نتائج البحث - "Trypanosoma brucei brucei enzymology"

1

رسالة جامعية

Targets and strategies for drug development against human African sleeping sickness

المساهمون: Umeå universitet. Institutionen för medicinsk kemi och biofysik

مصطلحات موضوعية: T. brucei thymidine kinase, T. brucei methylthioadenosine phosphorylase, FANA-A purine nucleoside analogues, Essential oils, Antimetabolites -- pharmacology, Deoxyadenosines -- pharmacology, Purine-nucleoside phosphorylase -- metabolism, Trypanosoma brucei brucei -- drug effects, Trypanosoma brucei brucei -- enzymology, Trypanosoma brucei brucei -- pathogenicity, Trypanosomiasis, African -- pathology, Evolution, molecular, Nucleotides -- metabolism, Protein multimerization, Protozoan proteins -- metabolism, Thymidine kinase -- metabolism

URL الوصول: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-131074

Degree: Diss. (sammanfattning) Umeå : Umeå universitet, 2017

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TbUTP10, a protein involved in early stages of pre-18S rRNA processing in Trypanosoma brucei

المؤلفون: Katherine M. McKenney, Achim Schnaufer, Juan D. Alfonzo, Aleš Horák, Anita Bär, Julius Lukeš, Drahomíra Faktorová, Hassan Hashimi, Mary Anne T. Rubio

المصدر: Faktorová, D, Bär, A, Hashimi, H, McKenney, K, Horák, A, Schnaufer, A, Rubio, M A T, Alfonzo, J D & Lukeš, J 2018, ' TbUTP10, a protein involved in early stages of pre-18S rRNA processing in Trypanosoma brucei ', Molecular and Biochemical Parasitology, vol. 225, pp. 84-93 . https://doi.org/10.1016/j.molbiopara.2018.09.003

مصطلحات موضوعية: 0301 basic medicine, Trypanosoma brucei brucei/enzymology, Nucleolus, Trypanosoma brucei brucei, Protozoan Proteins, Biology, Ribosome, Article, Ribosome assembly, 03 medical and health sciences, 0302 clinical medicine, Large ribosomal subunit, RNA, Ribosomal, 18S, RNA, Small Nucleolar, Eukaryotic Small Ribosomal Subunit, Gene Silencing, RNA Processing, Post-Transcriptional, RRNA processing, Molecular Biology, RNA, Small Nucleolar/metabolism, Genes, Essential, Eukaryotic Large Ribosomal Subunit, RNA, Ribosomal, 18S/metabolism, RNA-Binding Proteins, Ribosomal RNA, RNA-Binding Proteins/genetics, Cell biology, 030104 developmental biology, Protozoan Proteins/genetics, Parasitology, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::678723c204ca7797fa530b10c605956a
https://doi.org/10.1016/j.molbiopara.2018.09.003

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3

رسالة جامعية

Targeting the nucleotide metabolism of the mammalian pathogen Trypanosoma brucei

المؤلفون: Vodnala, Munender

مصطلحات موضوعية: Adenine -- chemistry, Adenosine kinase -- chemistry, Antimetabolites -- chemistry, Protozoan proteins -- chemistry, Protozoan proteins -- metabolism, Trypanosoma brucei brucei -- enzymology, Vidarabine -- chemistry, Nucleotides -- metabolism, Thymidine kinase -- metabolism, Ribonucleotide reductases -- chemistry, Ribonucleotide reductases -- metabolism, Escherichia coli -- enzymology, Escherichia coli proteins -- metabolism, T. brucei adenosine kinase, T. brucei thymidine kinase, T. brucei methylthioadenosine phosphorylase, Ribonucleotide reductase, Nucleoside analogs

URL الوصول: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-80904

Degree: Diss. (sammanfattning) Umeå : Umeå universitet, 2013

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رسالة جامعية

Salvage and de novo synthesis of nucleotides in Trypanosoma brucei and mammalian cells

المؤلفون: Fijolek, Artur

المساهمون: Umeå universitet. Tillämpad fysik och elektronik

مصطلحات موضوعية: Carbon-nitrogen ligases -- biosynthesis, Carbon-nitrogen ligases -- chemistry, Trypanosoma brucei brucei -- enzymology, Trypanosoma brucei gambiense -- enzymology, Trypanosomiasis, African -- therapy, Adenine -- chemistry, Adenosine kinase -- chemistry, Antimetabolites -- chemistry, Protozoan proteins -- chemistry, Vidarabine -- chemistry

URL الوصول: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1850

Degree: Diss. (sammanfattning) Umeå : Umeå universitet, 2008

5

رسالة جامعية

DNA precursor biosynthesis-allosteric regulation and medical applications

المؤلفون: Rofougaran, Reza

مصطلحات موضوعية: DNA helicases -- chemistry, DNA helicases -- metabolism, DNA, single-stranded -- metabolism, Adenine -- chemistry, Adenosine kinase -- chemistry, Antimetabolites -- chemistry, Protozoan proteins -- chemistry, Trypanosoma brucei brucei -- enzymology, Vidarabine -- chemistry, Protein structure, quaternary, Ribonucleotide reductases -- chemistry

URL الوصول: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1678

Degree: Diss. (sammanfattning) Umeå : Univ., 2008

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Disclosing the essentiality of ribose-5-phosphate isomerase B in Trypanosomatids

المؤلفون: Inês Loureiro, Nuno Santarém, Joana Tavares, Joana Faria, Sandra Macedo-Ribeiro, Pedro Cecílio, Anabela Cordeiro-da-Silva

المساهمون: Instituto de Investigação e Inovação em Saúde

المصدر: Scientific Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

مصطلحات موضوعية: 0301 basic medicine, Leishmaniasis, Visceral/parasitology, Trypanosoma brucei brucei/enzymology, Mutant, Protozoan Proteins, Gene Expression, Isomerase, medicine.disease_cause, Mice, Ribulosephosphates, Antiprotozoal Agents/pharmacology, Trypanosoma brucei brucei/drug effects, Leishmania infantum/enzymology, Leishmania infantum, Aldose-Ketose Isomerases, Leishmania infantum/genetics, Mutation, Multidisciplinary, Genes, Essential, Pyrrolidinones, 3. Good health, Complementation, Aldose-Ketose Isomerases/genetics, Ribose-5-phosphate isomerase, Trypanosoma brucei brucei/genetics, Biochemistry, Liver, Ribosemonophosphates/metabolism, Life Cycle Stages/genetics, Protozoan Proteins/genetics, Leishmaniasis, Visceral, Ribosemonophosphates, Trypanosomiasis, African/parasitology, Plasmids, Protozoan Proteins/metabolism, Isomerase activity, Pyrrolidinones/pharmacology, Trypanosoma brucei brucei, Antiprotozoal Agents, Plasmids/chemistry, Biology, Trypanosoma brucei, Article, 03 medical and health sciences, Leishmania infantum/growth & development, Liver/parasitology, Aldose-Ketose Isomerases/metabolism, medicine, Animals, Humans, Amino Acid Sequence, Gene, Life Cycle Stages/drug effects, Life Cycle Stages, 030102 biochemistry & molecular biology, Sequence Homology, Amino Acid, Genetic Complementation Test, Leishmania infantum/drug effects, Plasmids/metabolism, biology.organism_classification, Molecular biology, Disease Models, Animal, 030104 developmental biology, Trypanosomiasis, African, Ribulosephosphates/metabolism, Sequence Alignment, Gene Deletion

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cb73ed76e56ff21852cd4d0324b1d30

Find this article in full text from ProQuest

7

Expression, purification, characterization, and in vivo targeting of trypanosome CTP synthetase for treatment of African sleeping sickness.

المؤلفون: Fijolek, Artur, Hofer, Anders, Thelander, Lars

المصدر: Journal of biological chemistry. 282(16):11858-11865

مصطلحات موضوعية: Animals, Carbon-Nitrogen Ligases/*biosynthesis/*chemistry, Cytidine/chemistry, Cytosine/chemistry, Dose-Response Relationship, Drug, Enzyme Inhibitors/pharmacology, Humans, Kinetics, Male, Mice, Inbred C57BL, Trypanocidal Agents/pharmacology, Trypanosoma brucei brucei/*enzymology, Trypanosoma brucei gambiense/*enzymology, Trypanosomiasis, African/*therapy

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-6341
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=17331943&dopt=Citation

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Structural and mechanistic insights into type II trypanosomatid tryparedoxin-dependent peroxidases

المؤلفون: Alan H. Fairlamb, Janine König, Magnus S. Alphey

المصدر: Biochemical Journal

مصطلحات موضوعية: Cytosol/metabolism, Models, Molecular, Conformational change, Protozoan Proteins/chemistry, Peroxidases/chemistry, Trypanosoma brucei brucei/enzymology, trypanothione, His6, hexahistidine, Protozoan Proteins, Trypanothione, Recombinant Proteins/chemistry, GPX, glutathione peroxidase, Crystallography, X-Ray, Biochemistry, chemistry.chemical_compound, Cytosol, r.m.s.d., root mean square deviation, Models, PEG, poly(ethylene glycol), Cytosol/enzymology, glutathione peroxidase, Recombinant Proteins/metabolism, Leishmania, chemistry.chemical_classification, 0303 health sciences, Crystallography, Selenocysteine, Glutathione peroxidase, 030302 biochemistry & molecular biology, Peroxidases/metabolism, Tb, Trypanosoma brucei, Recombinant Proteins, Enzyme structure, Mitochondria, Pt, Populus trichocarpaxdeltoides (hybrid poplar), Peroxidases, dithiol-dependent peroxidase, Research Article, Peroxidase, Protozoan Proteins/metabolism, Trypanosoma, Stereochemistry, Molecular Sequence Data, Trypanosoma brucei brucei, Biology, Trypanosoma brucei, TryX, tryparedoxin, drug discovery, 03 medical and health sciences, TDPX, tryparedoxin-dependent peroxidase, Mitochondria/metabolism, Animals, Amino Acid Sequence, Molecular Biology, Lm, Leishmania major, 030304 developmental biology, Binding Sites, Molecular, Cell Biology, biology.organism_classification, Kinetics, Mitochondria/enzymology, chemistry, X-Ray, biology.protein, Sequence Alignment, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa44097614d3d382869884f1181444e7
https://doi.org/10.1042/bj20080889

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The Flagellar Arginine Kinase in Trypanosoma brucei Is Important for Infection in Tsetse Flies

المؤلفون: Ooi, Cher-Pheng, Rotureau, Brice, Gribaldo, Simonetta, Georgikou, Christina, Julkowska, Daria, Blisnick, Thierry, Perrot, Sylvie, Subota, Ines, Bastin, Philippe

المساهمون: Biologie Cellulaire des Trypanosomes, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Biologie Moléculaire du Gène chez les Extrêmophiles (BMGE), Institut Pasteur [Paris], This work was funded by the Institut Pasteur and by the Centre National de la Recherche Scientifique (CNRS). CPO was funded by a DIM Ile-de-France postdoctoral fellowship (DIM-MALINF-110071) and by a French Government Investissement d’Avenir programme, Laboratoire d’Excellence 'Integrative Biology of Emerging Infectious Diseases' (ANR-10-LABX-62-IBEID). IS was funded by a Fonds National de la Recherche du Luxembourg (TR-PHD BFR 07-023) fellowship and DJ by a Roux post-doctoral fellowship (Institut Pasteur). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript., ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)

المصدر: PLoS ONE
PLoS ONE, Public Library of Science, 2015, 10 (7), pp. e0133676. ⟨10.1371/journal.pone.0133676⟩
PLoS ONE, Vol 10, Iss 7, p e0133676 (2015)
PLoS ONE, 2015, 10 (7), pp. e0133676. ⟨10.1371/journal.pone.0133676⟩

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b9483bcdd91336545f9f5b3f577d160d
http://europepmc.org/articles/PMC4517888

Find this article in full text from ProQuest

10

Ribose 5-Phosphate Isomerase B Knockdown Compromises Trypanosoma brucei Bloodstream Form Infectivity

المؤلفون: Sandra Macedo-Ribeiro, Christine Clayton, Nilanjan Roy, Anabela Cordeiro-da-Siva, Nuno Santarém, Joana Faria, Inês Loureiro, Joana Tavares

المساهمون: Instituto de Investigação e Inovação em Saúde

المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 9, Iss 1, p e3430 (2015)

مصطلحات موضوعية: Glucose-6-phosphate isomerase, Isomerase activity, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, Trypanosoma brucei brucei/enzymology, Trypanosoma brucei brucei, Antibodies, Protozoan, Isomerase, Trypanosoma brucei, Pentose phosphate pathway, Gene Expression Regulation, Enzymologic, 03 medical and health sciences, chemistry.chemical_compound, Mice, Ribose, parasitic diseases, Aldose-Ketose Isomerases/metabolism, Animals, Cloning, Molecular, Trypanosoma brucei brucei/metabolism, Trypanosoma cruzi, Molecular Biology, Aldose-Ketose Isomerases, 030304 developmental biology, 0303 health sciences, biology, 030306 microbiology, lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, Biology and Life Sciences, lcsh:RA1-1270, biology.organism_classification, 3. Good health, Aldose-Ketose Isomerases/genetics, Infectious Diseases, Ribose-5-phosphate isomerase, Trypanosomiasis, African, chemistry, Biochemistry, Trypanosoma brucei brucei/genetics, Gene Knockdown Techniques, Parasitology, RNA Interference, Trypanosomiasis, African/parasitology, Trypanosomiasis, African/blood, Research Article

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3af85b00ee781bfac34009576d245503
https://repositorio-aberto.up.pt/handle/10216/118188

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