المؤلفون: Rowbotham SP; Stem Cell Program, Division of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA, 02115, USA.; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA., Li F; Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, 10016, USA., Dost AFM; Stem Cell Program, Division of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA, 02115, USA.; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA., Louie SM; Stem Cell Program, Division of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA, 02115, USA.; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA., Marsh BP; Stem Cell Program, Division of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA, 02115, USA.; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA., Pessina P; Stem Cell Program, Division of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA, 02115, USA.; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA., Anbarasu CR; Stem Cell Program, Division of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA, 02115, USA.; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA., Brainson CF; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, KY, 40536, USA., Tuminello SJ; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Lieberman A; Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Abramson Cancer Center, Philadelphia, PA, 19104, USA., Ryeom S; Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Abramson Cancer Center, Philadelphia, PA, 19104, USA., Schlaeger TM; Stem Cell Program, Division of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA, 02115, USA., Aronow BJ; Division of Biomedical Informatics, Cincinnati Children's Research Foundation, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA., Watanabe H; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA., Wong KK; Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, 10016, USA., Kim CF; Stem Cell Program, Division of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA, 02115, USA. carla.kim@childrens.harvard.edu.; Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA. carla.kim@childrens.harvard.edu.; Harvard Stem Cell Institute, Cambridge, MA, 02138, USA. carla.kim@childrens.harvard.edu.

المصدر: Nature communications [Nat Commun] 2018 Nov 19; Vol. 9 (1), pp. 4559. Date of Electronic Publication: 2018 Nov 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Disease Progression*, Histone Demethylases/*metabolism , Histone Methyltransferases/*metabolism , Lung Neoplasms/*metabolism, Adenocarcinoma of Lung/metabolism ; Animals ; Carcinogenesis ; Cell Line, Tumor/drug effects ; Cell Survival ; Disease Models, Animal ; Extracellular Matrix/genetics ; Histone Demethylases/drug effects ; Histone-Lysine N-Methyltransferase/drug effects ; Histone-Lysine N-Methyltransferase/metabolism ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Organoids/anatomy & histology ; Phenotype ; Proto-Oncogene Proteins p21(ras)/genetics

المؤلفون: Ruf-Zamojski F; Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai, New York, United States., Fribourg M; Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai, New York, United States., Ge Y; Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai, New York, United States., Nair V; Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai, New York, United States., Pincas H; Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai, New York, United States., Zaslavsky E; Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai, New York, United States., Nudelman G; Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai, New York, United States., Tuminello SJ; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, United States., Watanabe H; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, United States., Turgeon JL; University of California, Davis, Davis, CA, United States., Sealfon SC; Department of Neurology, Center for Advanced Research on Diagnostic Assays, Icahn School of Medicine at Mount Sinai, New York, United States.; Departments of Neuroscience and Pharmacological Sciences, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, United States.

المصدر: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2018 Feb 14; Vol. 9, pp. 34. Date of Electronic Publication: 2018 Feb 14 (Print Publication: 2018).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: PubMed not MEDLINE

المؤلفون: Zhang H, Brainson CF, Koyama S, Redig AJ, Chen T, Li S, Gupta M, Garcia-de-Alba C, Paschini M, Herter-Sprie GS, Lu G, Zhang X, Marsh BP, Tuminello SJ, Xu C, Chen Z, Wang X, Akbay EA, Zheng M, Palakurthi S, Sholl LM, Rustgi AK, Kwiatkowski DJ, Alan Diehl J, Bass AJ, Sharpless NE, Dranoff G, Hammerman PS, Ji H, Bardeesy N, Saur D, Watanabe H, Kim CF, Wong KK

المصدر: Nature communications [Nat Commun] 2017 Jun 09; Vol. 8, pp. 15901. Date of Electronic Publication: 2017 Jun 09.

نوع المنشور: Journal Article; Published Erratum

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: PubMed not MEDLINE

المؤلفون: Zhang H; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Fillmore Brainson C; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital Boston, Boston, Massachusetts 02115, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA., Koyama S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Redig AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Chen T; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Li S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Gupta M; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital Boston, Boston, Massachusetts 02115, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA., Garcia-de-Alba C; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital Boston, Boston, Massachusetts 02115, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA., Paschini M; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital Boston, Boston, Massachusetts 02115, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA., Herter-Sprie GS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Lu G; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Zhang X; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Marsh BP; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital Boston, Boston, Massachusetts 02115, USA., Tuminello SJ; Department of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA., Xu C; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Chen Z; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Wang X; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Akbay EA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Zheng M; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Palakurthi S; Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA., Sholl LM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Rustgi AK; University of Pennsylvania Perelman School of Medicine, Division of Gastroenterology, Department of Medicine and Genetics, Abramson Cancer Center, Philadelphia, Pennsylvania 19104, USA., Kwiatkowski DJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Diehl JA; Department of Biochemical and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA., Bass AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Sharpless NE; University of North Carolina Lineberger Comprehensive Cancer Center, UNC School of Medicine, Chapel Hill, North Carolina 27599, USA., Dranoff G; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Hammerman PS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA., Ji H; Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.; School of Life Science and Technology, Shanghai Tech University, Shanghai 200120, China., Bardeesy N; Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02144, USA., Saur D; Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, München 81675, Germany.; German Cancer Research Center (DKFZ) and German Cancer Consortium (DKTK), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany., Watanabe H; Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA., Kim CF; Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital Boston, Boston, Massachusetts 02115, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.; Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA., Wong KK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.; Belfer Institute for Applied Cancer Science, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.; Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, New York 10016, USA.

المصدر: Nature communications [Nat Commun] 2017 Apr 07; Vol. 8, pp. 14922. Date of Electronic Publication: 2017 Apr 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma/*genetics , Carcinoma, Squamous Cell/*genetics , Lung Neoplasms/*genetics , Polycomb Repressive Complex 2/*genetics , Protein Serine-Threonine Kinases/*genetics, AMP-Activated Protein Kinases ; Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Animals ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Enhancer of Zeste Homolog 2 Protein/genetics ; Enhancer of Zeste Homolog 2 Protein/metabolism ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic ; Histones/metabolism ; Kaplan-Meier Estimate ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Methylation ; Mice, 129 Strain ; Mice, Knockout ; Polycomb Repressive Complex 2/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins p21(ras)/genetics ; Proto-Oncogene Proteins p21(ras)/metabolism ; Tumor Cells, Cultured