المؤلفون: Cherrie K. Donawho, Jennifer J. Bouska, Chang Park, Yan Luo, Yan Shi, Xuesong Liu, Eric F. Johnson, Donald J. Osterling, Thomas D. Penning, Paul Ellis, Vincent L. Giranda, Jianchun Gong, Alexander R. Shoemaker, Viraj B. Gandhi, Gui-Dong Zhu, Amanda M. Olson

المصدر: Bioorganic & Medicinal Chemistry. 20:4635-4645

مصطلحات موضوعية: Models, Molecular, Pyridines, Clinical Biochemistry, Poly (ADP-Ribose) Polymerase-1, Administration, Oral, Pharmaceutical Science, Antineoplastic Agents, Poly(ADP-ribose) Polymerase Inhibitors, Pharmacology, Crystallography, X-Ray, Biochemistry, Poly (ADP-Ribose) Polymerase Inhibitor, Mice, Structure-Activity Relationship, Drug Discovery, medicine, Animals, Structure–activity relationship, Potency, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Temozolomide, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Drug discovery, Organic Chemistry, Cancer, Neoplasms, Experimental, medicine.disease, Xenograft Model Antitumor Assays, Mice, Inbred C57BL, Pyridazines, Enzyme, PARP inhibitor, Molecular Medicine, Female, Poly(ADP-ribose) Polymerases, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6144cafe54a77ad8539097bb36e28bd1
https://doi.org/10.1016/j.bmc.2012.06.021

المؤلفون: Gui-Dong Zhu, Xuesong Liu, Yan Shi, Thomas D. Penning, Viraj B. Gandhi, Chang Park, Vered Klinghofer, Vincent L. Giranda, Yan Luo, Eric F. Johnson

المصدر: Bioorganic & Medicinal Chemistry Letters. 20:1023-1026

مصطلحات موضوعية: Tertiary amine, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Carboxamide, Isoindoles, Poly(ADP-ribose) Polymerase Inhibitors, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Neoplasms, Drug Discovery, medicine, Oxindole, Molecular Biology, Chemistry, Hydrogen bond, Organic Chemistry, Amides, Intramolecular force, PARP inhibitor, Lactam, Molecular Medicine, Poly(ADP-ribose) Polymerases, Pharmacophore

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::929701d4d80100ea0c052b63fadaa574
https://doi.org/10.1016/j.bmcl.2009.12.042

المؤلفون: Viraj B. Gandhi, Kennan C. Marsh, Vered Klinghofer, Elizabeth H. Fry, Eric F. Johnson, David Frost, Amanda M. Olson, Vincent L. Giranda, Jianchun Gong, Chang H. Park, Yan Luo, Jennifer J. Bouska, Wolfgang Wernet, Roland Grandel, Gui-Dong Zhu, W. Lubisch, Saul H. Rosenberg, Sheela A. Thomas, Yan Shi, Cherrie K. Donawho, Xuesong Liu, Thomas D. Penning, Velitchka Bontcheva-Diaz

المصدر: Bioorganic & Medicinal Chemistry. 16:6965-6975

مصطلحات موضوعية: Benzimidazole, medicine.drug_class, Poly ADP ribose polymerase, Transplantation, Heterologous, Clinical Biochemistry, Melanoma, Experimental, Pharmaceutical Science, Breast Neoplasms, Carboxamide, Poly(ADP-ribose) Polymerase Inhibitors, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Antineoplastic Combined Chemotherapy Protocols, Drug Discovery, Temozolomide, medicine, Animals, Humans, Potency, Enzyme Inhibitors, Molecular Biology, Polymerase, biology, Organic Chemistry, Xenograft Model Antitumor Assays, Dacarbazine, chemistry, Enzyme inhibitor, PARP inhibitor, biology.protein, Molecular Medicine, Benzimidazoles, Cisplatin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f9dfff4a264cde0e806e9b06f79cf0
https://doi.org/10.1016/j.bmc.2008.05.044

المؤلفون: Qun Li, Eric F. Johnson, Viraj B. Gandhi, Ran Guan, Saul H. Rosenberg, Jianchun Gong, Vincent S. Stoll, Keith W. Woods, Yan Luo, Vered Klinghofer, Xuesong Liu, Gui-Dong Zhu, Vincent L. Giranda, Mulugeta Mamo

المصدر: Bioorganic & Medicinal Chemistry. 15:2441-2452

مصطلحات موضوعية: Pyridines, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Pyrazolopyridine, Tumor Cells, Cultured, Humans, Structure–activity relationship, Enzyme Inhibitors, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, Serine/threonine-specific protein kinase, Indazole, biology, Organic Chemistry, Pancreatic Neoplasms, chemistry, Protein kinase domain, Enzyme inhibitor, biology.protein, Pyrazoles, Molecular Medicine, Proto-Oncogene Proteins c-akt

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a486867bc644c9ee02021f387171fdea
https://doi.org/10.1016/j.bmc.2007.01.010

المؤلفون: Saul H. Rosenberg, Xuesong Liu, Jianchun Gong, Jennifer J. Bouska, Shayna R. Magnone, Tilman Oltersdorf, Ran Guan, Eric F. Johnson, Ken Jarvis, Alexander R. Shoemaker, Viraj B. Gandhi, Ron De Jong, Vered Klinghofer, Yan Luo, Yan Shi, Chang Park, Qun Li, Vincent L. Giranda, Anatol Oleksijew, Gui-Dong Zhu

المصدر: Bioorganic & Medicinal Chemistry Letters. 16:3424-3429

مصطلحات موضوعية: Models, Molecular, Indoles, Pyridines, Clinical Biochemistry, Pharmaceutical Science, AKT1, Antineoplastic Agents, Crystallography, X-Ray, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, GSK-3, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Oxindole, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, biology, Kinase, Organic Chemistry, Stereoisomerism, Xenograft Model Antitumor Assays, Oxindoles, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Signal transduction, Proto-Oncogene Proteins c-akt

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ba9c69c070958439e591d1a15212145
https://doi.org/10.1016/j.bmcl.2006.04.005

المؤلفون: Xuesong Liu, Keith W. Woods, Shayna R. Magnone, Jianchun Gong, Saul H. Rosenberg, Vincent L. Giranda, Jennifer J. Bouska, Eric F. Johnson, Gui-Dong Zhu, Anatol Oleksijew, Alexander R. Shoemaker, Viraj B. Gandhi, Tilman Oltersdorf, Vincent S. Stoll, Vered Klinghofer, Yan Luo, Akiyo Claiborne, Ron De Jong, Sheela A. Thomas, Yan Shi, Ran Guan, Qun Li

المصدر: Bioorganic & Medicinal Chemistry Letters. 16:3150-3155

مصطلحات موضوعية: Pyridines, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Crystallography, X-Ray, Biochemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, GSK-3, Cell Line, Tumor, Drug Discovery, Animals, Humans, Isoquinoline, Protein kinase A, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, Molecular Structure, biology, Chemistry, Organic Chemistry, Isoquinolines, Xenograft Model Antitumor Assays, Enzyme inhibitor, biology.protein, Molecular Medicine, Signal transduction, Proto-Oncogene Proteins c-akt, Lead compound

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1e4323d251336d4deafbd9eda295834
https://doi.org/10.1016/j.bmcl.2006.03.041

المؤلفون: Xuesong Liu, Gail Bukofzer, Chang H. Park, Yan Luo, Sheela A. Thomas, Kennan C. Marsh, David Frost, Vered Klinghofer, Amanda M. Olson, Thomas D. Penning, Viraj B. Gandhi, Cherrie K. Donawho, Elizabeth H. Fry, Eric F. Johnson, Jennifer J. Bouska, Fritz G. Buchanan, Luis E. Rodriguez, Vincent L. Giranda, Velitchka Bontcheva-Diaz, Donald J. Osterling, Yan Shi, Jianchun Gong, Gui-Dong Zhu

المصدر: Journal of medicinal chemistry. 53(8)

مصطلحات موضوعية: Models, Molecular, Benzimidazole, medicine.drug_class, Stereochemistry, Poly ADP ribose polymerase, Transplantation, Heterologous, Melanoma, Experimental, Biological Availability, Carboxamide, Antineoplastic Agents, Mice, SCID, Poly(ADP-ribose) Polymerase Inhibitors, Crystallography, X-Ray, Poly (ADP-Ribose) Polymerase Inhibitor, Carboplatin, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Antineoplastic Combined Chemotherapy Protocols, medicine, Temozolomide, Potency, Structure–activity relationship, Animals, Polymerase, biology, BRCA1 Protein, Stereoisomerism, Transplantation, Dacarbazine, Mice, Inbred C57BL, chemistry, Blood-Brain Barrier, biology.protein, Molecular Medicine, Benzimidazoles, Female, Drug Screening Assays, Antitumor, Neoplasm Transplantation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c570bdd2710139f17e2d617b98240cb
https://pubmed.ncbi.nlm.nih.gov/20337371

المؤلفون: Viraj B. Gandhi, Jianchun Gong, Yan Shi, Yan Luo, Donald J. Osterling, Jennifer J. Bouska, Amanda M. Olson, Kennan C. Marsh, Vered Klinghofer, David Frost, Velitchka Bontcheva-Diaz, Cherrie K. Donawho, Vincent L. Giranda, Gui-Dong Zhu, Xuesong Liu, Eric F. Johnson, Thomas D. Penning

المصدر: Journal of medicinal chemistry. 52(2)

مصطلحات موضوعية: Benzimidazole, Magnetic Resonance Spectroscopy, Veliparib, medicine.drug_class, Poly ADP ribose polymerase, Melanoma, Experimental, Biological Availability, Carboxamide, Antineoplastic Agents, Mice, SCID, Poly(ADP-ribose) Polymerase Inhibitors, Poly (ADP-Ribose) Polymerase Inhibitor, Carboplatin, chemistry.chemical_compound, Mice, Dogs, In vivo, Drug Discovery, medicine, Temozolomide, Potency, Animals, Humans, Enzyme Inhibitors, Cyclophosphamide, Haplorhini, Molecular biology, Rats, Dacarbazine, chemistry, Area Under Curve, PARP inhibitor, Molecular Medicine, Benzimidazoles, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904c2806eccea1986b854bd543bbf65c
https://pubmed.ncbi.nlm.nih.gov/19143569

المؤلفون: Yan Luo, Jianchun Gong, Viraj B. Gandhi, Jennifer J. Bouska, Ken Jarvis, Vincent L. Giranda, Gui-Dong Zhu, Kennan C. Marsh, Vered Klinghofer, David Frost, Eric F. Johnson, Saul H. Rosenberg, Sheela A. Thomas, Cherrie K. Donawho, Xuesong Liu, Thomas D. Penning, Yan Shi

المصدر: Bioorganicmedicinal chemistry letters. 18(14)

مصطلحات موضوعية: Benzimidazole, DNA Repair, Transcription, Genetic, Stereochemistry, medicine.drug_class, Poly ADP ribose polymerase, Chemistry, Pharmaceutical, Clinical Biochemistry, Substituent, Pharmaceutical Science, Carboxamide, Antineoplastic Agents, Poly(ADP-ribose) Polymerase Inhibitors, Biochemistry, chemistry.chemical_compound, Mice, Cell Line, Tumor, Drug Discovery, medicine, Animals, Enzyme Inhibitors, Molecular Biology, Polymerase, chemistry.chemical_classification, biology, Organic Chemistry, NAD+ ADP-Ribosyltransferase, DNA, Kinetics, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Benzimidazoles, Drug Screening Assays, Antitumor, Neoplasm Transplantation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31446f9f0bf6ebced675d7b556d88965
https://pubmed.ncbi.nlm.nih.gov/18586490

المؤلفون: James S. Polakowski, Xiaohong Song, R.B. Diebold, Gui-Dong Zhu, Saul H. Rosenberg, Ran Guan, Gary Gintant, Jianchun Gong, Eric F. Johnson, Amanda M. Olson, Qun Li, Jennifer J. Bouska, Xuesong Liu, Keith W. Woods, Vincent S. Stoll, Thomas J Campbell, Klinghofer, Sheela A. Thomas, Mulugeta Mamo, Ruth L. Martin, Thomas D. Penning, Vincent L. Giranda, T. Li, Kennan C. Marsh, Viraj B. Gandhi, Yan Luo

المصدر: Journal of medicinal chemistry. 50(13)

مصطلحات موضوعية: Models, Molecular, Indazoles, Stereochemistry, Protein Conformation, Pyridines, Administration, Oral, Biological Availability, Crystallography, X-Ray, Purkinje Fibers, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Dogs, In vivo, Drug Discovery, Animals, Protein kinase A, Protein kinase B, Indazole, biology, Kinase, Chemistry, Stereoisomerism, Rats, Biochemistry, Protein kinase domain, Enzyme inhibitor, biology.protein, Molecular Medicine, Pyrazoles, Signal transduction, Hypotension, Proto-Oncogene Proteins c-akt

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c829391bbcc39a3fdfbe77a4a0ec408a
https://pubmed.ncbi.nlm.nih.gov/17523610