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1
المؤلفون: Giles Pergl-Wilson, Anna King, Julia Hatto, Henry Danahay, David Andrew Sandham, Mariana Oana Popa, Emily Stanley, Parmjit Bahra, Urs Baettig, Rebecca Butler, Brian Cox, Lightfoot Megan, Christopher J. Page, Alice Young, Paul J. Groot-Kormelink, Trixie Wagner, Swarupa Kulkarni, Glyn Hughes, Edward Charles Hall, David J. Rowlands, Lee Edwards, Atwood K. Cheung, Matthew Spendiff, Tom Sharp, Kamlesh Bala, Stephen Paul Collingwood, Hazel Watson, Julia Koehler, Oliver Ross Steward, Anne-Lise Glotin, Penny Wright, Cara E. Brocklehurst, Ulrike Glaenzel, Ian Nicholls, Richard I. Robinson, Roger J. Taylor, Catherine Howsham, Brian Everatt, Darren Le Grand, Hedaythul Choudhury, Gareth Williams, Emma Budd, Martin Gosling, Pamela Tranter
المصدر: Journal of Medicinal Chemistry. 64:7241-7260
مصطلحات موضوعية: Cystic Fibrosis, Drug Evaluation, Preclinical, Administration, Oral, Aminopyridines, Cystic Fibrosis Transmembrane Conductance Regulator, Pulmonary disease, 01 natural sciences, Cystic fibrosis, Rats, Sprague-Dawley, Pathogenesis, Pulmonary Disease, Chronic Obstructive, Structure-Activity Relationship, 03 medical and health sciences, Therapeutic approach, Drug Discovery, medicine, Animals, Humans, Clinical efficacy, 030304 developmental biology, 0303 health sciences, COPD, biology, Chemistry, Potentiator, medicine.disease, Cystic fibrosis transmembrane conductance regulator, Rats, respiratory tract diseases, 0104 chemical sciences, Disease Models, Animal, 010404 medicinal & biomolecular chemistry, Solubility, Immunology, biology.protein, Molecular Medicine, Gene Deletion, Half-Life, Protein Binding
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2
المؤلفون: Julia Hatto, Oliver Ross Steward, Simon J. Watson, Anne-Marie D’Souza, Urs Baettig, Thomas Kuhnle, Richard I. Robinson, Eva Neumann, Benjamin Martin, Neil John Press, David Porter, Xinzhong Lai
المصدر: Organic Process Research & Development. 19:1038-1043
مصطلحات موضوعية: chemistry.chemical_classification, Base (chemistry), medicine.drug_class, Chemistry, Process development, Organic Chemistry, Linear sequence, Antagonist, Squaramide, Receptor antagonist, chemistry.chemical_compound, Yield (chemistry), medicine, Choline, Organic chemistry, Physical and Theoretical Chemistry
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3
المؤلفون: H Watson, Rosemary Sugar, Steve Collingwood, Nichola Smith, S Czarnecki, A. Schumacher, Ruth Lock, B Ethell, Chris Poll, Alice Young, Martin Gosling, Derek Paisley, J. Harris, T Faller, Kevin Coote, Gareth Williams, Urs Baettig, Morris Tweed, Henry Danahay, M Vyas, Juan R. Sabater, Paul J. Groot-Kormelink, William M. Abraham
المصدر: British Journal of Pharmacology. 172:2814-2826
مصطلحات موضوعية: Pharmacology, Epithelial sodium channel, medicine.medical_specialty, Hyperkalemia, Side effect, Mucociliary clearance, business.industry, respiratory system, Epithelial sodium channel blocker, Amiloride, Hypertonic saline, Endocrinology, In vivo, Internal medicine, medicine, medicine.symptom, business, medicine.drug
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4
المؤلفون: Trevor John Howe, Paul Nicklin, Michelle Bradley, Angela Glen, Cecile Mocquet, Andrew Dunstan, Urs Baettig, Gurdip Bhalay, Juliet Leighton-Davies, Charles Owen, Elizabeth M. Rosethorne, Clive Mccarthy, Zarin Brown, Peter Gedeck, Mohammed Akhlaq, Alice Li, Thomas H. Keller, Birgit Albrecht, David Beer, Steven J. Charlton
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:6249-6252
مصطلحات موضوعية: Chemokine, Molecular model, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Cell Line, Small Molecule Libraries, Chemokine receptor, Cricetulus, Cricetinae, Drug Discovery, medicine, Animals, Molecular Biology, biology, Chemistry, Organic Chemistry, Biological activity, biology.organism_classification, Drug Design, biology.protein, Molecular Medicine, Chemokines, Pharmacophore
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5
المؤلفون: Gurdip Bhalay, David Beer, Stephen Paul Collingwood, Sarah Craig, Nicholas James Devereux, Rowan Stringer, Sandra Haberthuer, Trevor John Howe, Angela Glen, Katharine L. Turner, Andrew Dunstan, Heinz E. Moser, Ruth Arnold, Mauro Zurini, Sylvie Gomez, Paul Nicklin, Simon J. Watson, Urs Baettig, Reto Naef, David Andrew Sandham, Stephen Jelfs
المصدر: Bioorganic & Medicinal Chemistry Letters. 12:2587-2590
مصطلحات موضوعية: Models, Molecular, Phosphodiesterase Inhibitors, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Isozyme, Chemical synthesis, chemistry.chemical_compound, Drug Discovery, medicine, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Phosphoric Diester Hydrolases, Chemistry, Organic Chemistry, Sulfonamide (medicine), Xanthine, In vitro, Enzyme, Enzyme inhibitor, Xanthines, cGMP-specific phosphodiesterase type 5, biology.protein, Molecular Medicine, medicine.drug
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6
المؤلفون: David C. Budd, David Bryan Harrison, Christopher Walker, Lucy Barker, Morris Tweed, Brian Everatt, Louise Bidlake, Rowan Stringer, Clive Aldcroft, Gurdip Bhalay, Catherine Leblanc, Emma Michelle Campbell, Urs Baettig, Simon J. Watson, Rachael Profit, Jennifer Willis, Gareth Williams, David Beer, Katharine L. Turner, Steven Whitebread, Zarin Brown, David Andrew Sandham, Gerald Dubois, Jodie Manini, Katy S Thompson, Brian Cox, Caroline Wilson
المصدر: Bioorganicmedicinal chemistry letters. 17(15)
مصطلحات موضوعية: medicine.drug_class, High-throughput screening, Clinical Biochemistry, Receptors, Prostaglandin, Pharmaceutical Science, Biological Availability, Acetates, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Oral administration, Drug Discovery, medicine, Potency, Animals, Humans, Receptors, Immunologic, Receptor, Molecular Biology, Chemistry, Organic Chemistry, Antagonist, Receptor antagonist, Bioavailability, Rats, Eosinophils, Molecular Medicine
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7
المؤلفون: Peter D. Kane, Andrew Mitchelson, Colin Dell, Lyndon Nigel Brown, Sheila Garman, Morris Tweed, Alex Furzer, Garrick Smith, Mark Talbot, Clive Victor Walker, John Ambler, Diana Janus, Urs Baettig, Derek E. Brundish, Nicholas Wills, Xiaoling Cockcroft
المصدر: Bioorganicmedicinal chemistry letters. 10(14)
مصطلحات موضوعية: Models, Molecular, Serine Proteinase Inhibitors, Molecular model, Arginine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Antithrombins, Structure-Activity Relationship, Thrombin, Drug Discovery, medicine, Chymotrypsin, Trypsin, Fibrinolysin, Molecular Biology, chemistry.chemical_classification, Sulfonamides, Alanine, biology, Bicyclic molecule, Molecular Structure, Organic Chemistry, Amino acid, Thiazoles, chemistry, Enzyme inhibitor, Drug Design, Pipecolic Acids, biology.protein, Molecular Medicine, Kallikreins, Discovery and development of direct thrombin inhibitors, medicine.drug, Factor Xa Inhibitors
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8
المؤلفون: Vito Grimaudo, Eli Alon, Urs Baettig, Philipp C. Nett, Ossi R. Koechli, Roman Kocian
المصدر: Survey of Anesthesiology. :171
مصطلحات موضوعية: Adult, medicine.medical_specialty, Indoles, Adolescent, medicine.drug_class, Nausea, Vomiting, Premedication, Tropisetron, Placebo, Postoperative Complications, Double-Blind Method, medicine, Antiemetic, Humans, Adverse effect, Aged, business.industry, Genitalia, Female, Middle Aged, Surgery, Anesthesiology and Pain Medicine, Anesthesia, Antiemetics, Female, Serotonin Antagonists, medicine.symptom, business, Postoperative nausea and vomiting, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6dde187961d4aa26a0afd8340864bc
https://doi.org/10.1097/00132586-199706000-00040