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المؤلفون: Jim Cassidy, Owen J. Sansom, William C. Clark, Luis Serrano, Volker M. Stucke, Martin J Drysdale, Martin R Turner, Arafath Kaja Najumudeen, R.P. Fordham, Karen Pickering, Lucas B. Zeiger, Ewan J. McGhee, Saskia M. Brachmann, Ann Hedley, Andrew D. Campbell, Kathryn Gilroy, Jeanette A. Johansson, Maureen M. Bain, David F. Vincent, Kevin Myant, Christina Kiel, Kurt I. Anderson, Benjamin LeRoy Miller, Angeliki Malliri, S.R. van Hoof, Sigrid K. Fey, Jan Paul Medema, E.B. Unal, Anna-Karin E. Johnsson, Catherine Nixon, Laura M. Machesky, Douglas Strathdee
المساهمون: Center of Experimental and Molecular Medicine, Radiotherapy, CCA - Cancer biology and immunology, Najumudeen, AK [0000-0002-3764-5721], Zeiger, LB [0000-0002-8712-3112], Gay, DM [0000-0002-7407-1245], Machesky, LM [0000-0002-7592-9856], Nixon, C [0000-0002-8085-2160], Johnsson, AE [0000-0002-0018-700X], Strathdee, D [0000-0003-2959-4327], Anderson, KI [0000-0002-9324-9598], Malliri, A [0000-0001-6848-090X], Turner, M [0000-0002-3801-9896], Serrano, L [0000-0002-5276-1392], Myant, K [0000-0001-8017-1093], Campbell, AD [0000-0003-3930-1276], Sansom, OJ [0000-0001-9540-3010], Apollo - University of Cambridge Repository, Najumudeen, A. K. [0000-0002-3764-5721], Zeiger, L. B. [0000-0002-8712-3112], Gay, D. M. [0000-0002-7407-1245], Machesky, L. M. [0000-0002-7592-9856], Nixon, C. [0000-0002-8085-2160], Johnsson, A. E. [0000-0002-0018-700X], Strathdee, D. [0000-0003-2959-4327], Anderson, K. I. [0000-0002-9324-9598], Malliri, A. [0000-0001-6848-090X], Turner, M. [0000-0002-3801-9896], Serrano, L. [0000-0002-5276-1392], Myant, K. [0000-0001-8017-1093], Campbell, A. D. [0000-0003-3930-1276], Sansom, O. J. [0000-0001-9540-3010]
المصدر: Nature communications, 12(1):56. Nature Publishing Group
Nature Communications
Pickering, KA, Gilroy, K, Cassidy, JW, Fey, SK, Najumudeen, AK, Zeiger, LB, Vincent, DF, Gay, DM, Johansson, J, Fordham, RP, Miller, B, Clark, W, Hedley, A, Unal, EB, Kiel, C, McGhee, E, Macheskey, LM, Nixon, C, Johnsson, AE, Bain, M, Strathdee, D, van Hoof, SR, Medema, JP, Anderson, KI, Brachmann, SM, Stucke, VM, Malliri, A, Drysdale, M, Turner, M, Serrano, L, Myant, K B, Campbell, AD & Sansom, OJ 2021, ' A RAC-GEF network critical for early intestinal tumourigenesis ', Nature Communications . https://doi.org/10.1038/s41467-020-20255-4
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
University of Edinburgh-PUREمصطلحات موضوعية: 0301 basic medicine, VAV3, rac1 GTP-Binding Protein, VAV2, Carcinogenesis, Homeòstasi, General Physics and Astronomy, Imaging, 0302 clinical medicine, Guanine Nucleotide Exchange Factors, Homeostasis, T-Lymphoma Invasion and Metastasis-inducing Protein 1, Wnt Signaling Pathway, Mice, Knockout, Multidisciplinary, Wnt signaling pathway, article, Phenotype, Up-Regulation, Colon cancer, Intestines, Organ Specificity, 030220 oncology & carcinogenesis, 64/60, Signal transduction, 631/67/70, Signal Transduction, Science, Adenomatous Polyposis Coli Protein, RAC1, 13/106, 631/67/1504/1885/1393, Biology, General Biochemistry, Genetics and Molecular Biology, 38/91, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Downregulation and upregulation, 14/33, Animals, Proto-Oncogene Proteins c-vav, Cancer models, Tumors, General Chemistry, 030104 developmental biology, Mutation, 13/51, Cancer research, Intestins -- Càncer, Genètica
وصف الملف: application/pdf; text/xml; application/zip
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a4588ea791829c408931197ab3e425
https://pure.amc.nl/en/publications/a-racgef-network-critical-for-early-intestinal-tumourigenesis(1d3b7cc2-5483-46a6-accd-e659022a288b).html -
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المؤلفون: Kirsty J. Martin, Volker M. Stucke, Martin J. Drysdale, Saskia M. Brachmann, Kurt I. Anderson, Juliana P. Schwarz, Owen J. Sansom, Ewan J. McGhee
المصدر: PLoS ONE
PLoS ONE, Vol 13, Iss 1, p e0183585 (2018)مصطلحات موضوعية: 0301 basic medicine, Fluorescence-lifetime imaging microscopy, Luminescence, Imaging Techniques, Science, Cyan, Equipment, Biosensing Techniques, Research and Analysis Methods, Fluorophotometry, Fluorescence, Green fluorescent protein, 03 medical and health sciences, Spectrum Analysis Techniques, Mathematical and Statistical Techniques, Fluorescence Microscopy, 0302 clinical medicine, Fluorescence Imaging, Fluorescence Resonance Energy Transfer, Luminescent Proteins, Microscopy, Multidisciplinary, Physics, Electromagnetic Radiation, Light Microscopy, Biology and Life Sciences, Detectors, Biosensors, 030104 developmental biology, Förster resonance energy transfer, Energy Transfer, Spectrophotometry, Physical Sciences, Medicine, Time Domain Analysis, Engineering and Technology, Synthetic Biology, mCherry, Biological system, Mathematical Functions, Biosensor, Synthetic Biosensors, 030217 neurology & neurosurgery, Research Article, Protein Binding
وصف الملف: application/pdf
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المؤلفون: Kris Gevaert, Volker M. Stucke, Joël Vandekerckhove, Evy Timmerman, Alan Hall
المساهمون: UCL
المصدر: Molecular Biology of the Cell, Vol. 18, no. 5, p. 1744-1755 (2007)
مصطلحات موضوعية: DNA, Complementary, Polarity (physics), Molecular Sequence Data, Plasma protein binding, Biology, Transfection, Cell Line, Tight Junctions, Discs Large Homolog 1 Protein, Adherens junction, Cell polarity, Humans, Amino Acid Sequence, Molecular Biology, Adaptor Proteins, Signal Transducing, Epithelial polarity, Membrane Glycoproteins, Base Sequence, Tight junction, Cell Polarity, Membrane Proteins, Epithelial Cells, Articles, Cell Biology, Recombinant Proteins, Protein Structure, Tertiary, Cell biology, Membrane protein, Caco-2, RNA Interference, Caco-2 Cells, HeLa Cells, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c6e322758d94ddf1cdc94fd798b06e
https://doi.org/10.1091/mbc.e06-11-0980 -
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المؤلفون: Volker M. Stucke, Silvia Martin-Lluesma, Erich A. Nigg
المصدر: Science. 297:2267-2270
مصطلحات موضوعية: RNA, Untranslated, Cell cycle checkpoint, Mad2, Mad1, Chromosomal Proteins, Non-Histone, Mitosis, Cell Cycle Proteins, Spindle Apparatus, Protein Serine-Threonine Kinases, Biology, Microtubules, Two-Hybrid System Techniques, Chromosomes, Human, Humans, Gene Silencing, RNA, Small Interfering, Kinetochores, Multidisciplinary, Kinetochore, Calcium-Binding Proteins, Nuclear Proteins, Protein-Tyrosine Kinases, G2-M DNA damage checkpoint, Cell biology, Spindle apparatus, Repressor Proteins, Cytoskeletal Proteins, Spindle checkpoint, Phenotype, Mitotic exit, Mad2 Proteins, biological phenomena, cell phenomena, and immunity, Microtubule-Associated Proteins, Protein Kinases, HeLa Cells, Signal Transduction
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المؤلفون: Christine Stephan, William R. Sellers, Deborah Castelletti, Jeffery A. Porter, Julie L. Bernard, Sandra Mollé, Mark Stump, Tami Hood, Joshua M. Korn, Audrey Kauffmann, Giorgio G. Galli, Kristine Yu, Li Li, Marc Hattenberger, Javad Golji, Zainab Jagani, Marco Wallroth, Tobias Schmelzle, Philippe Megel, Raymond Pagliarini, Rosemary Barrett, Yingzi Yue, Richard S. Eldridge, Jan Weiler, Alberto C. Vitari, Konstantinos J. Mavrakis, Kalyani Gampa, Elizabeth Ackley, Rosalie deBeaumont, Qiong Shen, Joel Berger, Tanja Schouwey, Franklin Chung, E. Robert McDonald, Gregory McAllister, Christelle Stamm, Frances Shanahan, Aurore Desplat, Iris Kao, Thomas A. Perkins, Antoine de Weck, Kavitha Venkatesan, Albert Lai, Jennifer Johnson, Roland Widmer, David A. Ruddy, Avnish Kapoor, Brian Repko, François Gauter, Nicholas Keen, Tanushree Phadke, Eric Billy, Sosathya Sovath, Typhaine Martin, Elizabeth Frias, Justina X. Caushi, Vic E. Myer, Malini Varadarajan, William C. Forrester, Fei Feng, Hans Bitter, Ralph Tiedt, Yue Liu, Jing Zhang, Dorothee Abramowski, Dhiren Belur, Volker M. Stucke, Odile Weber, Mathias Jenal, Ali Farsidjani, Jianjun Yu, Rebecca Billig, JiaJia Feng, A. B. Meyer, Kristen Hurov, Veronica Gibaja, Michael D. Jones, Daisy Flemming, Donald A. Dwoske, Jilin Liu, Clara Delaunay, William Duong, Frank Buxton, Kaitlin J. Macchi, Saskia M. Brachmann, Alice T. Loo, Craig Mickanin, Francesco Hofmann, Frank Stegmeier, Kristy Haas, Gregory R. Hoffman, Marta Cortes-Cros, Roger Caothien, Shumei Liu, Serena J. Silver, Michael R. Schlabach, Emma Lees, Nadire Ramadan, Qiumei Liu, Zhenhai Gao
المصدر: Cell. 170:577-592.e10
مصطلحات موضوعية: 0301 basic medicine, Lineage (genetic), Tumor suppressor gene, Mutant, Biology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, RNA interference, Cell Line, Tumor, Neoplasms, medicine, Humans, Gene Regulatory Networks, RNA, Small Interfering, Gene, Gene Library, Genetics, Gene knockdown, Cancer, Translation (biology), Oncogenes, medicine.disease, 030104 developmental biology, Multiprotein Complexes, RNA Interference, Signal Transduction, Transcription Factors
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المؤلفون: Volker M. Stucke, Delphine Gorses, Francesco Hofmann
المصدر: Cell Cycle. 7:830-832
مصطلحات موضوعية: Wnt signaling pathway, Cell Biology, Importin, Biology, RNA Helicase A, Molecular biology, Ubiquitin ligase, GSK-3, biology.protein, Casein kinase 1, Nuclear transport, Molecular Biology, Nuclear localization sequence, Developmental Biology
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المصدر: Methods in molecular biology (Clifton, N.J.). 986
مصطلحات موضوعية: Drug Design, Neoplasms, Humans, Antineoplastic Agents, Molecular Targeted Therapy, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::88422d19a4bfd6dfb53916eaf3ed70b9
https://pubmed.ncbi.nlm.nih.gov/23436402 -
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المصدر: Target Identification and Validation in Drug Discovery ISBN: 9781627033107
مصطلحات موضوعية: Drug discovery, Computer science, media_common.quotation_subject, Cancer drugs, Perspective (graphical), Oncology drug, Identification (biology), Relevance (information retrieval), Computational biology, Pharmacology, Function (engineering), media_common, Variety (cybernetics)
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9c1a25081d444e4b77fc25c276f358bc
https://doi.org/10.1007/978-1-62703-311-4_1 -
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المؤلفون: Erich A. Nigg, Christoph Baumann, Volker M. Stucke
المصدر: Chromosoma. 113(1)
مصطلحات موضوعية: Cell Cycle Proteins, Protein Serine-Threonine Kinases, PLK1, Microtubules, Spindle pole body, Antibodies, Genetics, Humans, Centrosome duplication, Kinase activity, Kinetochores, Genetics (clinical), Centrosome, Binding Sites, biology, Kinetochore, Cyclin-dependent kinase 2, Nuclear Proteins, Protein-Tyrosine Kinases, Immunohistochemistry, Cell biology, Spindle checkpoint, Cytoskeletal Proteins, biology.protein, Protein Kinases
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10Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication
المؤلفون: Herman H W Silljé, Lionel Arnaud, Erich A. Nigg, Volker M. Stucke
المصدر: The EMBO journal. 21(7)
مصطلحات موضوعية: Cell cycle checkpoint, RNA, Untranslated, Microinjections, Gene Expression, Mitosis, Cell Cycle Proteins, Spindle Apparatus, Biology, Protein Serine-Threonine Kinases, General Biochemistry, Genetics and Molecular Biology, Spindle pole body, Article, Mice, Tumor Cells, Cultured, Animals, Humans, Centrosome duplication, CHEK1, Gene Silencing, RNA, Small Interfering, Kinetochores, Molecular Biology, Centrosome, Mice, Inbred BALB C, General Immunology and Microbiology, Kinetochore, General Neuroscience, Cell Cycle, G2-M DNA damage checkpoint, Protein-Tyrosine Kinases, Mitotic spindle checkpoint, Cell biology, Spindle checkpoint, Protein Kinases, HeLa Cells, Signal Transduction