المؤلفون: Tomas Bohr, Poul G. Hjorth, Sebastian C. Holst, Sabina Hrabětová, Vesa Kiviniemi, Tuomas Lilius, Iben Lundgaard, Kent-Andre Mardal, Erik A. Martens, Yuki Mori, U. Valentin Nägerl, Charles Nicholson, Allen Tannenbaum, John H. Thomas, Jeffrey Tithof, Helene Benveniste, Jeffrey J. Iliff, Douglas H. Kelley, Maiken Nedergaard

المصدر: iScience, Vol 25, Iss 9, Pp 104987- (2022)

مصطلحات موضوعية: Neuroscience, Neuroanatomy, Systems biology, Science

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004222012597; https://doaj.org/toc/2589-0042

URL الوصول: https://doaj.org/article/33ffdd5decaa48649e91d28e1138f5aa

المؤلفون: Elsi Verrinder, Niklas Wester, Elli Leppänen, Tuomas Lilius, Eija Kalso, Bjo̷rn Mikladal, Ilkka Varjos, Jari Koskinen, Tomi Laurila

المصدر: ACS Omega, Vol 6, Iss 17, Pp 11563-11569 (2021)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2470-1343

URL الوصول: https://doaj.org/article/35910821430f45d584993980d4e7e77f

المؤلفون: Niklas Wester, Elsi Mynttinen, Jarkko Etula, Tuomas Lilius, Eija Kalso, Esko I. Kauppinen, Tomi Laurila, Jari Koskinen

المصدر: ACS Omega, Vol 4, Iss 18, Pp 17726-17734 (2019)

مصطلحات موضوعية: Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2470-1343

URL الوصول: https://doaj.org/article/14e1d62a46c64989861fff3e0c0fc16e

المؤلفون: Anssi J. H. Mykkänen, Suvi Taskinen, Mikko Neuvonen, Maria Paile‐Hyvärinen, E. Katriina Tarkiainen, Tuomas Lilius, Tuija Tapaninen, Janne T. Backman, Aleksi Tornio, Mikko Niemi

المساهمون: INDIVIDRUG - Individualized Drug Therapy, HUSLAB, Department of Clinical Pharmacology, University of Helsinki, Janne Backman / Principal Investigator, Clinicum, Medicum

مصطلحات موضوعية: Pharmacology, Simvastatin, Genotype, PHARMACOGENETICS, Liver-Specific Organic Anion Transporter 1, CHOLESTEROL, Organic Anion Transporters, GENETIC-VARIATION, ABCB1, METABOLISM, Polymorphism, Single Nucleotide, SLCO1B1, POLYMORPHISM, CYP3A4 ALLELIC VARIANTS, 317 Pharmacy, ACID, Cytochrome P-450 CYP3A, Humans, Pharmacology (medical), Prospective Studies, 3111 Biomedicine, Retrospective Studies, HAPLOTYPE RECONSTRUCTION

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28dd98398f896401cb776dd3a6e6a25
http://hdl.handle.net/10138/347820

المؤلفون: Evan Hunter Stanton, Niklas Daniel Åke Persson, Ryszard Stefan Gomolka, Tuomas Lilius, Björn Sigurðsson, Hedok Lee, Anna Lenice Ribeiro Xavier, Helene Benveniste, Maiken Nedergaard, Yuki Mori

المصدر: Magnetic Resonance in Medicine. 85:3326-3342

مصطلحات موضوعية: Cisterna magna, 030218 nuclear medicine & medical imaging, Gadobutrol, Xylazine, Mice, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, medicine, Animals, Anesthesia, Radiology, Nuclear Medicine and imaging, Cerebrospinal Fluid, Isoflurane, business.industry, Brain, Magnetic Resonance Imaging, Dynamic contrast-enhanced MRI, Anesthetic, Glymphatic system, business, Glymphatic System, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abf3f9ec674e07a5e2339ee714694bf
https://doi.org/10.1002/mrm.28645

المؤلفون: Tuomas Lilius, Boriss Sagalajev, Pekka Rauhala, Antti Pertovaara, Eija Kalso, Hanna Viisanen

المساهمون: Department of Pharmacology, Department of Physiology, Faculty of Medicine, University of Helsinki, INDIVIDRUG - Individualized Drug Therapy, Research Programs Unit, HUSLAB, Medicum, Department of Clinical Pharmacology, Pekka Rauhala / Principal Investigator, HUS Perioperative, Intensive Care and Pain Medicine, Eija Kalso / Principal Investigator, University Management, Department of Diagnostics and Therapeutics, Anestesiologian yksikkö, Helsinki University Hospital Area, SLEEPWELL Research Program, Antti Pertovaara / Principal Investigator

المصدر: Viisanen, H, Lilius, T O, Sagalajev, B, Rauhala, P, Kalso, E & Pertovaara, A 2020, ' Neurophysiological response properties of medullary pain-control neurons following chronic treatment with morphine or oxycodone : Modulation by acute ketamine ', Journal of Neurophysiology, vol. 124, no. 3, pp. 790-801 . https://doi.org/10.1152/jn.00343.2020

مصطلحات موضوعية: Male, Nociception, Physiology, rostroventromedial medulla, ROSTRAL VENTROMEDIAL MEDULLA, Pharmacology, 3124 Neurology and psychiatry, Rats, Sprague-Dawley, 0302 clinical medicine, 030202 anesthesiology, Medicine, IN-VIVO, Medulla Oblongata, ON-CELLS, Behavior, Animal, Morphine, General Neuroscience, 1184 Genetics, developmental biology, physiology, Drug Tolerance, 3. Good health, Analgesics, Opioid, Hyperalgesia, Ketamine, medicine.symptom, Oxycodone, medicine.drug, Analgesic, Rostroventromedial medulla, NMDA RECEPTOR ANTAGONIST, Receptors, N-Methyl-D-Aspartate, PERIAQUEDUCTAL GRAY, 03 medical and health sciences, OPIOID-INDUCED HYPERALGESIA, Animals, TOLERANCE, Opioid-induced hyperalgesia, business.industry, 3112 Neurosciences, CANCER PAIN, Rats, Analgesic opioid tolerance, Opioid, OFF-CELLS, Rostral ventromedial medulla, business, analgesic opioid tolerance, Excitatory Amino Acid Antagonists, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6000857bb67435a147cedcda02b6f4
https://doi.org/10.1152/jn.00343.2020

المؤلفون: Tuomas Lilius, Hanna Viisanen, Katarzyna Anna Dudek, Fredrik Harry Gustav Ahlström, Jouko Laitila, Eija Kalso, Kert Mätlik, Pekka Rauhala, Kim Juhani Blomqvist

المساهمون: Department of Pharmacology, Faculty of Medicine, University of Helsinki, INDIVIDRUG - Individualized Drug Therapy, Operations Management Unit, Research Programs Unit, HUSLAB, Department of Clinical Pharmacology, Helsinki University Hospital Area, HUS Perioperative, Intensive Care and Pain Medicine, Eija Kalso / Principal Investigator, Department of Diagnostics and Therapeutics, Anestesiologian yksikkö, Pekka Rauhala / Principal Investigator, Medicum

المصدر: Blomqvist, K J, Dudek, K A, Viisanen, H, Matlik, K, Ahlstrom, F H G, Laitila, J, Kalso, E A, Rauhala, P V & Lilius, T O 2022, ' Antagonism of peripheral opioid receptors by methylnaltrexone does not prevent morphine tolerance in rats ', Journal of Neuroscience Research, vol. 100, no. 1, pp. 329-338 . https://doi.org/10.1002/jnr.24638
Journal of Neuroscience Research

مصطلحات موضوعية: 0301 basic medicine, Male, Narcotic Antagonists, Receptors, Opioid, mu, methylnaltrexone, Pharmacology, Naltrexone, 3124 Neurology and psychiatry, Rats, Sprague-Dawley, 0302 clinical medicine, Drug tolerance, Opioid receptor, ANTINOCICEPTION, PHARMACOLOGY, Morphine, SCR_002798, PAIN, morphine, Drug Tolerance, Methylnaltrexone, NOCICEPTION, 3. Good health, Analgesics, Opioid, Nociception, DOGS, 317 Pharmacy, analgesics, naltrexone, medicine.drug, medicine.drug_class, INHIBITION, METABOLISM, 03 medical and health sciences, Cellular and Molecular Neuroscience, QUATERNARY NARCOTIC-ANTAGONISTS, drug tolerance, medicine, Animals, RRID, Dose-Response Relationship, Drug, business.industry, Antagonist, 3112 Neurosciences, Rats, Quaternary Ammonium Compounds, MICE, 030104 developmental biology, Opioid, Receptors, Opioid, opioid, business, 030217 neurology & neurosurgery, N-METHYLNALTREXONE

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abc143dc2a9cc9d9140206a8fec43310
https://curis.ku.dk/ws/files/289227935/Antagonism_of_peripheral_opioid.pdf

المؤلفون: Kristian Mortensen, Tuomas Lilius, Marko Rosenholm, Björn Sigurðsson, Douglas H. Kelley, Maiken Nedergaard

المصدر: SSRN Electronic Journal.

مصطلحات موضوعية: History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::915961e703661e9e50ba61e812fa09a2
https://doi.org/10.2139/ssrn.4308439

المؤلفون: Eija Kalso, Hua Jiang, Sami Sainio, Bjørn F. Mikladal, Ilkka Varjos, Tomi Laurila, Niklas Wester, Esko I. Kauppinen, Elsi Mynttinen, Jari Koskinen, Tuomas Lilius

المساهمون: Microsystems Technology, Physical Characteristics of Surfaces and Interfaces, University of Helsinki, Canatu Oy, SLAC National Accelerator Laboratory, NanoMaterials, Department of Electrical Engineering and Automation, Department of Chemistry and Materials Science, Department of Applied Physics, Aalto-yliopisto, Aalto University, HUSLAB, Medicum, Department of Pharmacology, Department of Clinical Pharmacology, Helsinki University Hospital Area, HUS Perioperative, Intensive Care and Pain Medicine, Eija Kalso / Principal Investigator, Department of Diagnostics and Therapeutics, Anestesiologian yksikkö

المصدر: Analytical Chemistry

مصطلحات موضوعية: Surface Properties, 116 Chemical sciences, Analgesic, CODEINE, 010402 general chemistry, 01 natural sciences, Article, Analytical Chemistry, NEXAFS, chemistry.chemical_compound, Nafion, medicine, DRUGS, Particle Size, ABUSE, Electrodes, HUMAN-PLASMA, SPECTROSCOPY, Chromatography, Molecular Structure, Nanotubes, Carbon, 010401 analytical chemistry, Codeine, VOLTAMMETRIC OXIDATION, ALCOHOLS, Electrochemical Techniques, Buffer solution, ACIDS, 3. Good health, 0104 chemical sciences, Fluorocarbon Polymers, chemistry, Opioid, Oxymorphone, X-RAY-ABSORPTION, Electrode, Oxycodone, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b0da4f25baf7d1d75da3c4a5a6d762
https://doi.org/10.1021/acs.analchem.0c00450

المؤلفون: Elsi Mynttinen, Tomi Laurila, Eija Kalso, Niklas Wester, Esko I. Kauppinen, Jarkko Etula, Jari Koskinen, Tuomas Lilius

المساهمون: HUSLAB, Medicum, Department of Pharmacology, University of Helsinki, Department of Clinical Pharmacology, HUS Perioperative, Intensive Care and Pain Medicine, Eija Kalso / Principal Investigator, University Management, Department of Diagnostics and Therapeutics, Anestesiologian yksikkö, Physical Characteristics of Surfaces and Interfaces, Microsystems Technology, NanoMaterials, Department of Electrical Engineering and Automation, Department of Chemistry and Materials Science, Department of Applied Physics, Aalto-yliopisto, Aalto University

المصدر: ACS Omega, Vol 4, Iss 18, Pp 17726-17734 (2019)
ACS Omega

مصطلحات موضوعية: PHARMACOKINETICS, General Chemical Engineering, 116 Chemical sciences, Inorganic chemistry, 02 engineering and technology, Carbon nanotube, MEMBRANES, 010402 general chemistry, 01 natural sciences, Article, law.invention, DOPAMINE, chemistry.chemical_compound, Electron transfer, RAMAN-SPECTROSCOPY, law, Nafion, DRUGS, QD1-999, ELECTROCHEMICAL DETERMINATION, Precipitation (chemistry), VOLTAMMETRIC OXIDATION, General Chemistry, 021001 nanoscience & nanotechnology, Ascorbic acid, 0104 chemical sciences, METABOLITE, Chemistry, Membrane, chemistry, Linear range, Electrode, 3111 Biomedicine, ACETAMINOPHEN, 0210 nano-technology, BEHAVIOR

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a180d05f8f42fdcedd2a9d406e95f2c5
https://doaj.org/article/14e1d62a46c64989861fff3e0c0fc16e