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1
المؤلفون: Chrystelle Girardet, Magali Mathieu, François Vallée, Jacques Le-Roux, Fangxian Sun, Laurence Fabien, Corinne Terrier, Celine Ginesty, Bruno Filoche-Romme, Florence Gruss-Leleu, Maysoun Shomali, Monsif Bouaboula, Sylvie Beccari, Pascal Desmazeau, Gilles Lebourg, Tsiala Benard, Victor Certal, Pascale Vicat, Andrew Hebert, Carlos Garcia-Echeverria, Laurent Schio, Youssef El-Ahmad, Gary Mccort, Claire Muller, Maurice Brollo, Mikhail Levit, Luc Bertin, Hong Cheng, Véronique Loyau, Valerie Steier, Fabienne Thompson, Audrey Louboutin, Fabienne Pilorge, Alexey Rak, Frank Halley, Patrick Richepin, Christelle Perrault, Pierre-Yves Abecassis, Michel Tabart, Albane Courjaud
المصدر: Journal of Medicinal Chemistry. 63:512-528
مصطلحات موضوعية: 0303 health sciences, biology, Fulvestrant, Chemistry, Estrogen receptor, medicine.disease, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Breast cancer, Hormone receptor, Drug Discovery, biology.protein, medicine, Cancer research, Molecular Medicine, Aromatase, Receptor, Estrogen receptor alpha, Tamoxifen, 030304 developmental biology, medicine.drug
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2
المؤلفون: Jessica Mestadier, Sandrine Valence, Elisa Francesconi, Conception Nemecek, Mireille Kenigsberg, Celine Lefranc, Véronique Do-Vale, Tsiala Benard, Françoise Bégassat, Fabrice Bonche, Hélène Goulaouic, Loreley Calvet, Jean-Paul Nicolas, Coumaran Egile, Christelle Castell, Christine Delaisi, Anne-Marie Lefebvre
المصدر: Molecular Cancer Therapeutics. 14:384-394
مصطلحات موضوعية: Azoles, MAPK/ERK pathway, Cancer Research, Antineoplastic Agents, Apoptosis, Mice, SCID, Tumor initiation, Pharmacology, Biology, Metastasis, Adenosine Triphosphate, Cell Movement, Stomach Neoplasms, Cell Line, Tumor, medicine, Animals, Humans, Urea, Benzothiazoles, Phosphorylation, Protein Kinase Inhibitors, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, Dose-Response Relationship, Drug, Kinase, Autophosphorylation, Gene Amplification, Proto-Oncogene Proteins c-met, medicine.disease, HEK293 Cells, Oncology, Mutation, Administration, Intravenous, Female, Tyrosine kinase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0beefff4d1ef21d5059e266e3201cd6
https://doi.org/10.1158/1535-7163.mct-14-0428 -
3
المؤلفون: Benoit Pasquier, Youssef El-Ahmad, Bruno Filoche-Rommé, Christine Dureuil, Florence Fassy, Pierre-Yves Abecassis, Magali Mathieu, Thomas Bertrand, Tsiala Benard, Cédric Barrière, Samira El Batti, Jean-Philippe Letallec, Véronique Sonnefraud, Maurice Brollo, Laurence Delbarre, Véronique Loyau, Fabienne Pilorge, Luc Bertin, Patrick Richepin, Jérôme Arigon, Jean-Robert Labrosse, Jacques Clément, Florence Durand, Romain Combet, Pierre Perraut, Vincent Leroy, Frédéric Gay, Dominique Lefrançois, François Bretin, Jean-Pierre Marquette, Nadine Michot, Anne Caron, Christelle Castell, Laurent Schio, Gary McCort, Hélène Goulaouic, Carlos Garcia-Echeverria, Baptiste Ronan
المصدر: Journal of Medicinal Chemistry. 58:376-400
مصطلحات موضوعية: Male, Models, Molecular, Stereochemistry, Molecular Sequence Data, Antineoplastic Agents, Mice, SCID, Pyrimidinones, Plasma protein binding, Crystallography, X-Ray, Rats, Sprague-Dawley, chemistry.chemical_compound, In vivo, Cell Line, Tumor, Neoplasms, Morpholine, Drug Discovery, Animals, Humans, Transferase, Amino Acid Sequence, Enzyme Inhibitors, Trifluoromethyl, Molecular Structure, Sequence Homology, Amino Acid, Drug discovery, Kinase, fungi, Synthon, Bridged Bicyclo Compounds, Heterocyclic, Class III Phosphatidylinositol 3-Kinases, Xenograft Model Antitumor Assays, Protein Structure, Tertiary, Models, Chemical, chemistry, Area Under Curve, Thermodynamics, Molecular Medicine, Caco-2 Cells, HeLa Cells, Protein Binding
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4
المؤلفون: Jean Pierre Marquette, Andreas Karlsson, Sylvie Monget, Thomas Bertrand, Jean Christophe Carry, Frank Halley, Marc Antoine Perrin, Jean Paul Nicolas, Tsiala Benard, Angela Virone-Oddos, Luc Bertin, Céline Amara, Hélène Bonnevaux, Laurence Delbarre, Gilles Doerflinger, Pierre Yves Abecassis, Youssef El-Ahmad, Véronique Charrier, Victor Certal, Bruno Filoche-Romme, Florence Gruss-Leleu, Sébastien Perron, Alexey Rak, Patrick Richepin, Stephane Guerif, Carlos Garcia-Echeverria, Loic Vincent, Nadine Michot, Magali Mathieu, Véronique Loyau, Olivier Lemaitre, Maurice Brollo, Christoph Lengauer, Houlfa Guizani, Laurent Schio, Fabienne Thompson, Cécile Delorme
المصدر: Journal of Medicinal Chemistry. 57:903-920
مصطلحات موضوعية: Male, Cell Membrane Permeability, Indoles, Phosphatase, Molecular Conformation, Biological Availability, Antineoplastic Agents, Mice, SCID, Pyrimidinones, Crystallography, X-Ray, Mice, Rats, Nude, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, In vivo, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, PTEN, Tensin, Pyrimidone, Phosphoinositide-3 Kinase Inhibitors, Mice, Inbred BALB C, biology, PTEN Phosphohydrolase, Stereoisomerism, In vitro, Rats, Molecular Docking Simulation, Solubility, chemistry, Structural biology, Biochemistry, Indoline, Microsomes, Liver, biology.protein, Cancer research, Heterografts, Molecular Medicine, Female, Drug Screening Assays, Antitumor, Neoplasm Transplantation, Protein Binding
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5
المؤلفون: Jean Christophe Carry, Youssef El-Ahmad, Bruno Filoche-Romme, Frank Halley, Loic Vincent, Andreas Karlsson, Thomas Bertrand, Christoph Lengauer, Tsiala Benard, Pierre Yves Abecassis, Peter Below, Alexey Rak, Jean Paul Nicolas, Gilles Lebourg, Audrey Louboutin, Victor Certal, Laurent Schio, Cécile Delorme, Nadine Michot, Fabienne Pilorge, Fabienne Chatreaux, Pascale Lejeune, Fabienne Thompson, Angela Virone-Oddos, Isabelle Vade, Hélène Bonnevaux, Jean Pierre Marquette, Odile Angouillant-Boniface
المصدر: Journal of Medicinal Chemistry. 55:4788-4805
مصطلحات موضوعية: Models, Molecular, Gene isoform, Benzimidazole, Class I Phosphatidylinositol 3-Kinases, Antineoplastic Agents, Mice, SCID, Pyrimidinones, Pharmacology, Crystallography, X-Ray, medicine.disease_cause, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, PTEN, Tensin, Pyrimidone, Phosphorylation, PI3K/AKT/mTOR pathway, Benzoxazoles, Molecular Structure, biology, Kinase, Chemistry, Macrophages, PTEN Phosphohydrolase, Neoplasms, Experimental, Fibroblasts, Xenograft Model Antitumor Assays, Isoenzymes, biology.protein, Molecular Medicine, Benzimidazoles, Carcinogenesis, Proto-Oncogene Proteins c-akt, Protein Binding
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المؤلفون: Véronique Do-Vale, Fabrice Bonche, Tsiala Benard, Mireille Kenigsberg, Jean-Paul Nicolas, Coumaran Egile, Christoph Lengauer, Jessica Mestadier, Conception Nemecek, Françoise Bégassat, Loreley Calvet, Hélène Goulaouic, Christine Delaisi
المصدر: Cancer Research. 72:845-845
مصطلحات موضوعية: MAPK/ERK pathway, Cancer Research, Kinase, business.industry, Autophosphorylation, Pharmacology, Oncology, Apoptosis, Medicine, Signal transduction, Receptor, business, Protein kinase B, PI3K/AKT/mTOR pathway
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e43d804e12437d8ab2c8b48d1936840a
https://doi.org/10.1158/1538-7445.am2012-845 -
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المؤلفون: Cécile Delorme, Hélène Bonnevaux, Jean-Paul Nicolas, Christoph Lengauer, Joerg Bussenius, Fabienne Thompson, Paul Foster, Laurent Debussche, Franck Halley, Angela Virone-Oddos, Andreas Karlsson, David J. Matthews, Jean-Christophe Carry, Tsiala Benard, Pascale Lejeune, Pierre-Yves Abecassis, Oliver Raeber, Laurent Schio, Jing Wang, Renaud Morales, Victor Certal, Lam Nguyen, Kenneth D. Rice, Ron Aoyama, Chris Jaeger, Nadine Michot, Torsten Trowe
المصدر: Cancer Research. 70:4475-4475
مصطلحات موضوعية: Gene isoform, Cancer Research, Kinase, Cancer, Pharmacology, Biology, medicine.disease, Oncology, medicine, biology.protein, Phosphorylation, Cytotoxic T cell, PTEN, Protein kinase B, PI3K/AKT/mTOR pathway
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::44bde52ddc69b542ab2be70d1d212923
https://doi.org/10.1158/1538-7445.am10-4475
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