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المؤلفون: Suchira Gallage, Adnan Ali, Jose Efren Barragan Avila, Diran Herebian, Mohammad M. Karimi, Elaine E. Irvine, Domhnall McHugh, Anne T. Schneider, Mihael Vucur, Verena Keitel, Jesús Gil, Dominic J. Withers, Tom Luedde, Mathias Heikenwalder
المساهمون: Wellcome Trust, Medical Research Council
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 3, Pp 875-878 (2022)مصطلحات موضوعية: TBA, total bile acid, WD, Western diet, ALP, alkaline phosphatase, Hepatology, Liver Neoplasms, Gastroenterology, RC799-869, Diseases of the digestive system. Gastroenterology, H-TBA, high total bile acid, Mice, Inbred C57BL, Mice, Non-alcoholic Fatty Liver Disease, Research Letter, Animals, NASH, nonalcoholic steatohepatitis, L-TBA, low total bile acid
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المؤلفون: Hunter A Hidalgo, Amy Scarborough, Zhen Li, Thomas E. Sharp, David J. Polhemus, J. Stephen Jenkins, Timothy Matsuura, Jeffery D. Schumacher, Daniel P. Kelly, David J. Lefer, Traci T. Goodchild
المصدر: JACC: Basic to Translational Science
مصطلحات موضوعية: heart failure with preserved ejection fraction, 0301 basic medicine, obesity, medicine.medical_specialty, animal models of human disease, hypertension, HDL, high-density lipoprotein, DBP, diastolic blood pressure, HFpEF, heart failure with preserved ejection fraction, Disease, DOCA, 11-deoxycorticosterone acetate, 030204 cardiovascular system & hematology, Novel Translational Models, metabolic syndrome, 03 medical and health sciences, PCWP - Pulmonary capillary wedge pressure, 0302 clinical medicine, LDL, low-density lipoprotein, Internal medicine, Western diet, medicine, EF, ejection fraction, HFrEF, heart failure with reduced ejection fraction, WD, Western diet, business.industry, SBP, systolic blood pressure, DBP - Diastolic blood pressure, medicine.disease, PCWP, pulmonary capillary wedge pressure, TC, total cholesterol, LV, left ventricle, 030104 developmental biology, Heart failure, IVGTT, intravenous glucose tolerance test, Cardiology, EC50, half-maximal effective concentration, Metabolic syndrome, Cardiology and Cardiovascular Medicine, Heart failure with preserved ejection fraction, business, Large animal
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المؤلفون: Menghao Huang, Kushan Chowdhury, Zhigang Fang, X. Charlie Dong, Ming O. Li, Suthat Liangpunsakul, Hyeong-Geug Kim
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 921-942 (2021)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: 0301 basic medicine, Sestrins, MPO, myeloperoxidase, Mitogen-Activated Protein Kinase Kinase 7, RC799-869, DMSO, dimethyl sulfoxide, FoxO, forkhead box O, Sesn1/2/3, sestrin1/2/3, medicine.disease_cause, TKO, triple knockout, Mice, PCR, polymerase chain reaction, 0302 clinical medicine, GSH, glutathione, Phosphorylation, NF-κB, nuclear factor kappa B, Original Research, Cat, catalase, Mice, Knockout, Sestrin, Gpx3, glutathione peroxidase 3, Il6, interleukin 6, WD, Western diet, biology, Chemistry, Kinase, Fatty liver, Tgfbr1, transforming growth factor beta receptor 1, Gastroenterology, Col1a1, collagen type 1 alpha 1, Nox1, NADPH oxidase 1, Diseases of the digestive system. Gastroenterology, Dgat2, diacylglycerol O-acyltransferase 2, Cell biology, Keap1, Kelch-like ECH-associated protein 1, C-Jun N-Terminal Kinase, Liver, Lipotoxicity, c-Jun N-terminal kinases, JNK, c-Jun N-terminal kinase, 030211 gastroenterology & hepatology, Disease Susceptibility, Signal transduction, NASH, nonalcoholic steatohepatitis, Gss, glutathione synthetase, Pdgfrb, platelet-derived growth factor receptor beta, Timp1, tissue inhibitor of metalloproteinase 1, Fasn, fatty acid synthase, Fatty Liver Disease, Sod, superoxide dismutase, Acta2, smooth muscle actin alpha 2, ER, endoplasmic reticulum, PA, palmitic acid, 03 medical and health sciences, 4-HNE, 4-hydroxynonenal, MKK, mitogen-activated protein kinase kinase, medicine, Animals, Humans, Srebp, sterol regulatory element-binding protein, Protein kinase A, KD, knockdown, MDA, malondialdehyde, Inflammation, KO, knockout, Hepatology, NRF2, nuclear factor erythroid 2-related like 2, JNK Mitogen-Activated Protein Kinases, Lipid Metabolism, medicine.disease, Tgfb1, transforming growth factor beta 1, WT, wild-type, mTORC, mechanistic target of rapamycin complex, Fatty Liver, AMPK, AMP-activated protein kinase, Disease Models, Animal, Oxidative Stress, Scd1, stearoyl-CoA desaturase 1, 030104 developmental biology, Gene Expression Regulation, Cytoprotection, Hepatocytes, biology.protein, BSA, bovine serum albumin, SD, standard deviation, DHE, dihydroethidium, PERK, protein kinase R-like endoplasmic reticulum kinase, Tnf, tumor necrosis factor, Biomarkers, Oxidative stress
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1574bc0f082fa7f7fd23bf88f6f9c6fc
http://www.sciencedirect.com/science/article/pii/S2352345X21000862 -
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المؤلفون: Anthony M. Diomino, David A. Brenner, Hyeok Choon Kwon, Gibraan Rahman, Sara Brin Rosenthal, Tatiana Kisseleva, Linshan Shang, Souradipta Ganguly, Ruoyu Wang, Debanjan Dhar, Rob Knight, Pejman Soorosh, Mojgan Hosseini, Yanhan Wang, Bernd Schnabl, German R. Aleman Muench
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 3, Pp 891-920 (2021)
Cellular and molecular gastroenterology and hepatology, vol 12, iss 3مصطلحات موضوعية: Cirrhosis, medicine.medical_treatment, Cell Cycle Proteins, RC799-869, Gastroenterology, Mice, 0302 clinical medicine, Fibrosis, Aetiology, Original Research, Cancer, Liver Disease, Liver Neoplasms, ILC, innate lymphoid cell, Diseases of the digestive system. Gastroenterology, Immunohistochemistry, HSC, hepatic stellate cell, DSI, distal small intestine, Editorial, FACS, fluorescence-activated cell sorter, 030211 gastroenterology & hepatology, FITC, fluorescein isothiocyanate, NASH, nonalcoholic steatohepatitis, Western, IHC, immunohistochemistry, medicine.medical_specialty, Carcinoma, Hepatocellular, Knockout, CVD, cardiovascular disease, Hyperphagia, digestive system, 03 medical and health sciences, Humans, RPCA, robust principal component analysis, Dyslipidemias, Animal, nutritional and metabolic diseases, Hepatocellular, PE, Phycoerythrin, Hepatocellular Carcinoma, Gene signature, medicine.disease, WT, wild-type, digestive system diseases, IL, interleukin, LBP, lipopolysaccharide binding protein, 030104 developmental biology, NAFLD, nonalcoholic fatty liver disease, MIP2, Macrophage Inflammatory Protein 2, Digestive Diseases, Biomarkers, Liver Inflammation, Liver Cirrhosis, 0301 basic medicine, Chemokine, CXCL2, C-X-C motif chemokine ligand 2, Adipose tissue, Nonalcoholic Steatohepatitis, Gut Inflammation, Oral and gastrointestinal, Hepatitis, Risk Factors, Non-alcoholic Fatty Liver Disease, 2.1 Biological and endogenous factors, Mice, Knockout, TNF, tumor necrosis factor, WD, Western diet, biology, rRNA, ribosomal RNA, Cytokine, Hepatocellular carcinoma, LPS, lipopolysaccharide, Disease Susceptibility, medicine.symptom, eWAT, white adipose tissue (epididymal fat), NASH Regression, Biotechnology, Liver Cancer, APC, Allophycocyanin, Chronic Liver Disease and Cirrhosis, PBS, phosphate-buffered saline, Inflammation, CD-HFD, choline-deficient high-fat diet, SI, small intestine, Rare Diseases, FBS, fetal bovine serum, ALT, alanine aminotransferase, Internal medicine, medicine, Animals, IFN, interferon, Obesity, Nutrition, Hepatology, business.industry, Gene Expression Profiling, CKD, chronic kidney disease, Carcinoma, qRT-PCR, quantitative reverse-transcription polymerase chain reaction, Diet, Disease Models, Animal, Good Health and Well Being, Diet, Western, Disease Models, biology.protein, Insulin Resistance, HCC, hepatocellular carcinoma, business
وصف الملف: application/pdf
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المؤلفون: Romil Saxena, Wenjie Cai, Yang Zhang, Menghao Huang, Xiaolin Zhong, Kushan Chowdhury, Robert F. Schwabe, Suthat Liangpunsakul, Hyeong-Geug Kim, X. Charlie Dong
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 341-364 (2020)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: Liver Cirrhosis, 0301 basic medicine, Steatosis, Nonalcoholic Steatohepatitis, Pathogenesis, PCR, polymerase chain reaction, 0302 clinical medicine, SMAD3, SMAD family member 3, Fibrosis, Sirtuin 6, Sirtuins, Original Research, GFP, green fluorescent protein, WD, Western diet, Fatty liver, Gastroenterology, SIRT6, sirtuin 6, HSC, hepatic stellate cell, mRNA, messenger RNA, ChIP, chromatin immunoprecipitation, Sirtuin, shRNA, short hairpin RNA, TGFB, transforming growth factor β, 030211 gastroenterology & hepatology, Lrat, lecithin retinol acyltransferase, medicine.symptom, NASH, nonalcoholic steatohepatitis, SIRT6, Deacetylation, PBS, phosphate-buffered saline, Inflammation, Biology, 03 medical and health sciences, ALT, alanine aminotransferase, Tg, transgenic, Hepatic Stellate Cells, medicine, Humans, lcsh:RC799-869, KO, knockout, Hepatology, medicine.disease, WT, wild-type, digestive system diseases, 030104 developmental biology, Cancer research, biology.protein, Hepatic stellate cell, DMEM, Dulbecco’s modified Eagle medium, lcsh:Diseases of the digestive system. Gastroenterology, NAFLD, nonalcoholic fatty liver disease, HA, hemagglutinin, Transforming growth factor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e993c50fadc362faaa1fba27859fd85
http://www.sciencedirect.com/science/article/pii/S2352345X20300497 -
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المؤلفون: Tirthadipa Pradhan-Sundd
المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1199-1201 (2021)مصطلحات موضوعية: Male, Arteriosclerosis, SREBP, sterol regulatory element-binding protein, CREB3L3, FGF21, fibroblast growth factor 21, Bioinformatics, CREB3L3, cAMP responsive element-binding protein 3 like 3, Mice, Enterohepatic Circulation, Cyclic AMP Response Element-Binding Protein, Insig, insulin-induced gene, Original Research, GFP, green fluorescent protein, Mice, Knockout, Sterol Regulatory Element Binding Proteins, TBA, total bile acid, WD, Western diet, TG, triglyceride, Chemistry, Gastroenterology, Editorial, Hyperlipidemia, LPL, lipoprotein lipase, Female, lipids (amino acids, peptides, and proteins), Sterol Regulatory Element Binding Protein 1, HDL, high-density lipoprotein, Hyperlipidemias, SREBP, ER, endoplasmic reticulum, Competition (economics), Tg, transgenic, FFA, free fatty acid, medicine, Animals, Humans, lcsh:RC799-869, KO, knockout, PPARα, peroxisome proliferator-activated receptor alpha, Hepatology, PLA, proximity ligation assay, S1P, site-1 protease, Lipogenesis, SREBF, sterol regulatory element-binding factor, VLDL, very-low-density lipoprotein, Atherosclerosis, Lipid Metabolism, medicine.disease, Sterol regulatory element-binding protein, Mice, Inbred C57BL, TC, total cholesterol, Gene Expression Regulation, Receptors, LDL, Apo, apolipoprotein, HPLC, high-performance liquid chromatography, HSV, herpes simplex virus, lcsh:Diseases of the digestive system. Gastroenterology, LXR, liver X receptor
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المؤلفون: Aaron J. Donner, Rosanne M. Crooke, Adam E. Mullick, Richard G. Lee, Mingxia Liu, Thomas A. Bell
المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100101-(2021)مصطلحات موضوعية: Endothelial lipase, antisense oligonucleotide, EL, endothelial lipase, Biochemistry, chemistry.chemical_compound, Mice, Endocrinology, ANGPTL3, cardiovascular disease, RCT, reverse cholesterol transport, Hyperlipidemia, hyperlipidemia, LOF, loss-of-function, chemistry.chemical_classification, Mice, Knockout, WD, Western diet, Reverse cholesterol transport, tg, transgenic, lipids (amino acids, peptides, and proteins), ASCVD, atherosclerotic cardiovascular disease, coronary artery disease, Research Article, medicine.medical_specialty, HDL, Transgene, ASO, antisense oligonucleotide, QD415-436, ANGPTL3, angiopoietin-like protein 3, TPC, total plasma cholesterol, lipids, Internal medicine, medicine, Animals, Humans, Loss function, Angiopoietin-Like Protein 3, LSC, liquid scintillation counting, 3H-CHE, 3H-cholesteryl hexadecyl ether, FCR, fractional catabolic rate, Cholesterol, Cholesterol, HDL, cholesterol, Biological Transport, Cell Biology, FHBL2, familial combined hypobetalipoproteinemia, Oligonucleotides, Antisense, medicine.disease, reverse cholesterol transport, Mice, Inbred C57BL, Enzyme, chemistry, atherosclerosis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a3dd6baedbaa871b44ae87791eadae9
http://europepmc.org/articles/PMC8417398 -
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المؤلفون: Robert Augustin, Lotte Bjerre Knudsen, Klaus Stensgaard Frederiksen, Jane Nøhr, Ib Klewe, Joseph Polex-Wolf, Günaj Rakipovski, Bidda Rolin, Camilla Ingvorsen, Jacob Hecksher-Sørensen
المصدر: JACC: Basic to Translational Science
JACC: Basic to Translational Science, Vol 3, Iss 6, Pp 844-857 (2018)مصطلحات موضوعية: Apolipoprotein E, lcsh:Diseases of the circulatory (Cardiovascular) system, obesity, 030209 endocrinology & metabolism, Inflammation, Type 2 diabetes, 030204 cardiovascular system & hematology, Pharmacology, Systemic inflammation, 03 medical and health sciences, PRECLINICAL RESEARCH, 0302 clinical medicine, Diabetes mellitus, LDL, low-density lipoprotein, TIMP, tissue inhibitor of metalloproteinases, medicine, IFN, interferon, TNF, tumor necrosis factor, WD, Western diet, diabetes, GLP, glucagon-like peptide, business.industry, Liraglutide, Semaglutide, medicine.disease, IL, interleukin, MMP, matrix metalloproteinase, lcsh:RC666-701, inflammation, LDL receptor, CD163, cluster of differentiation 163 molecule, OPN, osteopontin, RNA, ribonucleic acid, LPS, lipopolysaccharide, lipids (amino acids, peptides, and proteins), medicine.symptom, atherosclerosis, Cardiology and Cardiovascular Medicine, business, GLP-1, NASH, nonalcoholic steatohepatitis, medicine.drug
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المؤلفون: Yu-Jui Yvonne Wan, Mohamed R. Ali, Prasant Kuma Jena, Ying Hu, Lili Sheng, Hui Xin Liu
المصدر: JHEP reports : innovation in hepatology, vol 2, iss 2
JHEP Reports, Vol 2, Iss 2, Pp-(2020)
JHEP Reportsمصطلحات موضوعية: FGF21, Steatosis, insulin tolerance test, ALT, ITT, HDAC, histone deacetylase, PFUs, Pharmacology, PPREs, sirtuin 1, 0302 clinical medicine, obeticholic acid, HDAC, Aetiology, PHHs, Western diet, RARβ, retinoic acid receptor β, 0303 health sciences, Liver Disease, Gastroenterology, 3. Good health, FXR, 030220 oncology & carcinogenesis, alcoholic steatosis, CD, control diet, PPREs, peroxisome proliferative-response elements, non-alcoholic steatohepatitis, PHHs, primary human hepatocytes, RT-PCR, 03 medical and health sciences, peroxisome proliferative-response elements, FXR, farnesoid X receptor, SIRT1, OCA, NPCs, non-parenchymal cells, ALP, alkaline phosphatase, RT-PCR, reverse transcription PCR, medicine.disease, 3' untranslated region, PFUs, plaque-forming units, primary human hepatocytes, chemistry, histone deacetylase, Metabolic syndrome, Digestive Diseases, GLP-1, farnesoid X receptor, retinoic acid receptor β, FGF21, fibroblast growth factor 21, chemistry.chemical_compound, non-parenchymal cells, reverse transcription PCR, 2.1 Biological and endogenous factors, Immunology and Allergy, WD, Western diet, Diabetes, Fatty liver, lipopolysaccharide, Obeticholic acid, NPCs, CD, OCA, obeticholic acid, PGC1α, PPAR-activated receptor-γ coactivator-1α, plaque-forming units, LPS, lipopolysaccharide, alkaline phosphatase, Research Article, Biotechnology, LPS, SIRT1, sirtuin 1, glucagon-like peptide, alanine aminotransferase, Chronic Liver Disease and Cirrhosis, fibroblast growth factor 21, PPAR-activated receptor-γ coactivator-1α, metabolic syndrome, Insulin resistance, WD, ALT, alanine aminotransferase, PGC1α, GLP-1, glucagon-like peptide, Internal Medicine, medicine, insulin sensitivity, lcsh:RC799-869, Metabolic and endocrine, ITT, insulin tolerance test, Nutrition, 030304 developmental biology, RARβ, Hepatology, 3'-UTR, 3' untranslated region, AMPK, control diet, ALP, Farnesoid X receptor, lcsh:Diseases of the digestive system. Gastroenterology, 3'-UTR
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3625129ec67d53ff4404e6219139031
https://escholarship.org/uc/item/7h290833 -
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المؤلفون: Takayoshi Suganami, Shuji Terai, Shunsuke Nojiri, Masahiro Ogawa, Tomoaki Yoshida, Atsunori Tsuchiya, Suguru Takeuchi, Takayuki Watanabe, Yoshihiro Ogawa, Masaaki Takamura, Michiko Itoh
المصدر: Regenerative Therapy
Regenerative Therapy, Vol 14, Iss, Pp 252-261 (2020)مصطلحات موضوعية: 0301 basic medicine, NAFLD, non-alcoholic fatty liver disease, Cirrhosis, MC4R, melanocortin-4 receptor-deficient, Lipopolysaccharide, ALT, alanine transaminase, NASH, non-alcoholic steatohepatitis, Biomedical Engineering, Adipose tissue, MSC, mesenchymal stem cell, Small extracellular vesicles, Pharmacology, hCLS, hepatic crown-like structure, Biomaterials, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, MCD, methionine-choline-deficient diet, Fibrosis, sEV, small extracellular vesicle, medicine, lcsh:QH573-671, Receptor, Non-alcoholic steatohepatitis, lcsh:R5-920, WD, Western diet, biology, business.industry, lcsh:Cytology, ND, normal diet, Mesenchymal stem cell, medicine.disease, 030104 developmental biology, chemistry, Alanine transaminase, biology.protein, Mesenchymal stem cells, Original Article, Steatohepatitis, business, lcsh:Medicine (General), HCC, hepatocellular carcinoma, T-bil, total bilirubin, T-cho, total cholesterol, 030217 neurology & neurosurgery, Developmental Biology