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1
المؤلفون: Christian Voitenleitner, Huichang Zhang, Renae M. Crosby, Kirsten M. Kahler, Feng Wang, John F. Miller, Elizabeth M. Turner, Daniel J. Price, Jing Fang, Andrew Maynard, Vincent W.-F. Tai, Katrina L. Creech, Andrew J. Peat, J. Brad Shotwell, Shawn P. Williams, Amanda Mathis, Jeffrey J. Pouliot, Pek Yoke Chong
المصدر: Journal of Medicinal Chemistry. 62:3254-3267
مصطلحات موضوعية: Viral protein, Hepatitis C virus, Hepacivirus, Pharmacology, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, 01 natural sciences, Mice, 03 medical and health sciences, chemistry.chemical_compound, Dogs, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Benzofuran, NS5B, Polymerase, Nucleic Acid Synthesis Inhibitors, 030304 developmental biology, 0303 health sciences, Molecular Structure, biology, Boronic Acids, Rats, 0104 chemical sciences, Macaca fascicularis, 010404 medicinal & biomolecular chemistry, chemistry, Drug Design, biology.protein, Molecular Medicine, Boronic acid, Half-Life
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2
المؤلفون: Zhiping Xiong, Jeffrey J. Pouliot, Daniel J. Price, Andrew Maynard, Dulce Garrido, Andrew J. Peat, Katrina L. Creech, Todd M. Baughman, John W. Seal, Vincent W.-F. Tai, Luz Helena Kryn
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:2288-2294
مصطلحات موضوعية: Stereochemistry, viruses, Hepacivirus, Clinical Biochemistry, Pharmaceutical Science, Viral Nonstructural Proteins, Virus Replication, Antiviral Agents, Biochemistry, chemistry.chemical_compound, Drug Discovery, Pyridine, Humans, Potency, Spiro Compounds, Molecular Targeted Therapy, Replicon, Molecular Biology, EC50, biology, Organic Chemistry, biology.organism_classification, In vitro, Viral replication, chemistry, Drug Design, Molecular Medicine, Piperidine
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3
المؤلفون: Subramanian Baskaran, Renae M. Crosby, John W. Seal, Zhiping Z. Xiong, Mi Xie, Hamilton D. Dickson, Roopa Rai, Pek Yoke Chong, Uli Schmitz, Jeffrey J. Pouliot, Derek J. Parks, J. Brad Shotwell, Amanda Mathis, Michael Thomson, Daniel J. Price, Jing Fang, Jack Maung, Katrina L. Creech, Dulce Garrido, Vincent W.-F. Tai, Andrew J. Peat
المصدر: ACS Medicinal Chemistry Letters. 3:565-569
مصطلحات موضوعية: business.industry, viruses, Hepatitis C virus, Organic Chemistry, virus diseases, Hepatitis C, Synergistic combination, Pharmacology, medicine.disease, medicine.disease_cause, Biochemistry, Small molecule, digestive system diseases, In vitro, Drug Discovery, medicine, Replicon, business, IC50, EC50
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4
المؤلفون: David Sperandio, Shailaja Kasibhatla, Alberto Estevez, Bill Maske, Emma J. Shelton, Jeffrey R. Spencer, Sui Xiong Cai, Ben Cebon, John Drewe, Chris Reed, Jason Oeh, Ling Qiu, Peter Sabbatini, Anthony Neri, Paul A. Sprengeler, Ben Tseng, Jennifer Zeitz, Cindy Brown, Robert Yee, John Herich, Vincent W.-F. Tai, Catherine Magill, John Eksterowicz, Doris Graupe, Joane Litvak, Darren Wong, Julia Lohman, Yong Ni, Seema Kantak, Keith Pararajasingham
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:4554-4558
مصطلحات موضوعية: medicine.drug_class, Poly ADP ribose polymerase, Clinical Biochemistry, Pharmaceutical Science, Apoptosis, Carboxamide, DNA laddering, Biochemistry, Mice, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Cytotoxicity, Oxazoles, Molecular Biology, Caspase, Molecular Structure, biology, Chemistry, Organic Chemistry, Amides, Xenograft Model Antitumor Assays, Cell culture, biology.protein, Molecular Medicine, Female
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5
المؤلفون: Liang Liu, Heleen Scheerens, David Sperandio, Jeffrey R. Spencer, Bernie Hirschbein, Mary E. McGrath, Rohan Mendonca, Michael J. Green, Alisha Kellogg, Margaret Nguyen, James W. Janc, Jerlyn Beltman, Paul A. Sprengeler, Chang-Sun Lee, Ashwini Gadre, Tong Lin, Julia Lohman, Vincent W.-F. Tai
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:4085-4089
مصطلحات موضوعية: Models, Molecular, Proteases, Clinical Biochemistry, Administration, Oral, Biological Availability, Pharmaceutical Science, Tryptase, Biochemistry, Chemical synthesis, Serine, Structure-Activity Relationship, Oral administration, Drug Discovery, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Serine Endopeptidases, Organic Chemistry, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, Tryptases
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6
المؤلفون: Paul A. Sprengeler, James W. Janc, Michael J. Green, Bradley A. Katz, Vincent W.-F. Tai, Jeffrey R. Spencer, Joseph D. Ho, Mary E. McGrath, Michael Graupe, Robb Yee, Erik Gjerstad, Angeles Estiarte, Chang-Sun Lee, Chandru Venkataramani, Yang Liu, Isabelle Lehoux, Hirschbein Bernard L, John R. Somoza, David Sperandio, Liang Liu
المصدر: Biochemistry. 45:5964-5973
مصطلحات موضوعية: Models, Molecular, chemistry.chemical_classification, Serine protease, Serine Proteinase Inhibitors, biology, Protein Conformation, Stereochemistry, Serine Endopeptidases, Peptide, Tryptase, Tripeptide, Crystallography, X-Ray, Mast cell, Biochemistry, Off targets, medicine.anatomical_structure, chemistry, Hydrolase, biology.protein, medicine, Potency, Tryptases
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7
المؤلفون: Paul A. Sprengeler, Hui Hon Chung, Martin Sendzik, Vincent W.-F. Tai, Jeffrey R. Spencer, Bradley A. Katz, Richard L. Mackman, William D. Shrader, Allen Darin Arthur, Kyle Elrod, J. Guy Breitenbucher, Erik Verner, James W. Janc, Christine Luong, Aleks Kolesnikov
المصدر: Journal of Molecular Biology. 329:93-120
مصطلحات موضوعية: Models, Molecular, Steric effects, Serine Proteinase Inhibitors, Protein Conformation, Stereochemistry, medicine.medical_treatment, Static Electricity, Crystallography, X-Ray, Structure-Activity Relationship, Thrombin, Structural Biology, medicine, Animals, Humans, Trypsin, Molecular Biology, Serine protease, Binding Sites, Protease, biology, Chemistry, Hydrogen bond, Active site, Hydrogen Bonding, Hydrogen-Ion Concentration, Urokinase-Type Plasminogen Activator, Small molecule, Kinetics, Drug Design, biology.protein, Benzimidazoles, Cattle, Trypsin Inhibitors, medicine.drug
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8
المؤلفون: Barbara Imperiali, Vincent W.-F Tai, Carlos J. Bosques
المصدر: Tetrahedron Letters. 42:7207-7210
مصطلحات موضوعية: chemistry.chemical_classification, Protein glycosylation, Organic Chemistry, Peptide, Chitobiose, Biochemistry, Combinatorial chemistry, Glycopeptide, chemistry.chemical_compound, chemistry, Drug Discovery, Stereoselectivity, Asparagine, Prion protein, Selectivity
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9
المؤلفون: Vincent W.-F. Tai, Tony K. M. Shing
المصدر: The Journal of Organic Chemistry. 64:2140-2144
مصطلحات موضوعية: Goniotriol, Chemistry, Organic Chemistry, Combinatorial chemistry
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10
المؤلفون: Vincent W.-F. Tai, Barbara Imperiali
المصدر: Tetrahedron Letters. 39:7215-7218
مصطلحات موضوعية: inorganic chemicals, Stereochemistry, organic chemicals, Model study, Organic Chemistry, Diol, Intramolecular cyclization, Ring (chemistry), Biochemistry, chemistry.chemical_compound, chemistry, Drug Discovery, heterocyclic compounds, Acid hydrolysis, Sulfate