المؤلفون: Kundert, K, Lucas, JE, Watters, KE, Fellmann, C, Ng, AH, Heineike, BM, Fitzsimmons, CM, Oakes, BL, Qu, J, Prasad, N, Rosenberg, OS, Savage, DF, El-Samad, H, Doudna, JA, Kortemme, T

المصدر: Nature communications. 10(1)

مصطلحات موضوعية: DNA, RNA, Guide, Ligands, Aptamers, Nucleotide, CRISPR-Cas Systems, Gene Editing, CRISPR-Associated Protein 9, Biochemistry and Cell Biology, Physical Sciences, Biological Sciences, Biotechnology, Genetics, Generic health relevance, RNA, Guide, Kinetoplastida

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/3t52t2n5

المؤلفون: Sanchez-Roige S; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. sanchezroige@ucsd.edu.; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. sanchezroige@ucsd.edu., Jennings MV; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Thorpe HHA; Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada., Mallari JE; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., van der Werf LC; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Bianchi SB; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Huang Y; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Lee C; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Mallard TT; Psychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Barnes SA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Wu JY; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Barkley-Levenson AM; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Boussaty EC; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Snethlage CE; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Schafer D; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Babic Z; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Winters BD; Department of Psychology, University of Guelph, Guelph, ON, Canada., Watters KE; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.; Department of Neurology, Yale School of Medicine, New Haven, CT, USA., Biederer T; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA., Mackillop J; Peter Boris Centre for Addictions Research, McMaster University and St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada and Homewood Research Institute, Guelph, ON, Canada., Stephens DN; Laboratory of Behavioural and Clinical Neuroscience, School of Psychology, University of Sussex, Brighton, UK., Elson SL; 23andMe, Inc., Sunnyvale, CA, USA., Fontanillas P; 23andMe, Inc., Sunnyvale, CA, USA., Khokhar JY; Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.; Schulich School of Medicine and Dentistry, Western University, London, ON, Canada., Young JW; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA., Palmer AA; Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. aap@ucsd.edu.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA. aap@ucsd.edu.

مؤلفون مشاركون: 23andMe Research Team

المصدر: Translational psychiatry [Transl Psychiatry] 2023 May 12; Vol. 13 (1), pp. 167. Date of Electronic Publication: 2023 May 12.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101562664 Publication Model: Electronic Cited Medium: Internet ISSN: 2158-3188 (Electronic) Linking ISSN: 21583188 NLM ISO Abbreviation: Transl Psychiatry Subsets: MEDLINE

مواضيع طبية MeSH: Genome-Wide Association Study* , Substance-Related Disorders*, Humans ; Animals ; Mice ; Phenotype ; Impulsive Behavior ; Personality/genetics ; Polymorphism, Single Nucleotide ; Cell Adhesion Molecules/genetics

المؤلفون: Watters KE; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA., Kirkpatrick J; Institute for Philosophy and Public Policy, George Mason University, Fairfax, VA, USA., Palmer MJ; Department of Bioengineering, Stanford University, Stanford, CA, USAs., Koblentz GD; Schar School of Policy and Government, George Mason University, Fairfax, VA, USA.

المصدر: Pathogens and global health [Pathog Glob Health] 2021 Mar; Vol. 115 (2), pp. 80-92. Date of Electronic Publication: 2021 Feb 16.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101583421 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2047-7732 (Electronic) Linking ISSN: 20477724 NLM ISO Abbreviation: Pathog Glob Health Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Cas Systems* , Clustered Regularly Interspaced Short Palindromic Repeats* , Global Health*, Gene Editing

المؤلفون: Park L; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, United States of America.; Graduate Program in Cell, Developmental and Molecular Biology, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts, United States of America., Luth ES; Department of Biology, Simmons University, Boston, Massachusetts, United States of America., Jones K; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, United States of America., Hofer J; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, United States of America., Nguyen I; Department of Biology, Simmons University, Boston, Massachusetts, United States of America., Watters KE; Graduate Program in Neuroscience, Graduate School of Biomedical Sciences, Tufts University School of Medicine, Boston, Massachusetts, United States of America., Juo P; Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, United States of America.

المصدر: PloS one [PLoS One] 2021 Feb 02; Vol. 16 (2), pp. e0245587. Date of Electronic Publication: 2021 Feb 02 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Caenorhabditis elegans/*genetics , Caenorhabditis elegans/*metabolism , Caenorhabditis elegans Proteins/*metabolism , DNA-Binding Proteins/*metabolism , Glutamic Acid/*metabolism , Receptors, AMPA/*metabolism , Signal Transduction/*genetics , Snail Family Transcription Factors/*metabolism , Transcription Factors/*metabolism, Animals ; Animals, Genetically Modified ; Caenorhabditis elegans Proteins/genetics ; DNA-Binding Proteins/genetics ; Gain of Function Mutation ; Interneurons/metabolism ; Locomotion/genetics ; Loss of Function Mutation ; Neuronal Plasticity/genetics ; RNA Interference ; Sensory Receptor Cells/metabolism ; Snail Family Transcription Factors/genetics ; Synapses/metabolism ; Transcription Factors/genetics ; Transgenes

المؤلفون: Eitzinger S; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA., Asif A; Department of Computer and Information Sciences, Pakistan Institute of Engineering and Applied Sciences (PIEAS), PO Nilore, Islamabad, Pakistan.; FAST School of Computing, National University of Computer and Emerging Sciences (NUCES), Islamabad, Pakistan., Watters KE; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA., Iavarone AT; QB3/Chemistry Mass Spectrometry Facility, University of California, Berkeley, Berkeley, CA 94720, USA., Knott GJ; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA., Doudna JA; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA.; Department of Chemistry, University of California Berkeley, Berkeley, CA 94720, USA.; Innovative Genomics Institute, University of California Berkeley, Berkeley, CA 94720, USA.; Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA 94158.; Howard Hughes Medical Institute, University of California Berkeley, Berkeley, CA 94720, USA.; Molecular Biophysics & Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA., Minhas FUAA; Department of Computer and Information Sciences, Pakistan Institute of Engineering and Applied Sciences (PIEAS), PO Nilore, Islamabad, Pakistan.; Department of Computer Science, University of Warwick, Coventry, CV4 7AL, UK.

المصدر: Nucleic acids research [Nucleic Acids Res] 2020 May 21; Vol. 48 (9), pp. 4698-4708.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

مواضيع طبية MeSH: Machine Learning*, Bacterial Proteins/*genetics , CRISPR-Associated Protein 9/*antagonists & inhibitors, Bacterial Proteins/chemistry ; Prophages/genetics ; Proteome ; Sequence Analysis, Protein ; Streptococcus/enzymology ; Streptococcus/genetics

المؤلفون: Watters KE; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720., Shivram H; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720., Fellmann C; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720.; Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA 94158.; Department of Cellular and Molecular Pharmacology, School of Medicine, University of California, San Francisco, CA 94158., Lew RJ; Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA 94158., McMahon B; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720., Doudna JA; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720; doudna@berkeley.edu.; Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA 94158.; Department of Chemistry, University of California, Berkeley, CA 94720.; Howard Hughes Medical Institute, University of California, Berkeley, CA 94720.; Innovative Genomics Institute, University of California, Berkeley, CA 94720.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Mar 24; Vol. 117 (12), pp. 6531-6539. Date of Electronic Publication: 2020 Mar 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Cas Systems*/genetics, Bacterial Proteins/*metabolism , CRISPR-Associated Protein 9/*antagonists & inhibitors , Enzyme Inhibitors/*metabolism , Staphylococcus/*genetics, Amino Acid Sequence ; Bacterial Proteins/genetics ; CRISPR-Associated Protein 9/genetics ; CRISPR-Associated Protein 9/metabolism ; Conserved Sequence ; DNA/metabolism ; Gene Editing ; Genome, Bacterial/genetics ; HEK293 Cells ; Humans ; Inverted Repeat Sequences ; Staphylococcus/chemistry ; Staphylococcus aureus/enzymology

المؤلفون: Carbone BE; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA., Abouleish M; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA., Watters KE; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA., Vogel S; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA., Ribic A; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA., Schroeder OH; NeuroProof GmbH, Friedrich Barnewitz-Str. 4, Rostock, Germany., Bader BM; NeuroProof GmbH, Friedrich Barnewitz-Str. 4, Rostock, Germany., Biederer T; Department of Neuroscience, Tufts University School of Medicine, Boston, MA, USA.

المصدر: Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2020 Jan 10; Vol. 30 (1), pp. 226-240.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9110718 Publication Model: Print Cited Medium: Internet ISSN: 1460-2199 (Electronic) Linking ISSN: 10473211 NLM ISO Abbreviation: Cereb Cortex Subsets: MEDLINE

مواضيع طبية MeSH: Docosahexaenoic Acids/*administration & dosage , Neurons/*drug effects , Neurons/*physiology , Synapses/*drug effects , Synapses/*physiology , Visual Cortex/*drug effects , Visual Cortex/*growth & development, Animals ; Cells, Cultured ; Dendrites/drug effects ; Dendrites/physiology ; Mice, Inbred C57BL ; Neural Pathways/cytology ; Neural Pathways/drug effects ; Neural Pathways/physiology ; Neurons/cytology ; Visual Acuity/physiology

المؤلفون: Knott GJ; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Thornton BW; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Lobba MJ; Department of Chemistry, University of California, Berkeley, CA, USA., Liu JJ; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Al-Shayeb B; Department of Plant and Microbial Biology, University of California, Berkeley, CA, USA., Watters KE; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA., Doudna JA; Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA. doudna@berkeley.edu.; Department of Chemistry, University of California, Berkeley, CA, USA. doudna@berkeley.edu.; Molecular Biophysics & Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. doudna@berkeley.edu.; Gladstone Institutes, San Francisco, CA, USA. doudna@berkeley.edu.; Howard Hughes Medical Institute, University of California, Berkeley, CA, USA. doudna@berkeley.edu.; Innovative Genomics Institute, University of California, Berkeley, CA, USA. doudna@berkeley.edu.

المصدر: Nature structural & molecular biology [Nat Struct Mol Biol] 2019 Apr; Vol. 26 (4), pp. 315-321. Date of Electronic Publication: 2019 Apr 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Cas Systems/*physiology, Adaptive Immunity/genetics ; Adaptive Immunity/physiology ; CRISPR-Cas Systems/genetics ; DNA Cleavage ; Endoribonucleases/genetics ; Endoribonucleases/metabolism ; Gene Editing/methods ; Protein Multimerization/genetics ; Protein Multimerization/physiology

المؤلفون: Watters KE; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Fellmann C; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.; Gladstone Institutes, San Francisco, CA 94158, USA., Bai HB; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Ren SM; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA., Doudna JA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA. doudna@berkeley.edu.; Gladstone Institutes, San Francisco, CA 94158, USA.; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.; Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.; Li Ka Shing Biomedical and Health Sciences Center, University of California, Berkeley, Berkeley, CA 94720, USA.; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

المصدر: Science (New York, N.Y.) [Science] 2018 Oct 12; Vol. 362 (6411), pp. 236-239. Date of Electronic Publication: 2018 Sep 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Cas Systems* , Gene Editing*, Bacterial Proteins/*antagonists & inhibitors , Endonucleases/*antagonists & inhibitors , Moraxella/*genetics, Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Cell Line ; Computational Biology/methods ; DNA Cleavage ; Genome, Bacterial ; Humans

المؤلفون: Watters KE; Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA., Choudhary K; Department of Biomedical Engineering and Genome Center, University of California Davis, Davis, CA, USA., Aviran S; Department of Biomedical Engineering and Genome Center, University of California Davis, Davis, CA, USA., Lucks JB; Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60201, USA., Perry KL; Plant Pathology and Plant-Microbe Biology Section, School of Integrative Plant Science, Cornell University, Ithaca, NY, USA., Thompson JR; Plant Pathology and Plant-Microbe Biology Section, School of Integrative Plant Science, Cornell University, Ithaca, NY, USA.

المصدر: Nucleic acids research [Nucleic Acids Res] 2018 Mar 16; Vol. 46 (5), pp. 2573-2584.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

مواضيع طبية MeSH: Cucumovirus/*genetics , RNA, Viral/*chemistry, Mutation ; Nucleic Acid Conformation