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1
المؤلفون: Sunghoon Ma, Julie Lougheed, Christopher Jaeger, Scott W. Womble, Jean-Claire Limun Manalo, Chris A. Buhr, Longcheng Wang, Wentao Zhang, Kenneth D. Rice, Steven Charles Defina, Abigail R. Kennedy, Timothy S. Heuer, Michael Yakes, Neel Kumar Anand, Tae-Gon Baik, Curtis Jeff Kimo, Joerg Bussenius, Angie I. Kim, Jonathan C. Li, Michael Pack, Csaba J. Peto, Monique Nicoll, Naing Aay, Simona Costanzo, Jae Lee, Garth Joseph Mcgrath, Charles M. Blazey, Tsze H. Tsang, Shiva Malek, Anagha Abhijit Joshi, Arlyn Arcalas, Ping Huang, Larisa Dubenko, Jean-Francois Martini, Katherine Lara, John M. Nuss, Owen Joseph Bowles
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:5396-5404
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Phthalic Acids, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Crystallography, X-Ray, Biochemistry, Protein content, Mice, chemistry.chemical_compound, Mouse xenograft, In vivo, Cell Line, Tumor, Neoplasms, Drug Discovery, Tumor regression, Animals, Humans, HSP90 Heat-Shock Proteins, Molecular Biology, Cell Proliferation, biology, Chemistry, Drug discovery, Organic Chemistry, Tropane, Hsp90, Small molecule, biology.protein, Molecular Medicine, Azabicyclo Compounds
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2
المؤلفون: Jeffry Kimo Curtis, Julie Lougheed, Stefan Engst, Peiwen Yu, Anagha Abhijit Joshi, Elena S. Koltun, Csaba J. Peto, Neel Kumar Anand, Jean-Claire Limun Manalo, Stuart Johnston, Steven Charles Defina, Abigail R. Kennedy, Naing Aay, Kenneth D. Rice, Larisa Dubenko, Tsze H. Tsang, Jean-Francois Martini, Simona Costanzo, John M. Nuss, Angie I. Kim, Owen Joseph Bowles, Joerg Bussenius, Charles M. Blazey
المصدر: ACS Medicinal Chemistry Letters. 3:416-421
مصطلحات موضوعية: MAPK/ERK pathway, business.industry, MEK inhibitor, Organic Chemistry, Allosteric regulation, Cancer, Pharmacology, medicine.disease, Biochemistry, Phenotype, In vitro, Downregulation and upregulation, In vivo, Drug Discovery, medicine, Cancer research, business
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3
المؤلفون: Kenneth D. Rice, Neel Kumar Anand, Moon Hwan Kim, Jason Jevious Parks, Tsze H. Tsang, Donna T. Le, Larisa Dubenko, Erick Wang Co, Steven Charles Defina, Joerg Bussenius, Lynne Canne-Bannen, David J. Matthews, John M. Nuss, Stefan Engst, Simona Costanzo, Richard George Khoury, A. Douglas Laird, Diva Sze-Ming Chan, Wei Xu, Owen Joseph Bowles, Maurizio Franzini, Vasu Jammalamadaka, Ping Huang, Amy Lew Tsuhako, Yong Wang, David W. Markby, Baili Chen, Morrison B. Mac, Rhett Ronald Klein, Nicole Miller, Charles M. Blazey
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:2693-2697
مصطلحات موضوعية: Models, Molecular, Pyridines, Proto-Oncogene Proteins c-akt, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Mice, Phosphatidylinositol 3-Kinases, Enzyme activator, Dogs, In vivo, Microsomes, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Molecular Structure, Kinase, Chemistry, Akt/PKB signaling pathway, Organic Chemistry, Ribosomal Protein S6 Kinases, 70-kDa, Cancer, Haplorhini, medicine.disease, Enzyme Activation, Cancer research, Pyrazoles, Molecular Medicine
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4
المؤلفون: Kenneth D. Rice, Yong Wang, Lynne Canne Bannen, Morrison B. Mac, Vasu Jammalamadaka, Simona Costanzo, Maurizio Franzini, Erick Wang Co, Nicole Miller, Larisa Dubenko, Steven Charles Defina, Joerg Bussenius, Neel Kumar Anand, Douglas Laird, David J. Matthews, John M. Nuss, Jason Jevious Parks, Amy Lew Tsuhako, Rhett Ronald Klein, Donna T. Le, Tsze H. Tsang, Baili Chen, Charles M. Blazey, Moon Hwan Kim, David W. Markby, Richard George Khoury, Wei Xu, Diva Sze-Ming Chan, Owen Joseph Bowles, Stefan Engst, Ping Huang
المصدر: Bioorganicmedicinal chemistry letters. 22(6)
مصطلحات موضوعية: Male, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biological Availability, Antineoplastic Agents, Pharmacology, Biochemistry, Pyrazolopyrimidine, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Pharmacokinetics, Cell Line, Tumor, Drug Discovery, Animals, Humans, Molecular Biology, Protein kinase B, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Chemistry, Kinase, Organic Chemistry, Ribosomal Protein S6 Kinases, 70-kDa, Xenograft Model Antitumor Assays, High-Throughput Screening Assays, Rats, Pyrimidines, Solubility, Ribosomal protein s6, Drug Design, Molecular Medicine, Pyrazoles, Lead compound, Signal Transduction
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