المؤلفون: Veselov MS; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, Ufa, Russian Federation, 450054. mark.veselov@phystech.edu.; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, Moscow Region, Russian Federation, 141700. mark.veselov@phystech.edu.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation. mark.veselov@phystech.edu., Ivanenkov YA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, Ufa, Russian Federation, 450054.; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, Moscow Region, Russian Federation, 141700.; Chemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3 GSP-1, Moscow, Russian Federation, 119991.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation.; ChemDiv, 6605 Nancy Ridge Drive, San Diego, CA, 92121, USA., Yamidanov RS; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, Ufa, Russian Federation, 450054., Osterman IA; Chemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3 GSP-1, Moscow, Russian Federation, 119991.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Sergiev PV; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Aladinskiy VA; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, Moscow Region, Russian Federation, 141700.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Aladinskaya AV; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, Moscow Region, Russian Federation, 141700.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Terentiev VA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, Ufa, Russian Federation, 450054.; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, Moscow Region, Russian Federation, 141700.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Ayginin AA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, Ufa, Russian Federation, 450054.; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, Moscow Region, Russian Federation, 141700., Skvortsov DA; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation., Komarova KS; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Chemeris AV; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, Ufa, Russian Federation, 450054., Baimiev AK; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, Ufa, Russian Federation, 450054., Sofronova AA; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russian Federation., Machulkin AE; Chemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3 GSP-1, Moscow, Russian Federation, 119991., Petrov RA; Chemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3 GSP-1, Moscow, Russian Federation, 119991., Maklakova SY; Chemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3 GSP-1, Moscow, Russian Federation, 119991., Bezrukov DS; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Filkov GI; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, Moscow Region, Russian Federation, 141700., Zainullina LF; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, Ufa, Russian Federation, 450054., Maximova MA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, Ufa, Russian Federation, 450054., Zileeva ZR; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, Ufa, Russian Federation, 450054., Kartsev VG; InterBioScreen Ltd, Chernogolovka, Moscow Region, Russian Federation., Vakhitova YV; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, Ufa, Russian Federation, 450054., Dontsova OA; Chemistry Department, Lomonosov Moscow State University, Leninskie Gory, Building 1/3 GSP-1, Moscow, Russian Federation, 119991.; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation.

المصدر: Molecular diversity [Mol Divers] 2020 Feb; Vol. 24 (1), pp. 233-239. Date of Electronic Publication: 2019 Apr 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: ESCOM Science Publishers Country of Publication: Netherlands NLM ID: 9516534 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-501X (Electronic) Linking ISSN: 13811991 NLM ISO Abbreviation: Mol Divers Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*chemistry , Anti-Bacterial Agents/*pharmacology , Indolizines/*chemistry , Pyridines/*chemistry, Cell Survival ; Drug Evaluation, Preclinical ; High-Throughput Screening Assays ; Microbial Sensitivity Tests ; Structure-Activity Relationship

المؤلفون: Ivanenkov YA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Yamidanov RS; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Osterman IA; Lomonosov Moscow State University, Chemistry Dept, Leninskie gory, Building 1/3, GSP-1, Moscow, 119991, Russian Federation., Sergiev PV; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Aladinskiy VA; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region, 141700, Russian Federation., Aladinskaya AV; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region, 141700, Russian Federation., Terentiev VA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Veselov MS; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Ayginin AA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Skvortsov DA; Lomonosov Moscow State University, Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, Russian Federation., Komarova KS; Lomonosov Moscow State University, Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, Russian Federation., Zagribelnyy BA; Lomonosov Moscow State University, Chemistry Dept, Leninskie gory, Building 1/3, GSP-1, Moscow, 119991, Russian Federation., Baimiev AK; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Shvetc KY; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Baimiev AK; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Sofronova AA; Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Moscow, Russian Federation., Machulkin AE; Lomonosov Moscow State University, Chemistry Dept, Leninskie gory, Building 1/3, GSP-1, Moscow, 119991, Russian Federation., Petrov RA; Lomonosov Moscow State University, Chemistry Dept, Leninskie gory, Building 1/3, GSP-1, Moscow, 119991, Russian Federation., Zainullina LF; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Maximova MA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Zileeva ZR; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Vakhitova YV; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Bezrukov DS; Lomonosov Moscow State University, Chemistry Dept, Leninskie gory, Building 1/3, GSP-1, Moscow, 119991, Russian Federation., Puchinina MM; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region, 141700, Russian Federation., Dontsova OA; Lomonosov Moscow State University, Chemistry Dept, Leninskie gory, Building 1/3, GSP-1, Moscow, 119991, Russian Federation.

المصدر: Current drug discovery technologies [Curr Drug Discov Technol] 2020; Vol. 17 (5), pp. 716-724.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101157212 Publication Model: Print Cited Medium: Internet ISSN: 1875-6220 (Electronic) Linking ISSN: 15701638 NLM ISO Abbreviation: Curr Drug Discov Technol Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery* , High-Throughput Screening Assays*, Anti-Bacterial Agents/*pharmacology , Thiophenes/*pharmacology, Anti-Bacterial Agents/chemistry ; Escherichia coli/drug effects ; Microbial Sensitivity Tests ; Staphylococcus aureus/drug effects ; Structure-Activity Relationship ; Thiophenes/chemistry

المؤلفون: Ivanenkov YA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russia.; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, 141700, Moscow, Russia.; Lomonosov Moscow State University, Chemistry Department, Leninskie Gory, Building 1/3, GSP-1, 119991, Moscow, Russia.; ChemDiv, 6605 Nancy Ridge Drive, San Diego, CA, 92121, USA., Yamidanov RS; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russia., Osterman IA; Lomonosov Moscow State University, Chemistry Department, Leninskie Gory, Building 1/3, GSP-1, 119991, Moscow, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Russia., Sergiev PV; Skolkovo Institute of Science and Technology, Skolkovo, Russia.; Lomonosov Moscow State University, Department of Chemistry, A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, Russia., Aladinskiy VA; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, 141700, Moscow, Russia., Aladinskaya AV; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, 141700, Moscow, Russia. anastasiya.aladinskaya@gmail.com., Terentiev VA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russia.; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, 141700, Moscow, Russia., Veselov MS; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russia.; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, 141700, Moscow, Russia., Ayginin AA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russia.; Moscow Institute of Physics and Technology (State University), 9 Institutskiy Lane, Dolgoprudny City, 141700, Moscow, Russia., Skvortsov DA; Lomonosov Moscow State University, Department of Chemistry, A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, Russia., Komarova KS; Skolkovo Institute of Science and Technology, Skolkovo, Russia.; Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Moscow, Russia., Sadovnikov SV; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russia., Matniyazov R; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russia., Sofronova AA; Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Moscow, Russia., Malyshev AS; Lomonosov Moscow State University, Faculty of Medicine, Moscow, Russia., Machulkin AE; Lomonosov Moscow State University, Chemistry Department, Leninskie Gory, Building 1/3, GSP-1, 119991, Moscow, Russia., Petrov RA; Lomonosov Moscow State University, Chemistry Department, Leninskie Gory, Building 1/3, GSP-1, 119991, Moscow, Russia., Lukianov D; Skolkovo Institute of Science and Technology, Skolkovo, Russia., Iarovenko S; Skolkovo Institute of Science and Technology, Skolkovo, Russia.; Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Moscow, Russia., Bezrukov DS; Lomonosov Moscow State University, Chemistry Department, Leninskie Gory, Building 1/3, GSP-1, 119991, Moscow, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Russia., Baymiev AK; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russia., Dontsova OA; Lomonosov Moscow State University, Chemistry Department, Leninskie Gory, Building 1/3, GSP-1, 119991, Moscow, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Russia.; Lomonosov Moscow State University, Department of Chemistry, A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, Russia.

المصدر: The Journal of antibiotics [J Antibiot (Tokyo)] 2019 Nov; Vol. 72 (11), pp. 827-833. Date of Electronic Publication: 2019 Jul 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0151115 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-1469 (Electronic) Linking ISSN: 00218820 NLM ISO Abbreviation: J Antibiot (Tokyo) Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , High-Throughput Screening Assays/*methods , Thiazoles/*pharmacology, Anti-Bacterial Agents/chemistry ; Cell Line, Tumor ; Cell Survival/drug effects ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Thiazoles/chemistry

المؤلفون: Zhavoronkov A; Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong. alex@insilico.com., Ivanenkov YA; Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong., Aliper A; Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong., Veselov MS; Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong., Aladinskiy VA; Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong., Aladinskaya AV; Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong., Terentiev VA; Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong., Polykovskiy DA; Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong., Kuznetsov MD; Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong., Asadulaev A; Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong., Volkov Y; Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong., Zholus A; Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong., Shayakhmetov RR; Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong., Zhebrak A; Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong., Minaeva LI; Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong., Zagribelnyy BA; Insilico Medicine Hong Kong Ltd, Pak Shek Kok, New Territories, Hong Kong., Lee LH; WuXi AppTec Co., Ltd, Shanghai, China., Soll R; WuXi AppTec Co., Ltd, Shanghai, China., Madge D; WuXi AppTec Co., Ltd, Shanghai, China., Xing L; WuXi AppTec Co., Ltd, Shanghai, China., Guo T; WuXi AppTec Co., Ltd, Shanghai, China., Aspuru-Guzik A; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.; Department of Computer Science, University of Toronto, Toronto, Ontario, Canada.; Vector Institute for Artificial Intelligence, Toronto, Ontario, Canada.; Canadian Institute for Advanced Research, Toronto, Ontario, Canada.

المصدر: Nature biotechnology [Nat Biotechnol] 2019 Sep; Vol. 37 (9), pp. 1038-1040. Date of Electronic Publication: 2019 Sep 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Deep Learning*, Discoidin Domain Receptor 1/*antagonists & inhibitors , Discoidin Domain Receptor 1/*metabolism , Drug Evaluation, Preclinical/*methods, Animals ; Discoidin Domain Receptor 1/genetics ; Dogs ; Enzyme Inhibitors ; Humans ; Mice ; Microsomes, Liver/metabolism ; Models, Molecular ; Molecular Structure ; Protein Conformation ; Rats

المؤلفون: Ivanenkov YA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Ufa, Russia.; Moscow Institute of Physics and Technology (State University), Dolgoprudny, Russia.; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.; Insilico Medicine, Inc. Johns Hopkins University, Rockville, MD, United States., Zhavoronkov A; Insilico Medicine, Inc. Johns Hopkins University, Rockville, MD, United States., Yamidanov RS; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Ufa, Russia.; Insilico Medicine, Inc. Johns Hopkins University, Rockville, MD, United States., Osterman IA; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Russia., Sergiev PV; Skolkovo Institute of Science and Technology, Skolkovo, Russia.; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia., Aladinskiy VA; Moscow Institute of Physics and Technology (State University), Dolgoprudny, Russia.; Insilico Medicine, Inc. Johns Hopkins University, Rockville, MD, United States., Aladinskaya AV; Moscow Institute of Physics and Technology (State University), Dolgoprudny, Russia.; Insilico Medicine, Inc. Johns Hopkins University, Rockville, MD, United States., Terentiev VA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Ufa, Russia.; Moscow Institute of Physics and Technology (State University), Dolgoprudny, Russia.; Insilico Medicine, Inc. Johns Hopkins University, Rockville, MD, United States., Veselov MS; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Ufa, Russia.; Moscow Institute of Physics and Technology (State University), Dolgoprudny, Russia.; Insilico Medicine, Inc. Johns Hopkins University, Rockville, MD, United States., Ayginin AA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Ufa, Russia.; Moscow Institute of Physics and Technology (State University), Dolgoprudny, Russia., Kartsev VG; InterBioScreen ltd, Chernogolovka, Russia., Skvortsov DA; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.; Faculty of Biology and Biotechnologies, Higher School of Economics, Moscow, Russia., Chemeris AV; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Ufa, Russia., Baimiev AK; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Ufa, Russia., Sofronova AA; Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia., Malyshev AS; Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia., Filkov GI; Moscow Institute of Physics and Technology (State University), Dolgoprudny, Russia., Bezrukov DS; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Russia., Zagribelnyy BA; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia., Putin EO; Computer Technologies Lab, ITMO University, St. Petersburg, Russia., Puchinina MM; Moscow Institute of Physics and Technology (State University), Dolgoprudny, Russia., Dontsova OA; Department of Chemistry, Lomonosov Moscow State University, Moscow, Russia.; Skolkovo Institute of Science and Technology, Skolkovo, Russia.; Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia.

المصدر: Frontiers in pharmacology [Front Pharmacol] 2019 Aug 27; Vol. 10, pp. 913. Date of Electronic Publication: 2019 Aug 27 (Print Publication: 2019).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE

المؤلفون: Ivanenkov YA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation.; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region, 141700, Russian Federation.; Lomonosov Moscow State University, Chemistry Dept, Leninskie gory, Building 1/3, GSP-1, Moscow, 119991, Russian Federation.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation.; ChemDiv, 6605 Nancy Ridge Drive, San Diego, CA 92121, United States., Yamidanov RS; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Osterman IA; Lomonosov Moscow State University, Chemistry Dept, Leninskie gory, Building 1/3, GSP-1, Moscow, 119991, Russian Federation.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Sergiev PV; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation.; Lomonosov Moscow State University, Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, Russian Federation., Aladinskiy VA; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region, 141700, Russian Federation.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Aladinskaya AV; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region, 141700, Russian Federation.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Terentiev VA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation.; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region, 141700, Russian Federation.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Veselov MS; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation.; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region, 141700, Russian Federation.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Ayginin AA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation.; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region, 141700, Russian Federation., Skvortsov DA; Lomonosov Moscow State University, Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, Russian Federation., Komarova KS; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation.; Lomonosov Moscow State University, Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, Russian Federation., Chemeris AV; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Baimiev AK; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Sofronova AA; Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Moscow, Russian Federation., Malyshev AS; Lomonosov Moscow State University, Faculty of Medicine, Moscow, Russian Federation., Machulkin AE; Lomonosov Moscow State University, Chemistry Dept, Leninskie gory, Building 1/3, GSP-1, Moscow, 119991, Russian Federation., Petrov RA; Lomonosov Moscow State University, Chemistry Dept, Leninskie gory, Building 1/3, GSP-1, Moscow, 119991, Russian Federation., Bezrukov DS; Lomonosov Moscow State University, Chemistry Dept, Leninskie gory, Building 1/3, GSP-1, Moscow, 119991, Russian Federation.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Filkov GI; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region, 141700, Russian Federation., Puchinina MM; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region, 141700, Russian Federation., Zainullina LF; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Maximova MA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Zileeva ZR; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Vakhitova YV; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Dontsova OA; Lomonosov Moscow State University, Chemistry Dept, Leninskie gory, Building 1/3, GSP-1, Moscow, 119991, Russian Federation.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation.; Lomonosov Moscow State University, Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, Russian Federation.

المصدر: Combinatorial chemistry & high throughput screening [Comb Chem High Throughput Screen] 2019 Aug 08; Vol. 22 (5), pp. 346-354.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9810948 Publication Model: Print Cited Medium: Internet ISSN: 1875-5402 (Electronic) Linking ISSN: 13862073 NLM ISO Abbreviation: Comb Chem High Throughput Screen Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*chemistry , Azetidines/*pharmacology, Anti-Bacterial Agents/pharmacology ; Azetidines/chemistry ; Escherichia coli/drug effects ; Microbial Sensitivity Tests ; Protein Biosynthesis/drug effects ; Triazoles/chemistry

المؤلفون: Ivanenkov YA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation.; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region 141700, Russian Federation.; Lomonosov Moscow State University, Chemistry Dept, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russian Federation.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation.; ChemDiv, 6605 Nancy Ridge Drive, San Diego, CA 92121, United States., Yamidanov RS; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Osterman IA; Lomonosov Moscow State University, Chemistry Dept, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russian Federation.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Sergiev PV; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation.; Lomonosov Moscow State University, Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, Russian Federation., Ayginin AA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation.; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region 141700, Russian Federation., Aladinskiy VA; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region 141700, Russian Federation., Aladinskaya AV; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region 141700, Russian Federation., Terentiev VA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation.; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region 141700, Russian Federation.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Veselov MS; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation.; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region 141700, Russian Federation.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Skvortsov DA; Lomonosov Moscow State University, Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, Russian Federation., Komarova KS; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation.; Lomonosov Moscow State University, Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, Russian Federation., Chemeris AV; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Zainullina LF; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Maximova MA; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Zileeva ZR; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Vakhitova YV; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Baymiev AK; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Baymiev AK; Institute of Biochemistry and Genetics Russian Academy of Science (IBG RAS) Ufa Scientific Centre, Oktyabrya Prospekt 71, 450054, Ufa, Russian Federation., Sofronova AA; Lomonosov Moscow State University, Faculty of Bioengineering and Bioinformatics, Moscow, Russian Federation., Machulkin AE; Lomonosov Moscow State University, Chemistry Dept, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russian Federation., Petrov RA; Lomonosov Moscow State University, Chemistry Dept, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russian Federation., Bezrukov DS; Lomonosov Moscow State University, Chemistry Dept, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russian Federation.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Puchinina MM; Moscow Institute of Physics and Technology (State University), 9 Institutskiy lane, Dolgoprudny City, Moscow Region 141700, Russian Federation., Lukianov DA; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation., Dontsova OA; Lomonosov Moscow State University, Chemistry Dept, Leninskie Gory, Building 1/3, GSP-1, Moscow 119991, Russian Federation.; Skolkovo Institute of Science and Technology, Skolkovo, Russian Federation.; Lomonosov Moscow State University, Department of Chemistry and A.N. Belozersky Institute of Physico-Chemical Biology, Moscow, Russian Federation.

المصدر: Combinatorial chemistry & high throughput screening [Comb Chem High Throughput Screen] 2019; Vol. 22 (6), pp. 400-410.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9810948 Publication Model: Print Cited Medium: Internet ISSN: 1875-5402 (Electronic) Linking ISSN: 13862073 NLM ISO Abbreviation: Comb Chem High Throughput Screen Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Escherichia coli/*drug effects , Furocoumarins/*pharmacology , Protein Biosynthesis/*drug effects, A549 Cells ; Anti-Bacterial Agents/chemistry ; Cells, Cultured ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Escherichia coli/growth & development ; Escherichia coli/metabolism ; Furocoumarins/chemistry ; HEK293 Cells ; High-Throughput Screening Assays ; Humans ; MCF-7 Cells ; Molecular Structure ; Structure-Activity Relationship

المؤلفون: Ivachtchenko AV, Ivanenkov YA, Veselov MS, Okun IM; 5924 Seacrest View Rd., San Diego, CA 92121, United States.

المصدر: Current Alzheimer research [Curr Alzheimer Res] 2017; Vol. 14 (3), pp. 268-294.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101208441 Publication Model: Print Cited Medium: Internet ISSN: 1875-5828 (Electronic) Linking ISSN: 15672050 NLM ISO Abbreviation: Curr Alzheimer Res Subsets: MEDLINE

مواضيع طبية MeSH: Heterocyclic Compounds, 3-Ring/*pharmacology , Memory Disorders/*drug therapy , Nootropic Agents/*pharmacology , Serotonin Antagonists/*pharmacology, Administration, Intravenous ; Administration, Oral ; Alzheimer Disease/drug therapy ; Animals ; Antipsychotic Agents/pharmacokinetics ; Antipsychotic Agents/pharmacology ; Antipsychotic Agents/toxicity ; Cell Line, Tumor ; Disease Models, Animal ; Dogs ; Drug Evaluation, Preclinical ; Female ; HEK293 Cells ; Heterocyclic Compounds, 3-Ring/pharmacokinetics ; Heterocyclic Compounds, 3-Ring/toxicity ; Humans ; Macaca mulatta ; Male ; Mice ; Nootropic Agents/pharmacokinetics ; Nootropic Agents/toxicity ; Peritoneal Absorption ; Rats, Sprague-Dawley ; Rats, Wistar ; Receptors, Serotonin/metabolism ; Schizophrenia/drug therapy ; Serotonin Antagonists/pharmacokinetics ; Serotonin Antagonists/toxicity

المؤلفون: Machulkin AE; a Moscow State University, Chemistry Dept, Leninskie Gory , Moscow , Russian Federation ;; b National University of Science and Technology MISiS , Moscow , Russian Federation ;, Ivanenkov YA; a Moscow State University, Chemistry Dept, Leninskie Gory , Moscow , Russian Federation ;; b National University of Science and Technology MISiS , Moscow , Russian Federation ;; c Moscow Institute of Physics and Technology (State University) , Dolgoprudny City , Russian Federation ;, Aladinskaya AV; c Moscow Institute of Physics and Technology (State University) , Dolgoprudny City , Russian Federation ;, Veselov MS; c Moscow Institute of Physics and Technology (State University) , Dolgoprudny City , Russian Federation ;, Aladinskiy VA; c Moscow Institute of Physics and Technology (State University) , Dolgoprudny City , Russian Federation ;, Beloglazkina EK; a Moscow State University, Chemistry Dept, Leninskie Gory , Moscow , Russian Federation ;, Koteliansky VE; a Moscow State University, Chemistry Dept, Leninskie Gory , Moscow , Russian Federation ;; d Skolkovo Institute of Science and Technology 'Scoltech' , Novaya , Russian Federation., Shakhbazyan AG; c Moscow Institute of Physics and Technology (State University) , Dolgoprudny City , Russian Federation ;, Sandulenko YB; c Moscow Institute of Physics and Technology (State University) , Dolgoprudny City , Russian Federation ;, Majouga AG; a Moscow State University, Chemistry Dept, Leninskie Gory , Moscow , Russian Federation ;; b National University of Science and Technology MISiS , Moscow , Russian Federation ;

المصدر: Journal of drug targeting [J Drug Target] 2016 Sep; Vol. 24 (8), pp. 679-93. Date of Electronic Publication: 2016 Mar 10.

نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9312476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2330 (Electronic) Linking ISSN: 10267158 NLM ISO Abbreviation: J Drug Target Subsets: MEDLINE

مواضيع طبية MeSH: Antigens, Surface/*metabolism , Drug Carriers/*chemistry , Glutamate Carboxypeptidase II/*metabolism , Prostatic Neoplasms/*drug therapy , Small Molecule Libraries/*chemistry, Binding Sites ; Drug Carriers/pharmacokinetics ; Humans ; Ligands ; Male ; Molecular Structure ; Molecular Targeted Therapy ; Prostatic Neoplasms/metabolism ; Protein Binding ; Small Molecule Libraries/pharmacokinetics ; Structure-Activity Relationship

المؤلفون: Ivanenkov YA; Moscow State University, Chemistry Dept., 119991 Moscow, Leninskie Gory, Building 1/3, GSP-1, Russian Federation; National University of Science and Technology MISiS, Moscow 119049, Russian Federation; Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, InstitutskiPereulok 9, Moskovskaya Oblast, Russian Federation. Electronic address: yai@chemdiv.com., Veselov MS; Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, InstitutskiPereulok 9, Moskovskaya Oblast, Russian Federation. Electronic address: vms@pharmcluster.ru., Rezekin IG; Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, InstitutskiPereulok 9, Moskovskaya Oblast, Russian Federation., Skvortsov DA; Moscow State University, Chemistry Dept., 119991 Moscow, Leninskie Gory, Building 1/3, GSP-1, Russian Federation., Sandulenko YB; Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, InstitutskiPereulok 9, Moskovskaya Oblast, Russian Federation., Polyakova MV; Moscow Institute of Physics and Technology (MIPT), Dolgoprudny, InstitutskiPereulok 9, Moskovskaya Oblast, Russian Federation., Bezrukov DS; Moscow State University, Chemistry Dept., 119991 Moscow, Leninskie Gory, Building 1/3, GSP-1, Russian Federation., Vasilevsky SV; Moscow State University, Chemistry Dept., 119991 Moscow, Leninskie Gory, Building 1/3, GSP-1, Russian Federation., Kukushkin ME; Moscow State University, Chemistry Dept., 119991 Moscow, Leninskie Gory, Building 1/3, GSP-1, Russian Federation., Moiseeva AA; Moscow State University, Chemistry Dept., 119991 Moscow, Leninskie Gory, Building 1/3, GSP-1, Russian Federation., Finko AV; Moscow State University, Chemistry Dept., 119991 Moscow, Leninskie Gory, Building 1/3, GSP-1, Russian Federation., Koteliansky VE; Moscow State University, Chemistry Dept., 119991 Moscow, Leninskie Gory, Building 1/3, GSP-1, Russian Federation., Klyachko NL; Moscow State University, Chemistry Dept., 119991 Moscow, Leninskie Gory, Building 1/3, GSP-1, Russian Federation; National University of Science and Technology MISiS, Moscow 119049, Russian Federation., Filatova LA; Moscow State University, Chemistry Dept., 119991 Moscow, Leninskie Gory, Building 1/3, GSP-1, Russian Federation., Beloglazkina EK; Moscow State University, Chemistry Dept., 119991 Moscow, Leninskie Gory, Building 1/3, GSP-1, Russian Federation; National University of Science and Technology MISiS, Moscow 119049, Russian Federation., Zyk NV; Moscow State University, Chemistry Dept., 119991 Moscow, Leninskie Gory, Building 1/3, GSP-1, Russian Federation., Majouga AG; Moscow State University, Chemistry Dept., 119991 Moscow, Leninskie Gory, Building 1/3, GSP-1, Russian Federation; National University of Science and Technology MISiS, Moscow 119049, Russian Federation. Electronic address: majouga@org.chem.msu.ru.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2016 Feb 15; Vol. 24 (4), pp. 802-11. Date of Electronic Publication: 2016 Jan 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*chemical synthesis , Antioxidants/*chemical synthesis , Hydantoins/*chemical synthesis , Organoselenium Compounds/*chemical synthesis, Antineoplastic Agents/pharmacology ; Antioxidants/pharmacology ; Azoles/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; Copper/chemistry ; Cyanates/chemistry ; Drug Screening Assays, Antitumor ; Glutathione Peroxidase/antagonists & inhibitors ; Glutathione Peroxidase/chemistry ; Humans ; Hydantoins/pharmacology ; Inhibitory Concentration 50 ; Isoindoles ; Organoselenium Compounds/pharmacology ; Pyridines/chemistry ; Quantum Theory ; Stereoisomerism ; Structure-Activity Relationship