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المؤلفون: Brendan T Finicle, Kazumi H Eckenstein, Alexey S Revenko, Brooke A Anderson, W Brad Wan, Alison N McCracken, Daniel Gil, David A Fruman, Stephen Hanessian, Punit P Seth, Aimee L Edinger
المصدر: Nucleic Acids Research. 51:1583-1599
مصطلحات موضوعية: Genetics
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1fde1b5fd23940ce7c0ce0235ad04603
https://doi.org/10.1093/nar/gkad023 -
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المؤلفون: W. Brad Wan, Audrey Low, Eric E. Swayze, Michael T. Migawa, Guillermo Vasquez, Michael Tanowitz, Punit P. Seth
المصدر: Nucleic Acid Therapeutics. 32:40-50
مصطلحات موضوعية: Stereochemistry, Phosphorothioate Oligonucleotides, Endosomes, Biochemistry, Mice, chemistry.chemical_compound, Therapeutic index, Drug Discovery, Genetics, Animals, Nucleotide, Molecular Biology, chemistry.chemical_classification, Nuclease, biology, Oligonucleotide, Phosphorus, Oligonucleotides, Antisense, Phosphonate, Therapeutic Index, chemistry, biology.protein, Molecular Medicine, Chemical stability, Isopropyl, DNA
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a3100ea938ad4987b8358f461c08ec
https://doi.org/10.1089/nat.2021.0064 -
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المؤلفون: Xue-hai Liang, Cheryl L De Hoyos, Punit P. Seth, Stanley T. Crooke, Graeme C Freestone, Michael E Ǿstergaard, Audrey Low, Guillermo Vasquez, Jinghua Yu, Eric E. Swayze, Michael T. Migawa, W. Brad Wan, Thazha P. Prakash
المصدر: Nucleic Acids Research
مصطلحات موضوعية: Male, AcademicSubjects/SCI00010, Ribonuclease H, Biology, 010402 general chemistry, 01 natural sciences, Mice, 03 medical and health sciences, chemistry.chemical_compound, Organophosphorus Compounds, Therapeutic index, Chemical Biology and Nucleic Acid Chemistry, Genetics, Animals, Humans, 030304 developmental biology, Mice, Inbred BALB C, 0303 health sciences, Nuclease, DNA, Oligonucleotides, Antisense, 0104 chemical sciences, Glucose, Liver, chemistry, NIH 3T3 Cells, Biophysics, biology.protein, Nucleic acid, HeLa Cells
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f4975e50676c63a8c248fb49e9635c5
https://doi.org/10.1093/nar/gkab047 -
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المؤلفون: Andres Berdeja, Michael T. Migawa, Susan F. Murray, Stanley T. Crooke, W. Brad Wan, Cheryl L De Hoyos, Audrey Low, Xue-hai Liang, Punit P. Seth, Eric E. Swayze, Michael E. Østergaard, Guillermo Vasquez, Wen Shen
المصدر: Nucleic Acids Research
مصطلحات موضوعية: RNase P, Ribonuclease H, Phosphorothioate Oligonucleotides, Cleavage (embryo), Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Chemical Biology and Nucleic Acid Chemistry, Genetics, Animals, 030304 developmental biology, 0303 health sciences, Nuclease, biology, Oligonucleotide, DNA, Oligonucleotides, Antisense, chemistry, 030220 oncology & carcinogenesis, Phosphodiester bond, biology.protein, Biophysics, RNA Cleavage, Chirality (chemistry), Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da31a5f4a9918cb691a94725195e60ae
https://doi.org/10.1093/nar/gkaa031 -
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المؤلفون: Edward N. Harris, Punit P. Seth, Colton M. Miller, W. Brad Wan
المصدر: Nucleic Acid Therapeutics
مصطلحات موضوعية: 0301 basic medicine, antisense oligonucleotide, Docosahexaenoic Acids, Endosome, media_common.quotation_subject, Cell Adhesion Molecules, Neuronal, Receptors, Lymphocyte Homing, Vesicular Transport Proteins, Phosphorothioate Oligonucleotides, Endosomes, Endocytosis, Biochemistry, EEA1, ASO, 03 medical and health sciences, 0302 clinical medicine, Stabilin, Drug Discovery, Genetics, Humans, Receptor, Internalization, Molecular Biology, media_common, rab5 GTP-Binding Proteins, Chemistry, endosome escape, HEK 293 cells, RNA, rab7 GTP-Binding Proteins, Original Articles, Oligonucleotides, Antisense, Cell biology, 030104 developmental biology, HEK293 Cells, RAB7A, rab GTP-Binding Proteins, 030220 oncology & carcinogenesis, Molecular Medicine, RNA, Long Noncoding, endosome maturation
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المؤلفون: W. Brad Wan, Punit P. Seth
المصدر: Journal of Medicinal Chemistry. 59:9645-9667
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Nuclease, biology, Oligonucleotide, Chemistry, Chemistry, Pharmaceutical, Molecular Conformation, Oligonucleotides, Medicinal chemistry, Combinatorial chemistry, Molecular conformation, 03 medical and health sciences, 030104 developmental biology, Drug Discovery, biology.protein, Humans, Molecular Medicine
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المؤلفون: Michael T. Migawa, W. Brad Wan, Eric E. Swayze, Michael E. Østergaard, Thazha P. Prakash, Garth A. Kinberger, Jinghua Yu, Guillermo Vasquez, Punit P. Seth
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:2194-2197
مصطلحات موضوعية: 0301 basic medicine, Acetylgalactosamine, Stereochemistry, Clinical Biochemistry, Nitromethanetrispropionic acid, Pharmaceutical Science, Conjugated system, Biochemistry, Mice, 03 medical and health sciences, chemistry.chemical_compound, parasitic diseases, Drug Discovery, Animals, Molecular Biology, Organic Chemistry, Oligonucleotides, Antisense, Scavenger Receptors, Class B, Nitro Compounds, carbohydrates (lipids), 030104 developmental biology, chemistry, Galactosamine, Antisense oligonucleotides, Hepatocytes, Nucleic acid, Molecular Medicine, Indicators and Reagents, lipids (amino acids, peptides, and proteins), Propionates, Conjugate
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المؤلفون: Sheri L. Booten, W. Brad Wan, Guillermo Vasquez, Susan F. Murray, Audrey Low, Punit P. Seth, Thazha P. Prakash, Heather M. Murray, Alfred E. Chappell, Jeff Crosby, Sebastien A. Burel, Todd Machemer, Armand Soriano, Hans Gaus, Michael T. Migawa, Patrick Cauntay, Jill Hsiao, Jinghua Yu, Mark J. Graham, Recaldo L. Carty, Mariam Aghajan, Michael E. Østergaard, Garth A. Kinberger, Karsten Schmidt, Eric E. Swayze
المصدر: Journal of Medicinal Chemistry. 59:2718-2733
مصطلحات موضوعية: Male, 0301 basic medicine, Tris, Acetylgalactosamine, Transgene, Mice, Transgenic, Conjugated system, N-Acetylgalactosamine, Mice, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Delivery Systems, 0302 clinical medicine, Drug Discovery, Animals, Humans, Structure–activity relationship, Factor XI, Apolipoprotein C-III, Mice, Inbred BALB C, Oligonucleotide, Oligonucleotides, Antisense, Scavenger Receptors, Class B, Molecular biology, Mice, Inbred C57BL, carbohydrates (lipids), 030104 developmental biology, chemistry, Biochemistry, 030220 oncology & carcinogenesis, Hepatocytes, Molecular Medicine, lipids (amino acids, peptides, and proteins), Conjugate
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المؤلفون: Guillermo Vasquez, Heather M. Murray, Walt F. Lima, Andres Berdeja, Eric E. Swayze, W. Brad Wan, Hans Gaus, Josh G. Nichols, Punit P. Seth, Christopher E. Hart, Michael T. Migawa, Sam Lee
المصدر: Nucleic Acids Research
مصطلحات موضوعية: Nuclease, biology, Bicyclic molecule, Oligonucleotide, Stereochemistry, Ribonuclease H, Single-Strand Specific DNA and RNA Endonucleases, Temperature, Phosphorothioate Oligonucleotides, Stereoisomerism, Biological activity, Context (language use), Oligonucleotides, Antisense, Fungal Proteins, Mice, Chemical Biology and Nucleic Acid Chemistry, Biochemistry, Genetics, biology.protein, Animals, Stereoselectivity, RNase H, Chirality (chemistry), Cells, Cultured
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b998d608d82c2dde1115aee2213c2418
https://doi.org/10.1093/nar/gku1115 -
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المؤلفون: Michael T. Migawa, Jinghua Yu, Eric E. Swayze, W. Brad Wan, Audrey Low, Hans Gaus, Alfred E. Chappell, Punit P. Seth, Garth A. Kinberger, Thazha P. Prakash, Michael E. Østergaard
المصدر: Bioorganicmedicinal chemistry letters. 25(19)
مصطلحات موضوعية: Acetylgalactosamine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Conjugated system, Biochemistry, N-Acetylgalactosamine, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Solid-phase synthesis, Organophosphorus Compounds, Drug Discovery, Structure–activity relationship, Animals, RNA, Messenger, Molecular Biology, Phosphoramidite, Dose-Response Relationship, Drug, Chemistry, Oligonucleotide, Organic Chemistry, Oligonucleotides, Antisense, Scavenger Receptors, Class B, carbohydrates (lipids), Liver, Antisense oligonucleotides, Molecular Medicine