المؤلفون: Němec V; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany.; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Remeš M; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Beňovský P; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Böck MC; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Šranková E; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Wong JF; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Cros J; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Williams E; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Tse LH; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Smil D; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada., Ensan D; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada., Isaac MB; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Gomolková R; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic., Ursachi VC; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic., Fafílek B; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic., Kahounová Z; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Víchová R; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Vacek O; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic.; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Berger BT; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany., Wells CI; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Corona CR; Promega Corporation, Madison, Wisconsin 53716, United States., Vasta JD; Promega Corporation, Madison, Wisconsin 53716, United States., Robers MB; Promega Corporation, Madison, Wisconsin 53716, United States., Krejci P; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic., Souček K; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic.; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Bullock AN; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Knapp S; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany., Paruch K; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Aug 08; Vol. 67 (15), pp. 12632-12659. Date of Electronic Publication: 2024 Jul 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Activin Receptors, Type II*/metabolism , Activin Receptors, Type II*/antagonists & inhibitors, Animals ; Humans ; Mice ; Activin Receptors, Type I/antagonists & inhibitors ; Activin Receptors, Type I/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry ; Structure-Activity Relationship ; Signal Transduction/drug effects ; Drug Discovery ; Molecular Probes/chemistry ; Bone Morphogenetic Proteins/metabolism ; Pyrazoles/chemistry ; Pyrazoles/pharmacology ; Pyrazoles/chemical synthesis

المؤلفون: Karl K; Department of Materials Science and Engineering, Institute for NanoBioTechnology, and Program in Molecular Biophysics, Johns Hopkins University, Baltimore, United States., Del Piccolo N; Department of Materials Science and Engineering, Institute for NanoBioTechnology, and Program in Molecular Biophysics, Johns Hopkins University, Baltimore, United States., Light T; Department of Materials Science and Engineering, Institute for NanoBioTechnology, and Program in Molecular Biophysics, Johns Hopkins University, Baltimore, United States., Roy T; Department of Materials Science and Engineering, Institute for NanoBioTechnology, and Program in Molecular Biophysics, Johns Hopkins University, Baltimore, United States., Dudeja P; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the CAS, Brno, Czech Republic., Ursachi VC; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic., Fafilek B; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the CAS, Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic., Krejci P; Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the CAS, Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic., Hristova K; Department of Materials Science and Engineering, Institute for NanoBioTechnology, and Program in Molecular Biophysics, Johns Hopkins University, Baltimore, United States.

المصدر: ELife [Elife] 2024 Apr 03; Vol. 12. Date of Electronic Publication: 2024 Apr 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Signal Transduction* , Fibroblast Growth Factors*, Female ; Pregnancy ; Humans ; Ligands ; Phosphorylation ; Bias ; Receptor, Fibroblast Growth Factor, Type 1/genetics

المؤلفون: Balan V; Faculty of Medical Bioengineering, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115, Romania. Electronic address: balan.vera@umfiasi.ro., Dodi G; Advanced Centre for Research-Development in Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115, Romania. Electronic address: gianina.dodi@umfiasi.ro., Mihai CT; Advanced Centre for Research-Development in Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115, Romania; Department of Experimental and Applied Biology, NIRDBS - Institute of Biological Research Iasi, Lascar Catargi 47, Iasi 700107, Romania. Electronic address: cosmin-teodor.mihai@umfiasi.ro., Serban AM; Faculty of Medical Bioengineering, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115, Romania; Natural Polymers, Bioactive and Biocompatible Materials Laboratory, Petru Poni Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley 41A, 700487, Iasi, Romania. Electronic address: serban.alexandru@icmpp.ro., Ursachi VC; Faculty of Medical Bioengineering, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115, Romania; Advanced Centre for Research-Development in Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115, Romania. Electronic address: vlad.ursachi@umfiasi.ro.

المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2021 Oct 01; Vol. 188, pp. 82-93. Date of Electronic Publication: 2021 Aug 04.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

مواضيع طبية MeSH: Chitosan/*chemistry , Macromolecular Substances/*chemistry , Nanostructures/*chemistry , Neoplasms/*drug therapy, Biotin/chemistry ; Biotinylation ; Chitosan/therapeutic use ; Drug Delivery Systems ; Humans ; Macromolecular Substances/therapeutic use ; Molecular Imaging ; Nanostructures/therapeutic use ; Nanotechnology/trends

المؤلفون: Ursachi VC; Faculty of Medical Bioengineering, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, Romania.; Advanced Centre for Research-Development in Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, Romania., Dodi G; Advanced Centre for Research-Development in Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, Romania., Rusu AG; Natural Polymers, Bioactive and Biocompatible Materials Laboratory, Petru Poni Institute of Macromolecular Chemistry, 700487 Iasi, Romania., Mihai CT; Advanced Centre for Research-Development in Experimental Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, Romania., Verestiuc L; Faculty of Medical Bioengineering, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, Romania., Balan V; Faculty of Medical Bioengineering, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 700115 Iasi, Romania.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2021 Jun 07; Vol. 26 (11). Date of Electronic Publication: 2021 Jun 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents, Phytogenic/*chemistry , Biotin/*chemistry , Chitosan/*analogs & derivatives , Magnetite Nanoparticles/*chemistry , Paclitaxel/*chemistry, Cell Line, Tumor ; Chitosan/chemistry ; Colloids/chemistry ; Delayed-Action Preparations/chemistry ; Drug Carriers/chemistry ; Drug Delivery Systems/methods ; Humans ; Hydrophobic and Hydrophilic Interactions/drug effects ; MCF-7 Cells ; Polymers/chemistry