المؤلفون: Chavez D; Department of Biology, Indiana University, Bloomington, Indiana, USA., Amarquaye GN; Department of Biology, Indiana University, Bloomington, Indiana, USA., Mejia-Santana A; Department of Biology, Indiana University, Bloomington, Indiana, USA., Dyotima; Department of Biology, Indiana University, Bloomington, Indiana, USA., Ryan K; Department of Biology, Indiana University, Bloomington, Indiana, USA., Zeng L; Department of Biochemistry and Molecular Biology, Indiana University Chemical Genomics Core Facility, School of Medicine, Indiana University, Indianapolis, Indiana, USA., Landeta C; Department of Biology, Indiana University, Bloomington, Indiana, USA. Electronic address: clandeta@iu.edu.

المصدر: The Journal of biological chemistry [J Biol Chem] 2024 Jun; Vol. 300 (6), pp. 107383. Date of Electronic Publication: 2024 May 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Warfarin*/metabolism , Warfarin*/chemistry , Vitamin K Epoxide Reductases*/metabolism , Vitamin K Epoxide Reductases*/chemistry , Vitamin K Epoxide Reductases*/genetics , Escherichia coli*/metabolism , Escherichia coli*/genetics , Escherichia coli*/enzymology , Escherichia coli Proteins*/metabolism , Escherichia coli Proteins*/chemistry , Escherichia coli Proteins*/genetics , Bacterial Proteins*/metabolism , Bacterial Proteins*/chemistry , Bacterial Proteins*/genetics, Humans ; Disulfides/chemistry ; Disulfides/metabolism ; Coumarins/metabolism ; Coumarins/chemistry ; Protein Disulfide-Isomerases/metabolism ; Protein Disulfide-Isomerases/chemistry ; Protein Disulfide-Isomerases/genetics ; Anticoagulants/chemistry ; Anticoagulants/metabolism ; Benzoquinones/metabolism ; Benzoquinones/chemistry ; Structure-Activity Relationship ; Protein Binding ; Membrane Proteins

المؤلفون: Geng K; Anhui Provincial Center for Drug Clinical Evaluation, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.; Wannan Medical College, Wuhu, Anhui, China., Shen C; Department of Clinical Pharmacy and Pharmacy Administration, West China College of Pharmacy, Sichuan University, Chengdu, Sichuan, China., Wang X; Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China., Wang X; Anhui Provincial Center for Drug Clinical Evaluation, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.; Wannan Medical College, Wuhu, Anhui, China., Shao W; Anhui Provincial Center for Drug Clinical Evaluation, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.; Wannan Medical College, Wuhu, Anhui, China., Wang W; Anhui Provincial Center for Drug Clinical Evaluation, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.; Wannan Medical College, Wuhu, Anhui, China., Chen T; Anhui Provincial Center for Drug Clinical Evaluation, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.; Wannan Medical College, Wuhu, Anhui, China., Sun H; Anhui Provincial Center for Drug Clinical Evaluation, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China., Xie H; Anhui Provincial Center for Drug Clinical Evaluation, Yijishan Hospital of Wannan Medical College, Wuhu, Anhui, China.

المصدر: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2024 May; Vol. 13 (5), pp. 853-869. Date of Electronic Publication: 2024 Mar 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Warfarin*/pharmacokinetics , Warfarin*/pharmacology , Warfarin*/administration & dosage , Fluconazole*/pharmacology , Fluconazole*/pharmacokinetics , Drug Interactions* , Cytochrome P-450 CYP2C9*/genetics , Cytochrome P-450 CYP2C9*/metabolism , Anticoagulants*/pharmacokinetics , Anticoagulants*/pharmacology , Anticoagulants*/administration & dosage , Models, Biological* , Vitamin K Epoxide Reductases*/genetics , Vitamin K Epoxide Reductases*/metabolism, Humans ; Polymorphism, Genetic ; International Normalized Ratio

المؤلفون: Stolyarchuk M; Centre Borelli, ENS Paris-Saclay, CNRS, Université Paris-Saclay, 4 Avenue des Sciences, 91190 Gif-sur-Yvette, France., Botnari M; Centre Borelli, ENS Paris-Saclay, CNRS, Université Paris-Saclay, 4 Avenue des Sciences, 91190 Gif-sur-Yvette, France., Tchertanov L; Centre Borelli, ENS Paris-Saclay, CNRS, Université Paris-Saclay, 4 Avenue des Sciences, 91190 Gif-sur-Yvette, France.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 09; Vol. 25 (8). Date of Electronic Publication: 2024 Apr 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Protein Disulfide-Isomerases*/metabolism , Protein Disulfide-Isomerases*/chemistry , Vitamin K Epoxide Reductases*/chemistry , Vitamin K Epoxide Reductases*/metabolism , Vitamin K Epoxide Reductases*/genetics , Molecular Dynamics Simulation*, Humans ; Disulfides/chemistry ; Disulfides/metabolism ; Sulfhydryl Compounds/chemistry ; Sulfhydryl Compounds/metabolism ; Models, Molecular ; Protein Conformation ; Oxidation-Reduction ; Protein Binding

المؤلفون: Xia X; Department of Pharmacy, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, #18 Daoshan Road, Fuzhou, 350001, China., Cai X; Department of Pharmacy, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, #18 Daoshan Road, Fuzhou, 350001, China., Chen J; Department of Pharmacy, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, #18 Daoshan Road, Fuzhou, 350001, China., Jiang S; Department of Pharmacy, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, #18 Daoshan Road, Fuzhou, 350001, China., Zhang J; Department of Pharmacy, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, #18 Daoshan Road, Fuzhou, 350001, China. pollyzhang2006@126.com.

المصدر: Scientific reports [Sci Rep] 2024 Jun 27; Vol. 14 (1), pp. 14846. Date of Electronic Publication: 2024 Jun 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Anticoagulants*/administration & dosage , Anticoagulants*/pharmacokinetics , Cytochrome P-450 CYP2C9*/genetics , Cytochrome P-450 CYP2C9*/metabolism , Vitamin K Epoxide Reductases*/genetics , Warfarin*/administration & dosage , Warfarin*/pharmacokinetics, Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Bayes Theorem ; China ; International Normalized Ratio ; East Asian People

المؤلفون: Camilleri E; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Ghobreyal M; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Bos MHA; Department of Internal Medicine, Division of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands., Reitsma PH; Department of Internal Medicine, Division of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands., Van Der Meer FJM; Department of Internal Medicine, Division of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands., Swen JJ; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands., Cannegieter SC; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Internal Medicine, Division of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands.; Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden University Medical Center, Leiden, The Netherlands., van Rein N; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Clinical Pharmacy and Toxicology, Leiden University Medical Center, Leiden, The Netherlands.

المصدر: Pharmacotherapy [Pharmacotherapy] 2024 Jun; Vol. 44 (6), pp. 416-424. Date of Electronic Publication: 2024 Apr 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 8111305 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9114 (Electronic) Linking ISSN: 02770008 NLM ISO Abbreviation: Pharmacotherapy Subsets: MEDLINE

مواضيع طبية MeSH: Vitamin K*/antagonists & inhibitors , Hemorrhage*/chemically induced , Hemorrhage*/genetics , Hemorrhage*/epidemiology , Vitamin K Epoxide Reductases*/genetics , Anticoagulants*/adverse effects , Polymorphism, Genetic*, Humans ; Female ; Male ; Aged ; Cohort Studies ; Middle Aged ; Cytochrome P-450 CYP2C9/genetics ; Genotype ; Cytochrome P450 Family 4/genetics ; Aged, 80 and over ; Carbon-Carbon Ligases/genetics ; Case-Control Studies

المؤلفون: Anand A; Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India., Hegde NC; Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India., Chhabra P; Department of Cardiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Purohit J; Department of Cardiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Kumar R; Department of Cardiothoracic and Vascular Surgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Gupta A; Department of Cardiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Lad DP; Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. deepesh.kem@gmail.com., Mohindra R; Department of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Mehrotra S; Department of Cardiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Vijayvergiya R; Department of Cardiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Kumar B; Department of Cardiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Sharma V; Department of Gastroenterology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Malhotra P; Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Ahluwalia J; Department of Hematology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Das R; Department of Hematology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India., Patil AN; Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India. patil.amol@pgimer.edu.in., Shafiq N; Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India., Malhotra S; Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.

المصدر: Annals of hematology [Ann Hematol] 2024 Jun; Vol. 103 (6), pp. 2133-2144. Date of Electronic Publication: 2024 Apr 18.

نوع المنشور: Journal Article; Randomized Controlled Trial; Comparative Study

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE

مواضيع طبية MeSH: Warfarin*/economics , Warfarin*/administration & dosage , Warfarin*/therapeutic use , Cytochrome P-450 CYP2C9*/genetics , International Normalized Ratio* , Vitamin K Epoxide Reductases*/genetics , Anticoagulants*/administration & dosage , Anticoagulants*/economics , Anticoagulants*/therapeutic use , Economics, Pharmaceutical*, Humans ; Female ; Male ; Middle Aged ; Aged ; Pharmacogenomic Testing/economics ; Adult ; Pharmacogenetics/economics ; Cost-Benefit Analysis

المؤلفون: Zhang S; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai., Zhao M; Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou., Zhong S; Department of Pharmacy, Guangdong Provincial People's Hospital, Guangdong., Niu J; Department of Cardiology, Jinan City People's Hospital, Jinan., Zhou L; Translational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou., Zhu B; Shanghai Baio Technology Co., Ltd., Shanghai., Su H; Department of Cardiology, Huhhot First Hospital, Huhhot., Cao W; Translational Medicine Center, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou., Xing Q; Institutes of Biomedical Sciences, Fudan University., Yan H; Reproductive, Medicine Center, Changhai Hospital, Navy Medical University, Shanghai., Han X; Department of Cardiology, Jinan City People's Hospital, Jinan., Fu Q; Pediatric Translational Medicine Institute, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai.; Shanghai Key Laboratory of Clinical Molecular Diagnostics for Pediatrics, Shanghai., Li Q; Department of Geriatrics, Shandong Provincial Third Hospital, Shandong., Chen L; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai., Yang F; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai., Zhang N; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai., Wu H; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai., He L; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai., Qin S; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai.

المصدر: Pharmacogenetics and genomics [Pharmacogenet Genomics] 2024 Jun 01; Vol. 34 (4), pp. 105-116. Date of Electronic Publication: 2024 Mar 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 101231005 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-6880 (Electronic) Linking ISSN: 17446872 NLM ISO Abbreviation: Pharmacogenet Genomics Subsets: MEDLINE

مواضيع طبية MeSH: Cytochrome P-450 CYP2C9*/genetics , Vitamin K Epoxide Reductases*/genetics , Warfarin*/adverse effects , Warfarin*/administration & dosage , Polymorphism, Single Nucleotide* , Anticoagulants*/adverse effects , Anticoagulants*/administration & dosage , Asian People*/genetics, Humans ; Female ; Male ; Middle Aged ; Aged ; Hemorrhage/chemically induced ; Hemorrhage/genetics ; China ; Adult ; Genotype ; Genetic Association Studies ; East Asian People

المؤلفون: Drent M; ILD Center of Excellence, Department of Respiratory Medicine, St. Antonius Hospital, 3435 CM Nieuwegein, The Netherlands.; Department of Pharmacology and Toxicology, Faculty of Health, Medicine, and Life Science, Maastricht University, 6200 MD Maastricht, The Netherlands.; Research Team, ILD Care Foundation, 6711 NR Ede, The Netherlands., Wijnen P; ILD Center of Excellence, Department of Respiratory Medicine, St. Antonius Hospital, 3435 CM Nieuwegein, The Netherlands.; Research Team, ILD Care Foundation, 6711 NR Ede, The Netherlands.; Department of Clinical Chemistry, Central Diagnostic Laboratory, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands., Bekers O; Department of Pharmacology and Toxicology, Faculty of Health, Medicine, and Life Science, Maastricht University, 6200 MD Maastricht, The Netherlands.; Department of Clinical Chemistry, Central Diagnostic Laboratory, Maastricht University Medical Centre, 6229 HX Maastricht, The Netherlands., Bast A; Department of Pharmacology and Toxicology, Faculty of Health, Medicine, and Life Science, Maastricht University, 6200 MD Maastricht, The Netherlands.; Research Team, ILD Care Foundation, 6711 NR Ede, The Netherlands.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 18; Vol. 25 (8). Date of Electronic Publication: 2024 Apr 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Vitamin K Epoxide Reductases*/genetics , Sarcoidosis*/genetics , Sarcoidosis*/complications , Nephrolithiasis*/genetics , Polymorphism, Single Nucleotide*, Humans ; Female ; Male ; Middle Aged ; Risk Factors ; Adult ; Genetic Predisposition to Disease ; Retrospective Studies ; Aged ; Alleles

المؤلفون: Botnari M; Centre Borelli, École Normale Supérieure (ENS) Paris-Saclay, Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay, 4 Avenue des Sciences, F-91190 Gif-sur-Yvette, France., Tchertanov L; Centre Borelli, École Normale Supérieure (ENS) Paris-Saclay, Centre National de la Recherche Scientifique (CNRS), Université Paris-Saclay, 4 Avenue des Sciences, F-91190 Gif-sur-Yvette, France.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Feb 07; Vol. 25 (4). Date of Electronic Publication: 2024 Feb 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Mutation, Missense* , Vitamin K Epoxide Reductases*/genetics , Vitamin K Epoxide Reductases*/metabolism, Humans ; Mutation ; Oxidation-Reduction ; Vitamin K/metabolism

المؤلفون: Falkenhagen U; PharMetrX Graduate Research Training Program, Berlin/Potsdam, Germany.; Institute of Mathematics, Mathematical Modelling and Systems Biology, University of Potsdam, Potsdam, Germany., Cavallari LH; College of Pharmacy, Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, USA., Duarte JD; College of Pharmacy, Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, Florida, USA., Kloft C; Institute of Pharmacy, Department of Clinical Pharmacy and Biochemistry, Freie Universität Berlin, Berlin, Germany., Schmidt S; College of Pharmacy, Department of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, University of Florida, Orlando, Florida, USA., Huisinga W; Institute of Mathematics, Mathematical Modelling and Systems Biology, University of Potsdam, Potsdam, Germany.

المصدر: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2024 Sep; Vol. 116 (3), pp. 795-806. Date of Electronic Publication: 2024 Apr 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Warfarin*/administration & dosage , International Normalized Ratio* , Anticoagulants*/administration & dosage , Cytochrome P-450 CYP2C9*/genetics , Models, Biological*, Humans ; Female ; Male ; Middle Aged ; Aged ; Vitamin K Epoxide Reductases/genetics ; Precision Medicine/methods ; Blood Coagulation/drug effects ; Adult ; Drug Monitoring/methods