المؤلفون: Irie K; Department of Applied Chemistry, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan., Jeelani G; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan., Nozaki T; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8654, Japan., Iwasaki A; Department of Applied Chemistry, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan.

المصدر: Journal of natural products [J Nat Prod] 2024 Sep 27; Vol. 87 (9), pp. 2292-2301. Date of Electronic Publication: 2024 Aug 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

مواضيع طبية MeSH: Cyanobacteria*/chemistry , Marine Biology* , Trypanosoma brucei rhodesiense*/drug effects, Molecular Structure ; Japan ; Lipopeptides/pharmacology ; Lipopeptides/chemistry ; Lipopeptides/isolation & purification ; Nuclear Magnetic Resonance, Biomolecular ; Trypanocidal Agents/pharmacology ; Trypanocidal Agents/chemistry ; Trypanocidal Agents/isolation & purification ; Proline/chemistry ; Proline/pharmacology ; Animals ; Trypanosomiasis, African/drug therapy

المؤلفون: Hartman CB; Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, South Africa., Dube PS; Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, South Africa., Legoabe LJ; Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, South Africa., Van Pelt N; Laboratory of Microbiology, Parasitology and Hygiene, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium., Matheeussen A; Laboratory of Microbiology, Parasitology and Hygiene, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium., Caljon G; Laboratory of Microbiology, Parasitology and Hygiene, Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium., Beteck RM; Centre of Excellence for Pharmaceutical Sciences, North-West University, Potchefstroom, South Africa.

المصدر: Archiv der Pharmazie [Arch Pharm (Weinheim)] 2024 Jun; Vol. 357 (6), pp. e2300319. Date of Electronic Publication: 2024 Feb 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Verlag GmbH & Co. KGaA Country of Publication: Germany NLM ID: 0330167 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4184 (Electronic) Linking ISSN: 03656233 NLM ISO Abbreviation: Arch Pharm (Weinheim) Subsets: MEDLINE

مواضيع طبية MeSH: Quinolines*/pharmacology , Quinolines*/chemical synthesis , Quinolines*/chemistry , Leishmania infantum*/drug effects , Antiprotozoal Agents*/pharmacology , Antiprotozoal Agents*/chemical synthesis , Antiprotozoal Agents*/chemistry , Trypanosoma cruzi*/drug effects , Parasitic Sensitivity Tests* , Trypanosoma brucei rhodesiense*/drug effects, Animals ; Mice ; Humans ; Structure-Activity Relationship ; Molecular Structure ; Trypanosoma brucei brucei/drug effects ; Dose-Response Relationship, Drug ; Macrophages/drug effects ; Macrophages/parasitology ; Fibroblasts/drug effects

المؤلفون: Nambala P; Department of Biochemistry and Sports Sciences, College of Natural Sciences, Makerere University, Kampala, Uganda.; Kamuzu University of Health Sciences, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi., Noyes H; Centre for Genomic Research, University of Liverpool, Liverpool, United Kingdom., Namulondo J; Department of Biotechnical and Diagnostic Sciences, College of Veterinary Medicine Animal Resources and Biosecurity, Makerere University, Kampala, Uganda., Nyangiri O; Department of Biotechnical and Diagnostic Sciences, College of Veterinary Medicine Animal Resources and Biosecurity, Makerere University, Kampala, Uganda., Alibu VP; Department of Biotechnical and Diagnostic Sciences, College of Veterinary Medicine Animal Resources and Biosecurity, Makerere University, Kampala, Uganda., Nerima B; Department of Biochemistry and Sports Sciences, College of Natural Sciences, Makerere University, Kampala, Uganda., MacLeod A; Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom., Matovu E; Department of Biotechnical and Diagnostic Sciences, College of Veterinary Medicine Animal Resources and Biosecurity, Makerere University, Kampala, Uganda., Musaya J; Kamuzu University of Health Sciences, Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Blantyre, Malawi., Mulindwa J; Department of Biochemistry and Sports Sciences, College of Natural Sciences, Makerere University, Kampala, Uganda.

مؤلفون مشاركون: TrypanoGEN+ Research Group as Members of the H3Africa Consortium

المصدر: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 May 03; Vol. 18 (5), pp. e0011516. Date of Electronic Publication: 2024 May 03 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE

مواضيع طبية MeSH: Trypanosoma brucei rhodesiense*/genetics , Transcriptome* , Trypanosomiasis, African*/parasitology, Malawi ; Humans ; Gene Expression Profiling ; Polymorphism, Single Nucleotide ; Male

المؤلفون: Di Chio C; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy., Starvaggi J; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy., Totaro N; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy., Previti S; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy., Natale B; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy., Cosconati S; Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania Luigi Vanvitelli, Via Vivaldi 43, 81100 Caserta, Italy., Bogacz M; Institute of Organic Chemistry & Macromolecular Chemistry, Friedrich Schiller University of Jena, Humboldtstraße, 10, DE 07743 Jena, Germany., Schirmeister T; Institute of Pharmacy and Biochemistry, University of Mainz, Staudingerweg 5, DE 55128 Mainz, Germany., Legac J; Department of Medicine, San Francisco General Hospital, University of California, 1001 Potrero Avenue, San Francisco, CA 94110, USA., Rosenthal PJ; Department of Medicine, San Francisco General Hospital, University of California, 1001 Potrero Avenue, San Francisco, CA 94110, USA., Zappalà M; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy., Ettari R; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres, 98166 Messina, Italy.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 17; Vol. 25 (8). Date of Electronic Publication: 2024 Apr 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Cysteine Proteinase Inhibitors*/pharmacology , Cysteine Proteinase Inhibitors*/therapeutic use , Cysteine Proteinase Inhibitors*/chemistry , Nitriles*/therapeutic use , Plasmodium falciparum*/drug effects , Trypanosoma brucei rhodesiense*/drug effects , Trypanosomiasis, African*/drug therapy, Humans ; Antimalarials/therapeutic use ; Antimalarials/pharmacology ; Cysteine Endopeptidases/metabolism ; Malaria/drug therapy ; Protozoan Proteins/antagonists & inhibitors ; Protozoan Proteins/metabolism ; Trypanocidal Agents/pharmacology ; Trypanocidal Agents/therapeutic use

المؤلفون: Wendo JK; The University of Nairobi, Department of Public Health, Pharmacology and Toxicology, Kangemi (Nairobi), Kenya.; The Technical University of Kenya, Department of Pharmaceutical Sciences and Technology, Nairobi, Kenya., Mbaria JM; The University of Nairobi, Department of Public Health, Pharmacology and Toxicology, Kangemi (Nairobi), Kenya., Nyariki JN; The Technical University of Kenya, Department of Biochemistry and Biotechnology, Nairobi, Kenya., Isaac AO; The Technical University of Kenya, Department of Pharmaceutical Sciences and Technology, Nairobi, Kenya.

المصدر: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Apr 15; Vol. 18 (4), pp. e0012103. Date of Electronic Publication: 2024 Apr 15 (Print Publication: 2024).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE

مواضيع طبية MeSH: Trypanosomiasis, African*/drug therapy , Trypanosomiasis, African*/parasitology , Oxidative Stress*/drug effects , Plant Extracts*/pharmacology , Ginkgo biloba*/chemistry , Trypanosoma brucei rhodesiense*/drug effects , Melarsoprol*/pharmacology, Animals ; Mice ; Male ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Anti-Inflammatory Agents/pharmacology ; Anti-Inflammatory Agents/administration & dosage ; Disease Models, Animal ; Brain/drug effects ; Brain/parasitology ; Brain/metabolism ; Brain/pathology ; Antioxidants/pharmacology ; Inflammation/drug therapy

المؤلفون: Taylor AE; Leicester School of Allied Health Sciences, De Montfort University, Leicester LE1 9BH, UK., Hering M; Leicester School of Allied Health Sciences, De Montfort University, Leicester LE1 9BH, UK., Elsegood MRJ; Department of Chemistry, Loughborough University, Loughborough LE11 3TU, UK., Teat SJ; Advanced Light Source, 1 Cyclotron Road, Lawrence Berkeley National Laboratory Berkeley, CA 94720-8229, United States., Weaver GW; Department of Chemistry, Loughborough University, Loughborough LE11 3TU, UK., Arroo RRJ; Leicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK., Kaiser M; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland; University of Basel, Petersplatz 1, 4003 Basel, Switzerland., Maeser P; Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland; University of Basel, Petersplatz 1, 4003 Basel, Switzerland., Bhambra AS; Leicester School of Allied Health Sciences, De Montfort University, Leicester LE1 9BH, UK. Electronic address: abhambra@dmu.ac.uk.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Sep 01; Vol. 109, pp. 129825. Date of Electronic Publication: 2024 May 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Pyrimidines*/pharmacology , Pyrimidines*/chemistry , Pyrimidines*/chemical synthesis , Trypanocidal Agents*/pharmacology , Trypanocidal Agents*/chemistry , Trypanocidal Agents*/chemical synthesis, Structure-Activity Relationship ; Parasitic Sensitivity Tests ; Molecular Structure ; Trypanosoma brucei brucei/drug effects ; Humans ; Trypanosoma brucei rhodesiense/drug effects ; Dose-Response Relationship, Drug ; Trypanosomiasis, African/drug therapy

المؤلفون: Kurisawa N; Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan., Jeelani G; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan., Nozaki T; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan., Agusta AL; Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan., Suenaga K; Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan., Iwasaki A; Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, 1-13-27 Kasuga, Bunkyo-ku, Tokyo 112-8551, Japan.

المصدر: Journal of natural products [J Nat Prod] 2024 Jul 26; Vol. 87 (7), pp. 1838-1843. Date of Electronic Publication: 2024 Jul 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

مواضيع طبية MeSH: Depsipeptides*/pharmacology , Depsipeptides*/chemistry , Depsipeptides*/isolation & purification , Cyanobacteria*/chemistry, Humans ; Molecular Structure ; HeLa Cells ; Trypanosoma brucei rhodesiense/drug effects ; Marine Biology ; Trypanocidal Agents/pharmacology ; Trypanocidal Agents/chemistry ; Drug Screening Assays, Antitumor ; Crystallography, X-Ray ; Nuclear Magnetic Resonance, Biomolecular

المؤلفون: Priotto G; Department of Control of Neglected Tropical Diseases, World Health Organization, Avenue Appia 20, 1211 Geneva 27, Switzerland., Franco JR; Department of Control of Neglected Tropical Diseases, World Health Organization, Avenue Appia 20, 1211 Geneva 27, Switzerland., Lejon V; Institut de Recherche pour le Développement, CIRAD, University of Montpellier, France., Büscher P; Institute of Tropical Medicine, Antwerp, Belgium., Matovu E; Animal Resources and Biosecurity, Makerere University, Kampala, Uganda., Ndung'u J; Foundation for Innovative New Diagnostics-Kenya, Nairobi, Kenya., Biéler S; Neglected Tropical Diseases Programme, Foundation for Innovative New Diagnostics, Geneva, Switzerland., Mumba D; Department of Parasitology, Institut National de Recherche Biomédicale, Kinshasa, Democratic Republic of the Congo., Van Reet N; Institute of Tropical Medicine, Antwerp, Belgium., Verlé P; Institute of Tropical Medicine, Antwerp, Belgium., Jamonneau V; Institut de Recherche pour le Développement, CIRAD, University of Montpellier, France., Simarro PP; Department of Control of Neglected Tropical Diseases, World Health Organization, Avenue Appia 20, 1211 Geneva 27, Switzerland., Ebeja AK; Communicable Disease Unit, World Health Organization Regional Office for Africa, Brazzaville, Congo., Sankara D; Department of Control of Neglected Tropical Diseases, World Health Organization, Avenue Appia 20, 1211 Geneva 27, Switzerland., Dagne DA; Department of Control of Neglected Tropical Diseases, World Health Organization, Avenue Appia 20, 1211 Geneva 27, Switzerland.

المصدر: Bulletin of the World Health Organization [Bull World Health Organ] 2023 Aug 01; Vol. 101 (8), pp. 529-534. Date of Electronic Publication: 2023 Jun 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: World Health Organization Country of Publication: Switzerland NLM ID: 7507052 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1564-0604 (Electronic) Linking ISSN: 00429686 NLM ISO Abbreviation: Bull World Health Organ Subsets: MEDLINE

مواضيع طبية MeSH: Trypanosoma brucei rhodesiense* , Trypanosomiasis, African*/diagnosis , Trypanosomiasis, African*/epidemiology , Trypanosomiasis, African*/parasitology, Animals ; Humans ; Africa, Southern ; Sensitivity and Specificity ; Diagnostic Tests, Routine

المؤلفون: Di Chio C; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.; Department of Clinical and Experimental Medicine, University of Messina, Via C. Valeria, 98125 Messina, Italy., Previti S; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy., Totaro N; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy., De Luca F; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy., Allegra A; Department of Human Pathology in Adulthood and Childhood 'Gaetano Barresi', University of Messina, Via Consolare Valeria 1, 98125 Messina, Italy., Schirmeister T; Institute of Pharmaceutical and Biomedical Sciences, University of Mainz, Staudingerweg 5, 55128 Mainz, Germany., Zappalà M; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy., Ettari R; Department of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 May 09; Vol. 24 (10). Date of Electronic Publication: 2023 May 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Curcumin*/pharmacology , Trypanosoma brucei rhodesiense*/drug effects, Cysteine Proteinase Inhibitors/pharmacology ; Dipeptides/pharmacology ; Nitriles ; Structure-Activity Relationship

المؤلفون: Bozdag M; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium., Mertens F; Laboratory of Physiopharmacology, Department of Pharmaceutical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium., Matheeussen A; Laboratory of Microbiology, Parasitology and Hygiene, Department of Biomedical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium., Van Pelt N; Laboratory of Microbiology, Parasitology and Hygiene, Department of Biomedical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium., Foubert K; Natural Products and Food Research and Analysis-Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium., Hermans N; Natural Products and Food Research and Analysis-Pharmaceutical Technology, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium., De Meyer GRY; Laboratory of Physiopharmacology, Department of Pharmaceutical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium., Augustyns K; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium., Martinet W; Laboratory of Physiopharmacology, Department of Pharmaceutical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium., Caljon G; Laboratory of Microbiology, Parasitology and Hygiene, Department of Biomedical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium., Van der Veken P; Laboratory of Medicinal Chemistry, Department of Pharmaceutical Sciences, Infla-Med Centre of Excellence, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk-Antwerp, Belgium.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 25; Vol. 25 (9). Date of Electronic Publication: 2024 Apr 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Pyrazoles*/pharmacology , Pyrazoles*/chemistry , Pyrazoles*/chemical synthesis , Trypanosoma cruzi*/drug effects, Humans ; Antiparasitic Agents/pharmacology ; Antiparasitic Agents/chemical synthesis ; Antiparasitic Agents/chemistry ; Drug Design ; Leishmania infantum/drug effects ; Structure-Activity Relationship ; Trypanosoma brucei rhodesiense/drug effects ; Antiprotozoal Agents/pharmacology ; Antiprotozoal Agents/chemical synthesis ; Antiprotozoal Agents/chemistry