucleotide Sequencing ; Mutation ; Protein Domains/genetics

المؤلفون: Cayla M; Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK. mathieu.cayla@york.ac.uk.; York Biomedical Research Institute, Department of Biology, University of York, York, UK. mathieu.cayla@york.ac.uk., Spanos C; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK., McWilliam K; Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK., Waskett E; Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK., Rappsilber J; Wellcome Centre for Cell Biology, University of Edinburgh, Edinburgh, UK., Matthews KR; Institute for Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, UK.

المصدر: Nature communications [Nat Commun] 2024 Apr 06; Vol. 15 (1), pp. 2972. Date of Electronic Publication: 2024 Apr 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Trypanosoma* , Trypanosoma brucei brucei*/genetics , Trypanosoma brucei brucei*/metabolism, Animals ; Mammals

المؤلفون: Seetsi A; Unit for Environmental Sciences and Management, North-West University, Potchefstroom, 2531, South Africa., N'Da DD; Centre of Excellence for Pharmaceutical Sciences (PHARMACEN), North-West University, Potchefstroom, 2521, South Africa., Nyembe N; Department of Zoology and Entomology, University of the Free State, Phuthaditjhaba, 9880, South Africa., Suganuma K; National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, 080-8555, Japan., Ramatla T; Unit for Environmental Sciences and Management, North-West University, Potchefstroom, 2531, South Africa; Gastrointestinal Research Unit, Department of Surgery, School of Clinical Medicine, University of the Free State, Bloemfontein, 9300, South Africa. Electronic address: ra21205450@gmail.com., Thekisoe O; Unit for Environmental Sciences and Management, North-West University, Potchefstroom, 2531, South Africa.

المصدر: Experimental parasitology [Exp Parasitol] 2024 Apr; Vol. 259, pp. 108711. Date of Electronic Publication: 2024 Feb 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0370713 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2449 (Electronic) Linking ISSN: 00144894 NLM ISO Abbreviation: Exp Parasitol Subsets: MEDLINE

مواضيع طبية MeSH: Trypanosoma* , Trypanosomiasis, African*/drug therapy , Trypanosomiasis, African*/veterinary , Trypanosomiasis, African*/parasitology , Tsetse Flies*/parasitology , Trypanosoma brucei brucei* , Trypanosoma congolense*, Animals ; Cattle ; Nitrofurantoin/pharmacology ; Mammals

المؤلفون: Yu L; Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China; Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China., Li Q; Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China; Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China., Jiang N; Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China; Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China., Fan R; Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China; Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China., Zhang N; Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China; Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China., Zhang Y; Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China; Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China., Sun W; Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China; Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China., Chen R; Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China; Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China., Feng Y; Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China; Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China., Sang X; Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China; Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China., Chen Q; Key Laboratory of Livestock Infectious Diseases, Ministry of Education, and Key Laboratory of Ruminant Infectious Disease Prevention and Control (East), Ministry of Agriculture and Rural Affairs, College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, 120 Dongling Road, Shenyang 110866, China; Research Unit for Pathogenic Mechanisms of Zoonotic Parasites, Chinese Academy of Medical Sciences, 120 Dongling Road, Shenyang 110866, China. Electronic address: qijunchen759@syau.edu.cn.

المصدر: International immunopharmacology [Int Immunopharmacol] 2024 Jun 15; Vol. 134, pp. 112250. Date of Electronic Publication: 2024 May 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Toll-Like Receptor 9*/metabolism , Toll-Like Receptor 9*/agonists , Trypanosoma brucei brucei*/immunology , Signal Transduction* , Trypanosomiasis, African*/immunology , Cytokines*/metabolism, Animals ; Mice ; Mice, Knockout ; Mice, Inbred C57BL ; Humans

المؤلفون: Corfu AI; Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy., Santarem N; Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal.; Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal., Luelmo S; Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal.; Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal., Mazza G; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Pascal 36, 20133 Milan, Italy., Greco A; Department of Pharmacy, University of Pisa, Via Bonanno 6, 56126 Pisa, Italy., Altomare A; Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy., Ferrario G; Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy., Nasta G; Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy., Keminer O; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Schnackenburgallee 114, 22525 Hamburg, Germany.; Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD), Schnackenburgallee 114, 22525 Hamburg, Germany., Aldini G; Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy., Tamborini L; Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy., Basilico N; Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Pascal 36, 20133 Milan, Italy., Parapini S; Department of Biomedical Sciences for Health, University of Milan, Via Pascal 36, 20133 Milan, Italy., Gul S; Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP), Schnackenburgallee 114, 22525 Hamburg, Germany.; Fraunhofer Cluster of Excellence for Immune-Mediated Diseases (CIMD), Schnackenburgallee 114, 22525 Hamburg, Germany., Cordeiro-da-Silva A; Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal.; Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal., Conti P; Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy., Borsari C; Department of Pharmaceutical Sciences, University of Milan, Via Mangiagalli 25, 20133 Milan, Italy.

المصدر: ACS infectious diseases [ACS Infect Dis] 2024 Jun 14; Vol. 10 (6), pp. 2222-2238. Date of Electronic Publication: 2024 May 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Oxadiazoles*/pharmacology , Oxadiazoles*/chemistry , Trypanosoma brucei brucei*/drug effects , Drug Discovery*, Humans ; Structure-Activity Relationship ; Antiparasitic Agents/pharmacology ; Antiparasitic Agents/chemistry ; Antimalarials/pharmacology ; Antimalarials/chemistry ; Antimalarials/chemical synthesis ; Leishmania infantum/drug effects ; Animals ; Antiprotozoal Agents/pharmacology ; Antiprotozoal Agents/chemistry

المؤلفون: Salem FM; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Ave., Cleveland, OH 44115, USA., Martin WR; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Ave., Cleveland, OH 44115, USA; Genomic Medicine Institute, Cleveland Clinic Genome Center, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA., Zhao X; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Ave., Cleveland, OH 44115, USA., Adbus Sayeed SK; Department of Biology, Geo. & Env. Sciences, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Ave., Cleveland, OH 44115, USA., Ighneim S; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Ave., Cleveland, OH 44115, USA., Greene M; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Ave., Cleveland, OH 44115, USA., Mohamed E; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Ave., Cleveland, OH 44115, USA., Orahoske CM; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Ave., Cleveland, OH 44115, USA., Zhang W; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Ave., Cleveland, OH 44115, USA., Li B; Department of Biology, Geo. & Env. Sciences, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Ave., Cleveland, OH 44115, USA. Electronic address: b.li37@csuohio.edu., Su B; Department of Chemistry, Center for Gene Regulation in Health and Disease, College of Arts and Sciences, Cleveland State University, 2121 Euclid Ave., Cleveland, OH 44115, USA. Electronic address: b.su@csuohio.edu.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Jun 01; Vol. 107, pp. 117751. Date of Electronic Publication: 2024 May 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Trypanosoma brucei brucei*/drug effects , Trypanocidal Agents*/pharmacology , Trypanocidal Agents*/chemical synthesis , Trypanocidal Agents*/chemistry, Animals ; Structure-Activity Relationship ; Mice ; Humans ; Administration, Oral ; Cell Proliferation/drug effects ; Molecular Structure ; Molecular Docking Simulation ; Tubulin/metabolism ; Parasitic Sensitivity Tests ; Dose-Response Relationship, Drug ; Tubulin Modulators/pharmacology ; Tubulin Modulators/chemical synthesis ; Tubulin Modulators/chemistry ; Trypanosomiasis, African/drug therapy