المؤلفون: Butz S; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.; Molecular Life Science PhD Program of the Life Science Zurich Graduate School, University of Zurich and ETH Zurich, Zurich, Switzerland., Schmolka N; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.; Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland., Karemaker ID; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland., Villaseñor R; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland.; Division of Molecular Biology, Biomedical Center Munich, Ludwig-Maximilians-University, Munich, Germany., Schwarz I; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland., Domcke S; Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.; Faculty of Science, University of Basel, Basel, Switzerland.; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Uijttewaal ECH; Institute of Molecular Biotechnology Austria (IMBA), Vienna BioCenter (VBC), Vienna, Austria., Jude J; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria., Lienert F; Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.; Faculty of Science, University of Basel, Basel, Switzerland., Krebs AR; Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.; European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany., de Wagenaar NP; Division of Genome Biology and Epigenetics, Institute of Biodynamics and Biocomplexity, Department of Biology, Science Faculty, Utrecht University, Utrecht, the Netherlands., Bao X; Division of Genome Biology and Epigenetics, Institute of Biodynamics and Biocomplexity, Department of Biology, Science Faculty, Utrecht University, Utrecht, the Netherlands., Zuber J; Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.; Medical University of Vienna, Vienna BioCenter (VBC), Vienna, Austria., Elling U; Institute of Molecular Biotechnology Austria (IMBA), Vienna BioCenter (VBC), Vienna, Austria., Schübeler D; Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.; Faculty of Science, University of Basel, Basel, Switzerland., Baubec T; Department of Molecular Mechanisms of Disease, University of Zurich, Zurich, Switzerland. t.baubec@uu.nl.; Division of Genome Biology and Epigenetics, Institute of Biodynamics and Biocomplexity, Department of Biology, Science Faculty, Utrecht University, Utrecht, the Netherlands. t.baubec@uu.nl.

المصدر: Nature genetics [Nat Genet] 2022 Nov; Vol. 54 (11), pp. 1702-1710. Date of Electronic Publication: 2022 Nov 04.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Genomic Imprinting* , DNA Methylation*/genetics, Mice ; Animals ; Base Sequence ; Epigenomics ; Chromatin/genetics ; Repressor Proteins/genetics

المؤلفون: Vos ESM; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands., Valdes-Quezada C; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands., Huang Y; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands., Allahyar A; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands., Verstegen MJAM; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands., Felder AK; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands., van der Vegt F; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands., Uijttewaal ECH; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands., Krijger PHL; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands., de Laat W; Oncode Institute, Hubrecht Institute-KNAW and University Medical Center Utrecht, 3584 CT Utrecht, the Netherlands. Electronic address: w.delaat@hubrecht.eu.

المصدر: Molecular cell [Mol Cell] 2021 Aug 05; Vol. 81 (15), pp. 3082-3095.e6. Date of Electronic Publication: 2021 Jun 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Enhancer Elements, Genetic*, CCCTC-Binding Factor/*metabolism , Chromatin/*genetics, Animals ; CCCTC-Binding Factor/genetics ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Chromatin/metabolism ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Gene Expression ; Mice ; Mouse Embryonic Stem Cells ; Nuclear Receptor Coactivator 2/genetics ; Promoter Regions, Genetic ; RNA-Binding Proteins/genetics ; Transcription Factors/genetics ; Cohesins

المؤلفون: de Wolf B; Oncode Institute, Hubrecht Institute - Royal Academy of Arts and Sciences and University Medical Centre Utrecht, Utrecht, The Netherlands., Oghabian A; Institute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Akinyi MV; Institute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Hanks S; Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK., Tromer EC; Oncode Institute, Hubrecht Institute - Royal Academy of Arts and Sciences and University Medical Centre Utrecht, Utrecht, The Netherlands.; Theoretical Biology and Bioinformatics, Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands., van Hooff JJE; Oncode Institute, Hubrecht Institute - Royal Academy of Arts and Sciences and University Medical Centre Utrecht, Utrecht, The Netherlands.; Theoretical Biology and Bioinformatics, Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands., van Voorthuijsen L; Oncode Institute, Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Science, Radboud University Nijmegen, Nijmegen, The Netherlands., van Rooijen LE; Theoretical Biology and Bioinformatics, Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands., Verbeeren J; Institute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Uijttewaal ECH; Oncode Institute, Hubrecht Institute - Royal Academy of Arts and Sciences and University Medical Centre Utrecht, Utrecht, The Netherlands., Baltissen MPA; Oncode Institute, Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Science, Radboud University Nijmegen, Nijmegen, The Netherlands., Yost S; Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK., Piloquet P; Service de Génétique Médicale, Unité de génétique Clinique, CHU Hotel Dieu, Nantes Cedex, France., Vermeulen M; Oncode Institute, Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Science, Radboud University Nijmegen, Nijmegen, The Netherlands., Snel B; Theoretical Biology and Bioinformatics, Biology, Science Faculty, Utrecht University, Utrecht, The Netherlands., Isidor B; Service de Génétique Médicale, Unité de génétique Clinique, CHU Hotel Dieu, Nantes Cedex, France., Rahman N; Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK., Frilander MJ; Institute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland., Kops GJPL; Oncode Institute, Hubrecht Institute - Royal Academy of Arts and Sciences and University Medical Centre Utrecht, Utrecht, The Netherlands.

المصدر: The EMBO journal [EMBO J] 2021 Jul 15; Vol. 40 (14), pp. e106536. Date of Electronic Publication: 2021 May 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

مواضيع طبية MeSH: Chromosomal Instability/*genetics , Chromosomes/*genetics , Mutation/*genetics , Spliceosomes/*genetics, Amino Acid Sequence ; Cell Cycle/genetics ; Cell Line ; Cell Line, Tumor ; HeLa Cells ; Humans ; Introns/genetics

المؤلفون: Lopes R; Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland. rui.lopes@novartis.com giorgio.galli@novartis.com., Sprouffske K; Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland., Sheng C; Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland., Uijttewaal ECH; Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland., Wesdorp AE; Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland., Dahinden J; Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland., Wengert S; Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland., Diaz-Miyar J; Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland., Yildiz U; Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland., Bleu M; Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland., Apfel V; Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland., Mermet-Meillon F; Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland., Krese R; Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland., Eder M; Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland., Olsen AV; Biotech Research and Innovation Centre (BRIC), The Finsen Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., Hoppe P; Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Basel, Switzerland., Knehr J; Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Basel, Switzerland., Carbone W; Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Basel, Switzerland., Cuttat R; Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Basel, Switzerland., Waldt A; Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Basel, Switzerland., Altorfer M; Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Basel, Switzerland., Naumann U; Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Basel, Switzerland., Weischenfeldt J; Biotech Research and Innovation Centre (BRIC), The Finsen Laboratory, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark., deWeck A; Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland., Kauffmann A; Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland., Roma G; Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, Basel, Switzerland., Schübeler D; Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland.; Faculty of Sciences, University of Basel, Basel, Switzerland., Galli GG; Disease area Oncology, Novartis Institute for Biomedical Research, CH-4002 Basel, Switzerland. rui.lopes@novartis.com giorgio.galli@novartis.com.

المصدر: Science advances [Sci Adv] 2021 Jul 02; Vol. 7 (27). Date of Electronic Publication: 2021 Jul 02 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

مواضيع طبية MeSH: Clustered Regularly Interspaced Short Palindromic Repeats* , Gene Regulatory Networks*, Carcinogenesis/genetics ; Epigenomics ; Genome, Human ; Humans ; Regulatory Elements, Transcriptional

المؤلفون: Chylinski K; Vienna Biocenter Core Facilities, Vienna Biocenter (VBC), Dr. Bohr Gasse 3, Vienna, Austria., Hubmann M; Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC), Dr. Bohr Gasse 3, 1030, Vienna, Austria., Hanna RE; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yanchus C; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Michlits G; Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC), Dr. Bohr Gasse 3, 1030, Vienna, Austria., Uijttewaal ECH; Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC), Dr. Bohr Gasse 3, 1030, Vienna, Austria., Doench J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Schramek D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Elling U; Institute of Molecular Biotechnology of the Austrian Academy of Science (IMBA), Vienna Biocenter (VBC), Dr. Bohr Gasse 3, 1030, Vienna, Austria. ulrich.elling@imba.oeaw.ac.at.

المصدر: Nature communications [Nat Commun] 2019 Nov 29; Vol. 10 (1), pp. 5454. Date of Electronic Publication: 2019 Nov 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Gene Editing/*methods , Mouse Embryonic Stem Cells/*metabolism , RNA, Guide, CRISPR-Cas Systems/*genetics, Animals ; CRISPR-Cas Systems ; Clustered Regularly Interspaced Short Palindromic Repeats ; Genetic Engineering ; Homologous Recombination ; Integrases ; Mice ; Mutagenesis ; RNA Polymerase III