المؤلفون: Lilia Falkenstern, Victoria Georgi, Stefanie Bunse, Volker Badock, Manfred Husemann, Ulrike Roehn, Timo Stellfeld, Mark Fitzgerald, Steven Ferrara, Detlef Stöckigt, Carlo Stresemann, Ingo V. Hartung, Amaury Fernández-Montalván

المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-21 (2024)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/86f7032f806147479748eda7c74b8341

المؤلفون: Ingo Hartung, Masoud Vedadi, Magda Szewczyk, Volker Badock, Carlo Stresemann, Holger Steuber, Dalia Barsyte-Lovejoy, Shawna Organ, Norbert Schmees, Clara D. Christ, Detlef Stoeckigt, Steven Kennedy, Stefan Gradl, Cheryl H. Arrowsmith, Megha Abbey, Stephan Siegel, Andrea Haegebarth, Manfred Husemann, Fengling Li, Marcus Bauser, Joerg Weiske, Irene Chau, Viacheslav V. Trush, Peter Brown

المصدر: SLAS Discovery. 26:947-960

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Thermal shift assay, High-throughput screening, Antineoplastic Agents, MAP3K2, Biochemistry, Analytical Chemistry, Small Molecule Libraries, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Humans, Binding site, Protein kinase A, Kinase, Drug discovery, Chemistry, Hydrogen Bonding, Isothermal titration calorimetry, Histone-Lysine N-Methyltransferase, High-Throughput Screening Assays, 030104 developmental biology, 030220 oncology & carcinogenesis, Molecular Medicine, Hydrophobic and Hydrophilic Interactions, Protein Binding, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31088aa45c9fd48a4764afae98765927
https://doi.org/10.1177/24725552211019409

المؤلفون: Stuart L. Schreiber, Lennart Schnirch, Katja Zimmermann, A. Hilpmann, Dieter Moosmayer, Laura Furst, Jutta Hoffmann, Vasanthi S. Viswanathan, John K. Eaton, Roman C. Hillig, Stefan Gradl, Volker Badock

المصدر: Acta Crystallographica. Section D, Structural Biology

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Stereochemistry, Crystal structure, ML162, Crystallography, X-Ray, 010402 general chemistry, GPX4, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Structural Biology, Humans, Enzyme Inhibitors, glutathione peroxidase 4, chemistry.chemical_classification, biology, Selenocysteine, Chemistry, HEK 293 cells, Active site, Phospholipid Hydroperoxide Glutathione Peroxidase, Research Papers, anti-oxidative defense system, ferroptosis, oxidoreductases, 0104 chemical sciences, HEK293 Cells, 030104 developmental biology, Structural biology, Covalent bond, biology.protein, covalent inhibitors, Selenoprotein, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad06bcee3485125c45eaad54d4024e2f
https://doi.org/10.1107/s2059798320016125

المؤلفون: J. Schroeder, Stefan Gradl, Volker Badock, Knut Eis, Benjamin Bader, Hans Briem, Clara D. Christ, Patrick Steigemann, Roman C. Hillig, Duy Nguyen, Jérémie Mortier, Marcus Bauser, Anders Friberg, Dieter Moosmayer, Franziska Siegel

المصدر: ChemMedChem. 15:827-832

مصطلحات موضوعية: Pharmacology, 010405 organic chemistry, Chemistry, Organic Chemistry, Allosteric regulation, Naphthyridinone, Druggability, Computational biology, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Workflow, Covalent bond, Docking (molecular), Drug Discovery, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Pharmacophore

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cd3a78dae00c2acf021360ef88b2d38f
https://doi.org/10.1002/cmdc.201900727

المؤلفون: Hans Briem, Benjamin Bader, Ulf Boemer, Brice Sautier, N. Bohnke, A. Hilpmann, Nicolas Werbeck, J. Kahmann, Volker Badock, D. Wegener, Knut Eis, J. Schroeder, K. Graham, Dieter Moosmayer, Christian Stegmann, J. Mastouri, K. Petersen, Jörg Weiske, Gerhard Siemeister, Roman C. Hillig, Lars Wortmann, F. von Nussbaum

المصدر: 'Proceedings of the National Academy of Sciences of the USA ', vol: 116, pages: 2551-2560 (2019)
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America 116(7), 2551-2560 (2019). doi:10.1073/pnas.1812963116

مصطلحات موضوعية: crystal structure, GTP', Crystallography, X-Ray, medicine.disease_cause, Biochemistry, Cell Line, Proto-Oncogene Proteins p21(ras), Drug Discovery, Fluorescence Resonance Energy Transfer, medicine, Humans, Small GTPase, Mode of action, Multidisciplinary, Chemistry, Drug discovery, fragment screen, SOS, Biological Sciences, High-Throughput Screening Assays, Cell biology, PNAS Plus, SOS1, ddc:500, Guanine nucleotide exchange factor, KRAS, Signal transduction, SOS1 Protein, small-molecule inhibitor, Protein Binding, Signal Transduction, RAS

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b81d68c52d5b8e57b984ebab279c8e8
https://doi.org/10.1073/pnas.1812963116

المؤلفون: Stuart L. Schreiber, Volker Badock, Anneke Kramm, Vasanthi S. Viswanathan, Roland Neuhaus, Besnik Bajrami, Dieter Moosmayer, Luke L. Cai, Claire Montagnon, Matthew J. Ryan, Kiel Lazarski, Michael Niehues, Laura Furst, Katja Zimmermann, Ashley Eheim, Sixun Chen, Paul A. Clemons, Sven Christian, Stefan Gradl, A. Hilpmann, John K. Eaton, Richard A. Ruberto, Roman C. Hillig

المصدر: Nat Chem Biol

مصطلحات موضوعية: Nitrile, Mice, SCID, Article, Small Molecule Libraries, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Cell Line, Tumor, Nitriles, Animals, Ferroptosis, Humans, Moiety, Structure–activity relationship, Prodrugs, Molecular Targeted Therapy, Enzyme Inhibitors, Rats, Wistar, Chloroacetamide, Molecular Biology, 030304 developmental biology, 0303 health sciences, 030302 biochemistry & molecular biology, Oxides, Cell Biology, Phospholipid Hydroperoxide Glutathione Peroxidase, Small molecule, Combinatorial chemistry, Selenocysteine, chemistry, Covalent bond, Molecular Probes, Electrophile, Lipid Peroxidation, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9dba21b4ff5e31f86e9c6937b70befa
https://europepmc.org/articles/PMC7251976/

المؤلفون: Jérémie, Mortier, Anders, Friberg, Volker, Badock, Dieter, Moosmayer, Jens, Schroeder, Patrick, Steigemann, Franziska, Siegel, Stefan, Gradl, Marcus, Bauser, Roman C, Hillig, Hans, Briem, Knut, Eis, Benjamin, Bader, Duy, Nguyen, Clara D, Christ

المصدر: Chemmedchem

مصطلحات موضوعية: free-energy perturbation (FEP), Dose-Response Relationship, Drug, Molecular Structure, Communication, Communications, molecular dynamics, Proto-Oncogene Proteins p21(ras), Structure-Activity Relationship, virtual library design, Allosteric Regulation, medicinal chemistry, Mutation, KRAS, Humans, Enzyme Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::38543b1608cf2b145245231d713abef9
https://pubmed.ncbi.nlm.nih.gov/32237114

المؤلفون: Jérémie Mortier, Marcus Bauser, Stefan Gradl, Volker Badock, Duy Nguyen, Hans Briem, J. Schroeder, Knut Eis, Benjamin Bader, Clara D. Christ, Dieter Moosmayer, Anders Friberg, Roman C. Hillig, Franziska Siegel, Patrick Steigemann

المصدر: ChemMedChem. 15:808-808

مصطلحات موضوعية: Pharmacology, Front cover, Workflow, Covalent bond, Computer science, Organic Chemistry, Drug Discovery, Allosteric regulation, Molecular Medicine, Computational biology, General Pharmacology, Toxicology and Pharmaceutics, Biochemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5b5e8be1f62517ddf217ce81b69398ae
https://doi.org/10.1002/cmdc.202000297

المؤلفون: John W. Cuozzo, Matthew A. Clark, Holly H. Soutter, Ying Zhang, Anthony D. Keefe, Vera Puetter, Hilmar Weinmann, Ingo Hartung, Detlef Stöckigt, Seong Joo Koo, Eric A. Sigel, Paolo A. Centrella, Oleg Fedorov, Simon Holton, Christoph E. Dumelin, Kilian Huber, Dawn M. Troast, Antonius Ter Laak, L. Diaz-Saez, Jan Hübner, Mátyás Gorjánácz, Volker Badock, Apirat Chaikuad, Markus Berger, Benno Kuropka, Vincent Rodeschini, James M. Bennett, Amaury Ernesto Fernandez-Montalvan, Didier M. Roche, Joerg Weiske

مصطلحات موضوعية: 0301 basic medicine, Gene isoform, Models, Molecular, Regulator, Ligands, Biochemistry, Article, Histones, 03 medical and health sciences, Cell Line, Tumor, Drug Discovery, Humans, Protein Isoforms, Epigenetics, Protein Interaction Maps, biology, Drug discovery, General Medicine, Molecular biology, Chromatin, Bromodomain, Cell biology, DNA-Binding Proteins, 030104 developmental biology, Histone, Acetylation, Molecular Probes, biology.protein, Molecular Medicine, ATPases Associated with Diverse Cellular Activities, Protein Multimerization

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6e59468d78b543d20e7ca9d3032de5
https://europepmc.org/articles/PMC6218015/

المؤلفون: Benno Kuropka, Kevin Pagel, Jörg Weiske, Melanie Göth, Volker Badock

المصدر: ChemMedChem. 12(15)

مصطلحات موضوعية: 0301 basic medicine, Thermal shift assay, Spectrometry, Mass, Electrospray Ionization, Electrospray ionization, Complex formation, 010402 general chemistry, Mass spectrometry, 01 natural sciences, Biochemistry, Automated data, 03 medical and health sciences, Fragment (logic), Protein–ligand complex, Drug Discovery, General Pharmacology, Toxicology and Pharmaceutics, Pharmacology, Chromatography, Chemistry, Organic Chemistry, Temperature, Proteins, 0104 chemical sciences, High-Throughput Screening Assays, 030104 developmental biology, Molecular Medicine, Primary screening

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::970d62d5db5eb72d1fd32335d8aa8e27
https://pubmed.ncbi.nlm.nih.gov/28618179