-
1
المؤلفون: Renato Skerlj, Tuya Ba, Ernest J. McEachern, Elyse Bourque, Ian Baird, Dominique Schols, Wilson Trevor R, Renee Mosi, Jonathan Langille, Yuanxi Zhou, Bryon Carpenter, Michael Bey, Simon P. Fricker, Dana Huskens, Duane Veale, Rebecca S.Y. Wong, Gary Bridger, Curtis Harwig, Veronique Bodart, Ron MacFarland, Markus Metz, Sanjay Danthi
المصدر: ACS Medicinal Chemistry Letters. 3:216-221
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, biology, business.industry, Purkinje fibers, Organic Chemistry, hERG, Human immunodeficiency virus (HIV), Pharmacology, medicine.disease_cause, Biochemistry, Bioavailability, Chemokine receptor, medicine.anatomical_structure, Drug Discovery, Lipophilicity, biology.protein, Medicine, Action potential duration, cardiovascular diseases, business, Ion channel
-
2
المؤلفون: Renato Skerlj, Gary Bridger, Yuanxi Zhou, Elyse Bourque, Ernest McEachern, Jonathan Langille, Curtis Harwig, Duane Veale, Wen Yang, Tongshong Li, Yongbao Zhu, Michael Bey, Ian Baird, Michael Sartori, Markus Metz, Renee Mosi, Kim Nelson, Veronique Bodart, Rebecca Wong, Simon Fricker, Ron Mac Farland, Dana Huskens, Dominique Schols
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:6950-6954
مصطلحات موضوعية: Tertiary amine, Anti-HIV Agents, Pyridines, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, CCR5 receptor antagonist, Pharmacology, Virus Replication, Biochemistry, Peripheral blood mononuclear cell, Chemical synthesis, Inhibitory Concentration 50, Dogs, Piperidines, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, virus diseases, Amides, In vitro, Rats, Viral replication, Drug Design, CCR5 Receptor Antagonists, HIV-1, Leukocytes, Mononuclear, Molecular Medicine
-
3
المؤلفون: Curtis Harwig, Dominique Schols, Gang Chen, Wen Yang, Duane Veale, Susan Nan, Simon P. Fricker, Alan Kaller, Danielle Guay, Jason M. Crawford, Michael Satori, Markus Metz, Yongbao Zhu, Helen Yee, Maria Krumpak, Elyse Bourque, Wilson Trevor R, David Bogucki, Bryon Carpenter, Michael Bey, David C. Leitch, Ron MacFarland, David Gauthier, Ian Baird, Rebecca Wong, Renato T. Skerlj, Jonathan Langille, Yuanxi Zhou, Gary Bridger, Renee Mosi, Ernest J. McEachern, Tuya Ba, Tong-Shuang Li, Krystyna Vocadlo, Veronique Bodart
المصدر: Journal of medicinal chemistry. 56(20)
مصطلحات موضوعية: Receptors, CCR5, Anti-HIV Agents, Cell Survival, hERG, Human immunodeficiency virus (HIV), CHO Cells, Pharmacology, medicine.disease_cause, Imidazolidines, Virus Replication, Benzoates, Chemokine receptor, Structure-Activity Relationship, Cricetulus, Piperidines, In vivo, Cricetinae, Drug Discovery, medicine, Animals, Humans, Cells, Cultured, Cardiotoxicity, biology, Molecular Structure, Chemistry, Imidazoles, In vitro, Receptor selectivity, HEK293 Cells, Biochemistry, Models, Chemical, Drug Design, Lipophilicity, CCR5 Receptor Antagonists, Host-Pathogen Interactions, biology.protein, HIV-1, Leukocytes, Mononuclear, Molecular Medicine
-
4
المؤلفون: Melanie Ruzek, Kim L. Nelson, Robert J. Scarborough, Stefan R. Idzan, Gary Bridger, Virginia Anastassov, Kathleen S. Neff, Gloria Lau, Marilyn C. Darkes, Rebecca S.Y. Wong, Jean Labrecque, Zefferino Santucci, Renee Mosi, Veronique Bodart, Ketan Patel, Simon P. Fricker, Ron MacFarland
المصدر: Biochemical pharmacology. 78(8)
مصطلحات موضوعية: Male, medicine.medical_specialty, Receptors, CXCR4, Maximum Tolerated Dose, Leukocytosis, Metabolic Clearance Rate, Pyridines, C-C chemokine receptor type 7, CHO Cells, Biology, Pharmacology, CXCR3, Kidney, Transfection, Biochemistry, CXCR4, Absorption, Cell Line, Chemokine receptor, Inhibitory Concentration 50, Mice, Cricetulus, Dogs, Heterocyclic Compounds, Internal medicine, Cricetinae, Calcium flux, medicine, Animals, Humans, Receptor, Fluorescent Dyes, Mice, Inbred BALB C, CXCR4 antagonist, Dose-Response Relationship, Drug, Molecular Structure, Chemotaxis, Antagonist, Fluoresceins, Chemokine CXCL12, Mice, Inbred C57BL, Endocrinology, Mice, Inbred DBA, Area Under Curve, Calcium, Half-Life, Protein Binding
-
5
المؤلفون: Markus Metz, Simon P. Fricker, Gary Bridger, Veronique Bodart, Rebecca S.Y. Wong, Jean Labrecque
المصدر: Molecular pharmacology. 74(6)
مصطلحات موضوعية: Models, Molecular, Benzylamines, Receptors, CXCR4, CXCR4 Inhibitor, Chemokine receptor CCR5, Anti-HIV Agents, Pyridines, C-C chemokine receptor type 7, C-C chemokine receptor type 6, CXCR3, Butylamines, Cyclams, Ligands, Binding, Competitive, Cell Line, Cell Fusion, Chemokine receptor, Heterocyclic Compounds, 1-Ring, Radioligand Assay, Cricetulus, Heterocyclic Compounds, Cricetinae, Animals, Humans, CXC chemokine receptors, Pharmacology, Binding Sites, biology, Biochemistry, Mutation, biology.protein, Aminoquinolines, Mutagenesis, Site-Directed, Molecular Medicine, Benzimidazoles, CCL21
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b084cb8c2bce11381f7cd624efe3d67
https://pubmed.ncbi.nlm.nih.gov/18768385
Find this issue from the American Chemical Society