المؤلفون: Sheikh, BN, Downer, NL, Phipson, B, Vanyai, HK, Kueh, AJ, McCarthy, DJ, Smyth, GK, Thomas, T, Voss, AK

مصطلحات الفهرس: Journal Article

URL: http://hdl.handle.net/11343/116037

المؤلفون: Bergamasco MI; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology and., Vanyai HK; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology and., Garnham AL; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology and., Geoghegan ND; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology and., Vogel AP; Centre for Neurosciences of Speech, University of Melbourne, Parkville, Victoria, Australia.; Redenlab Inc., Melbourne, Australia., Eccles S; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology and., Rogers KL; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology and., Smyth GK; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; School of Mathematics and Statistics, University of Melbourne, Parkville, Victoria, Australia., Blewitt ME; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology and., Hannan AJ; Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia.; Department of Anatomy and Physiology, University of Melbourne, Parkville, Victoria, Australia., Thomas T; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology and., Voss AK; The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.; Department of Medical Biology and.

المصدر: The Journal of clinical investigation [J Clin Invest] 2024 Apr 01; Vol. 134 (7). Date of Electronic Publication: 2024 Apr 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

مواضيع طبية MeSH: Abnormalities, Multiple*/drug therapy , Abnormalities, Multiple*/genetics , Acetylcarnitine*/pharmacology , Acetylcarnitine*/therapeutic use , Congenital Hypothyroidism* , Craniofacial Abnormalities*/drug therapy , Craniofacial Abnormalities*/genetics , Histone Acetyltransferases*/antagonists & inhibitors , Histone Acetyltransferases*/genetics , Histone Acetyltransferases*/metabolism , Intellectual Disability*/drug therapy , Intellectual Disability*/genetics , Joint Instability*, Animals ; Humans ; Mice ; Acetylation ; Blepharophimosis ; Chromatin ; Exons ; Facies ; Heart Defects, Congenital ; Histones/genetics

SCR Disease Name: Young Simpson syndrome

المؤلفون: Mah SYY; Walter and Eliza Hall Institute of Medical Research, Epigenetics and Development Division, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia., Vanyai HK; Walter and Eliza Hall Institute of Medical Research, Epigenetics and Development Division, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia., Li-Wai-Suen CSN; Walter and Eliza Hall Institute of Medical Research, Epigenetics and Development Division, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia., Garnham AL; Walter and Eliza Hall Institute of Medical Research, Epigenetics and Development Division, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia., Wynn J; Walter and Eliza Hall Institute of Medical Research, Epigenetics and Development Division, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia., Bergamasco MI; Walter and Eliza Hall Institute of Medical Research, Epigenetics and Development Division, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia., Malelang S; Walter and Eliza Hall Institute of Medical Research, Epigenetics and Development Division, Melbourne, VIC 3052, Australia., Wilcox S; Walter and Eliza Hall Institute of Medical Research, Epigenetics and Development Division, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia., Biben C; Walter and Eliza Hall Institute of Medical Research, Epigenetics and Development Division, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia., Smyth GK; Walter and Eliza Hall Institute of Medical Research, Epigenetics and Development Division, Melbourne, VIC 3052, Australia.; School of Mathematics and Statistics, University of Melbourne, VIC 3010, Australia., Thomas T; Walter and Eliza Hall Institute of Medical Research, Epigenetics and Development Division, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia., Voss AK; Walter and Eliza Hall Institute of Medical Research, Epigenetics and Development Division, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC 3052, Australia.

المصدر: Development (Cambridge, England) [Development] 2024 Mar 01; Vol. 151 (5). Date of Electronic Publication: 2024 Mar 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 8701744 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9129 (Electronic) Linking ISSN: 09501991 NLM ISO Abbreviation: Development Subsets: MEDLINE

مواضيع طبية MeSH: Lysine* , Heart Septal Defects, Ventricular* , Carrier Proteins*, Humans ; Animals ; Mice ; Cell Lineage ; Histones ; Acetylation ; Chromatin ; Transcription Factors ; Tumor Suppressor Proteins ; Homeodomain Proteins/genetics ; Cell Cycle Proteins ; Histone Acetyltransferases

المؤلفون: Mah SYY; Epigenetics and Development Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Vanyai HK; Epigenetics and Development Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Yang Y; Epigenetics and Development Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Voss AK; Epigenetics and Development Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia., Thomas T; Epigenetics and Development Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia.

المصدر: Frontiers in immunology [Front Immunol] 2023 May 18; Vol. 14, pp. 1119750. Date of Electronic Publication: 2023 May 18 (Print Publication: 2023).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Hematopoietic Stem Cell Transplantation* , Tumor Suppressor Proteins*/genetics , Transcription Factors*/genetics, Animals ; Mice ; Cell Count ; Chromatin/genetics ; Liver ; Lysine

المؤلفون: Vanyai HK; The Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK., Prin F; The Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK., Guillermin O; The Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK., Marzook B; The Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK., Boeing S; The Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK., Howson A; The Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK., Saunders RE; The Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK., Snoeks T; The Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK., Howell M; The Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK., Mohun TJ; The Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK., Thompson B; The Francis Crick Institute, 1 Midland Rd, St Pancras, NW1 1AT London, UK barry.thompson@anu.edu.au.; EMBL Australia, Department of Cancer Biology & Therapeutics, The John Curtin School of Medical Research, The Australian National University, 131 Garran Rd, Acton, 2601, Canberra, Australia.

المصدر: Development (Cambridge, England) [Development] 2020 Nov 12; Vol. 147 (21). Date of Electronic Publication: 2020 Nov 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 8701744 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-9129 (Electronic) Linking ISSN: 09501991 NLM ISO Abbreviation: Development Subsets: MEDLINE

مواضيع طبية MeSH: Morphogenesis*/genetics, Adaptor Proteins, Signal Transducing/*metabolism , Bone and Bones/*embryology , Bone and Bones/*metabolism , Cell Cycle Proteins/*metabolism , Protein Serine-Threonine Kinases/*metabolism , Trans-Activators/*metabolism, Animals ; Bone and Bones/abnormalities ; Bone and Bones/pathology ; Cartilage/pathology ; Cell Nucleus/metabolism ; Cell Proliferation ; Chondrocytes/metabolism ; Chondrocytes/pathology ; Cleft Palate/pathology ; Extracellular Matrix/genetics ; Extracellular Matrix/metabolism ; Gene Expression Regulation, Developmental ; Growth Plate/pathology ; Hippo Signaling Pathway ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Signal Transduction ; Tumor Suppressor Proteins/metabolism ; YAP-Signaling Proteins

المؤلفون: White CW; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology & Neuroscience, School of Life Sciences, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK; Harry Perkins Institute of Medical Research and Centre for Medical Research, The University of Western Australia, QEII Medical Centre, Nedlands, WA 6009, Australia; Australian Research Council Centre for Personalised Therapeutics Technologies, Australia. Electronic address: carl.white@perkins.uwa.edu.au., Caspar B; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology & Neuroscience, School of Life Sciences, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK., Vanyai HK; Epithelial Biology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK., Pfleger KDG; Harry Perkins Institute of Medical Research and Centre for Medical Research, The University of Western Australia, QEII Medical Centre, Nedlands, WA 6009, Australia; Australian Research Council Centre for Personalised Therapeutics Technologies, Australia; Dimerix Limited, Nedlands, WA 6009, Australia., Hill SJ; Cell Signalling and Pharmacology Research Group, Division of Physiology, Pharmacology & Neuroscience, School of Life Sciences, University of Nottingham, Queens Medical Centre, Nottingham NG7 2UH, UK; Centre of Membrane Proteins and Receptors, University of Birmingham and University of Nottingham, The Midlands, UK; Harry Perkins Institute of Medical Research and Centre for Medical Research, The University of Western Australia, QEII Medical Centre, Nedlands, WA 6009, Australia. Electronic address: stephen.hill@nottingham.ac.uk.

المصدر: Cell chemical biology [Cell Chem Biol] 2020 May 21; Vol. 27 (5), pp. 499-510.e7. Date of Electronic Publication: 2020 Feb 12.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Bioluminescence Resonance Energy Transfer Techniques* , CRISPR-Cas Systems* , Gene Editing*, Receptors, CXCR/*metabolism , Receptors, CXCR4/*metabolism, Clustered Regularly Interspaced Short Palindromic Repeats ; HEK293 Cells ; Humans ; Ligands ; Luciferases/analysis ; Luciferases/genetics ; Luciferases/metabolism ; Luminescent Proteins/analysis ; Luminescent Proteins/genetics ; Luminescent Proteins/metabolism ; Protein Binding ; Protein Conformation ; Receptors, CXCR/analysis ; Receptors, CXCR/genetics ; Receptors, CXCR4/analysis ; Receptors, CXCR4/genetics ; beta-Arrestins/analysis ; beta-Arrestins/genetics ; beta-Arrestins/metabolism

المؤلفون: Vanyai HK; Walter and Eliza Hall Institute of Medical Research, Melbourne, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia., Garnham A; Walter and Eliza Hall Institute of Medical Research, Melbourne, Parkville, VIC 3052, Australia., May RE; Walter and Eliza Hall Institute of Medical Research, Melbourne, Parkville, VIC 3052, Australia., McRae HM; Walter and Eliza Hall Institute of Medical Research, Melbourne, Parkville, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia., Collin C; Walter and Eliza Hall Institute of Medical Research, Melbourne, Parkville, VIC 3052, Australia., Wilcox S; Walter and Eliza Hall Institute of Medical Research, Melbourne, Parkville, VIC 3052, Australia., Smyth GK; Walter and Eliza Hall Institute of Medical Research, Melbourne, Parkville, VIC 3052, Australia.; Department School of Mathematics and Statistics, University of Melbourne, Parkville, VIC 3052, Australia., Thomas T; Walter and Eliza Hall Institute of Medical Research, Melbourne, Parkville, VIC 3052, Australia avoss@wehi.edu.au tthomas@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia., Voss AK; Walter and Eliza Hall Institute of Medical Research, Melbourne, Parkville, VIC 3052, Australia avoss@wehi.edu.au tthomas@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.

المصدر: Development (Cambridge, England) [Development] 2019 Jul 24; Vol. 146 (14). Date of Electronic Publication: 2019 Jul 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 8701744 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-9129 (Electronic) Linking ISSN: 09501991 NLM ISO Abbreviation: Development Subsets: MEDLINE

مواضيع طبية MeSH: Facial Bones/*embryology , Homeodomain Proteins/*genetics , Maxillofacial Development/*genetics , Skull/*embryology , Transcription Factors/*genetics, Animals ; Bone Development/genetics ; Cells, Cultured ; Embryo, Mammalian ; Facial Bones/metabolism ; Female ; Gene Expression Regulation, Developmental ; Genes, Homeobox ; Histone Acetyltransferases ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Mice, Transgenic ; Pregnancy ; Skull/metabolism

المؤلفون: Chiovitti A; Gene Technology Access Centre (GTAC), The University High School, Parkville, Victoria, Australia.; School of Biosciences, University of Melbourne, Victoria, Australia., Thorpe F; Gene Technology Access Centre (GTAC), The University High School, Parkville, Victoria, Australia., Gorman C; Gene Technology Access Centre (GTAC), The University High School, Parkville, Victoria, Australia., Cuxson JL; Gene Technology Access Centre (GTAC), The University High School, Parkville, Victoria, Australia., Robevska G; Gene Technology Access Centre (GTAC), The University High School, Parkville, Victoria, Australia., Szwed C; Gene Technology Access Centre (GTAC), The University High School, Parkville, Victoria, Australia., Duncan JC; Gene Technology Access Centre (GTAC), The University High School, Parkville, Victoria, Australia., Vanyai HK; Gene Technology Access Centre (GTAC), The University High School, Parkville, Victoria, Australia., Cross J; Texas A&M University, College Station, Texas, United States of America., Siemering KR; Australian Genome Research Facility (AGRF), Victorian Comprehensive Cancer Centre, Melbourne, Victoria, Australia., Sumner J; Museums Victoria, Carlton Gardens, Victoria, Australia.

المصدر: PloS one [PLoS One] 2019 Jan 10; Vol. 14 (1), pp. e0208604. Date of Electronic Publication: 2019 Jan 10 (Print Publication: 2019).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: DNA Barcoding, Taxonomic* , Models, Educational* , Science*, Animals ; Australia ; Base Sequence ; Feedback ; Genetic Variation ; Mitochondria/genetics ; Phylogeny ; Reptiles/classification ; Reptiles/genetics ; Species Specificity ; Students

المؤلفون: Grabow S; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia. Electronic address: sgrabow@merrimack.com., Kueh AJ; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia., Ke F; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia., Vanyai HK; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia., Sheikh BN; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia., Dengler MA; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia., Chiang W; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia., Eccles S; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia., Smyth IM; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC 3800, Australia; Department of Anatomy and Developmental Biology and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia., Jones LK; Development and Stem Cells Program, Monash Biomedicine Discovery Institute, Monash University, Melbourne, VIC 3800, Australia; Department of Anatomy and Developmental Biology and Department of Biochemistry and Molecular Biology, Monash University, Melbourne, VIC 3800, Australia., de Sauvage FJ; Department of Molecular Oncology, Genentech, South San Francisco, CA 94080, USA., Scott M; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia., Whitehead L; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia., Voss AK; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia. Electronic address: avoss@wehi.edu.au., Strasser A; The Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Melbourne, VIC 3052, Australia. Electronic address: strasser@wehi.edu.au.

المصدر: Cell reports [Cell Rep] 2018 Sep 18; Vol. 24 (12), pp. 3285-3295.e4.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Bcl-2-Like Protein 11/*genetics , Craniofacial Abnormalities/*genetics , Myeloid Cell Leukemia Sequence 1 Protein/*genetics , bcl-X Protein/*genetics, Animals ; Apoptosis ; Bcl-2-Like Protein 11/metabolism ; Cells, Cultured ; Female ; Heterozygote ; Male ; Mice ; Mice, Inbred C57BL ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; bcl-X Protein/metabolism

المؤلفون: Baell JB; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. Jonathan.Baell@monash.edu.; School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing, China. Jonathan.Baell@monash.edu., Leaver DJ; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Hermans SJ; ACRF Rational Drug Discovery Centre, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia., Kelly GL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Brennan MS; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Downer NL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia., Nguyen N; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Wichmann J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., McRae HM; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Yang Y; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Cleary B; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Lagiakos HR; Medicinal Chemistry Theme, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Mieruszynski S; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Pacini G; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia., Vanyai HK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Bergamasco MI; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., May RE; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia., Davey BK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Morgan KJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Sealey AJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Wang B; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; School of Pharmaceutical Sciences, Tsinghua University, Beijing, China., Zamudio N; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Wilcox S; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Garnham AL; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Sheikh BN; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Aubrey BJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Doggett K; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Chung MC; ACRF Rational Drug Discovery Centre, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia., de Silva M; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Bentley J; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Pilling P; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Hattarki M; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Dolezal O; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Dennis ML; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Falk H; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Ren B; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., White KL; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Rautela J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Newbold A; The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Hawkins ED; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Johnstone RW; The Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia., Huntington ND; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Peat TS; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Biomedical Program, Parkville, Victoria, Australia., Heath JK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Strasser A; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia., Parker MW; ACRF Rational Drug Discovery Centre, St Vincent's Institute of Medical Research, Fitzroy, Victoria, Australia.; Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia., Smyth GK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Mathematics and Statistics, University of Melbourne, Parkville, Victoria, Australia., Street IP; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Monahan BJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.; Cancer Therapeutics CRC, Parkville, Victoria, Australia., Voss AK; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia. avoss@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. avoss@wehi.edu.au., Thomas T; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, Victoria, Australia. tthomas@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia. tthomas@wehi.edu.au.

المصدر: Nature [Nature] 2018 Aug; Vol. 560 (7717), pp. 253-257. Date of Electronic Publication: 2018 Aug 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Benzenesulfonates/*pharmacology , Cellular Senescence/*drug effects , Histone Acetyltransferases/*antagonists & inhibitors , Hydrazines/*pharmacology , Lymphoma/*drug therapy , Lymphoma/*pathology , Sulfonamides/*pharmacology, Acetylation/drug effects ; Animals ; Benzenesulfonates/therapeutic use ; Cell Proliferation/drug effects ; Cells, Cultured ; Drug Development ; Fibroblasts ; Gene Expression Regulation, Neoplastic/drug effects ; Histone Acetyltransferases/deficiency ; Histone Acetyltransferases/genetics ; Histones/chemistry ; Histones/metabolism ; Hydrazines/therapeutic use ; Lymphoma/enzymology ; Lymphoma/genetics ; Lysine/chemistry ; Lysine/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Models, Molecular ; Sulfonamides/therapeutic use