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المؤلفون: Chrystelle Girardet, Magali Mathieu, François Vallée, Jacques Le-Roux, Fangxian Sun, Laurence Fabien, Corinne Terrier, Celine Ginesty, Bruno Filoche-Romme, Florence Gruss-Leleu, Maysoun Shomali, Monsif Bouaboula, Sylvie Beccari, Pascal Desmazeau, Gilles Lebourg, Tsiala Benard, Victor Certal, Pascale Vicat, Andrew Hebert, Carlos Garcia-Echeverria, Laurent Schio, Youssef El-Ahmad, Gary Mccort, Claire Muller, Maurice Brollo, Mikhail Levit, Luc Bertin, Hong Cheng, Véronique Loyau, Valerie Steier, Fabienne Thompson, Audrey Louboutin, Fabienne Pilorge, Alexey Rak, Frank Halley, Patrick Richepin, Christelle Perrault, Pierre-Yves Abecassis, Michel Tabart, Albane Courjaud
المصدر: Journal of Medicinal Chemistry. 63:512-528
مصطلحات موضوعية: 0303 health sciences, biology, Fulvestrant, Chemistry, Estrogen receptor, medicine.disease, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Breast cancer, Hormone receptor, Drug Discovery, biology.protein, medicine, Cancer research, Molecular Medicine, Aromatase, Receptor, Estrogen receptor alpha, Tamoxifen, 030304 developmental biology, medicine.drug
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المؤلفون: Valerie Steier, Hélène Le-Borgne, Maryse Lowinski, Annick Parent, Magali Mathieu, David Papin, Florence Fassy, Laure Delarbre, Laurent Debussche, Rak Alexey, Jean-Pierre Marquette, Francis Duffieux, Jacques Houtmann, Bruno Genet, Cécile Delorme, Patrick Didier, Thomas Bertrand, Annabelle Lamberton
المصدر: Small GTPases
مصطلحات موضوعية: Acetonitriles, Antineoplastic Agents, Biology, medicine.disease_cause, Biochemistry, Piperazines, Proto-Oncogene Proteins p21(ras), Pancreatic cancer, Neoplasms, medicine, Humans, neoplasms, Gene, Mutation, Drug discovery, Cancer, Cell Biology, medicine.disease, digestive system diseases, respiratory tract diseases, Cell biology, Pyrimidines, Cancer research, KRAS, Signalling pathways, Research Paper
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المؤلفون: Derek J. Wilson, Stephen Li, Salvador F. Ausar, Thomas Bertrand, Jessica Duprez, Roger H. Brookes, Alexey Rak, D. Andrew James, Artur Pedyczak, Shaolong Zhu, Valerie Steier, Anthony Sheung, Michael X Cohen
المصدر: Communications Biology
'Communications Biology ', vol: 3, pages: 427-1-427-12 (2020)
Communications Biology, Vol 3, Iss 1, Pp 1-12 (2020)مصطلحات موضوعية: 0301 basic medicine, Protein vaccines, Protein Conformation, Whooping Cough, Protein subunit, Mutant, Medicine (miscellaneous), chemical and pharmacologic phenomena, CHO Cells, Pertussis toxin, Crystallography, X-Ray, complex mixtures, General Biochemistry, Genetics and Molecular Biology, Article, Bordetella pertussis, 03 medical and health sciences, 0302 clinical medicine, Protein structure, Cricetulus, Cricetinae, Animals, Humans, Mass cytometry, lcsh:QH301-705.5, X-ray crystallography, Pertussis Vaccine, Mass spectrometry, Chemistry, Immunogenicity, Wild type, Deuterium Exchange Measurement, Toxoids, Molecular biology, 030104 developmental biology, lcsh:Biology (General), Pertussis Toxin, NAD+ kinase, General Agricultural and Biological Sciences, 030217 neurology & neurosurgery
وصف الملف: application/pdf
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المؤلفون: François Vallée, Philipp Baaske, Melanie Maschberger, Valerie Steier, Kwame Amaning, Pawel Linke, Stefan Duhr, Alexey Rak, Dennis Breitsprecher
المصدر: Journal of Biomolecular Screening
مصطلحات موضوعية: Models, Molecular, Protein Denaturation, Fragment-based lead discovery, MAP Kinase Kinase 1, Gene Expression, Nanotechnology, Computational biology, Crystallography, X-Ray, Ligands, Biochemistry, drug discovery, protein aggregation, Analytical Chemistry, Diffusion, Small Molecule Libraries, biophysical screening, Fragment (logic), Robustness (computer science), binding affinity, High-Throughput Screening Assays, Humans, Protein Kinase Inhibitors, Chemistry, Drug discovery, Microscale thermophoresis, Temperature, Surface Plasmon Resonance, Molecular Medicine, Technical Notes, Protein Binding, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccda5276ff3c3bca4802dc0c481fac35
https://doi.org/10.1177/1087057115618347 -
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المؤلفون: Gary McCort, Rosalia Arrebola, Loreley Calvet, Baptiste Ronan, Fabrice Vergne, Francis Duffieux, Alexey Rak, Isabelle Meaux, David Papin, Florence Fassy, Cecile Delorme, Magali Matthieu, Jean-Paul Nicolas, Christophe Marcireau, Valerie Steier, Pierre-Yves Abecassis, Valerie Czepczor, Heather A. Thomson, Christopher D. Hupp, J.P. Guilinger, Ying Zhang, Anthony D. Keefe, John W. Cuozzo, Julie Liu, Laurent Debussche
المصدر: Cancer Research. 79:3070-3070
مصطلحات موضوعية: Cancer Research, Oncology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cad2d9863f8a3a9d67e7a56774e2a777
https://doi.org/10.1158/1538-7445.am2019-3070 -
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المؤلفون: Gary Mccort, Sylvie Llopart, Cyrielle Andouche, François Vallée, Cécile Delorme, Frédéric Foucalt, Maryse Lowinski, Nathalie Derimay, Kwame Amaning, Nis Halland, Antonio Ugolini, Valerie Steier, Alexey Rak, Christophe Marcireau, Stephanie Vougier
المصدر: Bioorganicmedicinal chemistry letters. 23(12)
مصطلحات موضوعية: Models, Molecular, Virtual screening, Chemistry, Drug discovery, In silico, Organic Chemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, MAP Kinase Kinase 1, Pharmaceutical Science, Computational biology, Crystallography, X-Ray, Biochemistry, Molecular biology, Rapid identification, Structure-Activity Relationship, Drug Discovery, Molecular Medicine, Humans, Fluorometry, Enzyme Inhibitors, Phosphorylation, Molecular Biology
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