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المؤلفون: Nicola G. Wallis, Alison J.-A. Woolford, Nicola E. Wilsher, Neil T. Thompson, Lukas Stanczuk, Alpesh D. Shah, Caroline J. Richardson, Sharna J. Rich, David C. Rees, Michael Reader, Marc O'Reilly, David Norton, Christopher W. Murray, Sandra Muench, Vanessa Martins, John F. Lyons, Justyna Kucia-Tran, Christopher J. Hindley, Tom D. Heightman, Roberta Ferraldeschi, Charlotte East, Aurélie Courtin, Juan Castro, Jessica L. Brothwood, Luke Bevan, Valerio Berdini, Joanne M. Munck
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c83a97aa3dd2ed35fbdc9ef36e9bb5
https://doi.org/10.1158/1535-7163.22521489.v1 -
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المؤلفون: Nicola G. Wallis, Alison J.-A. Woolford, Nicola E. Wilsher, Neil T. Thompson, Lukas Stanczuk, Alpesh D. Shah, Caroline J. Richardson, Sharna J. Rich, David C. Rees, Michael Reader, Marc O'Reilly, David Norton, Christopher W. Murray, Sandra Muench, Vanessa Martins, John F. Lyons, Justyna Kucia-Tran, Christopher J. Hindley, Tom D. Heightman, Roberta Ferraldeschi, Charlotte East, Aurélie Courtin, Juan Castro, Jessica L. Brothwood, Luke Bevan, Valerio Berdini, Joanne M. Munck
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185aef78c19fca4a606a8b2c178f1341
https://doi.org/10.1158/1535-7163.22521498.v1 -
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المؤلفون: Neil T. Thompson, David R. Newell, Christopher Murray, Julie Irving, John Lyons, Eddy Freyne, Edward J. Lewis, Jose Cosme, Andrew Pike, Brent L. Graham, Lindsay A. Devine, Susanne Bethell, Abarna Thiru, Ruth Feltell, Darcey Miller, Maria Carr, Sharna Rich, Michael A. Batey, Christopher Hamlett, Michael Reader, Martyn Frederickson, Alistair O'Brien, Emma Vickerstaffe, Rajdeep K. Benning, Andrew Madin, Charlotte Griffiths Jones, Douglas Ross, Lynsey Fazal, Tim Perera, Patrick Angibaud, Peter King, Anne Cleasby, Valerio Berdini, Gordan Saxty, George Ward, Matthew Squires
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::605eebdec9c9d2137ffcbba68a3b82cd
https://doi.org/10.1158/1535-7163.c.6535227 -
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المؤلفون: Neil T. Thompson, David R. Newell, Christopher Murray, Julie Irving, John Lyons, Eddy Freyne, Edward J. Lewis, Jose Cosme, Andrew Pike, Brent L. Graham, Lindsay A. Devine, Susanne Bethell, Abarna Thiru, Ruth Feltell, Darcey Miller, Maria Carr, Sharna Rich, Michael A. Batey, Christopher Hamlett, Michael Reader, Martyn Frederickson, Alistair O'Brien, Emma Vickerstaffe, Rajdeep K. Benning, Andrew Madin, Charlotte Griffiths Jones, Douglas Ross, Lynsey Fazal, Tim Perera, Patrick Angibaud, Peter King, Anne Cleasby, Valerio Berdini, Gordan Saxty, George Ward, Matthew Squires
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe1a33d4a31585a984d85c6194526c9
https://doi.org/10.1158/1535-7163.22496319 -
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المؤلفون: Neil T. Thompson, Nicola G. Wallis, Michael Reader, Christopher J. Hindley, Juan Castro, John Lyons, David C. Rees, Nicola E. Wilsher, Caroline Richardson, Tom D. Heightman, Lukas Stanczuk, Alpesh Shah, Sharna J. Rich, Charlotte East, Valerio Berdini, Marc O'Reilly, Justyna Kucia-Tran, Jessica L. Brothwood, Joanne M. Munck, Alison Jo-Anne Woolford, Sandra Muench, Christopher William Murray, David Norton, Luke Bevan, Aurélie Courtin, Roberta Ferraldeschi, Vanessa Martins
المصدر: Molecular Cancer Therapeutics. 20:1757-1768
مصطلحات موضوعية: Male, MAPK/ERK pathway, Cancer Research, Indoles, Mice, Nude, Apoptosis, Ribosomal s6 kinase, Mice, Downregulation and upregulation, Cell Movement, In vivo, Tumor Cells, Cultured, Animals, Humans, Phosphorylation, Extracellular Signal-Regulated MAP Kinases, Protein Kinase Inhibitors, Cell Proliferation, Mice, Inbred BALB C, biology, Chemistry, Effector, Cell Cycle, Xenograft Model Antitumor Assays, In vitro, Gene Expression Regulation, Neoplastic, Pyrimidines, Oncology, Drug Resistance, Neoplasm, Cell culture, Colonic Neoplasms, Cancer research, biology.protein
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6856599564530823950e091fd6e69a67
https://doi.org/10.1158/1535-7163.mct-20-0909 -
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المؤلفون: Michael Reader, Aurélie Courtin, Steven Howard, Nicola G. Wallis, Jonathan Shannon, Hugh Walton, Christopher William Murray, Joseph E. Coyle, Joanne M. Munck, Alison Jo-Anne Woolford, Torren M. Peakman, David C. Rees, James Edward Harvey Day, Charlotte Mary Griffiths-Jones, Marc O'Reilly, Alpesh Shah, David Norton, Valerio Berdini, Lynsey Fazal, Maria Grazia Carr, Charlotte East, Tom D. Heightman, Nicola E. Wilsher, Ildiko Maria Buck, Luke Bevan, Stuart Thomas Onions, Michael Cooke, Justyna Kucia-Tran, Sandra Muench, Nick Palmer, Sharna J. Rich, Vanessa Martins, David Cousin, Puja Pathuri, John P. Watts
المصدر: Journal of medicinal chemistry. 64(16)
مصطلحات موضوعية: Male, Indoles, Antineoplastic Agents, Crystallography, X-Ray, Proto-Oncogene Mas, Rats, Sprague-Dawley, Structure-Activity Relationship, Dogs, Pharmacokinetics, Neoplasms, Drug Discovery, Animals, Humans, In patient, Tumor growth, Phosphorylation, Rats, Wistar, Protein kinase A, Protein Kinase Inhibitors, Mitogen-Activated Protein Kinase 1, Mice, Inbred BALB C, Molecular Structure, Chemistry, Kinase, Xenograft Model Antitumor Assays, Clinical trial, Pyrimidines, Cancer research, Molecular Medicine, Once daily dosing, Protein Binding
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المؤلفون: Neil T. Thompson, Charlotte Mary Griffiths-Jones, John Lyons, Vanessa Martins, Nicola E. Wilsher, Tom D. Heightman, Harpreet K Saini, Juan Castro, Stuart Thomas Onions, David Cousin, Nicola G. Wallis, Valerio Berdini, Nick Palmer, Puja Pathuri, Caroline Richardson, Christopher William Murray, Charlotte East, John P. Watts, Marc O'Reilly, Sharna J. Rich, Hugh Walton, James Edward Harvey Day, Aurélie Courtin, Brent Graham, David C. Rees, Hannah Braithwaite, Michael Cooke, Ildiko Maria Buck, Michael Reader, Sandra Muench, Megan Cassidy, Jonathan Shannon, Joanne M. Munck, Alison Jo-Anne Woolford, David Norton, Lynsey Fazal
المصدر: Journal of Medicinal Chemistry. 61:4978-4992
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, MAPK/ERK pathway, Protein Conformation, Mutant, Administration, Oral, Biological Availability, Mice, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Kinome, Phosphorylation, Protein Kinase Inhibitors, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, Drug discovery, Chemistry, Cell growth, Melanoma, medicine.disease, 030104 developmental biology, Cell culture, 030220 oncology & carcinogenesis, Biocatalysis, Cancer research, Molecular Medicine
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المؤلفون: Yann Dudit, Zehong Wan, Don O. Somers, Yingxia Sang, Vipulkumar Kantibhai Patel, Pascal Grondin, Joseph E. Coyle, Veronique Beneton, Rachel McMenamin, Lee William Page, Philip J. Day, Alison Jo-Anne Woolford, Lionel Trottet, Valerio Berdini, Florent Potvain, Sharna J. Rich, Christopher William Murray, Pascal Huet, Lydia Y. W. Lee, Xiaomin Zhang, Eric S. Manas
المصدر: Journal of Medicinal Chemistry. 59:10738-10749
مصطلحات موضوعية: 0301 basic medicine, Virtual screening, biology, Lipoprotein-associated phospholipase A2, Active site, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, Fragment (logic), 030220 oncology & carcinogenesis, Drug Discovery, Lipophilicity, Lactam, biology.protein, Molecular Medicine, Bioassay, lipids (amino acids, peptides, and proteins), IC50
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المؤلفون: Emiliano Tamanini, Joseph E. Coyle, Agnes C. L. Martin, Adam Hold, Elisabetta Chiarparin, Sharna J. Rich, Ludovic Drouin, Puja Pathuri, Rob L. M. van Montfort, Tom D. Heightman, Marcello Tortorici, Finn P. Holding, Jeff Yon, Amy Wood, Rosemary Burke, Fiona Jeganathan, Yvette Newbatt, Nader Amin, Jenny E. Harmer, Maura Westlake, Paul Acklam, Swen Hoelder, Valerio Berdini, Dominic Tisi
المصدر: ACS Chemical Biology. 11:3093-3105
مصطلحات موضوعية: 0301 basic medicine, Adenosine, Magnetic Resonance Spectroscopy, Protein Conformation, Stereochemistry, Mutant, Calorimetry, Biology, Crystallography, X-Ray, Biochemistry, Mass Spectrometry, Epigenesis, Genetic, 03 medical and health sciences, Sinefungin, Protein structure, SETD2, Transferase, Binding site, Binding Sites, Point mutation, Histone-Lysine N-Methyltransferase, Oncogenes, General Medicine, Small molecule, Repressor Proteins, 030104 developmental biology, Drug Design, Molecular Medicine, Chromatography, Liquid
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المؤلفون: Nicola G. Wallis, Valerio Berdini, S. Hiscock, T.G. Davies, H. Ochiiwa, Keisha Hearn, Y. Nakatsuru, Tomoko Smyth, Sharna J. Rich, Sandra Muench, Alpesh Shah, A. Price, Y. Shibata, T. Shimamura, Nicola E. Wilsher, C.N. Johnson, G. Chessari, Vanessa Martins, J.E.H. Day, C. Hamlett
المصدر: European Journal of Cancer. 138:S44
مصطلحات موضوعية: Cancer Research, Oncology, Biochemistry, Chemistry, Allosteric regulation, Identification (biology), Small molecule