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المؤلفون: Emilsson V; Icelandic Heart Association, Holtasmari 1, IS-201, Kopavogur, Iceland. valur@hjarta.is.; Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland. valur@hjarta.is., Gudmundsson EF; Icelandic Heart Association, Holtasmari 1, IS-201, Kopavogur, Iceland., Jonmundsson T; Icelandic Heart Association, Holtasmari 1, IS-201, Kopavogur, Iceland., Jonsson BG; Icelandic Heart Association, Holtasmari 1, IS-201, Kopavogur, Iceland., Twarog M; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA., Gudmundsdottir V; Icelandic Heart Association, Holtasmari 1, IS-201, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland., Li Z; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA., Finkel N; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA., Poor S; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA., Liu X; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA., Esterberg R; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA., Zhang Y; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA., Jose S; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA., Huang CL; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA., Liao SM; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA., Loureiro J; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA., Zhang Q; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA., Grosskreutz CL; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA., Nguyen AA; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA., Huang Q; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA., Leehy B; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA., Pitts R; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA., Aspelund T; Icelandic Heart Association, Holtasmari 1, IS-201, Kopavogur, Iceland., Lamb JR; Novartis Institutes for Biomedical Research, 10675 John Jay Hopkins Drive, San Diego, CA, 92121, USA., Jonasson F; Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland.; Department of Ophthalmology, University Hospital, Reykjavik, Iceland., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA., Cotch MF; Division of Epidemiology and Clinical Applications, National Eye Institute, National Institutes of Health, Bethesda, MD, USA., Jennings LL; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA., Gudnason V; Icelandic Heart Association, Holtasmari 1, IS-201, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, 101, Reykjavik, Iceland., Walshe TE; Novartis Institutes for Biomedical Research, 22 Windsor Street, Cambridge, MA, 02139, USA. tony.walshe@agios.com.

المصدر: Nature communications [Nat Commun] 2022 Jun 13; Vol. 13 (1), pp. 3401. Date of Electronic Publication: 2022 Jun 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Macular Degeneration*/genetics , Macular Degeneration*/metabolism , Proteogenomics*, Aged ; Genetic Loci ; Genome-Wide Association Study ; Humans ; Mendelian Randomization Analysis ; Risk Factors

المؤلفون: Flores RE; Department of Biology, Boston College, Chestnut Hill, MA, United States., Brown AK; Department of Biology, Boston College, Chestnut Hill, MA, United States., Taus L; Department of Biology, Boston College, Chestnut Hill, MA, United States., Khoury J; Department of Biology, Boston College, Chestnut Hill, MA, United States., Glover F; Department of Biology, Boston College, Chestnut Hill, MA, United States., Kami K; Human Metabolome Technologies, Boston, MA, United States., Sarangarajan R; Berg Health, LLC, Framingham, MA, United States., Walshe TE; Berg Health, LLC, Framingham, MA, United States., Narain NR; Berg Health, LLC, Framingham, MA, United States., Kiebish MA; Berg Health, LLC, Framingham, MA, United States., Shelton LM; Human Metabolome Technologies, Boston, MA, United States., Chinopoulos C; Department of Medical Biochemistry, Semmelweis University, Hungary., Seyfried TN; Department of Biology, Boston College, Chestnut Hill, MA, United States. Electronic address: thomas.seyfried@bc.edu.

المصدر: Biochimica et biophysica acta. Bioenergetics [Biochim Biophys Acta Bioenerg] 2018 Sep; Vol. 1859 (9), pp. 975-983. Date of Electronic Publication: 2018 Mar 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731706 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0005-2728 (Print) Linking ISSN: 00052728 NLM ISO Abbreviation: Biochim Biophys Acta Bioenerg Subsets: MEDLINE

مواضيع طبية MeSH: Brain Neoplasms/*pathology , Glioblastoma/*pathology , Hypoxia/*complications , Inflammation/*complications , Mycoplasma/*pathogenicity , Mycoplasma Infections/*complications , Succinates/*metabolism, Animals ; Brain Neoplasms/etiology ; Brain Neoplasms/metabolism ; Energy Metabolism ; Glioblastoma/etiology ; Glioblastoma/metabolism ; Metabolome ; Mice ; Tumor Cells, Cultured

المؤلفون: Walshe TE; From the Departments of Ophthalmology (T.E.W., N.G.d.P., P.A.D.) and Pathology (P.A.D.), Schepens Eye Research Institute, Massachusetts Eye and Ear, Harvard Medical School, Boston; and La Jolla Bioengineering Institute, San Diego, CA (N.G.d.P.)., dela Paz NG, D'Amore PA

المصدر: Arteriosclerosis, thrombosis, and vascular biology [Arterioscler Thromb Vasc Biol] 2013 Nov; Vol. 33 (11), pp. 2608-17. Date of Electronic Publication: 2013 Aug 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9505803 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4636 (Electronic) Linking ISSN: 10795642 NLM ISO Abbreviation: Arterioscler Thromb Vasc Biol Subsets: MEDLINE

مواضيع طبية MeSH: Endothelium, Vascular/*metabolism , Endothelium, Vascular/*physiopathology , Hemodynamics/*physiology , Signal Transduction/*physiology , Transforming Growth Factor beta3/*metabolism, Apoptosis/drug effects ; Apoptosis/physiology ; Human Umbilical Vein Endothelial Cells ; Humans ; Imidazoles/pharmacology ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; Nitric Oxide/metabolism ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein Serine-Threonine Kinases/metabolism ; Quinoxalines/pharmacology ; RNA, Messenger/metabolism ; Receptor, Transforming Growth Factor-beta Type I ; Receptors, Transforming Growth Factor beta/antagonists & inhibitors ; Receptors, Transforming Growth Factor beta/metabolism ; Signal Transduction/drug effects ; Stress, Mechanical

المؤلفون: Bagchi M; Department of Pathology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts, USA., Kim LA, Boucher J, Walshe TE, Kahn CR, D'Amore PA

المصدر: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2013 Aug; Vol. 27 (8), pp. 3257-71. Date of Electronic Publication: 2013 May 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

مواضيع طبية MeSH: Adipocytes/*metabolism , Adipose Tissue, Brown/*metabolism , Vascular Endothelial Growth Factor A/*metabolism , Vascular Endothelial Growth Factor Receptor-2/*metabolism, Adipocytes/cytology ; Adipocytes/drug effects ; Adipose Tissue, Brown/cytology ; Adipose Tissue, Brown/embryology ; Animals ; Apoptosis/drug effects ; Apoptosis/genetics ; Blotting, Western ; Caspase 3/metabolism ; Cell Differentiation/drug effects ; Cell Differentiation/genetics ; Cell Survival/drug effects ; Cell Survival/genetics ; Cells, Cultured ; Gene Expression ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microscopy, Electron ; Mitochondria/drug effects ; Mitochondria/metabolism ; Mitochondria/ultrastructure ; Reverse Transcriptase Polymerase Chain Reaction ; Vascular Endothelial Growth Factor A/genetics ; Vascular Endothelial Growth Factor A/pharmacology ; Vascular Endothelial Growth Factor Receptor-2/genetics

المؤلفون: Ford KM; Schepens Eye Research Institute/Massachusetts Eye and Ear, Boston, Massachusetts 02114, USA., Saint-Geniez M, Walshe TE, D'Amore PA

المصدر: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2012 Nov 07; Vol. 53 (12), pp. 7520-7. Date of Electronic Publication: 2012 Nov 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Electronic Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE

مواضيع طبية MeSH: Pregnancy, Animal*, Ciliary Body/*metabolism , Vascular Endothelial Growth Factor A/*biosynthesis, Animals ; Ciliary Body/embryology ; Ciliary Body/growth & development ; Enzyme-Linked Immunosorbent Assay ; Epithelium/metabolism ; Epithelium/ultrastructure ; Female ; Immunohistochemistry ; Mice ; Mice, Inbred C57BL ; Microscopy, Electron, Scanning Transmission ; Pregnancy

المؤلفون: dela Paz NG; Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute/Massachusett Eye and Ear, 20 Staniford Street, Boston, MA 02114, USA., Walshe TE, Leach LL, Saint-Geniez M, D'Amore PA

المصدر: Journal of cell science [J Cell Sci] 2012 Feb 15; Vol. 125 (Pt 4), pp. 831-43. Date of Electronic Publication: 2012 Mar 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE

مواضيع طبية MeSH: Stress, Mechanical*, Endothelial Cells/*cytology , Endothelial Cells/*metabolism , Vascular Endothelial Growth Factor A/*metabolism, Animals ; Arteries/cytology ; Capillaries/cytology ; Cell Survival ; Enzyme Activation ; Female ; Human Umbilical Vein Endothelial Cells ; Humans ; Kruppel-Like Transcription Factors/metabolism ; Male ; Mice ; Receptors, Vascular Endothelial Growth Factor/biosynthesis ; Receptors, Vascular Endothelial Growth Factor/metabolism ; Up-Regulation ; Vascular Endothelial Growth Factor A/biosynthesis ; Veins/cytology

المؤلفون: Sekiyama E; Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA., Saint-Geniez M, Yoneda K, Hisatomi T, Nakao S, Walshe TE, Maruyama K, Hafezi-Moghadam A, Miller JW, Kinoshita S, D'Amore PA

المصدر: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2012 Feb; Vol. 26 (2), pp. 567-75. Date of Electronic Publication: 2011 Nov 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE

مواضيع طبية MeSH: Choroidal Neovascularization/*prevention & control , Hot Temperature/*therapeutic use , Retinal Pigment Epithelium/*blood supply, Angiogenesis Inhibitors/genetics ; Angiogenesis Inhibitors/metabolism ; Animals ; Bruch Membrane/blood supply ; Bruch Membrane/metabolism ; Bruch Membrane/pathology ; Cell Line ; Choroidal Neovascularization/genetics ; Choroidal Neovascularization/metabolism ; Choroidal Neovascularization/pathology ; Elastic Tissue/metabolism ; Elastic Tissue/pathology ; Endostatins/genetics ; Endostatins/metabolism ; Eye Proteins/genetics ; Eye Proteins/metabolism ; Gene Expression ; Humans ; Lasers, Semiconductor/therapeutic use ; Macular Degeneration/genetics ; Macular Degeneration/metabolism ; Macular Degeneration/pathology ; Macular Degeneration/therapy ; Mice ; Mice, Inbred C57BL ; Nerve Growth Factors/genetics ; Nerve Growth Factors/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Retinal Pigment Epithelium/metabolism ; Retinal Pigment Epithelium/pathology ; Serpins/genetics ; Serpins/metabolism ; Thrombospondin 1/genetics ; Thrombospondin 1/metabolism ; Tropoelastin/metabolism ; Wet Macular Degeneration/genetics ; Wet Macular Degeneration/metabolism ; Wet Macular Degeneration/pathology ; Wet Macular Degeneration/prevention & control

المؤلفون: Walshe TE; Department of Ophthalmology, Harvard Medical School, Schepens Eye Research Institute, 20 Staniford Street, Boston, MA 02114, USA., Leach LL, D'Amore PA

المصدر: Neuroscience [Neuroscience] 2011 Aug 25; Vol. 189, pp. 123-31. Date of Electronic Publication: 2011 May 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 7605074 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7544 (Electronic) Linking ISSN: 03064522 NLM ISO Abbreviation: Neuroscience Subsets: MEDLINE

مواضيع طبية MeSH: Retinal Ganglion Cells/*metabolism , Transforming Growth Factor beta1/*physiology, Animals ; Apoptosis ; Biomarkers/metabolism ; Cell Differentiation ; Cell Line ; Cell Survival ; Cilia/metabolism ; Culture Media, Conditioned ; Epithelial Cells/metabolism ; Humans ; Intracellular Space/metabolism ; MAP Kinase Signaling System ; Neurites/physiology ; Rats ; Retinal Ganglion Cells/cytology ; Signal Transduction ; Smad Proteins/physiology ; Transforming Growth Factor beta1/pharmacology

المؤلفون: Walshe TE; Vascular Health Research Centre, Faculty of Science and Health, Dublin City University, Dublin, Ireland., Connell P, Cryan L, Ferguson G, Gardiner T, Morrow D, Redmond EM, O'Brien C, Cahill PA

المصدر: Investigative ophthalmology & visual science [Invest Ophthalmol Vis Sci] 2011 Jun 23; Vol. 52 (7), pp. 4472-83. Date of Electronic Publication: 2011 Jun 23.

نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Association For Research In Vision And Ophthalmology (Arvo) Country of Publication: United States NLM ID: 7703701 Publication Model: Electronic Cited Medium: Internet ISSN: 1552-5783 (Electronic) Linking ISSN: 01460404 NLM ISO Abbreviation: Invest Ophthalmol Vis Sci Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis/*physiology , DNA/*genetics , Endothelium, Vascular/*cytology , Hedgehog Proteins/*genetics , Pericytes/*cytology , Receptors, Notch/*genetics , Retina/*cytology, Animals ; Blotting, Western ; Cattle ; Cells, Cultured ; Endothelial Cells/cytology ; Endothelium, Vascular/metabolism ; Hedgehog Proteins/biosynthesis ; Humans ; Immunohistochemistry ; Pericytes/metabolism ; Polymerase Chain Reaction ; Receptors, Notch/biosynthesis ; Retina/metabolism ; Signal Transduction