المؤلفون: Vara BA; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Levi SM; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Achab A; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Candito DA; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Fradera X; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Lesburg CA; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Kawamura S; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Lacey BM; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Lim J; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Methot JL; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Xu Z; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Xu H; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Smith DM; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Piesvaux JA; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Miller JR; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Bittinger M; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Ranganath SH; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Bennett DJ; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., DiMauro EF; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States., Pasternak A; Discovery Chemistry, Computational and Structural Chemistry, Quantitative Biosciences, Pharmacokinetics and Drug Metabolism, Oncology Early Discovery, Merck & Co., Inc., Boston, Massachusetts 02115, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Mar 19; Vol. 12 (4), pp. 653-661. Date of Electronic Publication: 2021 Mar 19 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Mennie KM; Department of Discovery Chemistry , Merck & Co. Inc. , 33 Avenue Louis Pasteur , Boston , Massachusetts 02115 , United States., Vara BA; Department of Discovery Chemistry , Merck & Co. Inc. , 33 Avenue Louis Pasteur , Boston , Massachusetts 02115 , United States., Levi SM; Department of Discovery Chemistry , Merck & Co. Inc. , 33 Avenue Louis Pasteur , Boston , Massachusetts 02115 , United States.

المصدر: Organic letters [Org Lett] 2020 Jan 17; Vol. 22 (2), pp. 556-559. Date of Electronic Publication: 2020 Jan 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE

مواضيع طبية MeSH: Hydrocarbons, Brominated/*chemistry , Pharmaceutical Preparations/*chemistry , Protein Kinase Inhibitors/*chemistry, Molecular Structure ; Oxidation-Reduction ; Pharmaceutical Preparations/chemical synthesis ; Protein Kinase Inhibitors/chemical synthesis

المؤلفون: Vara BA; Roy and Diana Vagelos Laboratories , Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , USA . Email: gmolandr@sas.upenn.edu., Li X; Roy and Diana Vagelos Laboratories , Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , USA . Email: gmolandr@sas.upenn.edu., Berritt S; Roy and Diana Vagelos Laboratories , Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , USA . Email: gmolandr@sas.upenn.edu., Walters CR; Roy and Diana Vagelos Laboratories , Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , USA . Email: gmolandr@sas.upenn.edu., Petersson EJ; Roy and Diana Vagelos Laboratories , Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , USA . Email: gmolandr@sas.upenn.edu., Molander GA; Roy and Diana Vagelos Laboratories , Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , USA . Email: gmolandr@sas.upenn.edu.

المصدر: Chemical science [Chem Sci] 2017 Nov 13; Vol. 9 (2), pp. 336-344. Date of Electronic Publication: 2017 Nov 13 (Print Publication: 2018).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: eCollection Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE

المؤلفون: Vilgelm AE; Tennessee Valley Healthcare System, Department of Veterans Affairs, Nashville, TN, United States; Vanderbilt University School of Medicine, Department of Cancer Biology, Nashville, TN, United States. Electronic address: anna.e.vilgelm@vanderbilt.edu., Cobb P; Tennessee Valley Healthcare System, Department of Veterans Affairs, Nashville, TN, United States; Vanderbilt University School of Medicine, Department of Cancer Biology, Nashville, TN, United States., Malikayil K; Meharry Medical College, Nashville, TN, United States., Flaherty D; Vanderbilt University Flow Cytometry Shared Resource, Nashville, TN, United States., Andrew Johnson C; Tennessee Valley Healthcare System, Department of Veterans Affairs, Nashville, TN, United States; Vanderbilt University School of Medicine, Department of Cancer Biology, Nashville, TN, United States., Raman D; University of Toledo, Toledo, OH, United States., Saleh N; Tennessee Valley Healthcare System, Department of Veterans Affairs, Nashville, TN, United States; Vanderbilt University School of Medicine, Department of Cancer Biology, Nashville, TN, United States., Higgins B; Pharma Research and Early Development, Roche Innovation Center, New York, NY, United States., Vara BA; Department of Chemistry, Vanderbilt Institute of Chemical Biology, Nashville, TN, United States., Johnston JN; Department of Chemistry, Vanderbilt Institute of Chemical Biology, Nashville, TN, United States., Johnson DB; Division of Hematology and Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States., Kelley MC; Division of Surgical Oncology, Department of Surgery, Vanderbilt University School of Medicine, Nashville, TN, United States., Chen SC; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States., Ayers GD; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, United States., Richmond A; Tennessee Valley Healthcare System, Department of Veterans Affairs, Nashville, TN, United States; Vanderbilt University School of Medicine, Department of Cancer Biology, Nashville, TN, United States.

المصدر: EBioMedicine [EBioMedicine] 2017 Oct; Vol. 24, pp. 43-55. Date of Electronic Publication: 2017 Sep 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 101647039 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2352-3964 (Electronic) Linking ISSN: 23523964 NLM ISO Abbreviation: EBioMedicine Subsets: MEDLINE

مواضيع طبية MeSH: Azepines/*administration & dosage , DNA Damage/*drug effects , Imidazoles/*administration & dosage , Melanoma/*drug therapy , Piperazines/*administration & dosage , Proto-Oncogene Proteins c-mdm2/*antagonists & inhibitors , Pyrimidines/*administration & dosage , Pyrrolidines/*administration & dosage , para-Aminobenzoates/*administration & dosage, Animals ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Azepines/pharmacology ; Cell Line, Tumor ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; DNA Replication/drug effects ; HCT116 Cells ; Humans ; Imidazoles/pharmacology ; Melanoma/genetics ; Mice ; Piperazines/pharmacology ; Protein Binding/drug effects ; Proto-Oncogene Proteins c-mdm2/metabolism ; Pyrimidines/pharmacology ; Pyrrolidines/pharmacology ; Tumor Suppressor Protein p53/metabolism ; Xenograft Model Antitumor Assays ; para-Aminobenzoates/pharmacology

المؤلفون: Vara BA; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Patel NR; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Molander GA; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.

المصدر: ACS catalysis [ACS Catal] 2017 Jun 02; Vol. 7 (6), pp. 3955-3959. Date of Electronic Publication: 2017 May 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101562209 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2155-5435 (Print) NLM ISO Abbreviation: ACS Catal Subsets: PubMed not MEDLINE

المؤلفون: Vara BA; Roy and Diana Vagelos Laboratories , Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , USA . Email: gmolandr@sas.upenn.edu., Jouffroy M; Roy and Diana Vagelos Laboratories , Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , USA . Email: gmolandr@sas.upenn.edu., Molander GA; Roy and Diana Vagelos Laboratories , Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104-6323 , USA . Email: gmolandr@sas.upenn.edu.

المصدر: Chemical science [Chem Sci] 2017 Jan 01; Vol. 8 (1), pp. 530-535. Date of Electronic Publication: 2016 Sep 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE

المؤلفون: Gutiérrez-Bonet Á; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Tellis JC; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Matsui JK; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Vara BA; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States., Molander GA; Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania , 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, United States.

المصدر: ACS catalysis [ACS Catal] 2016 Dec 02; Vol. 6 (12), pp. 8004-8008. Date of Electronic Publication: 2016 Oct 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101562209 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2155-5435 (Print) NLM ISO Abbreviation: ACS Catal Subsets: PubMed not MEDLINE

المؤلفون: Vara BA; Department of Chemistry & Vanderbilt Institute of Chemical Biology, Vanderbilt University , Nashville, Tennessee 37235-1822, United States., Johnston JN; Department of Chemistry & Vanderbilt Institute of Chemical Biology, Vanderbilt University , Nashville, Tennessee 37235-1822, United States.

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2016 Oct 26; Vol. 138 (42), pp. 13794-13797. Date of Electronic Publication: 2016 Oct 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: PubMed not MEDLINE

المؤلفون: Vara BA; Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States., Struble TJ; Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States., Wang W; Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States., Dobish MC; Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States., Johnston JN; Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States.

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2015 Jun 17; Vol. 137 (23), pp. 7302-5. Date of Electronic Publication: 2015 Jun 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Acids/*chemistry , Alkalies/*chemistry , Carbon Dioxide/*chemistry , Ethylenediamines/*chemistry , Organometallic Compounds/*chemistry , Small Molecule Libraries/*chemical synthesis, Catalysis ; Molecular Structure ; Small Molecule Libraries/chemistry ; Stereoisomerism

المؤلفون: Sprague DJ; Department of Chemistry and Vanderbilt Institute of Chemical Biology, Vanderbilt University , Nashville, Tennessee 37235, United States., Nugent BM, Yoder RA, Vara BA, Johnston JN

المصدر: Organic letters [Org Lett] 2015 Feb 20; Vol. 17 (4), pp. 880-3. Date of Electronic Publication: 2015 Jan 31.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE

مواضيع طبية MeSH: Alkaloids/*chemical synthesis , Piperazines/*chemical synthesis, Alkaloids/chemistry ; Cycloaddition Reaction ; Hydrogen Bonding ; Molecular Structure ; Piperazines/chemistry ; Spiro Compounds/chemical synthesis ; Spiro Compounds/chemistry ; Stereoisomerism