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1
المؤلفون: Neil Upton, Tania O. Stean, Claire Roberts, Michael S. Hadley, Vicky Holland, Gary W. Price, Laurie J. Gordon, Jeannette M. Watson, Jenifer Powles, Claire M. Scott, Leanne Cutler, Tanya Coleman, Tom D. Heightman, Andrew Ayrton, Jean-Pierre Pilleux, Sarah L. Pardoe, Graham J. Riley, Laramie Mary Gaster, Nigel E. Austin, Brenda K. Trail, Derek N. Middlemiss
مصطلحات موضوعية: Adrenergic receptor, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Ligands, Biochemistry, Partial agonist, Structure-Activity Relationship, Dopamine, Drug Discovery, medicine, Animals, Receptor, Molecular Biology, 5-HT receptor, Brain Chemistry, Chemistry, Organic Chemistry, Isoquinolines, Receptor antagonist, Rats, Serotonin Receptor Agonists, Receptor, Serotonin, 5-HT1D, Receptors, Serotonin, Receptor, Serotonin, 5-HT1A, Receptor, Serotonin, 5-HT1B, Molecular Medicine, 5-HT1 receptor, Serotonin Antagonists, Serotonin, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86421f00e16772e71fb543436a7895c9
https://doi.org/10.1016/j.bmcl.2005.06.042 -
2
المؤلفون: Kim Winborn, Sarah C. Lappin, James S. Wright, Vicky Holland, Martin J. Gunthorpe, Harshad Kantilal Rami, Andrew D. Randall, Sandra Arpino, Graham D Smith, Julie Egerton, Stephen J. Brough, Mervyn Thompson, Jeffrey C. Jerman, Sara Luis Hannan, Darren Smart, John B. Davis
المصدر: Journal of Pharmacology and Experimental Therapeutics. 321:1183-1192
مصطلحات موضوعية: Hot Temperature, Patch-Clamp Techniques, Pyrrolidines, Guinea Pigs, TRPV1, TRPV Cation Channels, Pharmacology, Transfection, Binding, Competitive, Cell Line, Membrane Potentials, chemistry.chemical_compound, In vivo, Animals, Humans, Urea, Calcium Signaling, Patch clamp, Receptor, Cells, Cultured, Calcium signaling, Neurons, Dose-Response Relationship, Drug, Molecular Structure, Antagonist, Hydrogen-Ion Concentration, Rats, Electrophysiology, chemistry, Capsaicin, Competitive antagonist, Molecular Medicine, Acids
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::519bdcb9b1541b2a29cae2ecf14a8d24
https://doi.org/10.1124/jpet.106.116657 -
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المؤلفون: Jenifer Powles, Neil Upton, Kim Winborn, Nigel Deeks, Christopher N. Johnson, Tania Buck, Mahmood Ahmed, Brenda K. Trail, Darren Jason Mitchell, Mervyn Thompson, Vicky Holland, Laurie J. Gordon, Michael A. Briggs, Jon T. Seal, Stephen Moss, Ashley Garner, David R. Witty, Steven Mark Bromidge, Lorraine Campbell, Andrew D. Medhurst, Tania O. Stean, Geoffrey Stemp, Dieter Hamprecht
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:4867-4871
مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Molecular Conformation, Administration, Oral, Biological Availability, Pharmaceutical Science, Pharmacology, Blood–brain barrier, Biochemistry, Permeability, Piperazines, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Drug Discovery, medicine, Animals, Receptor, Molecular Biology, Bicyclic molecule, Organic Chemistry, Antagonist, Brain, Penetration (firestop), Receptor antagonist, Rats, medicine.anatomical_structure, chemistry, Blood-Brain Barrier, Receptors, Serotonin, 5-HT6 receptor, Molecular Medicine, Serotonin Antagonists, Penetrant (biochemical)
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4
المؤلفون: Neil Upton, Stephen J. Brough, Graham J. Riley, Kathryn R. Starr, Mark S. Duxon, Darren Smart, Jeff C. Jerman, Jennifer Stretton, Declan N.C. Jones, Vicky Holland, Roderick A. Porter, Amanda Johns, Wai Chan
المصدر: Psychopharmacology. 153:203-209
مصطلحات موضوعية: Male, Receptors, Neuropeptide, medicine.medical_specialty, medicine.drug_class, Motor Activity, Biology, Piperazines, Receptors, G-Protein-Coupled, Rats, Sprague-Dawley, Orexin-A, Orexin Receptors, Internal medicine, Receptor, Serotonin, 5-HT2C, medicine, Animals, Cloning, Molecular, Receptor, Pharmacology, Neurotransmitter Agents, Orexins, Neuropeptides, digestive, oral, and skin physiology, Intracellular Signaling Peptides and Proteins, Antagonist, Receptor antagonist, Grooming, Orexin receptor, Rats, Serotonin Receptor Agonists, Orexin, 5-HT2C receptor, Endocrinology, Receptors, Serotonin, Quinolines, Serotonin, Carrier Proteins, psychological phenomena and processes
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5
المؤلفون: Vicky Holland, Frank King, Saunders Dv, Graham J. Riley, Thomas P. Blackburn, Derek N. Middlemiss, D.Malcolm Duckworth, Graham Elgin Jones, Jerome Jones, Steven Mark Bromidge, Sean Lightowler, Guy A. Kennett, Martyn D. Wood, Susannah Davies, Steven Dabbs, Ian Thomson Forbes, Brenda K. Trail
المصدر: Bioorganic & Medicinal Chemistry Letters. 10:1863-1866
مصطلحات موضوعية: Indoles, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Administration, Oral, Aminopyridines, Pharmaceutical Science, Motor Activity, Biochemistry, Anxiolytic, Structure-Activity Relationship, Drug Discovery, Receptor, Serotonin, 5-HT2C, medicine, Animals, Humans, Inverse agonist, Structure–activity relationship, Serotonin Antagonists, Receptor, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, Antidepressive Agents, Rats, 5-HT2C receptor, Kinetics, Anti-Anxiety Agents, Drug Design, Receptors, Serotonin, Molecular Medicine, Antidepressant, Serotonin
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6
المؤلفون: Ian Thomson Forbes, Peter Ham, Thomas P. Blackburn, Saunders Dv, Guy A. Kennett, Angela Gadre, D.Malcolm Duckworth, Vicky Holland, Martyn D. Wood, Deepa Vyas, Steven Dabbs, Graham J. Riley, David T. Davies, Frank King, Susannah Davies, Graham Elgin Jones, Steven Mark Bromidge, Kevin M. Thewlis
المصدر: Bioorganic & Medicinal Chemistry. 7:2767-2773
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Pyridines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, In Vitro Techniques, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Receptor, Serotonin, 5-HT2B, Drug Discovery, Receptor, Serotonin, 5-HT2C, Animals, Humans, Structure–activity relationship, Serotonin Antagonists, Molecular Biology, Phenylurea Compounds, Bicyclic molecule, Chemistry, Organic Chemistry, Affinities, Kinetics, Models, Chemical, Receptors, Serotonin, Indoline, Molecular Medicine, Selectivity
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7
المؤلفون: Christopher B. Naylor, Vicky Holland, Susannah Starr, Kevin M. Thewlis, Martyn D. Wood, D.Malcolm Duckworth, Steven Mark Bromidge, Frank King, Thomas P. Blackburn, Steven Dabbs, Peter Ham, Saunders Dv, Graham Elgin Jones, Ian Thomson Forbes, David T. Davies, Frank E. Blaney, Wyman Paul Adrian, and Graham J. Riley, Guy A. Kennett, Fiona Bailey
المصدر: Journal of Medicinal Chemistry. 41:1598-1612
مصطلحات موضوعية: Male, Models, Molecular, Indoles, Molecular model, Pyridines, Stereochemistry, Context (language use), Motor Activity, Chemical synthesis, Conflict, Psychological, Rats, Sprague-Dawley, Structure-Activity Relationship, Receptor, Serotonin, 5-HT2B, Drug Discovery, Receptor, Serotonin, 5-HT2C, Animals, Structure–activity relationship, Serotonin Antagonists, Social Behavior, Receptor, Indole test, Chemistry, Biological activity, Rats, Anti-Anxiety Agents, Receptors, Serotonin, Conditioning, Operant, Molecular Medicine
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المؤلفون: Mark James Bamford, Andrew R. Calver, David Matthew Wilson, Rebecca K. Davis, Nicholas Bailey, Isabel Jm Beresford, Jason Witherington, Susannah Davis, Jon Graham Anthony Steadman, Phillip Jeffrey, Vicky Holland, Joanne Schogger, Christopher A. Parr, Jeffrey Wald, Teresa Heslop, Michael A. Briggs, Terrance A. Panchal, Leanne Harris, Andrew D. Medhurst, Kim Brackenborough, David Kenneth Dean, Tania O. Stean, Brenda K. Trail, Nigel Quashie, Angela Worby, Stephen J. Brough, Barry Crook, James Apps, Andrew K. Takle, Robert P. Davis, Sanjeet Singh Sehmi
المصدر: Bioorganicmedicinal chemistry letters. 23(24)
مصطلحات موضوعية: Male, Niacinamide, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biology, Biochemistry, Benzazepine, Rats, Sprague-Dawley, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, In vivo, Drug Discovery, Animals, Humans, Receptors, Histamine H3, Molecular Biology, Organic Chemistry, Haplorhini, Benzazepines, Rats, chemistry, Microsomes, Liver, Molecular Medicine, Identification (biology), Histamine H3 receptor, Half-Life, Histamine H3 Antagonists, Protein Binding
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9
المؤلفون: Stephen J. Medhurst, Sandra Arpino, James Wright, Darren Jason Mitchell, Alexander J. Stevens, James Biggs, Kim Winborn, Susan Marie Westaway, John B. Davis, Jeffrey C. Jerman, Vicky Holland, Tanya Coleman, Jennifer E. Cryan, Geoffrey Stemp, Sarah C. Lappin, Jon T. Seal, Harshad Kantilal Rami, Leontine Saskia Trouw, Mervyn Thompson, Martin J. Gunthorpe
المصدر: Bioorganicmedicinal chemistry letters. 18(20)
مصطلحات موضوعية: Niacinamide, Stereochemistry, medicine.drug_class, Chemistry, Pharmaceutical, Clinical Biochemistry, Analgesic, Guinea Pigs, TRPV1, Pharmaceutical Science, Administration, Oral, TRPV Cation Channels, Carboxamide, Biochemistry, Chemical synthesis, Cell Line, chemistry.chemical_compound, Inhibitory Concentration 50, In vivo, Drug Discovery, medicine, Animals, Humans, Benzothiazoles, Molecular Biology, Inflammation, Nicotinamide, Chemistry, Organic Chemistry, Antagonist, In vitro, Rats, Models, Chemical, Drug Design, Molecular Medicine, Capsaicin
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10N-Tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl biaryl carboxamides as antagonists of TRPV1
المؤلفون: Harshad Kantilal Rami, Mervyn Thompson, John B. Davis, Geoffrey Stemp, Jeffrey C. Jerman, Kim Winborn, Ying-Kit Chung, Alexander J. Stevens, Susan Marie Westaway, Stephen J. Medhurst, James Wright, Vicky Holland
المصدر: Bioorganicmedicinal chemistry letters. 16(17)
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, High-throughput screening, Clinical Biochemistry, Guinea Pigs, TRPV1, Pharmaceutical Science, TRPV Cation Channels, Carboxamide, Biochemistry, Chemical synthesis, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Potency, Animals, Humans, Molecular Biology, Molecular Structure, Chemistry, Organic Chemistry, Antagonist, Isoquinolines, In vitro, Rats, Liver, Benzamides, Quinolines, Molecular Medicine, Capsaicin