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المؤلفون: Himmelbauer MK; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Bajrami B; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Basile R; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Capacci A; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Chen T; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Choi CK; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Gilfillan R; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Gonzalez-Lopez de Turiso F; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Gu C; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Hoemberger M; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Johnson DS; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Jones JH; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Kadakia E; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Kirkland M; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Lin EY; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Liu Y; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Ma B; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Magee T; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Mantena S; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Marx IE; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Metrick CM; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Mingueneau M; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Murugan P; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Muste CA; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Nadella P; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Nevalainen M; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Parker Harp CR; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Pattaropong V; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Pietrasiewicz A; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Prince RJ; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Purgett TJ; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Santoro JC; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Schulz J; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Sciabola S; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Tang H; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Vandeveer HG; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Wang T; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Yousaf Z; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Helal CJ; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States., Hopkins BT; Biogen Research and Development, 225 Binney Street, Cambridge, Massachusetts 02142, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 May 23; Vol. 67 (10), pp. 8122-8140. Date of Electronic Publication: 2024 May 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Agammaglobulinaemia Tyrosine Kinase*/antagonists & inhibitors , Agammaglobulinaemia Tyrosine Kinase*/metabolism , Multiple Sclerosis*/drug therapy , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/therapeutic use , Protein Kinase Inhibitors*/pharmacokinetics , Protein Kinase Inhibitors*/chemistry , Brain*/metabolism, Humans ; Animals ; Mice ; Drug Discovery ; Encephalomyelitis, Autoimmune, Experimental/drug therapy ; Rats ; Structure-Activity Relationship ; Cell Proliferation/drug effects ; Female

المؤلفون: Si C; DCR&T, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Fales KR; DCR&T, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Torrado A; DCR&T, Lilly Spain S.A., Avda de la Industria 30, Alcobendas Madrid, 28108, Spain., Frimpong K; DCR&T, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States., Kaoudi T; DCR&T, Lilly Spain S.A., Avda de la Industria 30, Alcobendas Madrid, 28108, Spain., Vandeveer HG; AMRI, 26 Corporate Circle, Albany, New York 12203, United States., Njoroge FG; DCR&T, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, United States.

المصدر: The Journal of organic chemistry [J Org Chem] 2016 May 20; Vol. 81 (10), pp. 4359-63. Date of Electronic Publication: 2016 May 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: PubMed not MEDLINE