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1
المؤلفون: Ching Kim Tye, Chunhong Yan, Sarah C. Traeger, Wayne Vaccaro, Yingru Zhang, Gerry Everlof, Jianqing Li, Henry Yip, Peng Li, John T. Hunt, Michael A. Poss, Gregory D. Vite, Mussari Christopher P, Steven Sheriff, Asoka Ranasinghe, Haiying Zhang, Richard A. Westhouse, Dharmpal S. Dodd, Richard Rampulla, Zheng Yang, Frank Marsilio, Derek J. Norris, Wen-Ching Han, Tram N. Huynh, Yufen Zhao, Patrice Gill, Nirmala Raghavan, Lalgudi S. Harikrishnan, Ashvinikumar V. Gavai, Susan Wee, John S. Tokarski, Dauh-Rurng Wu, Arvind Mathur, Mei-Li Wen, Huiping Zhang, David R. Tortolani, George V. Delucca, Krista Menard, Francis Y. Lee, Claude A. Quesnelle, Dawn Sun, Vijay T. Ahuja, Daniel O'malley, Christine Huang, Muthoni G. Kamau
المصدر: Journal of Medicinal Chemistry. 64:14247-14265
مصطلحات موضوعية: Drug, Proline, Phenylalanine, media_common.quotation_subject, Carbazoles, Administration, Oral, Antineoplastic Agents, Cell Cycle Proteins, Computational biology, BET inhibitor, Structure-Activity Relationship, Pharmacokinetics, In vivo, Drug Discovery, Transcriptional regulation, Humans, Potency, media_common, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Tryptophan, Signal transducing adaptor protein, Bromodomain, Molecular Medicine, Transcription Factors
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2دورية أكاديمية
المؤلفون: Gavai, Ashvinikumar V., Norris, Derek, Delucca, George, Tortolani, David, Tokarski, John S., Dodd, Dharmpal, O'Malley, Daniel, Yufen Zhao, Quesnelle, Claude, Gill, Patrice, Vaccaro, Wayne, Huynh, Tram, Ahuja, Vijay, Wen-Ching Han, Mussari, Christopher, Harikrishnan, Lalgudi, Kamau, Muthoni, Poss, Michael, Sheriff, Steven, Chunhong Yan
المصدر: Journal of Medicinal Chemistry; 10/14/2021, Vol. 64 Issue 19, p14247-14265, 19p
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3
المؤلفون: George L. Trainor, Jun Dai, Arvind Mathur, Francis Y. Lee, Sunilkumar Mandal, Yingru Zhang, Richard Rampulla, Kiran Babu Gona, Patrice Gill, Raja Thiruvenkadam, Victor R. Guarino, Wen-Ching Han, Ding Ren Shen, Aaron Balog, Mary Ellen Cvijic, Dauh-Rurng Wu, Gregory D. Vite, Krista Menard, Anne Rose, Sathiah Kandula, Ashvinikumar V. Gavai, Weifang Shan, John T. Hunt, Asoka Ranasinghe, Kelly McGlinchey, Richard A. Westhouse, Claude A. Quesnelle, Derek J. Norris, Mei-Li Wen, Ronald E. White, Kamalraj Thiyagarajan
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:1905-1909
مصطلحات موضوعية: Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Receptor, Solid tumor, Molecular Biology, Cell Proliferation, Benzodiazepinones, Dose-Response Relationship, Drug, Molecular Structure, Receptors, Notch, Chemistry, Organic Chemistry, Biological activity, Neoplasms, Experimental, medicine.disease, Leukemia, Orally active, Microsomes, Liver, Molecular Medicine, Drug Screening Assays, Antitumor
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4
المؤلفون: Claude A. Quesnelle, Patrice Gill, Richard Rampulla, Ching Su, Gerry Everlof, George L. Trainor, Ke Chen, Vinod Arora, Richard A. Westhouse, Celia D’Arienzo, Andrew J. Tebben, Weifang Shan, John T. Hunt, Derek J. Norris, Louis J. Lombardo, Zheng Yang, Arvind Mathur, Mei-Li Wen, Yingru Zhang, Dauh-Rurng Wu, Wen-Ching Han, Krista Menard, Victor R. Guarino, Asoka Ranasinghe, Richard E. Olson, Ashvinikumar V. Gavai, Bruce S. Fischer, Phil S. Baran, Anne Rose, Lan Xiao, Ronald E. White, Mary Ellen Cvijic, Gregory D. Vite, Ding Ren Shen, Jere E. Meredith, Haiqing Wang, Francis Y. Lee, Aaron Balog
المصدر: ACS Medicinal Chemistry Letters. 6:523-527
مصطلحات موضوعية: business.industry, Organic Chemistry, Pharmacology, medicine.disease, Biochemistry, T Acute Lymphoblastic Leukemia, Leukemia, In vivo, Drug Discovery, medicine, Receptor, business, Solid tumor, Clinical evaluation, Triple-negative breast cancer
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5
المؤلفون: Hai-Yun Xiao, Jieping Geng, David J. Fairfax, Thomas E. Spires, Wen-Ching Han, Marco M. Gottardis, Mark E. Salvati, Andrew Nation, Weifang Shan, Mary-Ellen Cvjic, Jing Chen, Liang Schweizer, Mary T. Obermeier, Gregory Scott Martin, Ricardo M. Attar, Gregory D. Vite, Aaron Balog, Ashvinikumar V. Gavai, Janet Dell-John, Cheryl A. Rizzo, Lana M. Rossiter, Linda B. Fleming, Christian L. Holst
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:4491-4495
مصطلحات موضوعية: Male, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Antiandrogen, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Cell Line, Tumor, Nitriles, Drug Discovery, medicine, Humans, Androgen Receptor Antagonists, Imide, Molecular Biology, Trifluoromethyl, Chemistry, Organic Chemistry, Prostatic Neoplasms, In vitro, Androgen receptor, Receptors, Androgen, Drug Design, Molecular Medicine
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6
المؤلفون: Hongjian Zhang, Brian E. Fink, David R. Langley, Harold Mastalerz, Ming Chang, Punit Marathe, Simone Oppenheimer, Dolatrai M. Vyas, Ping Chen, Bogdan Sleczka, John S. Tokarski, Francis Y. Lee, Kenneth J. Leavitt, Johnson Walter Lewis, Wen-Ching Han, Tai W. Wong, Ashvinikumar V. Gavai, Guifen Zhang, Henry Wong, Gregory D. Vite, Tarrant James G, Derek J. Norris
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:4947-4954
مصطلحات موضوعية: Insecta, Molecular model, Receptor, ErbB-2, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Adenosine Triphosphate, Piperidines, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, Pyrroles, Epidermal growth factor receptor, Molecular Biology, chemistry.chemical_classification, biology, Triazines, Chemistry, Kinase, Organic Chemistry, In vitro, ErbB Receptors, Enzyme, Models, Chemical, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor, Signal transduction, Neoplasm Transplantation
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7
المؤلفون: Pierre Dextraze, Gregory D. Vite, Arvind Mathur, Ashvinikumar V. Gavai, Simone Oppenheimer, Ping Chen, John S. Tokarski, Tai W. Wong, Francis Y. Lee, Harold Mastalerz, Henry Wong, Wen-Ching Han, Johnson Walter Lewis, Guifen Zhang, David R. Langley, Brian E. Fink, Tarrant James G, Ming Chang, Hongjian Zhang, Bindu Goyal, Ruediger Edward H, Punit Marathe, Dolatrai M. Vyas
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:2036-2042
مصطلحات موضوعية: Receptor, ErbB-2, Chemistry, Pharmaceutical, Ribose, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Phosphates, Inhibitory Concentration 50, Mice, chemistry.chemical_compound, Adenosine Triphosphate, Growth factor receptor, Morpholine, Drug Discovery, Animals, Humans, Pyrroles, Epidermal growth factor receptor, Enzyme Inhibitors, Binding site, Molecular Biology, chemistry.chemical_classification, biology, Triazines, Chemistry, Organic Chemistry, ErbB Receptors, Enzyme, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Caco-2 Cells, Signal transduction, Tyrosine kinase, Neoplasm Transplantation
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8
المؤلفون: Brian E. Fink, Bindu Goyal, Marco M. Gottardis, Gregory D. Vite, Raj N. Misra, Dan You, Thomas E. Spires, Derek J. Norris, Wen-Ching Han, Matthew V. Lorenzi, Ashvinikumar V. Gavai, John S. Tokarski, S. David Kimball, Hai-Yun Xiao
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:1532-1536
مصطلحات موضوعية: Models, Molecular, endocrine system, 17-Hydroxysteroid Dehydrogenases, Molecular model, medicine.drug_class, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Dehydrogenase, Carboxamide, Biochemistry, Steroid, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Testosterone, Enzyme Inhibitors, Hydroxysteroid dehydrogenase, Molecular Biology, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, Androstenedione, Alkaline Phosphatase, Azocines, In vitro, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
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9
المؤلفون: Daniel G.M. Roberts, Wan F. Lau, Wen-Ching Han, Martin L. Ogletree, William A. Schumacher, Tammy C. Wang, James Lin, Edwin J. Iwanowicz, S. David Kimball, Steven M. Seiler
المصدر: Bioorganic & Medicinal Chemistry Letters. 12:3183-3186
مصطلحات موضوعية: Serine Proteinase Inhibitors, Clinical Biochemistry, Pharmaceutical Science, Peptide, Biochemistry, Catalysis, Mice, Structure-Activity Relationship, Thrombin, In vivo, Drug Discovery, medicine, Animals, Humans, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, Active site, Biological activity, In vitro, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Oligopeptides, circulatory and respiratory physiology, medicine.drug
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10
المؤلفون: Rawlins David B, Kevin R. Webster, Michael A. Poss, Chieh Ying Chang, Roberta Batorsky, Craig R. Fairchild, Toomas Mitt, Weifang Shan, Kristen A. Kellar, Hai Yun Xiao, John S. Tokarski, John T. Hunt, Francis Y. Lee, Janet G. Mulheron, Kyoung S. Kim, Nikola P. Pavletich, David Bol, Amrita Kamath, John S. Sack, Urvashi V. Roongta, Zhen Wei Cai, Isia Bursuker, Raj N. Misra, William G. Humphreys, Songfeng Lu, Wen Ching Han, Punit Marathe, S. David Kimball, Hong Zhu, Ligang Qian
المصدر: Journal of Medicinal Chemistry. 45:3905-3927
مصطلحات موضوعية: Male, Models, Molecular, Stereochemistry, Benzeneacetamides, Antineoplastic Agents, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Retinoblastoma Protein, Chemical synthesis, Histones, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Aminothiazole, Cyclin E, Drug Discovery, CDC2-CDC28 Kinases, Tumor Cells, Cultured, Animals, Combinatorial Chemistry Techniques, Humans, Structure–activity relationship, Enzyme Inhibitors, Phosphorylation, Protein kinase A, Oxazoles, Oxazole, Mice, Inbred BALB C, biology, Cell Cycle, Cyclin-Dependent Kinase 2, Cyclin-dependent kinase 2, Active site, DNA Polymerase I, Cyclin-Dependent Kinases, Thiazoles, chemistry, Mice, Inbred DBA, Enzyme inhibitor, biology.protein, Molecular Medicine, Female, Drug Screening Assays, Antitumor, Protein Binding