المؤلفون: Struhl K; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: kevin@hms.harvard.edu.

المصدر: Trends in genetics : TIG [Trends Genet] 2024 Jun; Vol. 40 (6), pp. 471-479. Date of Electronic Publication: 2024 Apr 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Trends Journals Country of Publication: England NLM ID: 8507085 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0168-9525 (Print) Linking ISSN: 01689525 NLM ISO Abbreviation: Trends Genet Subsets: MEDLINE

مواضيع طبية MeSH: DNA Replication*/genetics , Enhancer Elements, Genetic* , RNA Polymerase III*/genetics , RNA Polymerase III*/metabolism , Transcription, Genetic*/genetics , V(D)J Recombination*/genetics, Animals ; Humans ; Gene Expression Regulation/genetics

المؤلفون: Chen R; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Lukianova E; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK., van der Loeff IS; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK.; Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, NE1 4LP Newcastle upon Tyne, UK., Spegarova JS; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Willet JDP; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., James KD; Institute of Immunology and Immunotherapy, University of Birmingham. B15 2TT Birmingham, UK., Ryder EJ; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK., Griffin H; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., IJspeert H; Department of Immunology, Erasmus University Medical Center, Rotterdam 3000 CA, Netherlands., Gajbhiye A; Biosciences Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Lamoliatte F; Biosciences Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Marin-Rubio JL; Biosciences Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Woodbine L; Genome Damage and Stability Centre, University of Sussex, BN1 9RQ Brighton, UK., Lemos H; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Swan DJ; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Pintar V; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Sayes K; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Ruiz-Morales ER; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK., Eastham S; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK., Dixon D; Biosciences Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Prete M; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK., Prigmore E; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK., Jeggo P; Genome Damage and Stability Centre, University of Sussex, BN1 9RQ Brighton, UK., Boyes J; Faculty of Biological Sciences, University of Leeds, LS2 9JT Leeds, UK., Mellor A; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Huang L; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., van der Burg M; Department of Immunology, Erasmus University Medical Center, Rotterdam 3000 CA, Netherlands., Engelhardt KR; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Stray-Pedersen A; Norwegian National Unit for Newborn Screening, Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo 0424, Norway., Erichsen HC; Division of Pediatric and Adolescent Medicine, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo 0424, Norway., Gennery AR; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK.; Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, NE1 4LP Newcastle upon Tyne, UK., Trost M; Biosciences Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK., Adams DJ; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK., Anderson G; Institute of Immunology and Immunotherapy, University of Birmingham. B15 2TT Birmingham, UK., Lorenc A; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK., Trynka G; Wellcome Sanger Institute, Wellcome Genome Campus, CB10 1SA Hinxton, UK.; Open Targets, Wellcome Genome Campus, CB10 1SA Hinxton, UK., Hambleton S; Translational and Clinical Research Institute, Newcastle University, NE2 4HH Newcastle upon Tyne, UK.; Great North Children's Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, NE1 4LP Newcastle upon Tyne, UK.

المصدر: Science immunology [Sci Immunol] 2024 May 24; Vol. 9 (95), pp. eade5705. Date of Electronic Publication: 2024 May 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101688624 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2470-9468 (Electronic) Linking ISSN: 24709468 NLM ISO Abbreviation: Sci Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Severe Combined Immunodeficiency*/genetics , Severe Combined Immunodeficiency*/immunology , V(D)J Recombination*/immunology , V(D)J Recombination*/genetics, Humans ; Animals ; Mice ; Male ; Female ; Infant ; B-Lymphocytes/immunology ; Homeodomain Proteins/genetics ; Homeodomain Proteins/immunology ; T-Lymphocytes/immunology ; Child, Preschool ; Mutation, Missense

المؤلفون: Zhang Y; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Li X; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Ba Z; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; National Institute of Biological Sciences, Beijing, China., Lou J; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Copenhagen University, Copenhagen, Denmark., Gaertner KE; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA.; Georgetown University, Washington, DC, USA., Zhu T; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Lin X; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Ye AY; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Alt FW; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. alt@enders.tch.harvard.edu.; Department of Genetics, Harvard Medical School, Boston, MA, USA. alt@enders.tch.harvard.edu., Hu H; Howard Hughes Medical Institute, Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. hongli.hu@childrens.harvard.edu.; Department of Genetics, Harvard Medical School, Boston, MA, USA. hongli.hu@childrens.harvard.edu.

المصدر: Nature [Nature] 2024 Jun; Vol. 630 (8015), pp. 189-197. Date of Electronic Publication: 2024 May 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Immunoglobulin Heavy Chains*/genetics , Immunoglobulin Joining Region*/genetics , Immunoglobulin kappa-Chains*/genetics , Immunoglobulin Variable Region*/genetics , V(D)J Recombination*/genetics, Animals ; Female ; Male ; Mice ; Alleles ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; Chromatin/genetics ; Chromatin/metabolism ; Chromatin/chemistry ; Cohesins/metabolism ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism

المؤلفون: Beilinson HA; Department of Microbiology, University of Chicago, Chicago, IL, United States., Erickson SA; Department of Immunobiology, Yale University, New Haven, CT, United States., Golovkina T; Department of Microbiology, University of Chicago, Chicago, IL, United States.; Committee on Microbiology, University of Chicago, Chicago, IL, United States.; Committee on Immunology, University of Chicago, Chicago, IL, United States.; Committee on Genetics, Genomics and System Biology, University of Chicago, Chicago, IL, United States.

المصدر: Frontiers in immunology [Front Immunol] 2024 Mar 05; Vol. 15, pp. 1345467. Date of Electronic Publication: 2024 Mar 05 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Antigen, T-Cell*/genetics , V(D)J Recombination*/genetics, Animals ; Mice ; Immunoglobulins/genetics ; Mammals

المؤلفون: Kumari R; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India., Roy U; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India., Desai S; Institute of Bioinformatics and Applied Biotechnology, Bangalore 560100, India., Mondal AS; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India., Nair RR; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India., Nilavar N; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India., Choudhary B; Institute of Bioinformatics and Applied Biotechnology, Bangalore 560100, India., Raghavan SC; Department of Biochemistry, Indian Institute of Science, Bangalore 560012, India.

المصدر: The Biochemical journal [Biochem J] 2023 Dec 20; Vol. 480 (24), pp. 2061-2077.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

مواضيع طبية MeSH: V(D)J Recombination*/genetics , MicroRNAs*/genetics, Humans ; Homeodomain Proteins/genetics ; Homeodomain Proteins/metabolism ; B-Lymphocytes

المؤلفون: Smirnova AO; Center for Molecular and Cellular Biology, Skolkovo Institute of Science and Technology, Moscow, Russia.; Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Miroshnichenkova AM; Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United Arab Emirates., Belyaeva LD; Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Kelmanson IV; Department of Biomolecular Sciences and Department of Molecular Neuroscience, Weizmann Institute of Science, Rehovot, Israel., Lebedev YB; Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.; Department of Molecular Technologies, Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russia., Mamedov IZ; Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia., Chudakov DM; Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.; Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United Arab Emirates.; Department of Molecular Technologies, Institute of Translational Medicine, Pirogov Russian National Research Medical University, Moscow, Russia.; Central European Institute of Technology, Masaryk University, Brno, Czechia., Komkov AY; Genomics of Adaptive Immunity Department, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.; Abu Dhabi Stem Cells Center (ADSCC), Abu Dhabi, United Arab Emirates.; Dmitry Rogachev National Medical and Research Center of Pediatric Hematology, Oncology, and Immunology, Moscow, Russia.

المصدر: Frontiers in immunology [Front Immunol] 2023 Sep 07; Vol. 14, pp. 1245175. Date of Electronic Publication: 2023 Sep 07 (Print Publication: 2023).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis* , Genes, T-Cell Receptor beta* , V(D)J Recombination*, Animals ; Humans ; Mice ; Rats ; Chromosome Aberrations ; Clone Cells ; Memory T Cells

المؤلفون: Hu Z; Department of BioAnalytical Sciences, Genentech Inc, South San Francisco, CA, United States., Cohen S; Department of BioAnalytical Sciences, Genentech Inc, South San Francisco, CA, United States., Swanson SJ; Department of BioAnalytical Sciences, Genentech Inc, South San Francisco, CA, United States.

المصدر: Frontiers in immunology [Front Immunol] 2023 Sep 01; Vol. 14, pp. 1237754. Date of Electronic Publication: 2023 Sep 01 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies*/genetics , Antibodies*/therapeutic use , V(D)J Recombination*, Humans ; Alleles ; Mutagenesis ; Mutation

المؤلفون: Li H; Department of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Rd, Guangzhou, 510120, China.; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Zhang Y; Department of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Rd, Guangzhou, 510120, China.; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Zhang B; Department of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Rd, Guangzhou, 510120, China.; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China., Chen D; Department of Pediatrics, The First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Rd, Guangzhou, 510120, China. dehuicheng2022@163.com.; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. dehuicheng2022@163.com.

المصدر: Pediatric rheumatology online journal [Pediatr Rheumatol Online J] 2023 Aug 14; Vol. 21 (1), pp. 84. Date of Electronic Publication: 2023 Aug 14.

نوع المنشور: Case Reports; Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101248897 Publication Model: Electronic Cited Medium: Internet ISSN: 1546-0096 (Electronic) Linking ISSN: 15460096 NLM ISO Abbreviation: Pediatr Rheumatol Online J Subsets: MEDLINE

مواضيع طبية MeSH: Lung Diseases*/etiology , Lupus Erythematosus, Systemic*/complications , Lupus Erythematosus, Systemic*/genetics , Lupus Erythematosus, Systemic*/diagnosis , V(D)J Recombination*, Humans ; B-Lymphocytes/pathology ; DNA-Activated Protein Kinase ; Hemorrhage/etiology ; Methylprednisolone/therapeutic use

المؤلفون: Fawzy MM; Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt., Nazmy MH; Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt., El-Sheikh AAK; Basic Health Sciences Department, College of Medicine, Princess Nourah bint Abdulrahman University, 11671, Riyadh, Saudi Arabia., Fathy M; Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia, 61519, Egypt. mostafa_fathe@minia.edu.eg.

المصدر: Immunologic research [Immunol Res] 2024 Jun; Vol. 72 (3), pp. 438-449. Date of Electronic Publication: 2024 Jan 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 8611087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0755 (Electronic) Linking ISSN: 0257277X NLM ISO Abbreviation: Immunol Res Subsets: MEDLINE

مواضيع طبية MeSH: DNA Methylation* , Homeodomain Proteins*/genetics , Homeodomain Proteins*/metabolism , CpG Islands*/genetics , Evolution, Molecular*, Humans ; Animals ; Mutagenesis ; Transposases/genetics ; Transposases/metabolism ; Mutation ; V(D)J Recombination/genetics ; DNA Transposable Elements/genetics ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism

المؤلفون: Liang Z; HHMI, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115., Zhao L; HHMI, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115., Ye AY; HHMI, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115., Lin SG; HHMI, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115., Zhang Y; HHMI, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115., Guo C; HHMI, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115., Dai HQ; HHMI, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115., Ba Z; HHMI, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115., Alt FW; HHMI, Boston Children's Hospital, Boston, MA 02115.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115.; Department of Genetics, Harvard Medical School, Boston, MA 02115.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jun 27; Vol. 120 (26), pp. e2306564120. Date of Electronic Publication: 2023 Jun 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: V(D)J Recombination*/genetics , Regulatory Sequences, Nucleic Acid*, Animals ; Mice ; Immunoglobulin Variable Region/genetics ; Immunoglobulin Variable Region/metabolism ; Precursor Cells, B-Lymphoid/metabolism ; Chromatin/metabolism