المؤلفون: Brevini, T, Maes, M, Webb, GJ, John, BV, Fuchs, CD, Buescher, G, Wang, L, Griffiths, C, Brown, ML, Scott, WE, Pereyra-Gerber, P, Gelson, WTH, Brown, S, Dillon, S, Muraro, D, Sharp, J, Neary, M, Box, H, Tatham, L, Stewart, J, Curley, P, Pertinez, H, Forrest, S, Mlcochova, P, Varankar, SS, Darvish-Damavandi, M, Mulcahy, VL, Kuc, RE, Williams, TL, Heslop, JA, Rossetti, D, Tysoe, OC, Galanakis, V, Vila-Gonzalez, M, Crozier, TWM, Bargehr, J, Sinha, S, Upponi, SS, Fear, C, Swift, L, Saeb-Parsy, K, Davies, SE, Wester, A, Hagstrom, H, Melum, E, Clements, D, Humphreys, P, Herriott, J, Kijak, E, Cox, H, Bramwell, C, Valentijn, A, Illingworth, CJR, Dahman, B, Bastaich, DR, Ferreira, RD, Marjot, T, Barnes, E, Moon, AM, Barritt, AS, Gupta, RK, Baker, S, Davenport, AP, Corbett, G, Gorgoulis, VG, Buczacki, SJA, Lee, JH, Matheson, NJ, Trauner, M, Fisher, AJ, Gibbs, P, Butler, AJ, Watson, CJE, Mells, GF, Dougan, G, Owen, A, Lohse, AW, Vallier, L, Sampaziotis, F

المصدر: Nature. 615(7950):134

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:152015779

المؤلفون: Sampaziotis, F, Justin, AW, Tysoe, OC, Sawiak, S, Cardoso-De-Brito, M, Ortmann, D, Yangou, L, Ross, A, Bargher, J, Bertero, A, Zonneveld, MCF, Pawlowski, M, Madrigal, P, Georgakopoulos, N, Pirmadjid, N, Zilbauer, M, Sinha, S, Hannan, NRF, Vallier, L

المساهمون: Sampaziotis, Fotios [0000-0003-0812-7586], Sawiak, Stephen [0000-0003-4210-9816], Madrigal, Pedro [0000-0003-1959-8199], Georgakopoulos, Nikitas [0000-0002-1879-6583], Zilbauer, Matthias [0000-0002-7272-0547], Sinha, Sanjay [0000-0001-5900-1209], Vallier, Ludovic [0000-0002-3848-2602], Apollo - University of Cambridge Repository

مصطلحات موضوعية: tissue engineering, regenerative medicine

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39eba637d9d6c6652e3123ce9bd45371
https://www.repository.cam.ac.uk/handle/1810/264945

المؤلفون: Islam D; Development & Stem Cell Biology program, Peter Gilligan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada., Israr I; Development & Stem Cell Biology program, Peter Gilligan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada., Taleb MAB; Development & Stem Cell Biology program, Peter Gilligan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada., Rao A; Development & Stem Cell Biology program, Peter Gilligan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada., Yosief R; Development & Stem Cell Biology program, Peter Gilligan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada., Sultana R; Development & Stem Cell Biology program, Peter Gilligan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada., Sampaziotis F; Wellcome-MRC Cambridge Stem Cell Institute, Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK., Tysoe OC; Wellcome-MRC Cambridge Stem Cell Institute, Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK., Trauner M; Hans Popper Laboratory of Molecular Hepatology, Department of Internal Medicine III, Division of Gastroenterology and Hepatology, Medical University of Vienna, Vienna, Austria., Karpen SJ; Division of Pediatric Gastroenterology, Department of Pediatrics, Hepatology, and Nutrition, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, Georgia, USA., Ghanekar A; Division of General Surgery, Department of Surgery, University Health Network & The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada., Kamath BM; Development & Stem Cell Biology program, Peter Gilligan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada.; Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, The Hospital for Sick Children and the University of Toronto, Toronto, Canada.

المصدر: Hepatology communications [Hepatol Commun] 2024 Feb 26; Vol. 8 (3). Date of Electronic Publication: 2024 Feb 26 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 101695860 Publication Model: eCollection Cited Medium: Internet ISSN: 2471-254X (Electronic) Linking ISSN: 2471254X NLM ISO Abbreviation: Hepatol Commun Subsets: MEDLINE

مواضيع طبية MeSH: Bile Acids and Salts* , Cholestasis*, Humans ; Inflammation Mediators ; Phenotype ; Signal Transduction

المؤلفون: Wesley BT; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Ross ADB; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Muraro D; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK., Miao Z; Wellcome Sanger Institute, Hinxton, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK., Saxton S; Departments of Bioengineering and Pathology, University of Washington, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA., Tomaz RA; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Morell CM; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Ridley K; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Zacharis ED; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Petrus-Reurer S; Department of Surgery, University of Cambridge, Cambridge, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Kraiczy J; Department of Paediatrics, University of Cambridge, Cambridge, UK., Mahbubani KT; Department of Surgery, University of Cambridge, Cambridge, UK., Brown S; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Garcia-Bernardo J; Wellcome Sanger Institute, Hinxton, UK., Alsinet C; Wellcome Sanger Institute, Hinxton, UK., Gaffney D; Wellcome Sanger Institute, Hinxton, UK., Horsfall D; Digital Institute, Newcastle University, Newcastle upon Tyne, UK., Tysoe OC; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Botting RA; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Stephenson E; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Popescu DM; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., MacParland S; University of Toronto, Toronto, Ontario, Canada., Bader G; University of Toronto, Toronto, Ontario, Canada., McGilvray ID; Multi-Organ Transplant Program, Toronto General Hospital Research Institute, Toronto, Ontario, Canada., Ortmann D; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Sampaziotis F; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Haniffa M; Wellcome Sanger Institute, Hinxton, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Stevens KR; Departments of Bioengineering and Pathology, University of Washington, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA., Zilbauer M; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Teichmann SA; Wellcome Sanger Institute, Hinxton, UK.; Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, Cambridge, UK., Vallier L; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. lv225@cam.ac.uk.; Department of Surgery, University of Cambridge, Cambridge, UK. lv225@cam.ac.uk.

المصدر: Nature cell biology [Nat Cell Biol] 2022 Oct; Vol. 24 (10), pp. 1487-1498. Date of Electronic Publication: 2022 Sep 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE

مواضيع طبية MeSH: Liver*/metabolism , Hepatocytes*/metabolism, Humans ; Cell Differentiation ; Organoids ; Transcription Factors/genetics ; Transcription Factors/metabolism

المؤلفون: Sampaziotis F; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK. fs347@cam.ac.uk lv225@cam.ac.uk.; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK., Muraro D; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK., Tysoe OC; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK., Sawiak S; Department of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, UK., Beach TE; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK., Godfrey EM; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK., Upponi SS; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK., Brevini T; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK., Wesley BT; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK., Garcia-Bernardo J; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK., Mahbubani K; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK., Canu G; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK., Gieseck R 3rd; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Berntsen NL; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Mulcahy VL; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.; Academic Department of Medical Genetics, University of Cambridge, Cambridge, Cambridgeshire, UK., Crick K; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK., Fear C; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK., Robinson S; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK., Swift L; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK., Gambardella L; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK., Bargehr J; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK., Ortmann D; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK., Brown SE; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK., Osnato A; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK., Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, Cambridgeshire, UK., Corbett G; Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK., Gelson WTH; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK., Mells GF; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.; Academic Department of Medical Genetics, University of Cambridge, Cambridge, Cambridgeshire, UK., Humphreys P; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK., Davies SE; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK., Amin I; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK., Gibbs P; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK., Sinha S; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK.; Department of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK., Teichmann SA; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK.; Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, Cambridgeshire, UK., Butler AJ; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK., See TC; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK., Melum E; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Hybrid Technology Hub-Centre of Excellence, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway., Watson CJE; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK.; National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre and the NIHR Blood and Transplant Research Unit (BTRU), Cambridge, Cambridgeshire, UK.; University of Cambridge in collaboration with Newcastle University and in partnership with NHS Blood and Transplant (NHSBT), Cambridge, Cambridgeshire, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.; Department of Surgery, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, UK., Vallier L; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, Cambridgeshire, UK. fs347@cam.ac.uk lv225@cam.ac.uk.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, Cambridgeshire, UK.

المصدر: Science (New York, N.Y.) [Science] 2021 Feb 19; Vol. 371 (6531), pp. 839-846.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Cell- and Tissue-Based Therapy*, Bile Duct Diseases/*therapy , Bile Ducts/*cytology , Bile Ducts, Intrahepatic/*physiology , Epithelial Cells/*cytology , Organoids/*transplantation, Animals ; Bile ; Bile Ducts/physiology ; Bile Ducts, Intrahepatic/cytology ; Common Bile Duct/cytology ; Epithelial Cells/physiology ; Gallbladder/cytology ; Gene Expression Regulation ; Humans ; Liver/physiology ; Liver Transplantation ; Mesenchymal Stem Cell Transplantation ; Mice ; Organoids/physiology ; RNA-Seq ; Tissue and Organ Procurement ; Transcriptome

المؤلفون: Rimland CA; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Immunopathogenesis Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.; Medical Scientist Training Program, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC., Tilson SG; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.; Welcome Trust Sanger Institute, Hinxton, United Kingdom.; Liver Diseases Branch, NIDDK, NIH, Bethesda, MD., Morell CM; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Tomaz RA; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Lu WY; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom.; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, The University of Birmingham, Birmingham, United Kingdom., Adams SE; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Immunopathogenesis Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD.; Department of Biological Sciences, North Carolina State University, Raleigh, NC., Georgakopoulos N; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Otaizo-Carrasquero F; Genomic Technologies Section, Research Technologies Branch, NIAID, NIH, Bethesda, MD., Myers TG; Genomic Technologies Section, Research Technologies Branch, NIAID, NIH, Bethesda, MD., Ferdinand JR; Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Gieseck RL 3rd; Immunopathogenesis Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD., Sampaziotis F; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Tysoe OC; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Ross A; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom., Kraiczy JM; Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom., Wesley B; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Muraro D; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.; Welcome Trust Sanger Institute, Hinxton, United Kingdom., Zilbauer M; Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom., Oniscu GC; Edinburgh Transplant Centre, Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh, United Kingdom., Hannan NRF; Division of Cancer and Stem Cells, School of Medicine, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom.; National Institute for Health Research Nottingham Digestive Diseases Biomedical Research Unit, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, United Kingdom., Forbes SJ; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, United Kingdom., Saeb-Parsy K; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom., Wynn TA; Immunopathogenesis Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD., Vallier L; Wellcome-Medical Research Council Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Surgery, University of Cambridge and National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, United Kingdom.

المصدر: Hepatology (Baltimore, Md.) [Hepatology] 2021 Jan; Vol. 73 (1), pp. 247-267.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE

مواضيع طبية MeSH: Bile Ducts, Extrahepatic/*cytology , Bile Ducts, Intrahepatic/*cytology , Epithelial Cells/*cytology , Organoids/*physiology, Animals ; Bile ; Bile Ducts, Extrahepatic/physiology ; Bile Ducts, Intrahepatic/physiology ; Cell Differentiation ; Common Bile Duct/cytology ; Epithelial Cells/physiology ; Gallbladder/cytology ; Gene Expression Regulation ; Humans ; Keratin-19/analysis ; Liver/physiology ; Mice ; RNA-Seq ; Tissue and Organ Procurement

المؤلفون: Brevini T; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Tysoe OC; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Sampaziotis F; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Hepatology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK. Electronic address: fs347@cam.ac.uk.

المصدر: Journal of hepatology [J Hepatol] 2020 Oct; Vol. 73 (4), pp. 918-932. Date of Electronic Publication: 2020 Jun 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE

مواضيع طبية MeSH: Biliary Tract/*pathology , Cholestasis/*therapy , Tissue Engineering/*methods, Animals ; Cholestasis/pathology ; Epithelial Cells/pathology ; Humans

المؤلفون: Tysoe OC; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, Department of Surgery, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Justin AW; Department of Engineering, University of Cambridge, Cambridge, UK., Brevini T; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, Department of Surgery, University of Cambridge, Cambridge, UK.; Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano, Milan, Italy., Chen SE; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, Department of Surgery, University of Cambridge, Cambridge, UK., Mahbubani KT; Department of Surgery, University of Cambridge, Cambridge, UK., Frank AK; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Department of Medicine III, University Hospital Aachen, Aachen, Germany., Zedira H; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, Department of Surgery, University of Cambridge, Cambridge, UK., Melum E; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Section for Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge, UK., Markaki AE; Department of Engineering, University of Cambridge, Cambridge, UK., Vallier L; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, Department of Surgery, University of Cambridge, Cambridge, UK. lv225@cam.ac.uk.; Department of Surgery, University of Cambridge, Cambridge, UK. lv225@cam.ac.uk., Sampaziotis F; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, Department of Surgery, University of Cambridge, Cambridge, UK. fs347@cam.ac.uk.; Department of Surgery, University of Cambridge, Cambridge, UK. fs347@cam.ac.uk.; Department of Hepatology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. fs347@cam.ac.uk.; Department of Medicine, University of Cambridge, Cambridge, UK. fs347@cam.ac.uk.

المصدر: Nature protocols [Nat Protoc] 2019 Jun; Vol. 14 (6), pp. 1884-1925. Date of Electronic Publication: 2019 May 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101284307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2799 (Electronic) Linking ISSN: 17502799 NLM ISO Abbreviation: Nat Protoc Subsets: MEDLINE

مواضيع طبية MeSH: Regeneration*, Bile Ducts/*cytology , Bile Ducts/*physiology , Organoids/*cytology , Organoids/*physiology , Tissue Engineering/*methods, Animals ; Biocompatible Materials/chemistry ; Cell Separation/methods ; Cells, Cultured ; Equipment Design ; Humans ; Mice ; Tissue Engineering/instrumentation ; Tissue Scaffolds/chemistry

المؤلفون: Sampaziotis F; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Department of Hepatology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Justin AW; Department of Engineering, University of Cambridge, Cambridge, UK., Tysoe OC; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Sawiak S; Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK., Godfrey EM; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Upponi SS; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Gieseck RL 3rd; Immunopathogenesis Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA., de Brito MC; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Berntsen NL; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway., Gómez-Vázquez MJ; Cambridge Genomic Services, Department of Pathology, University of Cambridge, Cambridge, UK., Ortmann D; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Yiangou L; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK., Ross A; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; University Department of Paediatrics, University of Cambridge, Cambridge, UK.; Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Bargehr J; Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.; Department of Medicine, School of Clinical Medicine, University of Cambridge, Cambridge, UK.; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK.; 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المصدر: Nature medicine [Nat Med] 2017 Aug; Vol. 23 (8), pp. 954-963. Date of Electronic Publication: 2017 Jul 03.

نوع المنشور: Journal Article; Video-Audio Media

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Bile Ducts, Extrahepatic/*physiology , Epithelial Cells/*cytology , Gallbladder/*physiology , Organoids/*physiology , Regeneration/*physiology , Tissue Engineering/*methods, Animals ; Bile Ducts, Extrahepatic/cytology ; Bile Ducts, Extrahepatic/injuries ; Biliary Tract/cytology ; Biliary Tract/injuries ; Biliary Tract/physiology ; Cell Transplantation ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Epithelial Cells/drug effects ; Epithelial Cells/metabolism ; Gallbladder/injuries ; Humans ; In Vitro Techniques ; Keratin-19/metabolism ; Keratin-7/metabolism ; Mice ; Organoids/cytology ; Organoids/drug effects ; Organoids/metabolism ; Secretin/pharmacology ; Somatostatin/pharmacology ; Tissue Scaffolds ; gamma-Glutamyltransferase/metabolism