المؤلفون: Whitson, RJ, Lee, A, Urman, NM, Mirza, A, Yao, CY, Brown, AS, Li, JR, Shankar, G, Fry, MA, Atwood, SX, Lee, EY, Hollmig, ST, Aasi, SZ, Sarin, KY, Scott, MP, Epstein, EH, Tang, JY, Oro, AE

المصدر: Whitson, RJ; Lee, A; Urman, NM; Mirza, A; Yao, CY; Brown, AS; et al.(2018). Noncanonical hedgehog pathway activation through SRF-MKL1 promotes drug resistance in basal cell carcinomas. Nature Medicine, 24(3), 271-281. doi: 10.1038/nm.4476. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8hs9c3sv

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od_______325::93553ba47d1b5fc46da3b0f02f345fa5
http://www.escholarship.org/uc/item/8hs9c3sv

المؤلفون: Kilgour JM; Department of Dermatology, Stanford Medicine Outpatient Center, Stanford University, Redwood City, California., Shah A; Department of Dermatology, Stanford Medicine Outpatient Center, Stanford University, Redwood City, California.; Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York., Urman NM; Department of Dermatology, Stanford Medicine Outpatient Center, Stanford University, Redwood City, California., Eichstadt S; Department of Dermatology, Stanford Medicine Outpatient Center, Stanford University, Redwood City, California.; Department of Dermatology, Tufts Medical Center, Boston, Massachusetts., Do HN; Department of Dermatology, Stanford Medicine Outpatient Center, Stanford University, Redwood City, California., Bailey I; Department of Dermatology, Stanford Medicine Outpatient Center, Stanford University, Redwood City, California., Mirza A; Department of Dermatology, Stanford Medicine Outpatient Center, Stanford University, Redwood City, California., Li S; Department of Dermatology, Stanford Medicine Outpatient Center, Stanford University, Redwood City, California., Oro AE; Department of Dermatology, Stanford Medicine Outpatient Center, Stanford University, Redwood City, California., Aasi SZ; Department of Dermatology, Stanford Medicine Outpatient Center, Stanford University, Redwood City, California., Sarin KY; Department of Dermatology, Stanford Medicine Outpatient Center, Stanford University, Redwood City, California. ksarin@stanford.edu.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Sep 01; Vol. 27 (17), pp. 4717-4725. Date of Electronic Publication: 2021 Aug 06.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Basal Cell*/drug therapy , Skin Neoplasms*/drug therapy, Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Administration, Topical ; Gels ; Prospective Studies ; Treatment Outcome

المؤلفون: Jia JL; Department of Dermatology, Stanford University School of Medicine, Stanford, California., Mills DE, Urman NM, Sarin KY

المصدر: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] [Dermatol Surg] 2021 Jul 01; Vol. 47 (7), pp. 1012-1013.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wolters Kluwer Health Country of Publication: United States NLM ID: 9504371 Publication Model: Print Cited Medium: Internet ISSN: 1524-4725 (Electronic) Linking ISSN: 10760512 NLM ISO Abbreviation: Dermatol Surg Subsets: MEDLINE

مواضيع طبية MeSH: Crowdsourcing/*statistics & numerical data , Fund Raising/*statistics & numerical data , Skin Neoplasms/*economics , Skin Neoplasms/*therapy, Carcinoma, Basal Cell/economics ; Carcinoma, Basal Cell/therapy ; Carcinoma, Squamous Cell/economics ; Carcinoma, Squamous Cell/therapy ; Fund Raising/methods ; Humans ; Lymphoma, T-Cell, Cutaneous/economics ; Lymphoma, T-Cell, Cutaneous/therapy ; Melanoma/economics ; Melanoma/therapy

المؤلفون: Mirza AN; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA., McKellar SA; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Urman NM; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Brown AS; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Hollmig T; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Aasi SZ; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA., Oro AE; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: oro@stanford.edu.

المصدر: Cell [Cell] 2019 Jan 10; Vol. 176 (1-2), pp. 198-212.e15. Date of Electronic Publication: 2018 Nov 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: DNA-Binding Proteins/*metabolism , Membrane Proteins/*metabolism , Zinc Finger Protein GLI1/*metabolism, 3T3 Cells ; Animals ; Carcinoma, Basal Cell/metabolism ; Cell Line ; Chromatin ; DNA-Binding Proteins/physiology ; HEK293 Cells ; Hedgehog Proteins/metabolism ; Hedgehog Proteins/physiology ; Histone Deacetylase 1/metabolism ; Humans ; Membrane Proteins/physiology ; Mice ; Molecular Chaperones/metabolism ; Nuclear Lamina/metabolism ; Nuclear Proteins/metabolism ; Protein Isoforms/metabolism ; Signal Transduction ; Trans-Activators/metabolism ; Transcription Factors/metabolism ; Zinc Finger Protein GLI1/physiology ; Zinc Fingers

المؤلفون: Whitson RJ; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Lee A; Children's Hospital Oakland Research Institute, Oakland, California, USA., Urman NM; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Mirza A; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Yao CY; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Brown AS; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Li JR; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Shankar G; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Fry MA; Children's Hospital Oakland Research Institute, Oakland, California, USA., Atwood SX; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental and Cell Biology, University of California, Irvine, Irvine, California, USA., Lee EY; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Hollmig ST; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Aasi SZ; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Sarin KY; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Scott MP; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Epstein EH Jr; Children's Hospital Oakland Research Institute, Oakland, California, USA., Tang JY; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA., Oro AE; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.; Department of Developmental Biology, Stanford University School of Medicine, Stanford, California, USA.

المصدر: Nature medicine [Nat Med] 2018 Mar; Vol. 24 (3), pp. 271-281. Date of Electronic Publication: 2018 Feb 05.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Basal Cell/*drug therapy , Drug Resistance, Neoplasm/*genetics , Serum Response Factor/*genetics , Trans-Activators/*genetics , Zinc Finger Protein GLI1/*genetics, Animals ; Carcinoma, Basal Cell/genetics ; Carcinoma, Basal Cell/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Gene Expression Regulation, Neoplastic/genetics ; Hedgehog Proteins ; Humans ; Mice ; Multiprotein Complexes/genetics ; Signal Transduction ; Transcriptional Activation

المؤلفون: Mirza AN; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA., Fry MA; Children's Hospital Oakland Research Institute, Oakland, California, USA., Urman NM; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA., Atwood SX; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA., Roffey J; CRUK Therapeutic Discovery Laboratories, London Bioscience Innovation Centre, London, United Kingdom., Ott GR; Teva Branded Pharmaceutical Products R&D, West Chester, Pennsylvania, USA., Chen B; Institute for Computational Health Sciences, UCSF, San Francisco, California, USA., Lee A; Children's Hospital Oakland Research Institute, Oakland, California, USA., Brown AS; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA., Aasi SZ; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA., Hollmig T; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA., Ator MA; Teva Branded Pharmaceutical Products R&D, West Chester, Pennsylvania, USA., Dorsey BD; Teva Branded Pharmaceutical Products R&D, West Chester, Pennsylvania, USA., Ruggeri BR; Teva Branded Pharmaceutical Products R&D, West Chester, Pennsylvania, USA., Zificsak CA; Teva Branded Pharmaceutical Products R&D, West Chester, Pennsylvania, USA., Sirota M; Institute for Computational Health Sciences, UCSF, San Francisco, California, USA., Tang JY; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA.; Children's Hospital Oakland Research Institute, Oakland, California, USA., Butte A; Institute for Computational Health Sciences, UCSF, San Francisco, California, USA., Epstein E; Children's Hospital Oakland Research Institute, Oakland, California, USA., Sarin KY; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA., Oro AE; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, California, USA.

المصدر: JCI insight [JCI Insight] 2017 Nov 02; Vol. 2 (21). Date of Electronic Publication: 2017 Nov 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Basal Cell/*drug therapy , Histone Deacetylase 1/*drug effects , Histone Deacetylase Inhibitors/*pharmacology , Isoenzymes/*drug effects , Protein Kinase C/*drug effects , Skin Neoplasms/*drug therapy, Allografts ; Animals ; Carcinoma, Basal Cell/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Computational Biology ; Drug Combinations ; Drug Discovery ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic/drug effects ; Hedgehogs/genetics ; Hedgehogs/metabolism ; Histone Deacetylase 1/genetics ; Histone Deacetylase 1/metabolism ; Histone Deacetylase Inhibitors/chemistry ; Isoenzymes/metabolism ; Mice ; Mice, Knockout ; Protein Kinase C/metabolism ; Signal Transduction ; Transcription Factors/drug effects ; Transcription Factors/genetics ; Zinc Finger Protein GLI1/genetics ; Zinc Finger Protein GLI1/metabolism

المؤلفون: Urman NM; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America., Mirza A; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America., Atwood SX; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America.; Department of Developmental and Cell Biology, Chao Family Comprehensive Cancer Center, University of California, Irvine, Irvine, CA, United States of America., Whitson RJ; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America., Sarin KY; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America., Tang JY; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America., Oro AE; Program in Epithelial Biology and Department of Dermatology, Stanford University School of Medicine, Stanford, CA, United States of America.

المصدر: PloS one [PLoS One] 2016 Dec 28; Vol. 11 (12), pp. e0168031. Date of Electronic Publication: 2016 Dec 28 (Print Publication: 2016).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Mutation* , Signal Transduction*, Carcinoma, Basal Cell/*metabolism , Hedgehog Proteins/*metabolism , Repressor Proteins/*genetics , Repressor Proteins/*metabolism , Skin Neoplasms/*metabolism, Animals ; Carcinogenesis ; Carcinoma, Basal Cell/genetics ; Carcinoma, Basal Cell/pathology ; Cell Proliferation ; Disease Progression ; HEK293 Cells ; Humans ; Mice ; Models, Molecular ; NIH 3T3 Cells ; Protein Conformation ; Repressor Proteins/chemistry ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Young Adult ; Zinc Finger Protein GLI1/metabolism

المؤلفون: Atwood SX; Department of Dermatology and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA., Sarin KY; Department of Dermatology and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA., Li JR; Department of Dermatology and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA., Yao CY; Department of Dermatology and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA., Urman NM; Department of Dermatology and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA., Chang ALS; Department of Dermatology and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA., Tang JY; Department of Dermatology and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA., Oro AE; Department of Dermatology and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA. Electronic address: oro@stanford.edu.

المصدر: The Journal of investigative dermatology [J Invest Dermatol] 2015 Aug; Vol. 135 (8), pp. 2138-2141. Date of Electronic Publication: 2015 Mar 24.

نوع المنشور: Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0426720 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1747 (Electronic) Linking ISSN: 0022202X NLM ISO Abbreviation: J Invest Dermatol Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Basal Cell/*genetics , Drug Resistance, Neoplasm/*genetics , Mutation/*genetics , Skin Neoplasms/*genetics, Genetic Variation ; Genome-Wide Association Study ; Hedgehog Proteins/genetics ; Humans ; Transcription Factors/genetics ; Zinc Finger Protein GLI1