المؤلفون: Kitamura S; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037.; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Lin TH; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Lee CD; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Takamura A; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037., Kadam RU; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Zhang D; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Zhu X; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Dada L; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Nagai E; Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461., Yu W; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037., Yao Y; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037., Sharpless KB; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037., Wolan DW; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037.; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA 92037.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 May 28; Vol. 121 (22), pp. e2310677121. Date of Electronic Publication: 2024 May 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Hemagglutinin Glycoproteins, Influenza Virus*/metabolism , Hemagglutinin Glycoproteins, Influenza Virus*/chemistry , Antiviral Agents*/pharmacology , Antiviral Agents*/chemistry, Humans ; Chemistry, Pharmaceutical/methods ; High-Throughput Screening Assays/methods ; Influenza, Human/drug therapy ; Influenza, Human/virology ; Crystallography, X-Ray/methods ; Click Chemistry/methods ; Animals ; Influenza A virus/drug effects ; Madin Darby Canine Kidney Cells ; Viral Fusion Protein Inhibitors/pharmacology ; Viral Fusion Protein Inhibitors/chemistry ; Dogs

المؤلفون: Freidel MR; Department of Pharmaceutical Sciences, College of Pharmacy, Thomas Jefferson University, 901 Walnut St. Suite 918, Philadelphia, PA 19170, USA., Vakhariya PA; Department of Pharmaceutical Sciences, College of Pharmacy, Thomas Jefferson University, 901 Walnut St. Suite 918, Philadelphia, PA 19170, USA., Sardarni SK; Department of Pharmaceutical Sciences, College of Pharmacy, Thomas Jefferson University, 901 Walnut St. Suite 918, Philadelphia, PA 19170, USA., Armen RS; Department of Pharmaceutical Sciences, College of Pharmacy, Thomas Jefferson University, 901 Walnut St. Suite 918, Philadelphia, PA 19170, USA.

المصدر: Viruses [Viruses] 2024 Apr 20; Vol. 16 (4). Date of Electronic Publication: 2024 Apr 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

مواضيع طبية MeSH: Clofazimine*/pharmacology , Clofazimine*/chemistry , Clofazimine*/metabolism , Protein Binding* , SARS-CoV-2*/drug effects , Spike Glycoprotein, Coronavirus*/metabolism , Spike Glycoprotein, Coronavirus*/chemistry , Spike Glycoprotein, Coronavirus*/antagonists & inhibitors, Humans ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Binding Sites ; COVID-19 Drug Treatment ; Indoles ; Molecular Docking Simulation ; Structure-Activity Relationship ; Sulfides ; Surface Plasmon Resonance ; Viral Fusion Protein Inhibitors/pharmacology ; Viral Fusion Protein Inhibitors/chemistry

المؤلفون: Wang LL; School of Veterinary Medicine and Biomedical Sciences, USA; Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA., Estrada L; School of Veterinary Medicine and Biomedical Sciences, USA; Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA., Wiggins J; Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA; School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA., Anantpadma M; Department of Microbiology & National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, MA, 02115, USA., Patten JJ; Department of Microbiology & National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, MA, 02115, USA., Davey RA; Department of Microbiology & National Emerging Infectious Diseases Laboratories, Boston University School of Medicine, Boston, MA, 02115, USA., Xiang SH; School of Veterinary Medicine and Biomedical Sciences, USA; Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE, 68583, USA. Electronic address: sxiang2@unl.edu.

المصدر: Antiviral research [Antiviral Res] 2022 Oct; Vol. 206, pp. 105399. Date of Electronic Publication: 2022 Aug 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE

مواضيع طبية MeSH: Filoviridae*/chemistry , Filoviridae*/drug effects , Receptors, Virus*/chemistry , Receptors, Virus*/metabolism , Viral Fusion Protein Inhibitors*/chemistry , Viral Fusion Protein Inhibitors*/pharmacology, Binding Sites ; Carrier Proteins/metabolism ; Cell Line ; Ebolavirus/physiology ; Endosomes/metabolism ; Hemorrhagic Fever, Ebola ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Ligands ; Membrane Glycoproteins/metabolism ; Niemann-Pick C1 Protein/metabolism ; Virus Internalization/drug effects

المؤلفون: Duan Q; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China., Xia S; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China., Jiao F; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China., Wang Q; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China., Wang R; Beijing Prosperous Biopharm Company, Beijing 100021, China., Lu L; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China., Jiang S; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China., Xu W; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai 200032, China.

المصدر: Viruses [Viruses] 2022 Mar 22; Vol. 14 (4). Date of Electronic Publication: 2022 Mar 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE

مواضيع طبية MeSH: SARS-CoV-2*/genetics , Viral Fusion Protein Inhibitors*/chemistry , Viral Fusion Protein Inhibitors*/pharmacology , COVID-19 Drug Treatment*, Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Coronavirus Infections/drug therapy ; Fibronectin Type III Domain ; Half-Life ; Mice ; Recombinant Fusion Proteins ; Spike Glycoprotein, Coronavirus/metabolism

SCR Organism: SARS-CoV-2 variants

المؤلفون: de Vries RD; Department of Viroscience, Erasmus MC, Rotterdam, Netherlands., Schmitz KS; Department of Viroscience, Erasmus MC, Rotterdam, Netherlands., Bovier FT; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli,' Caserta, Italy., Predella C; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Biomedical Engineering, Politecnico di Milano, Milan, Italy., Khao J; Digizyme Inc., Brookline, MA, USA., Noack D; Department of Viroscience, Erasmus MC, Rotterdam, Netherlands., Haagmans BL; Department of Viroscience, Erasmus MC, Rotterdam, Netherlands., Herfst S; Department of Viroscience, Erasmus MC, Rotterdam, Netherlands., Stearns KN; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Physiology and Cellular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Drew-Bear J; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Biswas S; Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA., Rockx B; Department of Viroscience, Erasmus MC, Rotterdam, Netherlands., McGill G; Digizyme Inc., Brookline, MA, USA.; Center for Molecular and Cellular Dynamics, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Dorrello NV; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Gellman SH; Department of Chemistry, University of Wisconsin-Madison, Madison, WI, USA., Alabi CA; Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA. caa238@cornell.edu r.deswart@erasmusmc.nl am939@cumc.columbia.edu mp3509@cumc.columbia.edu., de Swart RL; Department of Viroscience, Erasmus MC, Rotterdam, Netherlands. caa238@cornell.edu r.deswart@erasmusmc.nl am939@cumc.columbia.edu mp3509@cumc.columbia.edu., Moscona A; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. caa238@cornell.edu r.deswart@erasmusmc.nl am939@cumc.columbia.edu mp3509@cumc.columbia.edu.; Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Physiology and Cellular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Microbiology and Immunology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Porotto M; Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. caa238@cornell.edu r.deswart@erasmusmc.nl am939@cumc.columbia.edu mp3509@cumc.columbia.edu.; Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Experimental Medicine, University of Campania 'Luigi Vanvitelli,' Caserta, Italy.

المصدر: Science (New York, N.Y.) [Science] 2021 Mar 26; Vol. 371 (6536), pp. 1379-1382. Date of Electronic Publication: 2021 Feb 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19/*transmission , Lipopeptides/*administration & dosage , Membrane Fusion/*drug effects , SARS-CoV-2/*drug effects , Viral Fusion Protein Inhibitors/*administration & dosage , Virus Internalization/*drug effects, Administration, Intranasal ; Animals ; COVID-19/prevention & control ; COVID-19/virology ; Chlorocebus aethiops ; Disease Models, Animal ; Drug Design ; Ferrets ; Lipopeptides/chemistry ; Lipopeptides/pharmacokinetics ; Lipopeptides/pharmacology ; Mice ; Pre-Exposure Prophylaxis ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/physiology ; Spike Glycoprotein, Coronavirus/metabolism ; Tissue Distribution ; Vero Cells ; Viral Fusion Protein Inhibitors/chemistry ; Viral Fusion Protein Inhibitors/pharmacokinetics ; Viral Fusion Protein Inhibitors/pharmacology

المؤلفون: Wang X; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai 200032, China., Xia S; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai 200032, China., Wang Q; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai 200032, China., Xu W; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai 200032, China., Li W; Key Laboratory of Reproduction Regulation of National Health Commission, (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai 200032, China., Lu L; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai 200032, China., Jiang S; Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.; Key Laboratory of Reproduction Regulation of National Health Commission, (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai 200032, China.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2020 May 28; Vol. 21 (11). Date of Electronic Publication: 2020 May 28.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Betacoronavirus/*drug effects , Coronavirus Infections/*drug therapy , Protease Inhibitors/*therapeutic use , Viral Fusion Protein Inhibitors/*therapeutic use, Animals ; Betacoronavirus/physiology ; Humans ; Protease Inhibitors/adverse effects ; Protease Inhibitors/pharmacology ; SARS-CoV-2 ; Viral Fusion Protein Inhibitors/adverse effects ; Viral Fusion Protein Inhibitors/pharmacology ; Virus Internalization/drug effects

المؤلفون: Vendeville S; Janssen Pharmaceutica NV, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium., Tahri A; Janssen Pharmaceutica NV, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium., Hu L; Janssen Pharmaceutica NV, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium., Demin S; Janssen Pharmaceutica NV, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium., Cooymans L; Janssen Pharmaceutica NV, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium., Vos A; Janssen Pharmaceutica NV, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium., Kwanten L; Janssen Pharmaceutica NV, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium., Van den Berg J; Janssen Pharmaceutica NV, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium., Battles MB; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755, United States., McLellan JS; Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas 78712, United States., Koul A; Janssen Pharmaceutica NV, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium., Raboisson P; Janssen Pharmaceutica NV, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium., Roymans D; Janssen Pharmaceutica NV, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium., Jonckers THM; Janssen Pharmaceutica NV, Janssen Pharmaceutical Companies of Johnson & Johnson, Turnhoutseweg 30, 2340 Beerse, Belgium.

المصدر: Journal of medicinal chemistry [J Med Chem] 2020 Aug 13; Vol. 63 (15), pp. 8046-8058. Date of Electronic Publication: 2020 Jun 15.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents/*chemistry , Drug Discovery/*methods , Imidazolidines/*chemistry , Indoles/*chemistry , Respiratory Syncytial Virus, Human/*drug effects , Viral Fusion Protein Inhibitors/*chemistry, Administration, Oral ; Antiviral Agents/administration & dosage ; Crystallography, X-Ray/methods ; HeLa Cells ; Humans ; Imidazolidines/administration & dosage ; Indoles/administration & dosage ; Protein Structure, Secondary ; Respiratory Syncytial Virus, Human/physiology ; Viral Fusion Protein Inhibitors/administration & dosage

المؤلفون: Cockerill GS; ReViral Ltd., Stevenage Bioscience Catalyst, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2FX, U.K.

المصدر: Journal of medicinal chemistry [J Med Chem] 2020 Aug 13; Vol. 63 (15), pp. 8043-8045. Date of Electronic Publication: 2020 Aug 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents/*chemistry , Imidazolidines/*chemistry , Indoles/*chemistry , Respiratory Syncytial Virus, Human/*drug effects , Viral Fusion Protein Inhibitors/*chemistry, Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Crystallography, X-Ray/methods ; Humans ; Imidazolidines/pharmacology ; Imidazolidines/therapeutic use ; Indoles/pharmacology ; Indoles/therapeutic use ; Respiratory Syncytial Virus Infections/drug therapy ; Respiratory Syncytial Virus, Human/physiology ; Treatment Outcome ; Viral Fusion Protein Inhibitors/pharmacology

المؤلفون: van Dongen MJP; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands. mvandon@its.jnj.com wilson@scripps.edu.; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., Kadam RU; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Juraszek J; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Lawson E; Discovery Sciences, Janssen Research & Development, 1400 McKean Rd., Spring House, PA, USA., Brandenburg B; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands., Schmitz F; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Schepens WBG; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., Stoops B; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., van Diepen HA; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Jongeneelen M; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands., Tang C; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands., Vermond J; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., van Eijgen-Obregoso Real A; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Blokland S; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands., Garg D; Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA., Yu W; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA., Goutier W; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Lanckacker E; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium., Klap JM; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Peeters DCG; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., Wu J; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium., Buyck C; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., Jonckers THM; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium., Roymans D; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium., Roevens P; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium., Vogels R; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Janssen Infectious Diseases and Vaccines, Janssen Research & Development, Archimedesweg 4-6, Leiden, Netherlands., Koudstaal W; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Friesen RHE; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands., Raboisson P; Janssen Infectious Diseases and Vaccines, Janssen Research & Discovery, Turnhoutseweg 30, Beerse, Belgium., Dhanak D; Discovery Sciences, Janssen Research & Development, Turnhoutseweg 30, Beerse, Belgium.; Discovery Sciences, Janssen Research & Development, 1400 McKean Rd., Spring House, PA, USA., Goudsmit J; Janssen Prevention Center, Janssen Pharmaceutical Companies of Johnson & Johnson, Archimedesweg 6, Leiden, Netherlands.; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Wilson IA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA, USA. mvandon@its.jnj.com wilson@scripps.edu.; The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, USA.

المصدر: Science (New York, N.Y.) [Science] 2019 Mar 08; Vol. 363 (6431).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science

مواضيع طبية MeSH: Antibodies, Neutralizing/*chemistry , Biomimetic Materials/*pharmacology , Influenza A Virus, H1N1 Subtype/*drug effects , Influenza, Human/*prevention & control , Piperazines/*pharmacology , Pyridines/*pharmacology , Tetrazoles/*pharmacology , Viral Fusion Protein Inhibitors/*pharmacology , Virus Internalization/*drug effects, Administration, Oral ; Animals ; Biomimetic Materials/administration & dosage ; Biomimetic Materials/pharmacokinetics ; Bronchi/virology ; Cells, Cultured ; Dogs ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Hemagglutinin Glycoproteins, Influenza Virus/metabolism ; Humans ; Madin Darby Canine Kidney Cells ; Mice ; Piperazines/administration & dosage ; Piperazines/pharmacokinetics ; Pyridines/administration & dosage ; Pyridines/pharmacokinetics ; Respiratory Mucosa/virology ; Tetrazoles/administration & dosage ; Tetrazoles/pharmacokinetics ; Viral Fusion Protein Inhibitors/administration & dosage ; Viral Fusion Protein Inhibitors/pharmacokinetics

المؤلفون: González-Parra G; Department of Physics & Astronomy, Texas Christian University, 2800 S University Dr. Fort Worth, TX 76129, USA; Department of Mathematics, New Mexico Tech, Socorro, NM, USA., Dobrovolny HM; Department of Physics & Astronomy, Texas Christian University, 2800 S University Dr. Fort Worth, TX 76129, USA. Electronic address: h.dobrovolny@tcu.edu.

المصدر: Journal of theoretical biology [J Theor Biol] 2018 Nov 07; Vol. 456, pp. 62-73. Date of Electronic Publication: 2018 Jul 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 0376342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8541 (Electronic) Linking ISSN: 00225193 NLM ISO Abbreviation: J Theor Biol Subsets: MEDLINE

مواضيع طبية MeSH: Models, Biological*, Benzimidazoles/*therapeutic use , Pyridines/*therapeutic use , Respiratory Syncytial Virus Infections/*drug therapy , Respiratory Syncytial Viruses/*drug effects , Viral Fusion Protein Inhibitors/*therapeutic use, Animals ; Benzimidazoles/administration & dosage ; Benzimidazoles/pharmacology ; Chlorocebus aethiops ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Evaluation, Preclinical/methods ; Pyridines/administration & dosage ; Pyridines/pharmacology ; Respiratory Syncytial Virus Infections/virology ; Respiratory Syncytial Viruses/isolation & purification ; Respiratory Syncytial Viruses/physiology ; Viral Fusion Protein Inhibitors/administration & dosage ; Viral Fusion Protein Inhibitors/pharmacology ; Viral Load ; Virus Replication/drug effects