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1
المؤلفون: Zhixiong Ye, Elizabeth T. Birzin, Meng-Hsin Chen, Louis Locco, Sheng-Shung Pong, Ravi P. Nargund, Rupa M. Parmar, Roy G. Smith, Ying-Duo Gao, Scott D. Feighner, Wanda W.-S. Chan, James M. Schaeffer, Arthur A. Patchett, Raman K. Bakshi, Allan D. Blake, Andrew D. Howard, Susan P. Rohrer
المصدر: Bioorganic & Medicinal Chemistry Letters. 10:5-8
مصطلحات موضوعية: Models, Molecular, Agonist, Molecular model, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Receptors, Cell Surface, Carboxamide, Pharmacology, Biochemistry, Chemical synthesis, Receptors, G-Protein-Coupled, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Potency, Receptors, Ghrelin, Molecular Biology, Quinazolinone, Binding Sites, Human Growth Hormone, Chemistry, Organic Chemistry, In vitro, Rats, Kinetics, Drug Design, Quinazolines, Molecular Medicine, Secretagogue, Secretory Rate
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2
المؤلفون: Roy G. Smith, Wanda W.-S. Chan, Kang Cheng, Bridget Butler, William R. Schoen, Judith M. Pisano, Peter Lin, Matthew J. Wyvratt, Michael H. Fisher
المصدر: Bioorganic & Medicinal Chemistry Letters. 9:3237-3242
مصطلحات موضوعية: Pituitary gland, medicine.medical_specialty, Clinical Biochemistry, Biphenyl derivatives, Tetrazoles, Pharmaceutical Science, Peptide, Pharmacology, Growth hormone, Biochemistry, Endocrine secretion, Growth hormone secretagogue, Internal medicine, Drug Discovery, medicine, Animals, Molecular Biology, Cells, Cultured, chemistry.chemical_classification, Molecular Structure, Chemistry, Organic Chemistry, Benzazepines, In vitro, Rats, Rat Pituitary, medicine.anatomical_structure, Endocrinology, Growth Hormone, Pituitary Gland, Molecular Medicine
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3
المؤلفون: James M. Schaeffer, Edward C. Hayes, Susan P. Rohrer, M. Dashkevicz, Allan D. Blake, Wanda W.-S. Chan, Rupa M. Parmar, Roy G. Smith
المصدر: Biochemical and Biophysical Research Communications. 263:276-280
مصطلحات موضوعية: Male, endocrine system, medicine.medical_specialty, Indoles, Growth-hormone-releasing hormone receptor, Somatotropic cell, Biophysics, Growth Hormone-Releasing Hormone, Biochemistry, Anterior pituitary, Pituitary Gland, Anterior, Thyrotropin-releasing hormone receptor, Internal medicine, medicine, Animals, Receptors, Somatostatin, Rats, Wistar, Molecular Biology, Dose-Response Relationship, Drug, Chemistry, Cell Biology, Growth hormone–releasing hormone, Amides, Growth hormone secretion, Rats, medicine.anatomical_structure, Somatostatin, Endocrinology, Growth Hormone, Corticotropic cell, hormones, hormone substitutes, and hormone antagonists
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4
المؤلفون: Bridget Butler, Thomas M. Jacks, Roy G. Smith, Kang Cheng, Patrick P. Pollard, Wanda W.-S. Chan, Meng-Hsin Chen, Arthur A. Patchett, Liente Wei
المصدر: Bioorganic & Medicinal Chemistry Letters. 9:1261-1266
مصطلحات موضوعية: Indoles, Clinical Biochemistry, Pharmaceutical Science, Peptide, Peptide hormone, Growth hormone, Biochemistry, Somatotropin-releasing factor, Chemical synthesis, Dogs, In vivo, Drug Discovery, Animals, Humans, Spiro Compounds, Molecular Biology, chemistry.chemical_classification, Chemistry, Organic Chemistry, In vitro, Rats, Kinetics, Models, Chemical, Growth Hormone, Molecular Medicine, Secretagogue
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5
المؤلفون: Steven M. Hutchins, James M. Schaeffer, Lihu Yang, Wanda W.-S. Chan, Ralph T. Mosley, Alex Pasternak, Min Shu, Sylvia J. Degrado, Scott C. Berk, Forrest Foor, Roy G. Smith, John M. Klopp, Sudha W. Mitra, Arthur A. Patchett, Sheng-Jian Cai, Kevin T. Chapman, Yusheng Xiong, Rupa M. Parmar, Dong-Ming Shen, Allan D. Blake, Elizabeth T. Birzin, Susan P. Rohrer, Edward C. Hayes
المصدر: Science. 282:737-740
مصطلحات موضوعية: endocrine system, medicine.medical_specialty, Molecular Sequence Data, Pharmacology, Biology, Ligands, Somatostatin Receptor Agonist, Cell Line, Islets of Langerhans, Mice, Pituitary Gland, Anterior, Cricetinae, Internal medicine, Insulin Secretion, medicine, Somatostatin receptor 3, Animals, Insulin, Somatostatin receptor 2, Somatostatin receptor 1, Amino Acid Sequence, Receptors, Somatostatin, Receptor, Cells, Cultured, Glucagon-like peptide 1 receptor, Multidisciplinary, Somatostatin receptor, Membrane Proteins, Glucagon, Amides, Rats, Endocrinology, Somatostatin, Models, Chemical, Drug Design, Growth Hormone, hormones, hormone substitutes, and hormone antagonists
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6
المؤلفون: Arthur A. Patchett, Zhijian Lu, Bridget Butler, Thomas M. Jacks, Liente Wei, Gerard J. Hickey, Kang Cheng, Wanda W.-S. Chan, Klaus D. Schleim, James R. Tata
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:3657-3659
مصطلحات موضوعية: Oral dose, Indoles, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Drug Evaluation, Preclinical, Administration, Oral, Pharmaceutical Science, Growth hormone, Biochemistry, Somatotropin-releasing factor, Structure-Activity Relationship, Dogs, In vivo, Drug Discovery, Animals, Spiro Compounds, Amines, Molecular Biology, Biological studies, Chemistry, Organic Chemistry, Amides, In vitro, Rats, Models, Chemical, Drug Design, Growth Hormone, Pituitary Gland, Molecular Medicine
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7
المؤلفون: Nancy N. Tsou, Liente Wei, Zhijian Lu, Gerard J. Hickey, Roy G. Smith, Klaus D. Schleim, James R. Tata, Kwan Leung, Arthur A. Patchett, Shuet-Hing Lee Chiu, Wanda W.-S. Chan, Thomas M. Jacks, Bridget Butler, Kang Cheng
المصدر: Bioorganic & Medicinal Chemistry Letters. 7:2319-2324
مصطلحات موضوعية: Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Growth hormone, Biochemistry, Chemical synthesis, Orally active, Oral administration, Drug Discovery, Molecular Medicine, Molecular Biology, Short duration
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8
المؤلفون: Robert J. De Vita, Wanda W.-S. Chan, Bridget Butler, Alison J. Frontier, Kang Cheng, Michael H. Fisher, Roy G. Smith, William R. Schoen, Matthew J. Wyvratt
المصدر: Helvetica Chimica Acta. 80:1244-1259
مصطلحات موضوعية: Chemistry, Stereochemistry, Organic Chemistry, Growth hormone, Biochemistry, Combinatorial chemistry, Catalysis, Inorganic Chemistry, chemistry.chemical_compound, Drug Discovery, Lead structure, Side chain, Moiety, Physical and Theoretical Chemistry, Pharmacophore, Receptor, Linker, Derivative (chemistry)
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9
المؤلفون: Bridget Butler, Wanda W.-S. Chan, Liente Wei, Roy G. Smith, Marcia M. Murphy, Arthur A. Patchett, Kang Cheng, Gerard J. Hickey, Thomas M. Jacks, Ravi P. Nargund, David B. R. Johnston, James R. Tata
المصدر: Bioorganic & Medicinal Chemistry Letters. 7:663-668
مصطلحات موضوعية: chemistry.chemical_classification, medicine.medical_specialty, Dipeptide, Peptidomimetic, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Peptide, Growth hormone, Biochemistry, Chemical synthesis, In vitro, chemistry.chemical_compound, Endocrinology, chemistry, In vivo, Internal medicine, Drug Discovery, medicine, Molecular Medicine, Molecular Biology
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10
المؤلفون: Arthur A. Patchett, Mark G. Steiner, Bridget Butler, Wanda W.-S. Chan, Liente Wei, Kang Cheng, Meng-Hsin Chen, Roy G. Smith, Thomas M. Jacks
المصدر: Bioorganic & Medicinal Chemistry Letters. 6:2163-2168
مصطلحات موضوعية: medicine.medical_specialty, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Growth hormone, Biochemistry, In vitro, Rat Pituitary, Endocrinology, Orally active, In vivo, Growth hormone secretagogue, Internal medicine, Drug Discovery, medicine, Side chain, Molecular Medicine, Gh release, Molecular Biology