المؤلفون: Liang Ouyang, Yao Liu, Jie Liu, Lu Feng, Guan Wang, Yi Chen, Meng Wang, Tingting Jiang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 355-372 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: NTRK, neurotrophic receptor tyrosine kinase, FISH, fluorescence in situ hybridization, Review, Tropomyosin receptor kinase B, HNSCC, head and neck squamous cell carcinoma, Tropomyosin receptor kinase A, HTS, high-throughput screening, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase, Tropomyosin receptor kinase C, LMNA, lamin A/C, Receptor tyrosine kinase, TPM3, tropomyosin 3, 0302 clinical medicine, MASC, mammary analogue secretory carcinoma, PROTAC proteolysis targeting chimera, QKI, SQSTM1, sequestosome 1, TPR, translocated promoter region, General Pharmacology, Toxicology and Pharmaceutics, RABGTPase activating protein 1-like, RFWD2, AML, acute myeloid leukemia, 0303 health sciences, ICC, intrahepatic cholangiocarcinoma, TRK, tropomyosin receptor kinase, Neurotrophic receptor tyrosine kinase fusions, PPL, periplakin, TP53, tumor protein P53, SBC, secretory breast carcinoma, OAK, osteoarthritis of the knee, TFG, TRK-fused gene, ARHGEF2, Rho/Rac guanine nucleotide exchange factor 2, NT3, neurotrophin-3, quaking I protein, RABGAP1L, ETV6, ETS translocation variant 6, 030220 oncology & carcinogenesis, CR, complete response, CRC, colorectal cancer, BCAN, brevican, BDNF, brain-derived neurotrophic factor, BTBD1, BTB (POZ) domain containing 1, RTK, receptor tyrosine kinase, DOR, durable objective responses, CDK-2, cyclin-dependent kinase 2, Tyrosine kinase, EWG, electron-withdrawing group, ORR, overall response rate, Neurotrophin, NCCN, National Comprehensive Cancer Network, VCL, vinculin, NGF, nerve growth factor, MPRIP, myosin phosphatase Rho interacting protein, Biology, PAN3, poly(A) nuclease 3, TRIM24, tripartite motif containing 24, Small-molecule inhibitor, NTRK fusion cancer, SCYL3, SCY1 like pseudokinase 3, 03 medical and health sciences, NACC2, NACC family member 2, NSCLC, non-small cell lung cancer, SAR, structure–activity relationship, Protein kinase B, VEGFR2, vascular endothelial growth factor receptor 2, 030304 developmental biology, DFG, Asp-Phe-Gly, CTCs, sequencing of circulating tumor cells, lcsh:RM1-950, GBM, glioblastoma multiforme, NFASC, neurofascin, NGS, next-generation sequencing of tumor tissue, FDA, U.S. Food and Drug Administration, lcsh:Therapeutics. Pharmacology, nervous system, Trk receptor, IG-C2, Ig-like C2 type I, Cancer research, biology.protein, Tropomyosin receptor kinase, AFAP1, actin filament-associated protein 1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c737a8f0c0bb6776695689290564cb8a
http://www.sciencedirect.com/science/article/pii/S2211383520305864

المؤلفون: Fiegle, E, Doleschel, D, Koletnik, S, Rix, A, Weiskirchen, R, Borkham-Kamphorst, E, Kiessling, F, Lederle, W

المصدر: Neoplasia (New York, N.Y.)

مصطلحات موضوعية: Original article, CTLA-4, cytotoxic T-lymphocyte-associated protein 4, ARG1, arginase-1, chemical and pharmacologic phenomena, Treg cells, regulatory T cells, TARC, thymus and activation regulated chemokine, B7-H1 Antigen, TIE2, tyrosine kinase with immunoglobulin-like and EGF-like domains 2, Mice, IFN-γ, interferon- γ, Antineoplastic Agents, Immunological, Lymphocytes, Tumor-Infiltrating, T-Lymphocyte Subsets, TGF-β, transforming growth factor-β, Cell Line, Tumor, Animals, Humans, CTLA-4 Antigen, VEGFR2, vascular endothelial growth factor receptor 2, TEM, Tie2+ macrophages, Neovascularization, Pathologic, MRC1, macrophage mannose receptor 1, Macrophages, VEGF-A, vascular endothelial growth factor A, Liver Neoplasms, FOXP3, forkhead box protein P3, PD-1, programmed death 1, Magnetic Resonance Imaging, Xenograft Model Antitumor Assays, Tumor Burden, FAP, fibroblast-activated protein, PD-L1, programmed death-ligand 1, p.i., post-injection, Disease Models, Animal, Treatment Outcome, COX-2, cyclooxygenase-2, PDGF-B, platelet-derived growth factor B, CRC, colorectal cancer, Colonic Neoplasms, iNOS, inducible nitric oxide synthase, Disease Progression, DCE-MRI, dynamic contrast enhanced MRI, Cytokines, Female, PDGFR-β, platelet-derived growth factor receptor β, s.c., subcutaneous

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::ffe4dd06e4f23327921ac5dfe7437fd4
http://europepmc.org/articles/PMC6700499

المؤلفون: Miho Kurokawa, Akifumi Kuwano, Takeshi Goya, Hideo Suzuki, Masaki Kato, Shigeki Tashiro, Koji Imoto, Motoyuki Kohjima, Masatake Tanaka, Yoshihiro Ogawa

المصدر: Biochemistry and Biophysics Reports, Vol 27, Iss, Pp 101068-(2021)
Biochemistry and Biophysics Reports

مصطلحات موضوعية: Cirrhosis, AM, Adrenomedullin, HV, healthy volunteers, TGF-β, transforming growth factor-beta, Chronic liver disease, Biochemistry, SOD, Superoxide dismutase, ANGPTL4, Angiopoietin-like 4, Adrenomedullin, MCP-1, Monocyte chemoattractant protein-1, Biology (General), HIF, hypoxia inducible factor, LDH, lactate dehydrogenase, GPx, glutathione peroxidase, medicine.diagnostic_test, biology, VEGF, vascular endothelial growth factor, CH, chronic hepatitis, HCV, hepatitis C virus, Liver biopsy, TNF-α, Tumor Necrosis Factor-α, medicine.symptom, Research Article, medicine.medical_specialty, QH301-705.5, Biophysics, Serum albumin, QD415-436, Intrahepatic hypoxia, Peripheral blood mononuclear cell, Proinflammatory cytokine, ROS, reactive oxygen species, VEGFA, vascular endothelial growth factor A, PT, prothrombin time, Internal medicine, medicine, IL-6, Interleukin-6, VEGFR2, vascular endothelial growth factor receptor 2, business.industry, LC, liver cirrhosis, Hypoxia (medical), PBMC, Peripheral blood mononuclear cells, medicine.disease, Endocrinology, Peripheral blood mononuclear cells, CLD, chronic liver disease, HO-1, heme oxygenase -1, biology.protein, HCC, hepatocellular carcinoma, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24423659816f781c25c10f6191956e95
http://www.sciencedirect.com/science/article/pii/S240558082100162X

المؤلفون: Albina Fejza, Alessandra Capuano, Eliana Pivetta, E. Poletto, Roberto Doliana, Maurizio Mongiat, Eva Andreuzzi, Rosanna Pellicani, Lucrezia Camicia, Paola Spessotto, Renato V. Iozzo, Roberta Colladel, Greta Carobolante, Stefano Marastoni

المصدر: Matrix Biology Plus
Matrix Biology Plus, Vol 11, Iss, Pp 100068-(2021)

مصطلحات موضوعية: HDMEC, Ang-2, Angiogenesis, Biochemistry, HBVP, PDGF, platelet-derived growth factor, platelet-derived growth factor, Extracellular matrix, human brain vascular pericytes, HUVEC, vascular endothelial growth factor receptor 2, EDEN, EMI Domain ENdowed, vascular smooth muscle cells, Notch-3-R, Biology (General), Vascular stability, chemistry.chemical_classification, cluster of differentiation 93, human umbilical vein endothelial cells, Notch-3-R, Notch Receptor 3, human dermal vascular endothelial cells, Chemistry, PDGF, Cell biology, ECM, extracellular matrix, HB-EGF, VEGFR2, Ang-2, Angiopoietin-2, CD248, cluster of differentiation 248, CD93, cluster of differentiation 93, HB-EGF, heparin binding epidermal growth factor, HBVP, human brain vascular pericytes, HDMEC, human dermal vascular endothelial cells, HUVEC, human umbilical vein endothelial cells, VEGFA, vascular endothelial growth factor A, VEGFR2, vascular endothelial growth factor receptor 2, VSMCs, vascular smooth muscle cells, CD93, Drug delivery, VEGFA, Cell type, Histology, QH301-705.5, heparin binding epidermal growth factor, VSMCs, Biophysics, Settore BIO/11 - Biologia Molecolare, Context (language use), Article, Angiopoietin-2, Ang-2, Angiopeietin-2, Genetics, Molecular Biology, ECM, EDEN, Mechanism (biology), Cell Biology, vascular endothelial growth factor A, CD248, EMI Domain ENdowed, Notch Receptor 3, Glycoprotein, Homeostasis, cluster of differentiation 248

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::046c335b7734a9ee056a9b34d785f303
http://europepmc.org/articles/PMC8377000

المؤلفون: Qingqing, Dai, Yuhang, Yan, Xiangli, Ning, Gen, Li, Junlin, Yu, Ji, Deng, Lingling, Yang, Guo-Bo, Li

المصدر: Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: ROC curve, receiver operating characteristic curve, TNKS2, tankyrase 2, Metalloenzyme, HA, hydrogen-bond acceptor, Tryptophan 2,3-dioxygenase, RMSD, root mean square deviation, AUC, area under the curve, BRD4, bromodomain-containing protein 4, CatK, cathepsin K, GA, genetic algorithm, MB, metal coordination, HIV-P, human immunodeficiency virus protease, NDM, new delhi MBL, STK, serine threonine kinase, EX, exclusion volume, Metallo-β-lactamase, IMP, imipenemase, MMP, matrix metalloproteinase, NE, negatively charged center, CA2, carbonic anhydrase 2, AR, aromatic ring, RT, reverse transcriptase, SSEL, secondary structure element length, IDO1, indoleamine 2,3-dioxygenase 1, Original Article, RTK, receptor tyrosine kinase, HD, hydrogen-bond donor, Anchor pharmacophore, CTS, cathepsins, CV, covalent bonding, NP, without anchor pharmacophore features, Virtual screening, Indoleamine 2,3-dioxygenase, MIC, minimum inhibitory concentration, EF, enrichment factor, TDO, tryptophan 2,3-dioxygenase, MAPK14, mitogen-activated protein kinase 14, MBL, metallo-β-lactamase, ROCK1, rho-associated protein kinase 1, VEGFR2, vascular endothelial growth factor receptor 2, VIM, verona integron-encoded MBL, AMPC, asian mouse phenotyping consortium, AP, anchor pharmacophore, SBL, serine beta lactamase, TDSS, torsion-driving systematic search, HIV1-P, human immunodeficiency virus type 1 protease, BACE1, beta-secretase 1, LE, ligand efficiency, CDK2, cyclin-dependent kinase 2, CA, carbonic anhydrase, MMP13, matrix metallopeptidase 13, PO, positively charged center, HY, hydrophobic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::18c6dc977b69a367b015aaa9f409148b
https://pubmed.ncbi.nlm.nih.gov/34386329

المؤلفون: Amal I. Hassan, Eman I. Abdel-Gawad, Sameh A. Awwad

المصدر: Journal of Advanced Research, Vol 7, Iss 1, Pp 143-154 (2016)
Journal of Advanced Research

مصطلحات موضوعية: 0301 basic medicine, RIR, reference intensity ratio, Pathology, 5HT, serotonin, medicine.medical_treatment, chemistry.chemical_compound, DNA, deoxyribonucleic acid, 0302 clinical medicine, Nano-CaP, nano calcium phosphate, Myosin, Medicine, EAC, Ehrlich Ascites Carcinoma, Calcium phosphate (CaP) nanoparticles, lcsh:R5-920, Multidisciplinary, Solid tumor, TEM, transmission electron microscope, Neurotransmitters, IT, intratumoral, 8-OHDG, 8-hydroxy-deoxyguanosine, Vascular endothelial growth factor, Nanomedicine, medicine.anatomical_structure, FAK, focal adhesion kinase, 030220 oncology & carcinogenesis, Original Article, IP, intraperitoneal, XRD, X-ray diffraction, lcsh:Medicine (General), medicine.medical_specialty, ATP, adenosine triphosphate, Intraperitoneal injection, Ehrlich ascites carcinoma, 03 medical and health sciences, In vivo, Internal medicine, Carcinoma, SEM, scanning electron microscopy, lcsh:Science (General), General, EAC transplantation, VEGFR2, vascular endothelial growth factor receptor 2, business.industry, Skeletal muscle, medicine.disease, GABA, gamma aminobutyric acid, FTIR, Fourier transform infrared, 030104 developmental biology, Endocrinology, chemistry, Cancer cell, business, MAPK, mitogen-activated protein kinase, lcsh:Q1-390

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::849a324db1d2f89556efadfa0c8040e7
https://doi.org/10.1016/j.jare.2015.04.001

المؤلفون: Hulse, RP, Drake, RAR, Bates, DO, Donaldson, LF

المصدر: Neurobiology of Disease, Vol 96, Iss, Pp 186-200 (2016)
Neurobiology of Disease
Hulse, R P, Drake, R A R, Bates, D O & Donaldson, L F 2016, ' The control of alternative splicing by SRSF1 in myelinated afferents contributes to the development of neuropathic pain ', Neurobiology of Disease, vol. 96, pp. 186-200 . https://doi.org/10.1016/j.nbd.2016.09.009

مصطلحات موضوعية: Male, Vascular Endothelial Growth Factor A, Time Factors, Sensory Receptor Cells, Pyridines, SRSF1, Serine Arginine-rich Splicing Factor 1, SRPK1, SRPK1, Serine Arginine-rich Protein Kinase 1, Neuropathic pain, Nerve Fibers, Myelinated, Article, Antibodies, Functional Laterality, VEGF-A, lcsh:RC321-571, Animals, VEGF-A, vascular endothelial growth factor – A, Rats, Wistar, Protein Kinase Inhibitors, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Myelin Sheath, VEGFR2, vascular endothelial growth factor receptor 2, Pain Measurement, Spinal cord, Serine-Arginine Splicing Factors, PSNI, partial saphenous nerve ligation injury, Rats, SRSF1, Alternative Splicing, Disease Models, Animal, Neurology, Hyperalgesia, Vesicular Glutamate Transport Protein 1, Neuralgia, Phthalazines, Myelinated

وصف الملف: application/pdf; PDF

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::47f54d41ab11039a8949446f8226b159
http://eprints.nottingham.ac.uk/39593/

المؤلفون: Hulse, RP, Beazley-Long, N, Hua, J, Kennedy, H, Prager, J, Bevan, H, Qiu, Y, Fernandes, ES, Gammons, MV, Ballmer-Hofer, K, Gittenberger de Groot, AC, Churchill, AJ, Harper, SJ, Brain, SD, Bates, DO, Donaldson, LF

المصدر: Neurobiology of Disease
Neurobiology of disease
Neurobiology of Disease, Vol 71, Iss, Pp 245-259 (2014)

مصطلحات موضوعية: Male, Pain Threshold, Vascular Endothelial Growth Factor A, Sensory Receptor Cells, DNA, Recombinant, Neural Conduction, Alternative mRNA splicing, TRPV Cation Channels, Mice, Transgenic, SRPK1, serine arginine protein kinase 1, Antibodies, Article, lcsh:RC321-571, Mice, Ganglia, Spinal, VEGF-A, vascular endothelial growth factor-A, TRPV1, transient receptor potential vanilloid 1, Animals, RNA, Messenger, Enzyme Inhibitors, Rats, Wistar, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Benzofurans, Pain Measurement, VEGFR2, vascular endothelial growth factor receptor 2, IB4, isolectin B4, SRSF1, serine arginine splice factor 1, Nociceptors, Rats, PSNI, partial saphenous nerve ligation injury, Neuropathy, DRG, dorsal root ganglia, Disease Models, Animal, Neurology, Hyperalgesia, Quinolines, Neuralgia, CV, conduction velocity

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::7fa2bec7cc98cb18599b1a718cb8f5cf
https://pubmed.ncbi.nlm.nih.gov/25151644

المؤلفون: Kuwano A; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.; Department of Hepatology, Iizuka Hospital, 3-83 Yoshio-machi, Iizuka, Fukuoka, 820-8505, Japan., Tanaka M; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan., Suzuki H; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan., Kurokawa M; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan., Imoto K; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan., Tashiro S; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan., Goya T; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan., Kohjima M; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan., Kato M; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan., Ogawa Y; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.; CREST, Japan Agency for Medical Research and Development, 1-7-1 Otemachi, Chiyoda-ku, Tokyo, 100-0004, Japan.

المصدر: Biochemistry and biophysics reports [Biochem Biophys Rep] 2021 Jul 14; Vol. 27, pp. 101068. Date of Electronic Publication: 2021 Jul 14 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101660999 Publication Model: eCollection Cited Medium: Internet ISSN: 2405-5808 (Electronic) Linking ISSN: 24055808 NLM ISO Abbreviation: Biochem Biophys Rep Subsets: PubMed not MEDLINE

المؤلفون: Dai Q; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Yan Y; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Ning X; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Li G; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Yu J; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Deng J; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China., Yang L; College of Food and Bioengineering, Xihua University, Chengdu 610039, China., Li GB; Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.

المصدر: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Jul; Vol. 11 (7), pp. 1931-1946. Date of Electronic Publication: 2021 Jan 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B Subsets: PubMed not MEDLINE