نتائج البحث - "Ubiquitination drug effects"

1

Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake

المؤلفون: Peter L. Hordijk, Igor Kovacevic, Saskia Scheij, Emma C. L. Cook, Noam Zelcer, Jessica K. Nelson, Anke Loregger, Huib Ovaa, Marten A. Hoeksema

المساهمون: Graduate School, Medical Biochemistry, ACS - Diabetes & metabolism, ACS - Atherosclerosis & ischemic syndromes, AGEM - Endocrinology, metabolism and nutrition, Amsterdam Gastroenterology Endocrinology Metabolism, Landsteiner Laboratory, AII - Inflammatory diseases, Physiology, ICaR - Ischemia and repair

المصدر: Journal of biological chemistry, 291(9), 4813-4825. American Society for Biochemistry and Molecular Biology Inc.
Journal of Biological Chemistry, 291(9), 4813-4825. American Society for Biochemistry and Molecular Biology Inc.
Nelson, J K, Cook, E C L, Loregger, A, Hoeksema, M A, Scheij, S, Kovacevic, I, Hordijk, P L, Ovaa, H & Zelcer, N 2016, ' Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake ', Journal of Biological Chemistry, vol. 291, no. 9, pp. 4813-4825 . https://doi.org/10.1074/jbc.M115.698688

مصطلحات موضوعية: 0301 basic medicine, Ubiquitin-Specific Proteases/antagonists & inhibitors, Transcription, Genetic, LDL/metabolism, Recombinant Proteins/chemistry, Biochemistry, Transcription, Genetic/drug effects, Mice, Ubiquitin, Genes, Reporter, Orphan Nuclear Receptors/genetics, Receptors, Transcriptional regulation, Receptors, LDL/genetics, Enzyme Inhibitors, Promoter Regions, Genetic, Ubiquitin-Protein Ligases/chemistry, Cells, Cultured, Liver X Receptors, Enzyme Inhibitors/pharmacology, Cultured, biology, Ubiquitination/drug effects, Recombinant Fusion Proteins/chemistry, Orphan Nuclear Receptors, Lipids, Recombinant Proteins, Ubiquitin ligase, Absorption, Physiological, Lipoproteins, LDL, Physiological/drug effects, lipids (amino acids, peptides, and proteins), Ubiquitin-Specific Proteases, Transcription, Absorption, Physiological/drug effects, Lysosomes/drug effects, Recombinant Fusion Proteins, Ubiquitin-Protein Ligases, Cells, Lipoproteins, Human Umbilical Vein Endothelial Cells/cytology, LDL/genetics, Absorption, Cell Line, Promoter Regions, 03 medical and health sciences, Lipoproteins, LDL/metabolism, Human Umbilical Vein Endothelial Cells, Animals, Humans, Liver X receptor, Molecular Biology, Post-transcriptional regulation, Transcription factor, Promoter Regions, Genetic/drug effects, Reporter, Genetic/drug effects, Ubiquitination, Proteolysis/drug effects, Cell Biology, 030104 developmental biology, Nuclear receptor, Receptors, LDL, Amino Acid Substitution, Genes, LDL receptor, Proteolysis, Mutation, biology.protein, Lysosomes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cedf0913ddcfb2603c43cc631340d66d
https://doi.org/10.1074/jbc.m115.698688

2

Brefeldin A-Inhibited Guanine Nucleotide-Exchange Factor 1 (BIG1) Governs the Recruitment of Tumor Necrosis Factor Receptor-Associated Factor 2 (TRAF2) to Tumor Necrosis Factor Receptor 1 (TNFR1) Signaling Complexes

المؤلفون: Mei Tsuchida, Yosuke Kogue, Christian Spadini, Takuya Noguchi, Atsushi Matsuzawa, Yusuke Hirata

المصدر: International journal of molecular sciences, vol. 17, no. 11, pp. 1869
International Journal of Molecular Sciences; Volume 17; Issue 11; Pages: 1869
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 17, Iss 11, p 1869 (2016)

مصطلحات موضوعية: 0301 basic medicine, TRAF2, lcsh:Chemistry, chemistry.chemical_compound, Genes, Reporter, Guanine Nucleotide Exchange Factors, RNA, Small Interfering, Luciferases, lcsh:QH301-705.5, Spectroscopy, Gene knockdown, NF-kappa B, apoptosis, General Medicine, Brefeldin A, BIG1, Computer Science Applications, Cell biology, Protein Transport, Receptors, Tumor Necrosis Factor, Type I, tumor necrosis factor-α (TNF-α), Tumor necrosis factor alpha, Guanine nucleotide exchange factor, Protein Binding, Signal Transduction, Biology, Catalysis, Article, Inorganic Chemistry, 03 medical and health sciences, Mediator, Cell Line, Tumor, Humans, Physical and Theoretical Chemistry, Autocrine signalling, JNK, Molecular Biology, Apoptosis/drug effects, Gene Expression Regulation, Guanine Nucleotide Exchange Factors/antagonists & inhibitors, Guanine Nucleotide Exchange Factors/genetics, Guanine Nucleotide Exchange Factors/metabolism, HeLa Cells, JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors, JNK Mitogen-Activated Protein Kinases/genetics, JNK Mitogen-Activated Protein Kinases/metabolism, Luciferases/genetics, Luciferases/metabolism, NF-kappa B/antagonists & inhibitors, NF-kappa B/genetics, NF-kappa B/metabolism, Proteolysis/drug effects, RNA, Small Interfering/genetics, RNA, Small Interfering/metabolism, Receptors, Tumor Necrosis Factor, Type I/antagonists & inhibitors, Receptors, Tumor Necrosis Factor, Type I/genetics, Receptors, Tumor Necrosis Factor, Type I/metabolism, Signal Transduction/genetics, TNF Receptor-Associated Factor 2/antagonists & inhibitors, TNF Receptor-Associated Factor 2/genetics, TNF Receptor-Associated Factor 2/metabolism, Tumor Necrosis Factor-alpha/pharmacology, Ubiquitination/drug effects, Tumor Necrosis Factor-alpha, Organic Chemistry, JNK Mitogen-Activated Protein Kinases, Ubiquitination, TNF Receptor-Associated Factor 2, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, chemistry, Proteolysis, Tumor necrosis factor receptor 1