نتائج البحث - "Valeria Fantin"

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دورية أكاديمية

577 Non-clinical efficacy, pharmacokinetics, and pharmacodynamics of a novel bi-functional anti-CD73-TGFβRII-trap molecule in combination with immune checkpoint therapy

المؤلفون: Becky Yang, Ping Yi, Jens Brodbeck, Shiva Zaboli, Federico Campigotto, Marianna Zavodovskaya, Susanna Stinson, Jianhua He, Kyung-Hoon Kim, Monika Sobczyk, Rutwij Dave, Brian Carr, In Kyoung Mah, Scott Turner, Vivian Barry, Kelli Boyd, Valeria Fantin

المصدر: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2051-1426

URL الوصول: https://doaj.org/article/2573e5a7d8674f8f97980eab63bf8eab

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2

دورية أكاديمية

Targeting primary acute myeloid leukemia with a new CXCR4 antagonist IgG1 antibody (PF-06747143)

المؤلفون: Yanyan Zhang, Erika Saavedra, Ruoping Tang, Yin Gu, Patrick Lappin, Dusko Trajkovic, Shu-Hui Liu, Tod Smeal, Valeria Fantin, Stephane De Botton, Ollivier Legrand, Francois Delhommeau, Flavia Pernasetti, Fawzia Louache

المصدر: Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/49dab6606e4e44f2902c2a6f96a70cff

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3

Abstract 6378: An in vitro human CD8 T cell exhaustion model for the functional screening of immune checkpoint inhibitors

المؤلفون: Roberto Carrio, Margot Cucchetti, Mikielia Devonish, Louis Poisson, Mihaela Babiceanu, Andrew Kettring, Yingchun Liu, Donald Jackson, Evan Gomes, Jeremy Baudhuin, Donald R. Drake, Valeria Fantin, Anthony Byers, Ingrid Sassoon

المصدر: Cancer Research. 83:6378-6378

مصطلحات موضوعية: Cancer Research, Oncology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::096354087b76f0201a6a6bd8e61b2d3a
https://doi.org/10.1158/1538-7445.am2023-6378

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Characterization of the Selective Indoleamine 2,3-Dioxygenase-1 (IDO1) Catalytic Inhibitor EOS200271/PF-06840003 Supports IDO1 as a Critical Resistance Mechanism to PD-(L)1 Blockade Therapy

المصدر: Molecular Cancer Therapeutics. 17:2530-2542

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Indoles, T-Lymphocytes, medicine.medical_treatment, Succinimides, Antineoplastic Agents, Antibodies, Monoclonal, Humanized, B7-H1 Antigen, Substrate Specificity, Immune tolerance, Interferon-gamma, 03 medical and health sciences, chemistry.chemical_compound, Lymphocytes, Tumor-Infiltrating, 0302 clinical medicine, Downregulation and upregulation, Cell Line, Tumor, medicine, Animals, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, CTLA-4 Antigen, Enzyme Inhibitors, Indoleamine 2,3-dioxygenase, Kynurenine, Cell Proliferation, Mice, Inbred BALB C, Tumor microenvironment, Chemistry, Antibodies, Monoclonal, FOXP3, Stereoisomerism, Immunotherapy, Immune checkpoint, Mice, Inbred C57BL, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Biocatalysis, Cancer research, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4e86621e1bbba77214c450e8001b4c6
https://doi.org/10.1158/1535-7163.mct-17-1104

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Orally Bioavailable Small-Molecule CD73 Inhibitor (OP-5244) Reverses Immunosuppression through Blockade of Adenosine Production

المصدر: Journal of medicinal chemistry. 63(18)

مصطلحات موضوعية: Adenosine, medicine.medical_treatment, Organophosphonates, Administration, Oral, Adenosinergic, Pharmacology, CD8-Positive T-Lymphocytes, GPI-Linked Proteins, 01 natural sciences, 03 medical and health sciences, Structure-Activity Relationship, Dogs, Cancer immunotherapy, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Immunologic Factors, Enzyme Inhibitors, 5'-Nucleotidase, 030304 developmental biology, 0303 health sciences, Mice, Inbred BALB C, Molecular Structure, Chemistry, Immunosuppression, Nucleosides, Stereoisomerism, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Macaca fascicularis, Cell culture, Molecular Medicine, CD8, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06063be680b50d6de82ea33c0efe9b6
https://pubmed.ncbi.nlm.nih.gov/32865411

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6

Discovery of a Potent and Selective Steroidal Glucocorticoid Receptor Antagonist (ORIC-101)

المصدر: Journal of Medicinal Chemistry. 61:7767-7784

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f81c49a9d872813489456bfe0b3ed8dd
https://doi.org/10.1021/acs.jmedchem.8b00743

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7

577 Non-clinical efficacy, pharmacokinetics, and pharmacodynamics of a novel bi-functional anti-CD73-TGFβRII-trap molecule in combination with immune checkpoint therapy

المؤلفون: Shiva Zaboli, In Kyoung Mah, Kelli Boyd, Rutwij Dave, Monika Sobczyk, Scott M. Turner, Jens Brodbeck, Jianhua He, Brian Carr, Marianna Zavodovskaya, Susanna Stinson, Federico Campigotto, Ping Yi, Vivian Barry, Valeria Fantin, Becky Yang, Kyung-Hoon Kim

المصدر: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

مصطلحات موضوعية: Pharmacology, Cancer Research, Tumor microenvironment, biology, Chemistry, Microgram, Immunology, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Isotype, Immune checkpoint, Immune system, Oncology, Pharmacokinetics, Pharmacodynamics, biology.protein, Molecular Medicine, Immunology and Allergy, Antibody, RC254-282

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608ec67b4ee7fe897c9b9861ac9c8c87
https://doi.org/10.1136/jitc-2021-sitc2021.577

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8

A novel CXCR4 antagonist IgG1 antibody (PF-06747143) for the treatment of hematologic malignancies

المصدر: Blood Advances. 1:1088-1100

مصطلحات موضوعية: Lymphoid Neoplasia, CXCR4 antagonist, business.industry, Chronic lymphocytic leukemia, Myeloid leukemia, Hematology, Pharmacology, medicine.disease, CXCR4, Lymphoma, medicine.anatomical_structure, Cell killing, hemic and lymphatic diseases, Bone marrow neoplasm, medicine, Bone marrow, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c77a0ec73307415cfe149a84856c66d
https://doi.org/10.1182/bloodadvances.2016003921

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Palbociclib and Fulvestrant Act in Synergy to Modulate Central Carbon Metabolism in Breast Cancer Cells

المؤلفون: Nathan V. Lee, Linh Hoang, Gary Siuzdak, Nicholas J. W. Rattray, Benedikt Warth, Zhou Zhu, Stephen Dann, David J. Shields, Caroline H. Johnson, Amelia Palermo, Anthony Mazurek, Valeria Fantin, Todd VanArsdale, Yuping Cai

المصدر: Metabolites
Metabolites, Vol 9, Iss 1, p 7 (2019)
Volume 9
Issue 1

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fd020bb2979514e1196b7d72ade38c
https://doi.org/10.3390/metabo9010007

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Abstract B25: Development of a nanoparticle containing the PI3K/mTOR dual Inhibitor, gedatolisib, for cancer therapy

المؤلفون: Jennifer Lafontaine, Valeria Fantin, Anand Giddabasappa, Zhenxiong Wang, Wenhu Huang, Shubha Bagrodia, Susan Low, Hui Wang, Louise Cadzow, Young-Ho Song, Gabriel Troche, Ravi Visswanathan, Robert T. Abraham, Greg Troiano, Mary E. Spilker, Lianglin Zhang

المصدر: Molecular Cancer Research. 18:B25-B25

مصطلحات موضوعية: Cancer Research, business.industry, Cmax, medicine.disease, Tumor antigen, chemistry.chemical_compound, Prostate cancer, Therapeutic index, medicine.anatomical_structure, Oncology, chemistry, Prostate, Cancer research, medicine, Enzalutamide, business, Lung cancer, Molecular Biology, PI3K/AKT/mTOR pathway

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9ecfb61248f43179c8f71a3ecd9e25c9
https://doi.org/10.1158/1557-3125.pi3k-mtor18-b25

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