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لا يتم عرض هذه النتيجة على الضيوف.
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المؤلفون: Liu B; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA., Dong X; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Tessera Therapeutics, Somerville, MA, USA., Zheng C; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA., Keener D; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA., Chen Z; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA., Cheng H; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA., Watts JK; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Xue W; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA. wen.xue@umassmed.edu.; Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA, USA. wen.xue@umassmed.edu.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. wen.xue@umassmed.edu.; Department of Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. wen.xue@umassmed.edu., Sontheimer EJ; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA. erik.sontheimer@umassmed.edu.; Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA, USA. erik.sontheimer@umassmed.edu.; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA. erik.sontheimer@umassmed.edu.; Department of Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. erik.sontheimer@umassmed.edu.

المصدر: Nature biotechnology [Nat Biotechnol] 2024 Jul; Vol. 42 (7), pp. 1039-1045. Date of Electronic Publication: 2023 Sep 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Gene Editing*/methods , DNA-Directed DNA Polymerase*/metabolism , DNA-Directed DNA Polymerase*/genetics , DNA*/genetics, Humans ; Templates, Genetic ; CRISPR-Cas Systems/genetics

المؤلفون: Sarli SL; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA., Fakih HH; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA., Kelly K; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA., Devi G; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA., Rembetsy-Brown JM; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA., McEachern HR; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA., Ferguson CM; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA., Echeverria D; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA., Lee J; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA., Sousa J; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA., Sleiman HF; Department of Chemistry, McGill University, Montréal, Québec, Canada., Khvorova A; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Watts JK; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, USA.

المصدر: Nucleic acids research [Nucleic Acids Res] 2024 May 22; Vol. 52 (9), pp. 4799-4817.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

مواضيع طبية MeSH: Glioblastoma*/genetics , Glioblastoma*/metabolism , Glioblastoma*/pathology , RNA, Small Interfering*/genetics , RNA, Small Interfering*/chemistry , RNA, Small Interfering*/metabolism , RNA, Small Interfering*/therapeutic use , Xenograft Model Antitumor Assays* , Brain Neoplasms*/genetics , Oligonucleotides, Antisense*/chemistry , Oligonucleotides, Antisense*/therapeutic use, Animals ; Humans ; Mice ; Cell Line, Tumor ; Gene Silencing ; Mice, Nude

المؤلفون: Fang M; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, United States., Deibler SK; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, United States., Krishnamurthy PM; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, United States., Wang F; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, United States., Rodriguez P; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, United States., Banday S; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, United States., Virbasius CM; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, United States., Sena-Esteves M; Department of Neurology, University of Massachusetts Chan Medical School, Worcester, MA, United States., Watts JK; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, United States., Green MR; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, United States.

المصدر: Frontiers in neuroscience [Front Neurosci] 2024 Feb 21; Vol. 18, pp. 1348478. Date of Electronic Publication: 2024 Feb 21 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101478481 Publication Model: eCollection Cited Medium: Print ISSN: 1662-4548 (Print) Linking ISSN: 1662453X NLM ISO Abbreviation: Front Neurosci Subsets: PubMed not MEDLINE

المؤلفون: Bamidele N; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Zhang H; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Dong X; Tessera Therapeutics, Somerville, MA, 02143, USA., Cheng H; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Gaston N; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Feinzig H; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Cao H; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Kelly K; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Watts JK; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Xie J; Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.; Viral Vector Core, University of Massachusetts Chan Medical, School, Worcester, MA, 01605, USA.; Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.; Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Gao G; Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.; Viral Vector Core, University of Massachusetts Chan Medical, School, Worcester, MA, 01605, USA.; Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.; Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA., Sontheimer EJ; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA. erik.sontheimer@umassmed.edu.; Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA. erik.sontheimer@umassmed.edu.; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Massachusetts, MA, 01605, USA. erik.sontheimer@umassmed.edu.

المصدر: Nature communications [Nat Commun] 2024 Feb 17; Vol. 15 (1), pp. 1458. Date of Electronic Publication: 2024 Feb 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Associated Protein 9*/genetics , CRISPR-Associated Protein 9*/metabolism , Adenine*/metabolism, Gene Editing ; DNA/genetics ; CRISPR-Cas Systems

المؤلفون: Zhang H; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Kelly K; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Lee J; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Echeverria D; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Cooper D; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Panwala R; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Amrani N; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Chen Z; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Gaston N; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Wagh A; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Newby GA; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02139, USA., Xie J; Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Viral Vector Core, University of Massachusetts Chan Medical, School, Worcester, MA 01605, USA.; Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Liu DR; Merkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02139, USA., Gao G; Horae Gene Therapy Center, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Viral Vector Core, University of Massachusetts Chan Medical, School, Worcester, MA 01605, USA.; Department of Microbiology and Physiological Systems, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Wolfe SA; Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Khvorova A; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Watts JK; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; NeuroNexus Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Sontheimer EJ; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.; Li Weibo Institute for Rare Diseases Research, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA.

المصدر: Nucleic acids research [Nucleic Acids Res] 2024 Jan 25; Vol. 52 (2), pp. 977-997.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

مواضيع طبية MeSH: Gene Editing* , RNA, Guide, CRISPR-Cas Systems*, Animals ; Mice ; Tissue Distribution ; RNA/genetics ; Oligonucleotides