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المؤلفون: Artham S; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Juras PK; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Goyal A; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Chakraborty P; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Byemerwa J; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Liu S; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Wardell SE; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Chakraborty B; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Crowder D; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Lim F; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Strawser CH; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Newlin M; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Racioppi A; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Dent S; Division of Medical Oncology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Mirminachi B; Division of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Roper J; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.; Division of Gastroenterology, Department of Medicine, Duke University School of Medicine, Durham, NC, USA., Perou CM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Chang CY; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., McDonnell DP; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA.

المصدر: Science advances [Sci Adv] 2024 Sep 27; Vol. 10 (39), pp. eadp2442. Date of Electronic Publication: 2024 Sep 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

مواضيع طبية MeSH: Estrogens*/metabolism , Estrogens*/pharmacology , Signal Transduction*/drug effects , Breast Neoplasms*/metabolism , Breast Neoplasms*/pathology , Breast Neoplasms*/drug therapy , Eosinophils*/metabolism , Eosinophilia*/metabolism , Eosinophilia*/pathology , Receptors, Estrogen*/metabolism, Animals ; Female ; Mice ; Humans ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Immune Checkpoint Inhibitors/pharmacology ; Disease Models, Animal

المؤلفون: Safi R; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Wardell SE; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Watkinson P; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Qin X; Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA., Lee M; Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA., Park S; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Krebs T; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Dolan EL; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Blattler A; Oncogenesis Thematic Research Center, Bristol Myers Squibb, San Diego, CA, USA., Tsuji T; Oncogenesis Thematic Research Center, Bristol Myers Squibb, San Diego, CA, USA., Nayak S; Oncogenesis Thematic Research Center, Bristol Myers Squibb, San Diego, CA, USA., Khater M; Informatics and Predictive Sciences, Bristol Myers Squibb, San Diego, CA, USA., Fontanillo C; Informatics and Predictive Sciences, Bristol Myers Squibb, San Diego, CA, USA., Newlin MA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Kirkland ML; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Xie Y; Dana-Farber Cancer Institute, Boston, MA, USA., Long H; Dana-Farber Cancer Institute, Boston, MA, USA., Fink EC; Department of Cancer Biology, Loyola University, Maywood, IL, USA., Fanning SW; Department of Cancer Biology, Loyola University, Maywood, IL, USA., Runyon S; RTI International, Research Triangle Park, NC, USA., Brown M; Dana-Farber Cancer Institute, Boston, MA, USA., Xu S; Oncogenesis Thematic Research Center, Bristol Myers Squibb, San Diego, CA, USA., Owzar K; Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA.; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA., Norris JD; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., McDonnell DP; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA. Donald.McDonnell@duke.edu.

المصدر: Nature communications [Nat Commun] 2024 Sep 03; Vol. 15 (1), pp. 7675. Date of Electronic Publication: 2024 Sep 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Androgen*/metabolism , Receptors, Androgen*/genetics , Prostatic Neoplasms*/metabolism , Prostatic Neoplasms*/pathology , Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/drug therapy , Cell Proliferation*/drug effects , Androgens*/metabolism , Androgens*/pharmacology , Signal Transduction*/drug effects , TOR Serine-Threonine Kinases*/metabolism, Male ; Humans ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/drug effects ; Proto-Oncogene Proteins c-myc/metabolism ; Proto-Oncogene Proteins c-myc/genetics ; Protein Multimerization/drug effects ; Animals

المؤلفون: Mayro B; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710., Hoj JP; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710., Cerda-Smith CG; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710., Hutchinson HM; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710., Caminear MW; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710., Thrash HL; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710., Winter PS; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710., Wardell SE; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710., McDonnell DP; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710.; Duke Cancer Institute, Duke University School of Medicine, Durham, NC 27710., Wu C; Department of Orthopedic Surgery, Duke University School of Medicine, Durham, NC 27710., Wood KC; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710.; Duke Cancer Institute, Duke University School of Medicine, Durham, NC 27710., Pendergast AM; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710.; Duke Cancer Institute, Duke University School of Medicine, Durham, NC 27710.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Apr 18; Vol. 120 (16), pp. e2210418120. Date of Electronic Publication: 2023 Apr 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation* , Transcription Factors*/metabolism, Humans ; Cullin Proteins/metabolism ; Hypoxia ; Phosphorylation ; Protein Serine-Threonine Kinases/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Genes, abl ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Proto-Oncogene Proteins c-myc/metabolism ; Cleavage And Polyadenylation Specificity Factor/metabolism

المؤلفون: Russell S; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA., Lim F; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA., Peters PN; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University School of Medicine, Durham, NC 27710, USA., Wardell SE; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA., Whitaker R; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University School of Medicine, Durham, NC 27710, USA., Chang CY; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA., Previs RA; Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Duke University School of Medicine, Durham, NC 27710, USA., McDonnell DP; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.

المصدر: Cancers [Cancers (Basel)] 2022 Aug 30; Vol. 14 (17). Date of Electronic Publication: 2022 Aug 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Haines CN; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, U.S.A., Wardell SE; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, U.S.A., McDonnell DP; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, U.S.A.

المصدر: Essays in biochemistry [Essays Biochem] 2021 Dec 17; Vol. 65 (6), pp. 985-1001.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 0043306 Publication Model: Print Cited Medium: Internet ISSN: 1744-1358 (Electronic) Linking ISSN: 00711365 NLM ISO Abbreviation: Essays Biochem Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms*/drug therapy , Breast Neoplasms*/metabolism , Receptors, Estrogen*/metabolism , Receptors, Estrogen*/therapeutic use, Aromatase Inhibitors/pharmacology ; Aromatase Inhibitors/therapeutic use ; Female ; Humans ; Selective Estrogen Receptor Modulators/pharmacology ; Selective Estrogen Receptor Modulators/therapeutic use ; Signal Transduction ; Tumor Microenvironment

المؤلفون: Chakraborty B; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Byemerwa J; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Shepherd J; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Haines CN; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Baldi R; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Gong W; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Liu W; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Mukherjee D; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Artham S; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Lim F; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Bae Y; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Brueckner O; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Tavares K; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Wardell SE; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Hanks BA; Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA., Perou CM; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Chang CY; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., McDonnell DP; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA.

المصدر: The Journal of clinical investigation [J Clin Invest] 2021 Dec 01; Vol. 131 (23).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

مواضيع طبية MeSH: Signal Transduction* , Tumor Microenvironment*, Estrogens/*metabolism , Melanoma/*immunology , Myeloid Cells/*metabolism , Skin Neoplasms/*immunology, Animals ; CD8-Positive T-Lymphocytes/cytology ; Cell Line, Tumor ; Estrogen Receptor alpha/metabolism ; Female ; Fulvestrant/pharmacology ; Humans ; Immune System ; Macrophages/metabolism ; Melanoma/metabolism ; Melanoma, Experimental/metabolism ; Mice ; Mice, Inbred C57BL ; Neoplasm Metastasis ; RNA, Small Cytoplasmic/metabolism ; Receptors, Estrogen ; Skin Neoplasms/metabolism