المؤلفون: Moyo TK; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.; Levine Cancer Institute, Charlotte, North Carolina., Kishtagari A; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Villaume MT; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., McMahon B; University of Colorado, Denver, Colorado., Mohan SR; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Stopczynski T; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Quantitative Sciences, Vanderbilt University, Nashville, Tennessee., Chen SC; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Quantitative Sciences, Vanderbilt University, Nashville, Tennessee., Fan R; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Quantitative Sciences, Vanderbilt University, Nashville, Tennessee., Huo Y; Department of Electrical and Computer Engineering, Vanderbilt University School of Medicine, Nashville, Tennessee., Moon H; Department of Electrical and Computer Engineering, Vanderbilt University School of Medicine, Nashville, Tennessee., Tang Y; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee., Bejan CA; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee., Childress M; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee., Anderson I; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Rawling K; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Simons RM; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Moncrief A; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Caza R; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Dugger L; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Collins A; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Dudley CV; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Ferrell PB; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Immunobiology, Vanderbilt University School of Medicine, Nashville, Tennessee., Byrne M; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Strickland SA; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee., Ayers GD; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Quantitative Sciences, Vanderbilt University, Nashville, Tennessee., Landman BA; Department of Electrical and Computer Engineering, Vanderbilt University School of Medicine, Nashville, Tennessee.; Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee., Mason EF; Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, Tennessee., Mesa RA; Wake Forest Baptist Cancer Center, Winston-Salem, North Carolina., Palmer JM; Department of Internal Medicine, Mayo Clinic, Scottsdale, Arizona., Michaelis LC; Medical College of Wisconsin, Madison, Wisconsin., Savona MR; Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee.; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.; Center for Immunobiology, Vanderbilt University School of Medicine, Nashville, Tennessee.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2023 Jul 05; Vol. 29 (13), pp. 2375-2384.

نوع المنشور: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Primary Myelofibrosis*/drug therapy , Primary Myelofibrosis*/metabolism , Janus Kinase Inhibitors*/therapeutic use, Humans ; Aged ; Phosphatidylinositol 3-Kinases ; Pyrimidines/therapeutic use ; Nitriles/therapeutic use

المؤلفون: Fischer MA; Department of Medicine; Cancer Biology Program, Vanderbilt University School of Medicine., Song Y; Department of Hematologic Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Smilow Cancer Center, Yale University School of Medicine, New Haven., Arrate MP; Department of Medicine., Gbyli R; Smilow Cancer Center, Yale University School of Medicine, New Haven., Villaume MT; Department of Medicine; Cancer Biology Program, Vanderbilt University School of Medicine., Smith BN; Department of Medicine; Cancer Biology Program, Vanderbilt University School of Medicine; Department of Pediatrics., Childress MA; Department of Medicine; Cancer Biology Program, Vanderbilt University School of Medicine., Stricker TP; Vanderbilt-Ingram Cancer Center; Department of Pathology, Microbiology, and Immunology., Halene S; Smilow Cancer Center, Yale University School of Medicine, New Haven., Savona MR; Department of Medicine; Cancer Biology Program, Vanderbilt University School of Medicine; Vanderbilt-Ingram Cancer Center; Center for Immunobiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232. michael.savona@vanderbilt.edu.

المصدر: Haematologica [Haematologica] 2023 Feb 01; Vol. 108 (2), pp. 522-531. Date of Electronic Publication: 2023 Feb 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE

مواضيع طبية MeSH: Leukemia, Myeloid, Acute*/genetics , Myelodysplastic Syndromes*/drug therapy , Myelodysplastic Syndromes*/genetics , Myelodysplastic Syndromes*/metabolism, Animals ; Mice ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Proto-Oncogene Proteins c-bcl-2 ; Disease Models, Animal ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Bridged Bicyclo Compounds, Heterocyclic/therapeutic use ; Apoptosis ; Cell Line, Tumor

المؤلفون: Villaume MT; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN., Arrate MP; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN., Ramsey HE; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN., Sunthankar KI; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN., Jenkins MT; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN., Moyo TK; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN., Smith BN; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN; Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, TN., Fischer MA; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN., Childress MA; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN., Gorska AE; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN., Ferrell PB; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN; Center for Immunobiology, Vanderbilt University School of Medicine, Nashville, TN; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN., Savona MR; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN; Center for Immunobiology, Vanderbilt University School of Medicine, Nashville, TN; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN. Electronic address: michael.savona@vanderbilt.edu.

المصدر: Experimental hematology [Exp Hematol] 2021 May; Vol. 97, pp. 57-65.e5. Date of Electronic Publication: 2021 Feb 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Inc Country of Publication: Netherlands NLM ID: 0402313 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2399 (Electronic) Linking ISSN: 0301472X NLM ISO Abbreviation: Exp Hematol Subsets: MEDLINE

مواضيع طبية MeSH: Class I Phosphatidylinositol 3-Kinases/*antagonists & inhibitors , Heterocyclic Compounds, 4 or More Rings/*pharmacology , Leukemia, Myelomonocytic, Chronic/*drug therapy , Phosphoinositide-3 Kinase Inhibitors/*pharmacology , Pyrazoles/*pharmacology, Cell Line, Tumor ; Cell Survival/drug effects ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Drug Synergism ; Humans ; Leukemia, Myelomonocytic, Chronic/enzymology ; Molecular Targeted Therapy ; Nitriles ; Pyrimidines

المؤلفون: Villaume MT; Department of Medicine and Program in Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Savona MR; Department of Medicine and Program in Cancer Biology, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA. Electronic address: michael.savona@vanderbilt.edu.

المصدر: Best practice & research. Clinical haematology [Best Pract Res Clin Haematol] 2020 Jun; Vol. 33 (2), pp. 101170. Date of Electronic Publication: 2020 May 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101120659 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1924 (Electronic) Linking ISSN: 15216926 NLM ISO Abbreviation: Best Pract Res Clin Haematol Subsets: MEDLINE

مواضيع طبية MeSH: Hematologic Neoplasms*/classification , Hematologic Neoplasms*/diagnosis , Hematologic Neoplasms*/therapy , Myelodysplastic Syndromes*/classification , Myelodysplastic Syndromes*/diagnosis , Myelodysplastic Syndromes*/therapy , Myeloproliferative Disorders*/classification , Myeloproliferative Disorders*/diagnosis , Myeloproliferative Disorders*/therapy, Humans

المؤلفون: Villaume MT; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Patel D; Department of Hematology and Bone Marrow Transplant, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA., Lopez C; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Patel V; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Diggs P; Vanderbilt University School of Medicine, Nashville, TN, USA., Harmsen H; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Thompson MA; Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA., Morgan D; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Department of Hematology and Bone Marrow Transplant, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.

المصدر: World journal of oncology [World J Oncol] 2020 Jun; Vol. 11 (3), pp. 122-125. Date of Electronic Publication: 2020 May 14.

نوع المنشور: Case Reports

بيانات الدورية: Publisher: Elmer Press Country of Publication: Canada NLM ID: 101564097 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1920-454X (Electronic) Linking ISSN: 19204531 NLM ISO Abbreviation: World J Oncol Subsets: PubMed not MEDLINE

المؤلفون: Fischer MA; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN., Friedlander SY; Karyopharm Therapeutics Inc., Newton, MA; and., Arrate MP; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN., Chang H; Karyopharm Therapeutics Inc., Newton, MA; and., Gorska AE; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN., Fuller LD; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN., Ramsey HE; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN., Kashyap T; Karyopharm Therapeutics Inc., Newton, MA; and., Argueta C; Karyopharm Therapeutics Inc., Newton, MA; and., Debler S; Karyopharm Therapeutics Inc., Newton, MA; and., Byrne M; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN., Villaume MT; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN., Shaver AC; Department of Pathology, Microbiology and Immunology, and., Senapedis W; Karyopharm Therapeutics Inc., Newton, MA; and., Landesman Y; Karyopharm Therapeutics Inc., Newton, MA; and., Baloglu E; Karyopharm Therapeutics Inc., Newton, MA; and., Shacham S; Karyopharm Therapeutics Inc., Newton, MA; and., Savona MR; Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN.; Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN.

المصدر: Blood advances [Blood Adv] 2020 Feb 11; Vol. 4 (3), pp. 586-598.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE

مواضيع طبية MeSH: Bridged Bicyclo Compounds, Heterocyclic*/pharmacology , Hematologic Neoplasms*/drug therapy, Active Transport, Cell Nucleus ; Cell Line, Tumor ; Humans ; Sulfonamides

المؤلفون: Villaume MT; Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Sella E; Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Saul G; Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Borzilleri RM; Departments of Discovery Chemistry, Oncology Discovery and Leads Discovery & Optimization, Preclinical Optimization, Bristol-Myers Squibb Co. , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Fargnoli J; Departments of Discovery Chemistry, Oncology Discovery and Leads Discovery & Optimization, Preclinical Optimization, Bristol-Myers Squibb Co. , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Johnston KA; Departments of Discovery Chemistry, Oncology Discovery and Leads Discovery & Optimization, Preclinical Optimization, Bristol-Myers Squibb Co. , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Zhang H; Departments of Discovery Chemistry, Oncology Discovery and Leads Discovery & Optimization, Preclinical Optimization, Bristol-Myers Squibb Co. , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Fereshteh MP; Departments of Discovery Chemistry, Oncology Discovery and Leads Discovery & Optimization, Preclinical Optimization, Bristol-Myers Squibb Co. , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Dhar TG; Departments of Discovery Chemistry, Oncology Discovery and Leads Discovery & Optimization, Preclinical Optimization, Bristol-Myers Squibb Co. , Route 206 and Province Line Road, Princeton, New Jersey 08543, United States., Baran PS; Department of Chemistry, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

المصدر: ACS central science [ACS Cent Sci] 2016 Jan 27; Vol. 2 (1), pp. 27-31. Date of Electronic Publication: 2015 Dec 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101660035 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2374-7943 (Print) Linking ISSN: 23747943 NLM ISO Abbreviation: ACS Cent Sci Subsets: PubMed not MEDLINE

المؤلفون: Teufel R; Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego, La Jolla, CA 92037 (USA) http://scrippsscholars.ucsd.edu/bsmoore., Kaysser L, Villaume MT, Diethelm S, Carbullido MK, Baran PS, Moore BS

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2014 Oct 06; Vol. 53 (41), pp. 11019-22. Date of Electronic Publication: 2014 Aug 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

مواضيع طبية MeSH: Sesterterpenes/*biosynthesis, Bacterial Proteins/metabolism ; Cyclization ; Hemiterpenes/chemistry ; Organophosphorus Compounds/chemistry ; Sesterterpenes/chemistry ; Streptomyces/metabolism ; Terpenes/chemistry

المؤلفون: Villaume MT; Department of Chemistry, Scripps Research Institute, La Jolla, California 92037, USA., Baran PS; Department of Chemistry, Scripps Research Institute, La Jolla, California 92037, USA.

المصدر: Nature [Nature] 2014 Sep 18; Vol. 513 (7518), pp. 324-5.

نوع المنشور: Journal Article; Comment

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Alkenes/*chemical synthesis , Biological Products/*chemical synthesis , Fatty Alcohols/*chemical synthesis , Monosaccharides/*chemical synthesis , Pyrans/*chemical synthesis, Animals

المؤلفون: Dabrowski JA; Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, MA 02467, USA., Villaume MT, Hoveyda AH

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2013 Jul 29; Vol. 52 (31), pp. 8156-9. Date of Electronic Publication: 2013 Jun 18.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

مواضيع طبية MeSH: Aluminum/*chemistry , Carbon/*chemistry , Copper/*chemistry, Catalysis ; Heterocyclic Compounds/chemistry ; Methane/analogs & derivatives ; Methane/chemistry ; Organometallic Compounds/chemistry ; Stereoisomerism