لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

المؤلفون: Nilewski C; eFFECTOR Therapeutics, 11120 Roselle Street, Suite A, San Diego, CA 92121, United States. Electronic address: nilewski.christian@gene.com., Michels TD; eFFECTOR Therapeutics, 11120 Roselle Street, Suite A, San Diego, CA 92121, United States., Packard GK; eFFECTOR Therapeutics, 11120 Roselle Street, Suite A, San Diego, CA 92121, United States., Xiang AX; eFFECTOR Therapeutics, 11120 Roselle Street, Suite A, San Diego, CA 92121, United States., Sprengeler PA; eFFECTOR Therapeutics, 11120 Roselle Street, Suite A, San Diego, CA 92121, United States., Eam B; eFFECTOR Therapeutics, 11120 Roselle Street, Suite A, San Diego, CA 92121, United States., Fish S; eFFECTOR Therapeutics, 11120 Roselle Street, Suite A, San Diego, CA 92121, United States., Thompson PA; eFFECTOR Therapeutics, 11120 Roselle Street, Suite A, San Diego, CA 92121, United States., Wegerski CJ; eFFECTOR Therapeutics, 11120 Roselle Street, Suite A, San Diego, CA 92121, United States., Nevarez A; eFFECTOR Therapeutics, 11120 Roselle Street, Suite A, San Diego, CA 92121, United States., Clarine J; eFFECTOR Therapeutics, 11120 Roselle Street, Suite A, San Diego, CA 92121, United States., Sperry S; eFFECTOR Therapeutics, 11120 Roselle Street, Suite A, San Diego, CA 92121, United States., Ernst JT; eFFECTOR Therapeutics, 11120 Roselle Street, Suite A, San Diego, CA 92121, United States., Reich SH; eFFECTOR Therapeutics, 11120 Roselle Street, Suite A, San Diego, CA 92121, United States.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 Sep 01; Vol. 47, pp. 128111. Date of Electronic Publication: 2021 Aug 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Benzofurans/*pharmacology , Biological Products/*pharmacology , Eukaryotic Initiation Factor-4A/*antagonists & inhibitors , Triterpenes/*pharmacology, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Benzofurans/chemical synthesis ; Benzofurans/chemistry ; Biological Products/chemical synthesis ; Biological Products/chemistry ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Design ; Drug Screening Assays, Antitumor ; Eukaryotic Initiation Factor-4A/metabolism ; Humans ; Molecular Structure ; Structure-Activity Relationship ; Triterpenes/chemical synthesis ; Triterpenes/chemistry

المؤلفون: Thompson PA; eFFECTOR Therapeutics, Inc., San Diego, California. pthompson@effector.com., Eam B; eFFECTOR Therapeutics, Inc., San Diego, California., Young NP; eFFECTOR Therapeutics, Inc., San Diego, California., Fish S; eFFECTOR Therapeutics, Inc., San Diego, California., Chen J; eFFECTOR Therapeutics, Inc., San Diego, California., Barrera M; eFFECTOR Therapeutics, Inc., San Diego, California., Howard H; eFFECTOR Therapeutics, Inc., San Diego, California., Sung E; eFFECTOR Therapeutics, Inc., San Diego, California., Parra A; eFFECTOR Therapeutics, Inc., San Diego, California., Staunton J; eFFECTOR Therapeutics, Inc., San Diego, California., Chiang GG; eFFECTOR Therapeutics, Inc., San Diego, California., Gerson-Gurwitz A; eFFECTOR Therapeutics, Inc., San Diego, California., Wegerski CJ; eFFECTOR Therapeutics, Inc., San Diego, California., Nevarez A; eFFECTOR Therapeutics, Inc., San Diego, California., Clarine J; eFFECTOR Therapeutics, Inc., San Diego, California., Sperry S; eFFECTOR Therapeutics, Inc., San Diego, California., Xiang A; eFFECTOR Therapeutics, Inc., San Diego, California., Nilewski C; eFFECTOR Therapeutics, Inc., San Diego, California., Packard GK; eFFECTOR Therapeutics, Inc., San Diego, California., Michels T; eFFECTOR Therapeutics, Inc., San Diego, California., Tran C; eFFECTOR Therapeutics, Inc., San Diego, California., Sprengeler PA; eFFECTOR Therapeutics, Inc., San Diego, California., Ernst JT; eFFECTOR Therapeutics, Inc., San Diego, California., Reich SH; eFFECTOR Therapeutics, Inc., San Diego, California., Webster KR; eFFECTOR Therapeutics, Inc., San Diego, California.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2021 Jan; Vol. 20 (1), pp. 26-36. Date of Electronic Publication: 2020 Oct 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Oncogenes*, Eukaryotic Initiation Factor-4A/*antagonists & inhibitors , Lymphoma, B-Cell/*genetics , Lymphoma, B-Cell/*pathology , Protein Biosynthesis/*genetics , RNA, Messenger/*genetics, Animals ; Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; Drug Resistance, Neoplasm/drug effects ; Eukaryotic Initiation Factor-4A/metabolism ; Female ; Humans ; Mice, Inbred NOD ; Mice, SCID ; PTEN Phosphohydrolase/metabolism ; RNA, Messenger/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Xenograft Model Antitumor Assays ; Mice

المؤلفون: Nilewski C; eFFECTOR Therapeutics, 11180 Roselle Street, Suite A, San Diego, California 92121, United States., Michels TD; eFFECTOR Therapeutics, 11180 Roselle Street, Suite A, San Diego, California 92121, United States., Xiang AX; eFFECTOR Therapeutics, 11180 Roselle Street, Suite A, San Diego, California 92121, United States., Packard GK; eFFECTOR Therapeutics, 11180 Roselle Street, Suite A, San Diego, California 92121, United States., Sprengeler PA; eFFECTOR Therapeutics, 11180 Roselle Street, Suite A, San Diego, California 92121, United States., Eam B; eFFECTOR Therapeutics, 11180 Roselle Street, Suite A, San Diego, California 92121, United States., Fish S; eFFECTOR Therapeutics, 11180 Roselle Street, Suite A, San Diego, California 92121, United States., Thompson PA; eFFECTOR Therapeutics, 11180 Roselle Street, Suite A, San Diego, California 92121, United States., Wegerski CJ; eFFECTOR Therapeutics, 11180 Roselle Street, Suite A, San Diego, California 92121, United States., Ernst JT; eFFECTOR Therapeutics, 11180 Roselle Street, Suite A, San Diego, California 92121, United States., Reich SH; eFFECTOR Therapeutics, 11180 Roselle Street, Suite A, San Diego, California 92121, United States.

المصدر: Organic letters [Org Lett] 2020 Aug 21; Vol. 22 (16), pp. 6257-6261. Date of Electronic Publication: 2020 Jul 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: MEDLINE

مواضيع طبية MeSH: Benzofurans/*chemistry , Eukaryotic Initiation Factor-4A/*antagonists & inhibitors, Binding Sites ; Biological Products ; Eukaryotic Initiation Factor-4A/metabolism ; Humans ; Molecular Structure

المؤلفون: Garner CE; Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA., Wegerski CJ; Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA., Doyle-Eisele M; Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA., McDonald JD; Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA., Sanders JM; Division of National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA., Moeller BC; Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA., Waidyanatha S; Division of National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.

المصدر: Toxicology reports [Toxicol Rep] 2020 Jul 23; Vol. 7, pp. 883-892. Date of Electronic Publication: 2020 Jul 23 (Print Publication: 2020).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Ireland Ltd Country of Publication: Ireland NLM ID: 101630272 Publication Model: eCollection Cited Medium: Internet ISSN: 2214-7500 (Electronic) Linking ISSN: 22147500 NLM ISO Abbreviation: Toxicol Rep Subsets: PubMed not MEDLINE

المؤلفون: Ernst JT; Inception Therapeutics, 6175 Nancy Ridge Drive, San Diego, California 92121, United States., Thompson PA; eFFECTOR Therapeutics, 11180 Roselle Street, San Diego, California 92121, United States., Nilewski C; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Sprengeler PA; eFFECTOR Therapeutics, 11180 Roselle Street, San Diego, California 92121, United States., Sperry S; eFFECTOR Therapeutics, 11180 Roselle Street, San Diego, California 92121, United States., Packard G; Inception Therapeutics, 6175 Nancy Ridge Drive, San Diego, California 92121, United States., Michels T; GossamerBio., 3013 Science Park Road, San Diego, California 92121, United States., Xiang A; WuXi AppTec, 6114 Nancy Ridge Drive, San Diego, California 92121, United States., Tran C; eFFECTOR Therapeutics, 11180 Roselle Street, San Diego, California 92121, United States., Wegerski CJ; eFFECTOR Therapeutics, 11180 Roselle Street, San Diego, California 92121, United States., Eam B; Calporta Therapeutics, 11099 North Torrey Poines Rd., La Jolla, California 92037, United States., Young NP; Casma Therapeutics, 400 Technology Square, Cambridge, California 02139, United States., Fish S; Plexium, Inc., 11585 Sorrento Valley Rd., San Diego, California 92121, United States., Chen J; eFFECTOR Therapeutics, 11180 Roselle Street, San Diego, California 92121, United States., Howard H; Providence Portland Medical Center, 4805 NE Glisan Street, Portland, Oregon 97213, United States., Staunton J; eFFECTOR Therapeutics, 11180 Roselle Street, San Diego, California 92121, United States., Molter J; eFFECTOR Therapeutics, 11180 Roselle Street, San Diego, California 92121, United States., Clarine J; GossamerBio., 3013 Science Park Road, San Diego, California 92121, United States., Nevarez A; Escient Pharmaceuticals, 10578 Science Center Dr., San Diego, California 92121, United States., Chiang GG; eFFECTOR Therapeutics, 11180 Roselle Street, San Diego, California 92121, United States., Appleman JR; Primmune Therapeutics, 3210 Merryfield Row, San Diego, California 92121, United States., Webster KR; Frontier Medicines Corp., 151 Oyster Point Blvd., South San Francisco, California 94080, United States., Reich SH; eFFECTOR Therapeutics, 11180 Roselle Street, San Diego, California 92121, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2020 Jun 11; Vol. 63 (11), pp. 5879-5955. Date of Electronic Publication: 2020 May 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Benzofurans/*chemistry , Eukaryotic Initiation Factor-4A/*antagonists & inhibitors, Animals ; Benzofurans/pharmacokinetics ; Benzofurans/therapeutic use ; Binding Sites ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Crystallography, X-Ray ; Eukaryotic Initiation Factor-4A/genetics ; Eukaryotic Initiation Factor-4A/metabolism ; Female ; Half-Life ; Humans ; Ligands ; Mice ; Mice, Nude ; Molecular Dynamics Simulation ; Mutagenesis, Site-Directed ; Protein Structure, Tertiary ; RNA, Messenger/chemistry ; RNA, Messenger/metabolism ; Rats ; Structure-Activity Relationship

المؤلفون: Mutlu E; National Institute of Environmental Health Sciences, Durham, NC, USA., Garner CE; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA., Wegerski CJ; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA., McDonald JD; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA., McIntyre BS; National Institute of Environmental Health Sciences, Durham, NC, USA., Doyle-Eisele M; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA., Waidyanatha S; National Institute of Environmental Health Sciences, Durham, NC, USA.

المصدر: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2020 Jun; Vol. 50 (6), pp. 689-704. Date of Electronic Publication: 2019 Oct 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1366-5928 (Electronic) Linking ISSN: 00498254 NLM ISO Abbreviation: Xenobiotica Subsets: MEDLINE

مواضيع طبية MeSH: Benzophenones/*metabolism , Sunscreening Agents/*metabolism, Animals ; Humans ; Mice ; Mice, Inbred Strains ; Rats ; Rats, Sprague-Dawley

المؤلفون: Shipkowski KA; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States of America., Sanders JM; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States of America., McDonald JD; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, United States of America., Garner CE; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, United States of America., Doyle-Eisele M; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, United States of America., Wegerski CJ; Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, United States of America., Waidyanatha S; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States of America. Electronic address: waidyanathas@niehs.nih.gov.

المصدر: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2019 Sep 01; Vol. 378, pp. 114592. Date of Electronic Publication: 2019 May 14.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Choline/*administration & dosage , Choline/*metabolism , Deanol/*administration & dosage , Deanol/*metabolism, Administration, Intravenous ; Administration, Oral ; Animals ; Dimethylnitrosamine/metabolism ; Female ; Male ; Mice ; Rats ; Rats, Wistar ; Tissue Distribution/physiology

المؤلفون: Reich SH; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Sprengeler PA; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Chiang GG; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Appleman JR; Primmune Therapeutics, Inc. , 3210 Merryfield Row , San Diego , California 92121 , United States., Chen J; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Clarine J; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Eam B; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Ernst JT; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Han Q; Structure-Based Design, Inc. , 6048 Cornerstone Court West #D , San Diego , California 92121 , United States., Goel VK; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Han EZR; Structure-Based Design, Inc. , 6048 Cornerstone Court West #D , San Diego , California 92121 , United States., Huang V; Molecular Stethoscope , 10835 Road to the Cure #100 , San Diego , California 92121 , United States., Hung INJ; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Jemison A; Department of Chemistry , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104 , United States., Jessen KA; Oncternal Therapeutics , 3525 Del Mar Heights Road #821 , San Diego , California 92130 , United States., Molter J; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Murphy D; Molcentrics, Inc. , 11835 Carmel Mountain Road #1304-110 , San Diego , California 92128 , United States., Neal M; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Parker GS; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Shaghafi M; Abide Therapeutics , 10835 Road to the Cure, Suite 250 , San Diego , California 92121 , United States., Sperry S; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Staunton J; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Stumpf CR; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Thompson PA; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Tran C; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Webber SE; Polaris Pharmaceuticals , 9373 Towne Centre Drive #150 , San Diego , California 92121 , United States., Wegerski CJ; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States., Zheng H; Structure-Based Design, Inc. , 6048 Cornerstone Court West #D , San Diego , California 92121 , United States., Webster KR; eFFECTOR Therapeutics , 11180 Roselle Street , San Diego , California 92121 , United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2018 Apr 26; Vol. 61 (8), pp. 3516-3540. Date of Electronic Publication: 2018 Mar 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*therapeutic use , Intracellular Signaling Peptides and Proteins/*antagonists & inhibitors , Protein Kinase Inhibitors/*therapeutic use , Protein Serine-Threonine Kinases/*antagonists & inhibitors , Pyridines/*therapeutic use , Pyridones/*therapeutic use , Pyrimidines/*therapeutic use , Spiro Compounds/*therapeutic use, Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Catalytic Domain ; Cell Line, Tumor ; Drug Design ; Eukaryotic Initiation Factor-4E/chemistry ; Eukaryotic Initiation Factor-4E/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Mice ; Molecular Structure ; Phosphorylation ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Protein Serine-Threonine Kinases/metabolism ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Pyridines/pharmacology ; Pyridones/chemical synthesis ; Pyridones/chemistry ; Pyridones/pharmacology ; Pyrimidines/chemical synthesis ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; Rats ; Serine/chemistry ; Signal Transduction/drug effects ; Spiro Compounds/chemical synthesis ; Spiro Compounds/chemistry ; Spiro Compounds/pharmacology ; Xenograft Model Antitumor Assays

المؤلفون: Waidyanatha S; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States. Electronic address: waidyanathas@niehs.nih.gov., Ryan K; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States., Sanders JM; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States., McDonald JD; Lovelace Respiratory Research Institute, Albuquerque, NM, United States., Wegerski CJ; Lovelace Respiratory Research Institute, Albuquerque, NM, United States., Doyle-Eisle M; Lovelace Respiratory Research Institute, Albuquerque, NM, United States., Garner CE; Lovelace Respiratory Research Institute, Albuquerque, NM, United States.

المصدر: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2018 Jan 15; Vol. 339, pp. 151-160. Date of Electronic Publication: 2017 Dec 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Amino Acids, Diamino/*administration & dosage , Amino Acids, Diamino/*metabolism , Excitatory Amino Acid Agonists/*administration & dosage , Excitatory Amino Acid Agonists/*metabolism , Neurotoxins/*administration & dosage , Neurotoxins/*metabolism, Administration, Oral ; Animals ; Cyanobacteria Toxins ; Drug Administration Schedule ; Female ; Male ; Mice ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; Rodentia ; Tissue Distribution/drug effects ; Tissue Distribution/physiology